{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:45:35Z","timestamp":1777628735246,"version":"3.51.4"},"reference-count":103,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jbc.2026.111325","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T16:47:27Z","timestamp":1772038047000},"page":"111325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["HEXIM1\/P\u2013TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-1658","authenticated-orcid":false,"given":"Myo","family":"Htet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Estay-Olmos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-7093","authenticated-orcid":false,"given":"Yiyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4649-878X","authenticated-orcid":false,"given":"Brian E.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clorissa D.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aishwarya","family":"Rameshwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed R.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Hohman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4096-8601","authenticated-orcid":false,"given":"Vilas","family":"Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip L.","family":"De Jager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garrett A.","family":"Kaas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger J.","family":"Colbran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-1189","authenticated-orcid":false,"given":"Celeste B.","family":"Greer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.111325_bib1","article-title":"The regulation of transcription in memory consolidation","volume":"7","author":"Alberini","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jbc.2026.111325_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2019.107092","article-title":"Inhibition of transcription and translation in dorsal hippocampus does not interfere with consolidation of memory of intense training","volume":"166","author":"Medina","year":"2019","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.jbc.2026.111325_bib3","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0026-895X(25)13704-8","article-title":"Alpha-amanitin inhibition of mouse brain form II ribonucleic acid polymerase and passive avoidance retention","volume":"10","author":"Thut","year":"1974","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jbc.2026.111325_bib4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a005744","article-title":"Neuronal activity-regulated gene transcription in synapse development and cognitive function","volume":"3","author":"West","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jbc.2026.111325_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1034\/j.1601-183X.2003.00001.x","article-title":"Memory retrieval after contextual fear conditioning induces c-Fos and JunB expression in CA1 hippocampus","volume":"2","author":"Strekalova","year":"2003","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.jbc.2026.111325_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.nlm.2005.03.006","article-title":"Differential induction of c-Jun and fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks","volume":"84","author":"Teather","year":"2005","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.jbc.2026.111325_bib7","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1523\/JNEUROSCI.21-14-05089.2001","article-title":"Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268","volume":"21","author":"Guzowski","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2026.111325_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/nlme.2000.3967","article-title":"The genomic action potential","volume":"74","author":"Clayton","year":"2000","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.jbc.2026.111325_bib9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.55782\/ane-2000-1361","article-title":"Gene expression in learning processes","volume":"60","author":"Kaczmarek","year":"2000","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"key":"10.1016\/j.jbc.2026.111325_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102278","article-title":"Mild membrane depolarization in neurons induces immediate early gene transcription and acutely subdues responses to a successive stimulus","volume":"298","author":"Rienecker","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111325_bib11","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nn.2839","article-title":"Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II","volume":"14","author":"Saha","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2026.111325_bib12","doi-asserted-by":"crossref","first-page":"12335","DOI":"10.1074\/jbc.270.21.12335","article-title":"Purification of P-TEFb, a transcription factor required for the transition into productive elongation","volume":"270","author":"Marshall","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111325_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2022.12.006","article-title":"P-TEFb: the master regulator of transcription elongation","volume":"83","author":"Fujinaga","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111325_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.molcel.2005.06.027","article-title":"The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription","volume":"19","author":"Jang","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111325_bib15","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S1097-2765(03)00388-5","article-title":"Inhibition of P-TEFb (CDK9\/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA","volume":"12","author":"Yik","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111325_bib16","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1093\/nar\/gkn061","article-title":"LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated","volume":"36","author":"Krueger","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111325_bib17","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1101\/gad.1636008","article-title":"PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling","volume":"22","author":"Chen","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2026.111325_bib18","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/nar\/gkm063","article-title":"Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription","volume":"35","author":"Barboric","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111325_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0030076","article-title":"A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation","volume":"3","author":"Barboric","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2026.111325_bib20","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202318024","article-title":"HMBA ameliorates obesity by MYH9- and ACTG1-dependent regulation of hypothalamic neuropeptides","volume":"15","author":"Park","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jbc.2026.111325_bib21","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.4c00339","article-title":"Alzheimer's Disease: exploring the landscape of cognitive decline","author":"Tenchov","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jbc.2026.111325_bib22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer's disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111325_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12872","article-title":"Amyloid beta-induced elevation of O-GlcNAcylated c-Fos promotes neuronal cell death","volume":"18","author":"Choi","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.jbc.2026.111325_bib24","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.celrep.2019.06.073","article-title":"Integrating gene and protein expression reveals perturbed functional networks in Alzheimer's Disease","volume":"28","author":"Canchi","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111325_bib25","article-title":"'Arc'-hitecture of normal cognitive aging ageing","volume":"80","author":"Myrum","year":"2022","journal-title":"Res. Rev."