{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:54:22Z","timestamp":1792274062022,"version":"4.4.0"},"reference-count":162,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020668","name":"European Research Executive Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020655","name":"European Health and Digital Executive Agency","doi-asserted-by":"publisher","award":["101080229-2"],"award-info":[{"award-number":["101080229-2"]}],"id":[{"id":"10.13039\/100020655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000783","name":"Research Executive Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000783","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jbc.2026.111229","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:35:07Z","timestamp":1770136507000},"page":"111229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mechanisms of protein degradation in atrophying muscles: What have we learned during the past decade?"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-466X","authenticated-orcid":false,"given":"Shenhav","family":"Shemer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.111229_bib1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.cell.2010.07.011","article-title":"Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival","volume":"142","author":"Zhou","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.111229_bib2","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/s41467-017-01645-7","article-title":"Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival","volume":"8","author":"Segatto","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib3","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1038\/s41467-021-22842-5","article-title":"Direct contribution of skeletal muscle mesenchymal progenitors to bone repair","volume":"12","author":"Julien","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib4","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.cell.2021.02.047","article-title":"The molecular basis for sarcomere organization in vertebrate skeletal muscle","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.111229_bib5","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1083\/jcb.200901052","article-title":"During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation","volume":"185","author":"Cohen","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib6","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cmet.2007.09.009","article-title":"The E3 ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle","volume":"6","author":"Clarke","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2026.111229_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1083\/jcb.201110067","article-title":"Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy","volume":"198","author":"Cohen","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jmb.2005.09.068","article-title":"Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin","volume":"354","author":"Kudryashova","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib9","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.3390\/cells10081974","article-title":"UBE2L3, a partner of MuRF1\/TRIM63, is involved in the degradation of myofibrillar actin and myosin","volume":"10","author":"Peris-Moreno","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111229_bib10","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1096\/fj.11-180968","article-title":"Muscle actin is polyubiquitinylated in vitro and in vivo and targeted for breakdown by the E3 ligase MuRF1","volume":"25","author":"Polge","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.jbc.2026.111229_bib11","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1083\/jcb.201802018","article-title":"GSK3-\u03b2 promotes calpain-1-mediated desmin filament depolymerization and myofibril loss in atrophy","volume":"217","author":"Aweida","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1172\/JCI69253","article-title":"Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3?","volume":"124","author":"Kirk","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111229_bib13","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1111\/febs.15864","article-title":"New roles for desmin in maintenance of muscle homeostasis","volume":"289","author":"Agnetti","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.jbc.2026.111229_bib14","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202255175","article-title":"The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle","volume":"23","author":"Aweida","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/biom11010110","article-title":"Breakdown of filamentous myofibrils by the UPS-step by step","author":"Aweida","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jbc.2026.111229_bib16","first-page":"863","article-title":"Structure of the native myosin filament in the relaxed cardiac sarcomere","volume":"623","author":"Tamborrini","year":"2023","journal-title":"Nat. 2023"},{"key":"10.1016\/j.jbc.2026.111229_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107047","article-title":"Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target","volume":"26","author":"Baranowski","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.jbc.2026.111229_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-53886-y","article-title":"GSK3 inhibition improves skeletal muscle function and whole-body metabolism in male mouse models of Duchenne muscular dystrophy","volume":"15","author":"Marcella","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrd4467","article-title":"Muscle wasting in disease: molecular mechanisms and promising therapies","volume":"14","author":"Cohen","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jbc.2026.111229_bib20","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202113029","article-title":"Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation","volume":"154","author":"Ovejero","year":"2022","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib21","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302837120","article-title":"Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism","volume":"120","author":"Brunello","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111229_bib22","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2222005120","article-title":"In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells","volume":"120","author":"Chandler","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111229_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2416324122","article-title":"Dual-filament