{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:18:06Z","timestamp":1789759086012,"version":"4.0.1"},"reference-count":110,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy, Government of India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014186","name":"Saha Institute of Nuclear Physics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014186","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jbc.2026.111274","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:21:33Z","timestamp":1770855693000},"page":"111274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Attenuated lamin A\u2013prohibitin2 interaction leads to mitochondrial dysfunction in LMNA 289 A>G\u2013mediated dilated cardiomyopathy"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2703-2822","authenticated-orcid":false,"given":"Subhradip","family":"Nath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasish","family":"Prusty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-7225","authenticated-orcid":false,"given":"Sk Ramiz","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-5576","authenticated-orcid":false,"given":"Soumen Kanti","family":"Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-8296","authenticated-orcid":false,"given":"Kaushik","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.111274_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/boc.202300094","article-title":"Lamin A K97E leads to NF-\u03baB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy","volume":"116","author":"Sengupta","year":"2024","journal-title":"Biol. Cell"},{"key":"10.1016\/j.jbc.2026.111274_bib2","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/j.cub.2014.07.001","article-title":"Matrix elasticity regulates Lamin-A,C phosphorylation and turnover with feedback to actomyosin","volume":"24","author":"Buxboim","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jbc.2026.111274_bib3","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.1240104","article-title":"Nuclear Lamin-A scales with tissue stiffness and enhances matrix-directed differentiation","volume":"341","author":"Swift","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.111274_bib4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/19491034.2018.1449498","article-title":"Laminopathy-causing lamin A mutations reconfigure lamina-associated domains and local spatial chromatin conformation","volume":"9","author":"Briand","year":"2018","journal-title":"Nucleus"},{"key":"10.1016\/j.jbc.2026.111274_bib5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4161\/nucl.2.3.16003","article-title":"Gene expression, chromosome position and lamin A\/C mutations","volume":"2","author":"Puckelwartz","year":"2011","journal-title":"Nucleus"},{"key":"10.1016\/j.jbc.2026.111274_bib6","first-page":"1","article-title":"Epigenetics in LMNA-related cardiomyopathy","volume":"12","author":"Wang","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111274_bib7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/emmm.201201553","article-title":"Alterations in cardiac DNA methylation in human dilated cardiomyopathy","volume":"5","author":"Haas","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jbc.2026.111274_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00395-012-0245-9","article-title":"Epigenetic modifications in cardiovascular disease","volume":"107","author":"Lorenzen","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.jbc.2026.111274_bib9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ijcard.2016.03.062","article-title":"The role of epigenetic modifications in cardiovascular disease: a systematic review","volume":"212","author":"Muka","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jbc.2026.111274_bib10","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/physrev.00047.2005","article-title":"Nuclear lamins: laminopathies and their role in premature ageing","volume":"86","author":"Broers","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jbc.2026.111274_bib11","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nrg1906","article-title":"Human laminopathies: nuclei gone genetically awry","volume":"7","author":"Capell","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jbc.2026.111274_bib12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCRESAHA.116.309396","article-title":"DCM: genetic determinants and mechanisms","volume":"121","author":"McNally","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2026.111274_bib13","first-page":"99","article-title":"Novel linkage of LMNA single nucleotide polymorphism with dilated cardiomyopathy in an Indian case study","volume":"7","author":"Banerjee","year":"2015","journal-title":"IJC Hear. Vasc."},{"key":"10.1016\/j.jbc.2026.111274_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mco2.772","article-title":"Cardiomyopathy: pathogenesis and therapeutic interventions","volume":"5","author":"Huang","year":"2024","journal-title":"MedComm."},{"key":"10.1016\/j.jbc.2026.111274_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111274_bib16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.molcel.2015.12.002","article-title":"TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions","volume":"61","author":"Mart\u00ednez-Reyes","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111274_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312740","article-title":"Role of fatty acids \u03b2-Oxidation in the metabolic interactions between organs","volume":"25","author":"Panov","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.111274_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41580-024-00785-1","article-title":"Molecular mechanisms of mitochondrial dynamics","volume":"26","author":"T\u00e1bara","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111274_bib19","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.bbabio.2012.02.033","article-title":"Bioenergetic role of mitochondrial fusion and fission","volume":"1817","author":"Westermann","year":"2012","journal-title":"Biochim. Biophys. Acta - Bioenerg."