},{"key":"10.1016\/j.jbc.2026.111325_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0197-4580(96)00206-0","article-title":"Effect of aging on the basal expression of c-Fos, c-Jun, and Egr-1 proteins in the hippocampus","volume":"18","author":"Desjardins","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jbc.2026.111325_bib27","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0197-4580(98)00077-3","article-title":"Quantitative neuronal c-fos and c-jun expression in Alzheimer's disease","volume":"19","author":"Marcus","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jbc.2026.111325_bib28","doi-asserted-by":"crossref","first-page":"9402","DOI":"10.1523\/JNEUROSCI.2154-10.2010","article-title":"beta-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1","volume":"30","author":"Espana","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2026.111325_bib29","article-title":"Evaluation of class IIa histone deacetylases expression and in vivo epigenetic imaging in a transgenic mouse model of Alzheimer's Disease","volume":"22","author":"Chen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.111325_bib30","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s11055-023-01342-7","article-title":"Effect of BRD4 Inhibitor on Cognitive Deficit and c-Fos\/BDNF level in rats with Alzheimer's Disease","volume":"53","author":"Faraji","year":"2023","journal-title":"Neurosci. Behav. Physiol."},{"key":"10.1016\/j.jbc.2026.111325_bib31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.phrs.2016.02.007","article-title":"The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice","volume":"106","author":"Leggio","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jbc.2026.111325_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.202","article-title":"The BET\/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice","volume":"7","author":"Benito","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jbc.2026.111325_bib33","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s11011-022-00940-7","article-title":"Effects of inhibiting astrocytes and BET\/BRD4 chromatin reader on spatial memory and synaptic proteins in rats with Alzheimer's disease","volume":"37","author":"Nikkar","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jbc.2026.111325_bib34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.brainresbull.2021.12.004","article-title":"Simultaneous administration of bromodomain and histone deacetylase I inhibitors alleviates cognition deficit in Alzheimer's model of rats","volume":"179","author":"Badrikoohi","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jbc.2026.111325_bib35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2174\/1567205013666160427101832","article-title":"The BET-Bromodomain inhibitor JQ1 reduces inflammation and tau phosphorylation at Ser396 in the brain of the 3xTg model of Alzheimer's Disease","volume":"13","author":"Magistri","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.jbc.2026.111325_bib36","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1038\/onc.2013.32","article-title":"HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade","volume":"32","author":"Kim","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2026.111325_bib37","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.celrep.2015.10.013","article-title":"Histone deacetylases positively regulate transcription through the elongation machinery","volume":"13","author":"Greer","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111325_bib38","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1093\/nar\/gkx1225","article-title":"Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers","volume":"46","author":"Sanchez","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111325_bib39","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1084\/jem.20180520","article-title":"HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies","volume":"215","author":"Marie","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2026.111325_bib40","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/npp.2009.197","article-title":"Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease","volume":"35","author":"Kilgore","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jbc.2026.111325_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110429","article-title":"Assessment of suberoylanilide hydroxamic acid on a Alzheimer's disease model induced by beta-amyloid((1-42)) in aged female mice: neuromodulatory and epigenetic effect","volume":"375","author":"Athaide Rocha","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jbc.2026.111325_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13195-020-00746-8","article-title":"Trichostatin A ameliorates Alzheimer's disease-related pathology and cognitive deficits by increasing albumin expression and Abeta clearance in APP\/PS1 mice","volume":"13","author":"Su","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.jbc.2026.111325_bib43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3233\/JAD-2009-1134","article-title":"Dysregulation of histone acetylation in the APP\/PS1 mouse model of Alzheimer's disease","volume":"18","author":"Francis","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jbc.2026.111325_bib44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pbb.2014.09.009","article-title":"Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils","volume":"126","author":"Wang","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jbc.2026.111325_bib45","doi-asserted-by":"crossref","first-page":"9918","DOI":"10.1074\/jbc.M113.539015","article-title":"Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription","volume":"289","author":"Liu","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111325_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2018.142","article-title":"A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research","volume":"5","author":"De Jager","year":"2018","journal-title":"Sci. Data"},{"key":"10.1016\/j.jbc.2026.111325_bib47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000087446","article-title":"The Rush memory and aging Project: study design and baseline characteristics of the study cohort","volume":"25","author":"Bennett","year":"2005","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.jbc.2026.111325_bib48","doi-asserted-by":"crossref","first-page":"16360","DOI":"10.1074\/jbc.M500424200","article-title":"HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK","volume":"280","author":"Byers","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111325_bib49","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.neuron.2010.04.038","article-title":"Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex","volume":"66","author":"Cubelos","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2026.111325_bib50","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.bbrc.2019.11.004","article-title":"Cux2 