regulation of relaxation in mammalian fast skeletal muscle","volume":"122","author":"Hill","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111229_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41569-024-01063-5","article-title":"Functional control of myosin motors in the cardiac cycle","volume":"22","author":"Irving","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jbc.2026.111229_bib25","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1113\/jphysiol.2010.202044","article-title":"Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms","volume":"589","author":"Ochala","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61138","article-title":"The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function","volume":"10","author":"Clemens","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.jbc.2026.111229_bib27","article-title":"Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle","volume":"41","author":"D'Ercole","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115123","article-title":"Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS","volume":"44","author":"Ruggieri","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib29","doi-asserted-by":"crossref","first-page":"C1567","DOI":"10.1152\/ajpcell.00457.2023","article-title":"A critical discussion on the relationship between E3 ubiquitin ligases, protein degradation, and skeletal muscle wasting: it's not that simple","volume":"325","author":"Hughes","year":"2023","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib30","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.111229_bib31","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.251541198","article-title":"Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy","volume":"98","author":"Gomes","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111229_bib32","doi-asserted-by":"crossref","first-page":"C700","DOI":"10.1152\/ajpcell.00253.2020","article-title":"Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase","volume":"319","author":"Hughes","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100050","article-title":"Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2\u03b2","author":"Goodman","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jbc.2026.111229_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118788","article-title":"Role of calpains in promoting desmin filaments depolymerization and muscle atrophy","author":"Cohen","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.jbc.2026.111229_bib35","article-title":"Increased level of phosphorylated desmin and its degradation products in heart failure","author":"Bouvet","year":"2016","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib36","article-title":"Posttranslational modifications of desmin and their implication in biological processes and pathologies","author":"Winter","year":"2013","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib37","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00027.2017","article-title":"Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure","author":"Guichard","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib38","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1177\/153537020222701113","article-title":"Protein kinase C-mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart","volume":"227","author":"Huang","year":"2002","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.jbc.2026.111229_bib39","article-title":"Identification of the MuRF1 skeletal muscle ubiquitylome through quantitative proteomics","author":"Baehr","year":"2021","journal-title":"Function (Oxford, England)"},{"key":"10.1016\/j.jbc.2026.111229_bib40","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1083\/jcb.201304167","article-title":"Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation","volume":"204","author":"Cohen","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib41","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2200215119","article-title":"UBR2 targets myosin heavy chain IIb and IIx for degradation: molecular mechanism essential for cancer-induced muscle wasting","author":"Gao","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111229_bib42","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.celrep.2019.09.023","article-title":"HDAC4 controls muscle homeostasis through deacetylation of myosin heavy chain, PGC-1\u03b1, and Hsc70","volume":"29","author":"Luo","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/biom11060779","article-title":"Mechanisms that activate 26S proteasomes and enhance protein degradation","author":"Goldberg","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jbc.2026.111229_bib44","doi-asserted-by":"crossref","first-page":"C392","DOI":"10.1152\/ajpcell.00125.2016","article-title":"The ubiquitin proteasome system in atrophying skeletal muscle: roles and regulation","volume":"311","author":"Bilodeau","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib45","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.celrep.2018.03.136","article-title":"Skeletal muscle-specific methyltransferase METTL21C trimethylates p97 and regulates autophagy-associated protein breakdown","volume":"23","author":"Wiederstein","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib46","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.3390\/cells11203231","article-title":"The C-Terminus of the PSMA3 proteasome subunit preferentially traps intrinsically disordered proteins for