},{"key":"10.1016\/j.jbc.2026.111274_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.jbc.2026.111274_bib21","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1111\/j.1742-4658.2010.07809.x","article-title":"The role of prohibitin in cell signaling","volume":"277","author":"Mishra","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.jbc.2026.111274_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells8010071","article-title":"Prohibitins: a critical role in mitochondrial functions and implication in diseases","volume":"8","author":"Signorile","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111274_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41419-020-2374-7","article-title":"Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2026.111274_bib24","doi-asserted-by":"crossref","first-page":"12581","DOI":"10.1074\/jbc.RA119.007601","article-title":"In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way","volume":"294","author":"Li","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111274_bib25","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3390\/cells7120238","article-title":"Mitochondrial quality control mechanisms and the PHB (Prohibitin) complex","volume":"7","author":"Hernando-Rodr\u00edguez","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111274_bib26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/s12935-022-02765-x","article-title":"The function of prohibitins in mitochondria and the clinical potentials","volume":"22","author":"Oyang","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.jbc.2026.111274_bib27","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/jcp.24531","article-title":"Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway","volume":"229","author":"Chowdhury","year":"2014","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111274_bib28","doi-asserted-by":"crossref","first-page":"24834","DOI":"10.1074\/jbc.M312300200","article-title":"Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases","volume":"279","author":"Kurtev","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111274_bib29","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.1073\/pnas.96.12.6947","article-title":"An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens","volume":"96","author":"Montano","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jbc.2026.111274_bib30","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.jacbts.2024.05.011","article-title":"SIRT1 ameliorates Lamin A\/C deficiency-induced cardiac dysfunction by promoting mitochondrial bioenergetics","volume":"9","author":"Du","year":"2024","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.jbc.2026.111274_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0015167","article-title":"LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice","volume":"5","author":"Lu","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2026.111274_bib32","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/19491034.2015.1050568","article-title":"Sustained accumulation of prelamin A and depletion of Lamin A\/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates","volume":"6","author":"Sieprath","year":"2015","journal-title":"Nucleus"},{"key":"10.1016\/j.jbc.2026.111274_bib33","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0735-1097(02)01724-2","article-title":"Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A\/C defect-related disease","volume":"39","author":"Arbustini","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jbc.2026.111274_bib34","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1021\/bi400337t","article-title":"Structural alterations of Lamin A protein in dilated cardiomyopathy","volume":"52","author":"Bhattacharjee","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2026.111274_bib35","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1016\/j.bbagen.2017.08.016","article-title":"DCM associated LMNA mutations cause distortions in lamina structure and assembly","volume":"1861","author":"Bhattacharjee","year":"2017","journal-title":"Biochim. Biophys. Acta - Gen. Subj."},{"key":"10.1016\/j.jbc.2026.111274_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.1406459111","article-title":"Probing nuclear pore complex architecture with proximity-dependent biotinylation","volume":"111","author":"Kim","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jbc.2026.111274_bib37","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.201112098","article-title":"A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells","volume":"196","author":"Roux","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111274_bib38","doi-asserted-by":"crossref","first-page":"7886","DOI":"10.1038\/s41467-022-35639-x","article-title":"Actin-microtubule cytoskeletal interplay mediated by MRTF-A\/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations","volume":"13","author":"Le Dour","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111274_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2020.624216","article-title":"Mitochondrial function and dysfunction in dilated cardiomyopathy","volume":"8","author":"Ramaccini","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2026.111274_bib40","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1152\/ajpcell.00017.2014","article-title":"Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts","volume":"306","author":"Iqbal","year":"2014","journal-title":"Am. J. Physiol. - Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111274_bib41","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.chemosphere.2019.02.044","article-title":"Early mitochondrial fragmentation is a potential in vitro biomarker of environmental stress","volume":"223","author":"Perdiz","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.jbc.2026.111274_bib42","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1073\/pnas.0511154103","article-title":"Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology","volume":"103","author":"Yu","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jbc.2026.111274_bib43","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/s41592-021-01234-z","article-title":"Automated segmentation and tracking of mitochondria in live-cell time-lapse images","volume":"18","author":"Lefebvre","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2026.111274_bib44","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1111\/jcmm.17918","article-title":"OPA1, a molecular regulator of dilated cardiomyopathy","volume":"27","author":"Chen","year":"2023","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jbc.2026.111274_bib45","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3390\/genes14030566","article-title":"Reduced