expression regulated by Lhx2 in the upper layer neurons of the developing cortex","volume":"521","author":"Yang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2026.111325_bib51","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41586-024-07871-6","article-title":"Cellular communities reveal trajectories of brain ageing and Alzheimer's disease","volume":"633","author":"Green","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111325_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-024-07606-7","article-title":"Single-cell multiregion dissection of Alzheimer's disease","author":"Mathys","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111325_bib53","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1016\/j.celrep.2016.08.004","article-title":"Tcf4 regulates synaptic plasticity, DNA methylation, and memory function","volume":"16","author":"Kennedy","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111325_bib54","doi-asserted-by":"crossref","DOI":"10.1177\/1759091420974807","article-title":"Merits and limitations of studying neuronal depolarization-dependent processes using elevated external potassium","volume":"12","author":"Rienecker","year":"2020","journal-title":"ASN Neuro"},{"key":"10.1016\/j.jbc.2026.111325_bib55","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/CIRCRESAHA.107.157859","article-title":"Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor","volume":"102","author":"Montano","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2026.111325_bib56","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1038\/onc.2010.110","article-title":"HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland","volume":"29","author":"Ogba","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2026.111325_bib57","doi-asserted-by":"crossref","first-page":"9160","DOI":"10.1093\/nar\/gks682","article-title":"PKC phosphorylates HEXIM1 and regulates P-TEFb activity","volume":"40","author":"Fujinaga","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111325_bib58","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1128\/MCB.00975-07","article-title":"The transcription-dependent dissociation of P-TEFb-HEXIM1-7SK RNA relies upon formation of hnRNP-7SK RNA complexes","volume":"27","author":"Barrandon","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111325_bib59","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.chembiol.2010.07.012","article-title":"Halogen bonds form the basis for selective P-TEFb inhibition by DRB","volume":"17","author":"Baumli","year":"2010","journal-title":"Chem. Biol."},{"key":"10.1016\/j.jbc.2026.111325_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.579658","article-title":"Cyclin-Dependent kinase 9 (CDK9) inhibitor Atuveciclib suppresses intervertebral disk degeneration via the inhibition of the NF-kappaB signaling pathway","volume":"8","author":"Ni","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2026.111325_bib61","article-title":"Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism","volume":"4","author":"Lu","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.111325_bib62","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s10637-019-00868-3","article-title":"Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models","volume":"38","author":"Wang","year":"2020","journal-title":"Invest New Drugs"},{"key":"10.1016\/j.jbc.2026.111325_bib63","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41398-021-01618-x","article-title":"Adult brain neurons require continual expression of the schizophrenia-risk gene Tcf4 for structural and functional integrity","volume":"11","author":"Sarkar","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jbc.2026.111325_bib64","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gene.2005.01.015","article-title":"Characterization of Cdk9(55) and differential regulation of two Cdk9 isoforms","volume":"350","author":"Shore","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.jbc.2026.111325_bib65","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/nar\/gkab1228","article-title":"Disrupting the Cdk9\/Cyclin T1 heterodimer of 7SK snRNP for the Brd4 and AFF1\/4 guided reconstitution of active P-TEFb","volume":"50","author":"Zhou","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111325_bib66","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1371\/journal.ppat.0030146","article-title":"HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K\/Akt and activates HIV transcription","volume":"3","author":"Contreras","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2026.111325_bib67","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jsbmb.2017.02.008","article-title":"HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen","volume":"168","author":"Lama","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jbc.2026.111325_bib68","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13058-019-1228-7","article-title":"Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells","volume":"21","author":"Montano","year":"2019","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.jbc.2026.111325_bib69","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/s41588-025-02138-w","article-title":"An eRNA transcription checkpoint for diverse signal-dependent enhancer activation programs","volume":"57","author":"Wang","year":"2025","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2026.111325_bib70","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1038\/sj.emboj.7600275","article-title":"Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9\/cyclin T) inhibitor","volume":"23","author":"Michels","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2026.111325_bib71","doi-asserted-by":"crossref","first-page":"31793","DOI":"10.1074\/jbc.M102306200","article-title":"Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo","volume":"276","author":"Chao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111325_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108306","article-title":"BET bromodomains as novel epigenetic targets for brain health and disease","volume":"181","author":"Singh","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jbc.2026.111325_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49032-0","article-title":"de novo MEPCE nonsense variant associated with a neurodevelopmental disorder causes disintegration of 7SK snRNP and enhanced RNA polymerase II activation","volume":"9","author":"Schneeberger","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2026.111325_bib74","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/humu.22175","article-title":"Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism","volume":"33","author":"Alazami","year":"2012","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.jbc.2026.111325_bib75","doi-asserted-by":"crossref","DOI":"10.4172\/2161-0460.1000460","article-title":"Identification and analysis of alzheimer's candidate genes by an amplitude deviation algorithm","volume":"9","author":"Pang","year":"2019","journal-title":"J. Alzheimers