degradation","volume":"11","author":"Biran","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111229_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82951.sa2","article-title":"Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function","author":"Molendijk","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.jbc.2026.111229_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36817-1","article-title":"MYTHO is a novel regulator of skeletal muscle autophagy and integrity","author":"Leduc-Gaudet","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI165814","article-title":"C16ORF70\/Mytho promotes healthy ageing in C. elegans and prevents cellular senescence in mammals","volume":"134","author":"Franco-Romero","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111229_bib50","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","article-title":"Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy","volume":"117","author":"Sandri","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.111229_bib51","article-title":"Proteasome gene expression is controlled by the coordinated functions of multiple transcription factors","author":"Gilda","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2026.111229_bib52","doi-asserted-by":"crossref","first-page":"E9550","DOI":"10.1073\/pnas.1809934115","article-title":"ZFAND5\/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation","volume":"115","author":"Lee","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111229_bib53","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2215095120","article-title":"A TGF-\u03b2\/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer","author":"Dasgupta","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111229_bib54","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.00701.2024","article-title":"Role of myofiber-specific FoxP1 in pancreatic cancer-induced muscle wasting","volume":"328","author":"Schonk","year":"2025","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib55","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202402810R","article-title":"Muscle-specific Keap1 deletion enhances force production but does not prevent inactivity-induced muscle atrophy in mice","author":"Miranda","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2026.111229_bib56","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1152\/japplphysiol.00452.2009","article-title":"Alterations of protein turnover underlying disuse atrophy in human skeletal muscle","volume":"107","author":"Phillips","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib57","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1113\/JP281071","article-title":"A deep analysis of the proteomic and phosphoproteomic alterations that occur in skeletal muscle after the onset of immobilization","volume":"599","author":"Lin","year":"2021","journal-title":"J. Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib58","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112344","article-title":"TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes","author":"Shetty","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2026.111229_bib59","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1128\/MCB.00983-10","article-title":"Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways","volume":"31","author":"Long","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/cells9091970","article-title":"Mechanisms of IGF-1-Mediated regulation of skeletal muscle hypertrophy and atrophy","author":"Yoshida","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111229_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3354","article-title":"MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling","author":"Yi","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.04.003","article-title":"The ubiquitin ligase CHIP integrates proteostasis and aging by regulation of insulin receptor turnover","author":"Tawo","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.111229_bib63","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948791","article-title":"USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation","author":"Goldbraikh","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib64","doi-asserted-by":"crossref","DOI":"10.1210\/en.2018-00290","article-title":"Knockout of USP19 deubiquitinating enzyme prevents muscle wasting by modulating insulin and glucocorticoid signaling","author":"Coyne","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbc.2026.111229_bib65","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.omto.2019.12.011","article-title":"Wnt7a counteracts cancer Cachexia","volume":"16","author":"Schmidt","year":"2020","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.jbc.2026.111229_bib66","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/ncb2404","article-title":"Wnt7a-Fzd7 signalling directly activates the Akt\/mTOR anabolic growth pathway in skeletal muscle","volume":"14","author":"von Maltzahn","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib67","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13395-024-00367-x","article-title":"Wnt7a is required for regeneration of dystrophic skeletal muscle","volume":"14","author":"Gurriaran-Rodriguez","year":"2024","journal-title":"Skeletal muscle"},{"key":"10.1016\/j.jbc.2026.111229_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-022-04097-y","article-title":"Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis","author":"Kaiser","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11227-4","article-title":"mTORC1 and PKB\/Akt control the muscle response to denervation by regulating autophagy and HDAC4","author":"Castets","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18140-1","article-title":"The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia","author":"Ham","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib71","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00141-19","article-title":"Partial inhibition of mTORC1 in aged rats counteracts the decline in muscle mass and reverses molecular signaling associated with sarcopenia","author":"Joseph","year":"2019","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib72","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201583R","article-title":"Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy","author":"Tomaz