OPA1, mitochondrial fragmentation and increased susceptibility to apoptosis in granular corneal dystrophy type 2 corneal fibroblasts","volume":"14","author":"Choi","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.jbc.2026.111274_bib46","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/sj.cdd.4402145","article-title":"A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis","volume":"14","author":"Pellegrini","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jbc.2026.111274_bib47","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1083\/jcb.201709111","article-title":"INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division","volume":"217","author":"Chakrabarti","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111274_bib48","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41467-024-55758-x","article-title":"Mitochondria- and ER-associated actin are required for mitochondrial fusion","volume":"16","author":"Gatti","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111274_bib49","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41580-023-00613-y","article-title":"The multiple links between actin and mitochondria","volume":"24","author":"Fung","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111274_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2021.795838","article-title":"Regulation of mitochondrial function by the actin cytoskeleton","volume":"9","author":"Illescas","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2026.111274_bib51","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.3390\/antiox12122023","article-title":"Actin polymerization defects induce mitochondrial dysfunction in cellular models of nemaline myopathies","volume":"12","author":"Pi\u00f1ero-P\u00e9rez","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jbc.2026.111274_bib52","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1093\/hmg\/ddy215","article-title":"Cofilin-1 phosphorylation catalyzed by ERK1\/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by Lamin A\/C gene mutation","volume":"27","author":"Chatzifrangkeskou","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2026.111274_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaa8859","article-title":"ERK reinforces actin polymerization to power persistent edge protrusion during motility","volume":"8","author":"Mendoza","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jbc.2026.111274_bib54","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1152\/physrev.00026.2002","article-title":"Actin binding proteins: regulation of cytoskeletal microfilaments","volume":"83","author":"Dos Remedios","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jbc.2026.111274_bib55","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2018.0229","article-title":"Mechanotransduction: from the cell surface to the nucleus via RhoA","volume":"374","author":"Burridge","year":"2019","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.jbc.2026.111274_bib56","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3390\/cells9010132","article-title":"SUN1\/2 are essential for RhoA\/ROCK-Regulated actomyosin activity in isolated vascular smooth muscle cells","volume":"9","author":"Porter","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111274_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-01324-z","article-title":"Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1","volume":"7","author":"Schwartz","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2026.111274_bib58","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11010-009-0276-1","article-title":"Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts","volume":"335","author":"Hong","year":"2010","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.jbc.2026.111274_bib59","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1038\/onc.2009.299","article-title":"Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK\u2013ERK linkage","volume":"28","author":"Provenzano","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2026.111274_bib60","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1002\/jcp.23016","article-title":"RhoA\/ROCK, cytoskeletal dynamics, and focal adhesion kinase are required for mechanical stretch-induced tenogenic differentiation of human mesenchymal stem cells","volume":"227","author":"Xu","year":"2012","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.jbc.2026.111274_bib61","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3390\/biom11060824","article-title":"From the matrix to the nucleus and back: mechanobiology in the light of health, pathologies, and regeneration of oral periodontal tissues","volume":"11","author":"Dieterle","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jbc.2026.111274_bib62","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1083\/jcb.200906012","article-title":"Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation","volume":"188","author":"Pasapera","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111274_bib63","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1242\/jcs.03314","article-title":"A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions","volume":"120","author":"Zaidel-Bar","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jbc.2026.111274_bib64","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3390\/cancers13081871","article-title":"Inhibiting Fak\u2013paxillin interaction reduces migration and invadopodia-mediated matrix degradation in metastatic melanoma cells","volume":"13","author":"Mousson","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jbc.2026.111274_bib65","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.bbrc.2020.05.102","article-title":"Mutated Lamin A modulates stiffness in muscle cells","volume":"529","author":"Chatzifrangkeskou","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2026.111274_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122371","article-title":"Prohibitin 2: a key regulator of cell function","volume":"338","author":"Zhang","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.jbc.2026.111274_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26508\/lsa.202302091","article-title":"Mitochondrial membrane potential acts as a retrograde signal to regulate cell cycle progression","volume":"6","author":"Gorospe","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.jbc.2026.111274_bib68","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/cyto.a.20033","article-title":"Efficacy of MitoTracker GreenTM and CMXRosamine to measure changes in mitochondrial membrane potentials in living cells and tissues","volume":"61","author":"Pendergrass","year":"2004","journal-title":"Cytom A"},{"key":"10.1016\/j.jbc.2026.111274_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.102964","article-title":"Protocol for analyzing energy metabolic pathway dependency in human liver cancer cell lines","volume":"5","author":"Islam","year":"2024","journal-title":"STAR Protoc."