{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:13:19Z","timestamp":1776384799050,"version":"3.51.2"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360215"],"award-info":[{"award-number":["32360215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900652"],"award-info":[{"award-number":["81900652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jbc.2026.111202","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:14:09Z","timestamp":1769213649000},"page":"111202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl\u2212 currents in the early distal convoluted tubule of the mouse kidney"],"prefix":"10.1016","volume":"302","author":[{"given":"Lixia","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiwen","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.111202_bib1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/j.2040-4603.2019.tb00065.x","article-title":"Renal chloride channels in relation to sodium chloride transport","volume":"9","author":"Teulon","year":"2018","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1085\/jgp.200208737","article-title":"A chloride channel at the basolateral membrane of the distal-convoluted tubule: a candidate ClC-K channel","volume":"121","author":"Lourdel","year":"2003","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib3","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1113\/JP270043","article-title":"Discovery of CLC transport proteins: cloning, structure, function and pathophysiology","volume":"593","author":"Jentsch","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib4","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20171243","article-title":"Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney","volume":"38","author":"Nomura","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jbc.2026.111202_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1681\/ASN.2016010085","article-title":"The ClC-K2 chloride channel is critical for salt handling in the distal nephron","volume":"28","author":"Hennings","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jbc.2026.111202_bib6","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1073\/pnas.86.8.2863","article-title":"The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes","volume":"86","author":"Inoue","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111202_bib7","doi-asserted-by":"crossref","first-page":"F1208","DOI":"10.1152\/ajprenal.00280.2006","article-title":"Attenuated vasoconstrictor responses to endothelin in afferent arterioles during a high-salt diet","volume":"292","author":"Schneider","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib8","doi-asserted-by":"crossref","first-page":"F326","DOI":"10.1152\/ajprenal.2000.279.2.F326","article-title":"Endothelin inhibits thick ascending limb chloride flux via ET(B) receptor-mediated NO release","volume":"279","author":"Plato","year":"2000","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib9","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1161\/HYPERTENSIONAHA.107.108126","article-title":"Collecting duct-derived endothelin regulates arterial pressure and Na excretion via nitric oxide","volume":"51","author":"Schneider","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.jbc.2026.111202_bib10","doi-asserted-by":"crossref","first-page":"F1274","DOI":"10.1152\/ajprenal.00190.2006","article-title":"Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention","volume":"291","author":"Ge","year":"2006","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib11","doi-asserted-by":"crossref","first-page":"F144","DOI":"10.1152\/ajprenal.2001.281.1.F144","article-title":"Evidence for endothelin involvement in the response to high salt","volume":"281","author":"Pollock","year":"2001","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174445","article-title":"Effects of systemic and renal intramedullary endothelin-1 receptor blockade on tissue NO and intrarenal hemodynamics in normotensive and hypertensive rats","volume":"910","author":"B\u0105dzy\u0144ska","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jbc.2026.111202_bib13","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1113\/JP273610","article-title":"Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia","volume":"595","author":"Tokonami","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib14","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1369\/jhc.5A6888.2006","article-title":"Distribution of endothelin receptor subtypes ETA and ETB in the rat kidney","volume":"54","author":"Wendel","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.jbc.2026.111202_bib15","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1093\/ndt\/gfs457","article-title":"Parvalbumin: calcium and magnesium buffering in the distal nephron","volume":"27","author":"Olinger","year":"2012","journal-title":"Nephrol. Dial Transpl."},{"key":"10.1016\/j.jbc.2026.111202_bib16","doi-asserted-by":"crossref","first-page":"14849","DOI":"10.1073\/pnas.0702810104","article-title":"Renal expression of parvalbumin is critical for NaCl handling and response to diuretics","volume":"104","author":"Belge","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111202_bib17","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1172\/JCI116338","article-title":"Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells","volume":"91","author":"Hirata","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111202_bib18","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/01.HYP.37.2.516","article-title":"Role of endothelin B receptors in enhancing endothelium-dependent nitric oxide-mediated vascular relaxation during high salt diet","volume":"37","author":"Giardina","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.jbc.2026.111202_bib19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1055\/s-0038-1646177","article-title":"Nitric oxide-mediated vasorelaxation","volume":"70","author":"Ignarro","year":"1993","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.jbc.2026.111202_bib20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/01.RES.0000200178.34179.93","article-title":"Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO\/cGMP-dependent pathway","volume":"98","author":"Mongillo","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2026.111202_bib21","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2741\/1803","article-title":"Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase","volume":"11","author":"Lincoln","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jbc.2026.111202_bib22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev-physiol-012110-142247","article-title":"Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications","volume":"73","author":"Garvin","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2021.102796","article-title":"Endothelin