da Silva","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2026.111229_bib73","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/s41467-020-14895-9","article-title":"A signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size","volume":"11","author":"Eid Mutlak","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib74","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.908001","article-title":"Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes","volume":"15","author":"Fernandez","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2026.111229_bib75","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146415","article-title":"Insulin and IGF-1 receptors regulate complex I\u2013Dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle","author":"Bhardwaj","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111229_bib76","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13395-024-00366-y","article-title":"Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4)","volume":"14","author":"Sermersheim","year":"2024","journal-title":"Skeletal muscle"},{"key":"10.1016\/j.jbc.2026.111229_bib77","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00602.2025","article-title":"Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size","author":"Baehr","year":"2025","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib78","doi-asserted-by":"crossref","first-page":"C45","DOI":"10.1152\/ajpcell.00432.2020","article-title":"Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism","volume":"320","author":"Hughes","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113329","article-title":"PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors","author":"Kim","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib80","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1096\/fba.2020-00043","article-title":"TAK1 preserves skeletal muscle mass and mitochondrial function through redox homeostasis","volume":"2","author":"Roy","year":"2020","journal-title":"FASEB Bioadv."},{"key":"10.1016\/j.jbc.2026.111229_bib81","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay9592","article-title":"Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia","author":"Sartori","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jbc.2026.111229_bib82","doi-asserted-by":"crossref","DOI":"10.1186\/s13395-023-00329-9","article-title":"The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling","author":"Jaime","year":"2024","journal-title":"Skeletal Muscle"},{"key":"10.1016\/j.jbc.2026.111229_bib83","doi-asserted-by":"crossref","DOI":"10.1186\/s13395-025-00373-7","article-title":"ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice","author":"Egerman","year":"2025","journal-title":"Skeletal Muscle"},{"key":"10.1016\/j.jbc.2026.111229_bib84","first-page":"1512","volume":"13","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.jbc.2026.111229_bib85","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.molmed.2024.02.002","article-title":"Ectodysplasin A2 receptor signaling in skeletal muscle pathophysiology","volume":"30","author":"\u00d6zen","year":"2024","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jbc.2026.111229_bib86","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1111\/bph.15625","article-title":"Inhibition of heat shock protein (HSP) 90 reverses signal transducer and activator of transcription (STAT) 3-mediated muscle wasting in cancer cachexia mice","volume":"178","author":"Niu","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jbc.2026.111229_bib87","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2424046122","article-title":"Control of circadian muscle glucose metabolism through the BMAL1-HIF axis in obesity","volume":"122","author":"Chaikin","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111229_bib88","article-title":"Inflammation o'clock: interactions of circadian rhythms with inflammation-induced skeletal muscle atrophy","author":"Morena da Silva","year":"2023","journal-title":"J. Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108140","article-title":"The GSK-3\u03b2-FBXL21 axis contributes to circadian TCAP degradation and skeletal muscle function","author":"Wirianto","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167485","article-title":"Tcap deficiency impedes striated muscle function and heart regeneration with elevated ROS and autophagy","volume":"1870","author":"Zhao","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.jbc.2026.111229_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.992413","article-title":"Increasing plasma L-kynurenine impairs mitochondrial oxidative phosphorylation prior to the development of atrophy in murine skeletal muscle: a pilot study","volume":"13","author":"Palzkill","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib92","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1002\/jcsm.13220","article-title":"Evidence for inefficient contraction and abnormal mitochondrial activity in sarcopenia using magnetic resonance spectroscopy","volume":"14","author":"Stephenson","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jbc.2026.111229_bib93","article-title":"Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength","author":"Xu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib94","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153746","article-title":"Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia","author":"Wyart","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00018-025-05695-9","article-title":"Muscle mTOR controls iron homeostasis and ferritinophagy via NRF2, HIFs and AKT\/PKB signaling