},{"key":"10.1016\/j.jbc.2026.111274_bib70","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.96892.3","article-title":"Untargeted pixel-by-pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging","volume":"13","author":"Cheng","year":"2025","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.111274_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000282","article-title":"Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum","volume":"4","author":"Gieger","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jbc.2026.111274_bib72","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/ng.507","article-title":"A genome-wide perspective of genetic variation in human metabolism","volume":"42","author":"Illig","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2026.111274_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-13-120","article-title":"On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies","volume":"13","author":"Petersen","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jbc.2026.111274_bib74","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ng.837","article-title":"A genome-wide association study of metabolic traits in human urine","volume":"43","author":"Suhre","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2026.111274_bib75","first-page":"1","article-title":"Regulation of lipid metabolism by lamin in mutation-related diseases","volume":"13","author":"Peng","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jbc.2026.111274_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11306-016-0956-2","article-title":"A targeted metabolomics assay for cardiac metabolism and demonstration using a mouse model of dilated cardiomyopathy","volume":"12","author":"West","year":"2016","journal-title":"Metabolomics"},{"key":"10.1016\/j.jbc.2026.111274_bib77","first-page":"1","article-title":"The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry","volume":"6","author":"Liu","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.jbc.2026.111274_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep34648","article-title":"Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network","volume":"6","author":"Moriyama","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2026.111274_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-019-1131-1","article-title":"Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner","volume":"38","author":"Qin","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2026.111274_bib80","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1038\/s41467-023-40084-5","article-title":"Nuclear translocation of mitochondrial dehydrogenases as an adaptive cardioprotective mechanism","volume":"14","author":"Srivastava","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111274_bib81","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf615","article-title":"Liquid \u2013 liquid phase separation of Lamin drives altered chr omatin or ganization in cardiomyopathic mutations of Lamin A","volume":"53","author":"Nath","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111274_bib82","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/iub.1366","article-title":"Prohibitin 2: at a communications crossroads","volume":"67","author":"Bavelloni","year":"2015","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jbc.2026.111274_bib83","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2014.04.016","article-title":"DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling","volume":"20","author":"Richter-Dennerlein","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2026.111274_bib84","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad0116","article-title":"Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice","volume":"350","author":"Wai","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.111274_bib85","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/CIRCRESAHA.118.314238","article-title":"DNA damage Response\/TP53 pathway is activated and contributes to the pathogenesis of dilated cardiomyopathy associated with LMNA (Lamin A\/C) mutations","volume":"124","author":"Chen","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2026.111274_bib86","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3390\/cells12050757","article-title":"Elevated levels of lamin A promote HR and NHEJ-mediated repair mechanisms in high-grade ovarian serous carcinoma cell line","volume":"12","author":"Sengupta","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111274_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40104-025-01180-2","article-title":"ROS-DRP1-mediated excessive mitochondrial fission and autophagic flux inhibition contribute to heat stress-induced apoptosis in goat sertoli cells","volume":"16","author":"Wen","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.jbc.2026.111274_bib88","doi-asserted-by":"crossref","first-page":"D46","DOI":"10.1093\/nar\/gkac1067","article-title":"ChIPBase v3.0: the encyclopedia of transcriptional regulations of non-coding RNAs and protein-coding genes","volume":"51","author":"Huang","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111274_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-52129-1","article-title":"Actomyosin contractility scales with myoblast elongation and enhances differentiation through YAP nuclear export","volume":"9","author":"Bruy\u00e8re","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2026.111274_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-017-0792-x","article-title":"Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects","volume":"15","author":"Daveg\u00e5rdh","year":"2017","journal-title":"BMC Med."