B receptors impair baroreflex function and increase blood pressure variability during high salt diet","volume":"232","author":"Becker","year":"2021","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.jbc.2026.111202_bib24","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/hr.2009.112","article-title":"Inhibitory effect of ETB receptor on Na(+)-K(+) ATPase activity by extracellular Ca(2+) entry and Ca(2+) release from the endoplasmic reticulum in renal proximal tubule cells","volume":"32","author":"Liu","year":"2009","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.jbc.2026.111202_bib25","doi-asserted-by":"crossref","first-page":"F1315","DOI":"10.1152\/ajprenal.00450.2005","article-title":"Endothelin-1 stimulates NO production and inhibits cAMP accumulation in rat inner medullary collecting duct through independent pathways","volume":"290","author":"Stricklett","year":"2006","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib26","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1074\/jbc.M804322200","article-title":"Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production","volume":"284","author":"Herrera","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111202_bib27","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.kint.2020.05.050","article-title":"Low-dose L-NAME induces salt sensitivity associated with sustained increased blood volume and sodium-chloride cotransporter activity in rodents","volume":"98","author":"Wang","year":"2020","journal-title":"Kidney Int."},{"key":"10.1016\/j.jbc.2026.111202_bib28","doi-asserted-by":"crossref","first-page":"F755","DOI":"10.1152\/ajprenal.00270.2015","article-title":"Nitric oxide inhibits basolateral 10-pS Cl(-) channels through the cGMP\/PKG signaling pathway in the thick ascending limb of C57BL\/6 mice","volume":"310","author":"Wu","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0284707","article-title":"Inhibitory effect of S-nitroso-N-acetylpenicillamine on the basolateral 10-pS Cl- channel in thick ascending limb","volume":"18","author":"Ye","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2026.111202_bib30","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/S0021-9258(19)68134-2","article-title":"Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues","volume":"257","author":"Martins","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111202_bib31","first-page":"F543","article-title":"Chloride channels in apical membrane of primary cultures of rabbit distal bright convoluted tubule","volume":"266","author":"Poncet","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1113\/jphysiol.1995.sp020715","article-title":"A small-conductance Cl- channel in the mouse thick ascending limb that is activated by ATP and protein kinase A","volume":"485","author":"Guinamard","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib33","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/bbrc.1996.0877","article-title":"Regulation of chloride channel trafficking by cyclic AMP via protein kinase A-independent pathway in A6 renal epithelial cells","volume":"223","author":"Shintani","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2026.111202_bib34","doi-asserted-by":"crossref","first-page":"F877","DOI":"10.1152\/ajprenal.00449.2007","article-title":"cGMP decreases surface NKCC2 levels in the thick ascending limb: role of phosphodiesterase 2 (PDE2)","volume":"295","author":"Ares","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.2000.80.1.277","article-title":"Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy","volume":"80","author":"Reilly","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jbc.2026.111202_bib36","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1681\/ASN.0000000000000297","article-title":"Enriched single-nucleus RNA-sequencing reveals unique attributes of distal convoluted tubule cells","volume":"35","author":"Su","year":"2024","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jbc.2026.111202_bib37","doi-asserted-by":"crossref","first-page":"F1028","DOI":"10.1152\/ajprenal.0148.2001","article-title":"Localization of thiazide-sensitive Na(+)-Cl(-) cotransport and associated gene products in mouse DCT","volume":"281","author":"C\u00e2mpean","year":"2001","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib38","first-page":"422","article-title":"Mechanisms of sodium, potassium and chloride transport by the renal distal tubule","volume":"13","author":"Ellison","year":"1987","journal-title":"Miner Electrolyte Metab."},{"key":"10.1016\/j.jbc.2026.111202_bib39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/BF00585057","article-title":"Electrophysiological characterization of rabbit distal convoluted tubule cell","volume":"414","author":"Yoshitomi","year":"1989","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.jbc.2026.111202_bib40","doi-asserted-by":"crossref","first-page":"F534","DOI":"10.1152\/ajprenal.00284.2020","article-title":"Distal convoluted tubule Cl(-) concentration is modulated via K(+) channels and transporters","volume":"319","author":"Su","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jbc.2026.111202_bib41","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.kint.2017.10.023","article-title":"Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel","volume":"93","author":"Wang","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/j.jbc.2026.111202_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/MNH.0000000000000185","article-title":"Endothelin-1 and the kidney: new perspectives and recent findings","volume":"25","author":"De Miguel","year":"2016","journal-title":"Curr. Opin. Nephrol. Hypertens."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826000724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826000724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:34:40Z","timestamp":1776382480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826000724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0021925826000724"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111202","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl\u2212 currents in the early distal convoluted tubule of the mouse kidney","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"111202"}}