Dis. Parkinsonism"},{"key":"10.1016\/j.jbc.2026.111325_bib76","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1523\/JNEUROSCI.20-11-03993.2000","article-title":"Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory","volume":"20","author":"Guzowski","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2026.111325_bib77","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.nlm.2014.12.013","article-title":"Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice","volume":"119","author":"Zalcman","year":"2015","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.jbc.2026.111325_bib78","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.1523\/JNEUROSCI.23-27-09116.2003","article-title":"Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS","volume":"23","author":"Fleischmann","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2026.111325_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12091","article-title":"Extra-coding RNAs regulate neuronal DNA methylation dynamics","volume":"7","author":"Savell","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111325_bib80","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1101\/lm.3.5.402","article-title":"Suppression of c-fos induction in rat brain impairs retention of a brightness discrimination reaction","volume":"3","author":"Grimm","year":"1997","journal-title":"Learn Mem."},{"key":"10.1016\/j.jbc.2026.111325_bib81","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainres.2009.10.049","article-title":"Temporal gene expression profile of the hippocampus following trace fear conditioning","volume":"1308","author":"Sirri","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.jbc.2026.111325_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003699","article-title":"Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories","volume":"9","author":"Crepaldi","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jbc.2026.111325_bib83","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1101\/lm.045112.117","article-title":"Experience-dependent epigenomic reorganization in the hippocampus","volume":"24","author":"Duke","year":"2017","journal-title":"Learn Mem."},{"key":"10.1016\/j.jbc.2026.111325_bib84","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12929-025-01128-8","article-title":"Beyond vessels: unraveling the impact of VEGFs on neuronal functions and structure","volume":"32","author":"Aksan","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jbc.2026.111325_bib85","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-18368-w","article-title":"Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition","volume":"7","author":"Dey","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2026.111325_bib86","doi-asserted-by":"crossref","first-page":"12721","DOI":"10.1073\/pnas.1612331113","article-title":"An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb","volume":"113","author":"Kobbi","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111325_bib87","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1073\/pnas.0505519103","article-title":"Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons","volume":"103","author":"Guzowski","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111325_bib88","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0166-4328(02)00270-X","article-title":"Massed but not spaced training impairs spatial memory","volume":"139","author":"Commins","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jbc.2026.111325_bib89","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2120717119","article-title":"The neural substrate of spatial memory stabilization depends on the distribution of the training sessions","volume":"119","author":"Mastrorilli","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111325_bib90","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature17955","article-title":"A shared neural ensemble links distinct contextual memories encoded close in time","volume":"534","author":"Cai","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111325_bib91","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fnhum.2019.00315","article-title":"Human memories can be linked by temporal proximity","volume":"13","author":"Yetton","year":"2019","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.jbc.2026.111325_bib92","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semcdb.2017.09.006","article-title":"Arc protein: a flexible hub for synaptic plasticity and cognition","volume":"77","author":"Nikolaienko","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2026.111325_bib93","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-179939","article-title":"Religious orders Study and rush memory and aging Project","volume":"64","author":"Bennett","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jbc.2026.111325_bib94","article-title":"Association of ten VEGF family genes with Alzheimer's disease endophenotypes at single cell resolution","volume":"21","author":"Wu","year":"2025","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jbc.2026.111325_bib95","doi-asserted-by":"crossref","first-page":"628","DOI":"10.2174\/156720512801322573","article-title":"Overview and findings from the religious orders study","volume":"9","author":"Bennett","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.jbc.2026.111325_bib96","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2174\/156720512801322663","article-title":"Overview and findings from the rush memory and aging Project","volume":"9","author":"Bennett","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.jbc.2026.111325_bib97","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neurobiolaging.2023.01.010","article-title":"Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer's disease","volume":"126","author":"Seto","year":"2023","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jbc.2026.111325_bib98","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111325_bib99","first-page":"S1","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer's Disease","volume":"18","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jbc.2026.111325_bib100","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2026.111325_bib101","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf018","article-title":"edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets","volume":"53","author":"Chen","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111325_bib102","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jbc.2026.111325_bib103","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molcel.2016.03.013","article-title":"Stress from nucleotide depletion activates the transcriptional regulator HEXIM1 to suppress melanoma","volume":"62","author":"Tan","year":"2016","journal-title":"Mol. Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582600195X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582600195X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:56:50Z","timestamp":1777427810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582600195X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":103,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S002192582600195X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111325","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HEXIM1\/P\u2013TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111325","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"111325"}}