},{"key":"10.1016\/j.jbc.2026.111274_bib91","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1365-2362.2010.02441.x","article-title":"Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy","volume":"41","author":"Alexander","year":"2011","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111274_bib92","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000524722","article-title":"Metabolic and metabolomics insights into dilated cardiomyopathy","volume":"78","author":"Ampong","year":"2022","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.jbc.2026.111274_bib93","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s42255-023-00835-6","article-title":"Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition","volume":"5","author":"Morant-Ferrando","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jbc.2026.111274_bib94","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2337\/db11-1437","article-title":"Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes","volume":"61","author":"Rosca","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.jbc.2026.111274_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-019-1265-2","article-title":"Elevated level of mitochondrial reactive oxygen species via fatty acid \u03b2-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial-mesenchymal transition","volume":"10","author":"Wang","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jbc.2026.111274_bib96","first-page":"1","article-title":"Inosine enhances tumor mitochondrial respiration by inducing rag GTPases and nascent protein synthesis under nutrient starvation","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2026.111274_bib97","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cmet.2024.03.003","article-title":"Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity","volume":"36","author":"Tong","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2026.111274_bib98","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-biochem-060614-034115","article-title":"Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation","volume":"84","author":"Gruenbaum","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jbc.2026.111274_bib99","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-08495-0","article-title":"Clinical and metabolic consequences of a historic pathogenic Lamin A\/C founder variant","volume":"15","author":"Wong","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.jbc.2026.111274_bib100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083410","article-title":"Viscoelastic behavior of human lamin A proteins in the context of dilated cardiomyopathy","volume":"8","author":"Banerjee","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2026.111274_bib101","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1091\/mbc.E15-12-0844","article-title":"An improved smaller biotin ligase for BioID proximity labeling","volume":"27","author":"Kim","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jbc.2026.111274_bib102","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/bs.mie.2015.08.008","article-title":"BioID identification of lamin-associated proteins","volume":"569","author":"Mehus","year":"2016","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jbc.2026.111274_bib103","article-title":"Increased supraorganization of respiratory complexes is a dynamic multistep remodelling in response to proteostasis stress","volume":"133","author":"Rawat","year":"2021","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jbc.2026.111274_bib104","doi-asserted-by":"crossref","first-page":"32129","DOI":"10.1039\/D2RA05620H","article-title":"Slower diffusion and anomalous association of R453W lamin A protein alter nuclear architecture in AD-EDMD","volume":"12","author":"Mukherjee","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.jbc.2026.111274_bib105","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1038\/nprot.2007.459","article-title":"Detecting protein-protein interactions by far Western blotting","volume":"2","author":"Wu","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2026.111274_bib106","series-title":"The HADDOCK2.4 Web Server for Integrative Modeling of Biomolecular Complexes","author":"Honorato","year":"2024"},{"key":"10.1016\/j.jbc.2026.111274_bib107","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1039\/C7SM02214J","article-title":"Traction cytometry: regularization in the fourier approach and comparisons with finite element method","volume":"14","author":"Kulkarni","year":"2018","journal-title":"Soft Matter"},{"key":"10.1016\/j.jbc.2026.111274_bib108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/0471143030.cb1016s47","article-title":"Preparation of hydrogel substrates with tunable mechanical properties","volume":"47","author":"Tse","year":"2010","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111274_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11306-024-02096-0","article-title":"Identification of glucose-independent and reversible metabolic pathways associated with anti-proliferative effect of metformin in liver cancer cells","volume":"20","author":"Islam","year":"2024","journal-title":"Metabolomics"},{"key":"10.1016\/j.jbc.2026.111274_bib110","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.3390\/cancers15123158","article-title":"Integrating multi-omics analysis for enhanced diagnosis and treatment of glioblastoma: a comprehensive data-driven approach","volume":"15","author":"Barzegar Behrooz","year":"2023","journal-title":"Cancers (Basel)"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826001444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826001444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:29:03Z","timestamp":1776814143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826001444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":110,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0021925826001444"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111274","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Attenuated lamin A\u2013prohibitin2 interaction leads to mitochondrial dysfunction in LMNA 289 A>G\u2013mediated dilated cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111274","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"111274"}}