pathways","volume":"82","author":"Conjard-Duplany","year":"2025","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jbc.2026.111229_bib96","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10226-9","article-title":"DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass","author":"Favaro","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cmet.2024.10.021","article-title":"Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance","volume":"37","author":"Gherardi","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2026.111229_bib98","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s42255-024-00997-x","article-title":"Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia","volume":"6","author":"Membrez","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jbc.2026.111229_bib99","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100066R","article-title":"Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force","author":"Liu","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2026.111229_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2025.10.020","article-title":"NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging","author":"Chubanava","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2026.111229_bib101","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13135","article-title":"Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles","author":"Hinkley","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.jbc.2026.111229_bib102","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.00012.2025","article-title":"Human skeletal muscle disuse atrophy has profound and negative effects on the muscle metabolome and lipidome","author":"Kilroe","year":"2025","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jbc.2026.111229_bib103","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bbrc.2019.04.155","article-title":"Effect of skeletal muscle phenotype and gender on fasting-induced myokine expression in mice","volume":"514","author":"Jia","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib104","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgac173","article-title":"Skeletal muscle releases extracellular vesicles with distinct protein and microRNA signatures that function in the muscle microenvironment","volume":"1","author":"Watanabe","year":"2022","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.jbc.2026.111229_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25115715","article-title":"Inflammatory cytokine-induced muscle atrophy and weakness can be ameliorated by an inhibition of TGF-\u03b2-Activated Kinase-1","author":"Kanai","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.111229_bib106","doi-asserted-by":"crossref","first-page":"7908","DOI":"10.1126\/sciimmunol.adm7908","article-title":"Infection and chronic disease activate a systemic brain-muscle signaling axis","volume":"9","author":"Yang","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.jbc.2026.111229_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114925","article-title":"Muscle inflammation is regulated by NF-\u03baB from multiple cells to control distinct states of wasting in cancer cachexia","author":"Pryce","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib108","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.13668","article-title":"Local inflammation precedes diaphragm wasting and fibrotic remodelling in a mouse model of pancreatic cancer","author":"Neyroud","year":"2025","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jbc.2026.111229_bib109","doi-asserted-by":"crossref","first-page":"C1248","DOI":"10.1152\/ajpcell.00104.2009","article-title":"Smad2 and 3 transcription factors control muscle mass in adulthood","volume":"296","author":"Sartori","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib110","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/j.febslet.2010.04.039","article-title":"Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice","volume":"584","author":"Lipina","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2026.111229_bib111","doi-asserted-by":"crossref","DOI":"10.1172\/JCI135821","article-title":"Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs","author":"Solagna","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111229_bib112","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-30120-1","article-title":"The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy","author":"Graca","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib113","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s44318-024-00285-0","article-title":"FNDC1 is a myokine that promotes myogenesis and muscle regeneration","volume":"44","author":"Zhang","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2026.111229_bib114","doi-asserted-by":"crossref","first-page":"R674","DOI":"10.1152\/ajpregu.00104.2006","article-title":"IGF-1 is downregulated in experimental cancer cachexia","volume":"291","author":"Costelli","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib115","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/jcsm.12409","article-title":"Fibroblast growth factor 21 controls mitophagy and muscle mass","volume":"10","author":"Oost","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jbc.2026.111229_bib116","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqae004","article-title":"FGF21 induces skeletal muscle atrophy and increases amino acids in female mice: a potential role for glucocorticoids","volume":"165","author":"Larson","year":"2024","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbc.2026.111229_bib117","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","article-title":"Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states","volume":"5","author":"Badman","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2026.111229_bib118","doi-asserted-by":"crossref","first-page":"E326","DOI":"10.1152\/ajpendo.00311.2023","article-title":"Effects of interleukin-15 on autophagy regulation in the skeletal muscle of mice","volume":"326","author":"Tanaka","year":"2024","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jbc.2026.111229_bib119","article-title":"Liver-secreted Hexosaminidase A regulates insulin-like growth factor signalling and glucose transport in skeletal muscle","author":"Montgomery","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.jbc.2026.111229_bib120","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.stem.2016.09.010","article-title":"Myogenic Progenitor cells control extracellular matrix production by fibroblasts during skeletal muscle hypertrophy","volume":"20","author":"Fry","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jbc.2026.111229_bib121","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.stemcr.2018.01.023","article-title":"Exosome-mediated benefits of cell therapy in mouse and human models of Duchenne muscular dystrophy","volume":"10","author":"Aminzadeh","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib122","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1093\/hmg\/ddx252","article-title":"Autologous intramuscular transplantation of engineered satellite cells induces exosome-mediated systemic expression of Fukutin-related protein and rescues disease phenotype in a murine model of limb-girdle muscular dystrophy type 2I","volume":"26","author":"Frattini","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2026.111229_bib123","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/s43587-021-00143-2","article-title":"Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles","volume":"1","author":"Sahu","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.jbc.2026.111229_bib124","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.977617","article-title":"Extracellular vesicle-derived miRNAs improve stem cell-based therapeutic approaches in muscle wasting conditions","volume":"13","author":"Yedigaryan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2026.111229_bib125","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1093\/gerona\/gly207","article-title":"MicroRNAs in skeletal muscle aging: current issues and perspectives","volume":"74","author":"Jung","year":"2019","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.jbc.2026.111229_bib126","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1038\/s41467-022-30778-7","article-title":"Control of CRK-RAC1 activity by the miR-1\/206\/133 miRNA family is essential for neuromuscular junction function","volume":"13","author":"Klockner","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib127","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev-physiol-022516-034255","article-title":"Neuromuscular junction formation, aging, and disorders","volume":"80","author":"Li","year":"2018","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2025.112749","article-title":"The role of microRNAs in dexamethasone-induced skeletal muscle atrophy","volume":"205","author":"Ren","year":"2025","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jbc.2026.111229_bib129","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/jcsm.12578","article-title":"A subset of microRNAs in the Dlk1-Dio3 cluster regulates age-associated muscle atrophy by targeting Atrogin-1","volume":"11","author":"Shin","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jbc.2026.111229_bib130","doi-asserted-by":"crossref","first-page":"30335","DOI":"10.1073\/pnas.2016112117","article-title":"Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice","volume":"117","author":"Casta\u00f1o","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111229_bib131","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41556-022-00893-0","article-title":"Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis","volume":"24","author":"Yan","year":"2022","journal-title":"Nat Cell Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib132","article-title":"Lnc-mg is a long non-coding RNA that promotes myogenesis","author":"Zhu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib133","article-title":"LncRNA-MEG3 regulates muscle mass and metabolic homeostasis by facilitating SUZ12 liquid\u2013liquid phase separation","author":"Yao","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jbc.2026.111229_bib134","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbagrm.2015.05.007","article-title":"Architectural RNAs (arcRNAs): a class of long noncoding RNAs that function as the scaffold of nuclear bodies","volume":"1859","author":"Chujo","year":"2016","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"10.1016\/j.jbc.2026.111229_bib135","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/nar\/gkz007","article-title":"Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network","volume":"47","author":"Alessio","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111229_bib136","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.omtn.2020.12.003","article-title":"Long noncoding RNA SMUL suppresses SMURF2 production-mediated muscle atrophy via nonsense-mediated mRNA decay","volume":"23","author":"Cai","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.jbc.2026.111229_bib137","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/j.ymthe.2018.09.014","article-title":"Long noncoding RNA lncMUMA reverses established skeletal muscle atrophy following mechanical unloading","volume":"26","author":"Zhang","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jbc.2026.111229_bib138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22052558","article-title":"An analysis of differentially expressed coding and long non-coding rnas in multiple models of skeletal muscle atrophy","volume":"22","author":"Hitachi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.111229_bib139","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-023-00683-w","article-title":"Decreased expression of H19\/miR-675 ameliorates muscle atrophy by regulating the IGF1R\/Akt\/FoxO signaling pathway","author":"Zhang","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.jbc.2026.111229_bib140","article-title":"Upregulation of FAM129B protects against glucocorticoid-induced skeletal muscle atrophy via regulating long non-coding RNA NEAT1","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jbc.2026.111229_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2023.09.068","article-title":"Protein-coding potential of non-canonical open reading frames in human transcriptome","volume":"684","author":"Kore","year":"2023","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"10.1016\/j.jbc.2026.111229_bib142","doi-asserted-by":"crossref","DOI":"10.3390\/proteomes9010009","article-title":"The dystrophin node as integrator of cytoskeletal Organization, lateral force transmission, fiber stability and cellular signaling in skeletal muscle","author":"Dowling","year":"2021","journal-title":"Proteomes"},{"key":"10.1016\/j.jbc.2026.111229_bib143","doi-asserted-by":"crossref","DOI":"10.3390\/cells10010061","article-title":"Master regulators of muscle atrophy: role of costamere components","author":"Gorza","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111229_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2005.10.004","article-title":"Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia","author":"Acharyya","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbc.2026.111229_bib145","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgac086","article-title":"Signatures of muscle disuse in spaceflight and bed rest revealed by single muscle fiber proteomics","volume":"1","author":"Murgia","year":"2022","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.jbc.2026.111229_bib146","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.16145","article-title":"Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles","author":"Swiderski","year":"2024","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.jbc.2026.111229_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123343","article-title":"Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia","author":"Swiderski","year":"2025","journal-title":"Life Sci."},{"key":"10.1016\/j.jbc.2026.111229_bib148","doi-asserted-by":"crossref","first-page":"C956","DOI":"10.1152\/ajpcell.00513.2020","article-title":"Phosphorylation of ERK and dystrophin S3059 protects against inflammation-associated C2C12 myotube atrophy","volume":"320","author":"Swiderski","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib149","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1113\/JP271973","article-title":"Mechano-signalling pathways in an experimental intensive critical illness myopathy model","volume":"594","author":"Corpeno Kalamgi","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib150","doi-asserted-by":"crossref","first-page":"C768","DOI":"10.1152\/ajpcell.00444.2023","article-title":"The mechanosensitive gene arrestin domain containing 2 regulates myotube diameter with direct implications for disuse atrophy with aging","volume":"326","author":"Laskin","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111229_bib151","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1126\/scitranslmed.adh2156","article-title":"Lesion level-dependent systemic muscle wasting after spinal cord injury is mediated by glucocorticoid signaling in mice","volume":"15","author":"Harrigan","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jbc.2026.111229_bib152","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133276","article-title":"Glucocorticoids counteract hypertrophic effects of myostatin inhibition in dystrophic muscle","author":"Hammers","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbc.2026.111229_bib153","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1172\/JCI91445","article-title":"Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy","volume":"127","author":"Quattrocelli","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111229_bib154","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211906","article-title":"Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin","volume":"219","author":"Quattrocelli","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2026.111229_bib155","doi-asserted-by":"crossref","DOI":"10.1172\/JCI177427","article-title":"Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1\u03b1\/Lipin1 axis in an aging-related sarcopenia model","volume":"134","author":"Prabakaran","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111229_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.jse.2024.05.037","article-title":"Overexpression of PRDM16 improves muscle function after rotator cuff tears","author":"Zhang","year":"2024","journal-title":"J. Shoulder Elbow Surg."},{"key":"10.1016\/j.jbc.2026.111229_bib157","article-title":"Muscle-specific ERR\u03b3 activation mitigates muscle atrophy after ACL injury","author":"Lu","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2026.111229_bib158","doi-asserted-by":"crossref","DOI":"10.1186\/s13395-019-0214-1","article-title":"LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force","author":"Ferreira","year":"2019","journal-title":"Skeletal Muscle"},{"key":"10.1016\/j.jbc.2026.111229_bib159","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s42003-020-1056-4","article-title":"Pre-innervated tissue-engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss","volume":"3","author":"Das","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jbc.2026.111229_bib160","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.2106\/JBJS.24.01322","article-title":"Muscle-derived mitochondria as a novel therapy for muscle degeneration after rotator cuff tears","volume":"107","author":"Xu","year":"2025","journal-title":"J. Bone Joint Surg."},{"key":"10.1016\/j.jbc.2026.111229_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.101912","article-title":"Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition","author":"Ducommun","year":"2024","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jbc.2026.111229_bib162","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2319724121","article-title":"Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling","author":"Correia","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826000992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826000992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:15:33Z","timestamp":1776381333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826000992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":162,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0021925826000992"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111229","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of protein degradation in atrophying muscles: What have we learned during the past decade?","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111229","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"111229"}}