{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:49:24Z","timestamp":1789616964213,"version":"build-2803163510"},"reference-count":98,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jbc.2026.111343","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:19:24Z","timestamp":1772641164000},"page":"111343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeting the Golgi apparatus enhances PD-L1 blockade and synergizes with oxaliplatin to improve immunotherapy efficacy"],"prefix":"10.1016","volume":"302","author":[{"given":"Haohuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxue","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanli","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-7684","authenticated-orcid":false,"given":"Mingzhou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.111343_bib1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41423-020-0488-6","article-title":"The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications","volume":"17","author":"Zhang","year":"2020","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.jbc.2026.111343_bib2","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1172\/JCI80011","article-title":"Anti-PD-1\/PD-L1 therapy of human cancer: past, present, and future","volume":"125","author":"Chen","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111343_bib3","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13045-017-0541-9","article-title":"Recent development in clinical applications of PD-1 and PD-L1 antibodies for cancer immunotherapy","volume":"10","author":"Liu","year":"2017","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jbc.2026.111343_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217498","article-title":"Regulation of PD-L1 glycosylation and advances in cancer immunotherapy","volume":"612","author":"Lee","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jbc.2026.111343_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202400340","article-title":"Zosuquidar promotes antitumor immunity by inducing autophagic degradation of PD-L1","volume":"11","author":"Ding","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jbc.2026.111343_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176831","article-title":"Novel insights into the regulation of exosomal PD-L1 in cancer: from generation to clinical application","volume":"979","author":"Liu","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jbc.2026.111343_bib7","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1038\/s41467-023-42661-0","article-title":"A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111343_bib8","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","article-title":"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response","volume":"560","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111343_bib9","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41422-018-0060-4","article-title":"Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.jbc.2026.111343_bib10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ccell.2019.06.008","article-title":"Removal of N-Linked glycosylation enhances PD-L1 detection and predicts Anti-PD-1\/PD-L1 therapeutic efficacy","volume":"36","author":"Lee","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbc.2026.111343_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-022-01280-9","article-title":"Structural insights into substrate recognition and translocation of human peroxisomal ABC transporter ALDP","volume":"8","author":"Xiong","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.jbc.2026.111343_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108707","article-title":"The efficacy of PD-1\/PD-L1 blockade in cold cancers and future perspectives","volume":"226","author":"Majidpoor","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jbc.2026.111343_bib13","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.gendis.2018.05.003","article-title":"Immunogenic effects of chemotherapy-induced tumor cell death","volume":"5","author":"Wang","year":"2018","journal-title":"Genes Dis."},{"key":"10.1016\/j.jbc.2026.111343_bib14","doi-asserted-by":"crossref","first-page":"11760","DOI":"10.1002\/anie.201506225","article-title":"Blocking of the PD-1\/PD-L1 interaction by a D-Peptide antagonist for cancer immunotherapy","volume":"54","author":"Chang","year":"2015","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.jbc.2026.111343_bib15","doi-asserted-by":"crossref","first-page":"9386","DOI":"10.1021\/acsnano.9b04166","article-title":"Chondroitin sulfate-linked prodrug nanoparticles target the Golgi apparatus for cancer metastasis treatment","volume":"13","author":"Li","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jbc.2026.111343_bib16","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.addr.2007.06.006","article-title":"Alternate routes for drug delivery to the cell interior: pathways to the Golgi apparatus and endoplasmic reticulum","volume":"59","author":"Tarrag\u00f3-Trani","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jbc.2026.111343_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41421-024-00722-8","article-title":"Structural insights into Human ABCD3-mediated peroxisomal Acyl-CoA translocation","volume":"10","author":"Li","year":"2024","journal-title":"Cell Discov"},{"key":"10.1016\/j.jbc.2026.111343_bib18","doi-asserted-by":"crossref","first-page":"10637","DOI":"10.1021\/acsnano.3c01733","article-title":"In situ sprayed nanovaccine suppressing exosomal PD-L1 by Golgi apparatus disorganization for postsurgical melanoma immunotherapy","volume":"17","author":"Ye","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jbc.2026.111343_bib19","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.pan.2023.10.008","article-title":"Protein expression and localization of ABC transporters in pancreatic adenocarcinoma: prognostic role of ABCC8","volume":"23","author":"Cervenkova","year":"2023","journal-title":"Pancreatology"},{"key":"10.1016\/j.jbc.2026.111343_bib20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/17425255.2021.1887139","article-title":"The role of non-coding RNAs in ABC transporters regulation and their clinical implications of multidrug resistance in cancer","volume":"17","author":"Wang","year":"2021","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.jbc.2026.111343_bib21","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.vaccine.2011.12.105","article-title":"Impaired production of TNF-\u03b1 by dendritic cells of older adults leads to a lower CD8+ T cell response against influenza","volume":"30","author":"Liu","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jbc.2026.111343_bib22","doi-asserted-by":"crossref","first-page":"8576","DOI":"10.4049\/jimmunol.181.12.8576","article-title":"IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17","volume":"181","author":"Henry","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2026.111343_bib23","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1158\/2326-6066.CIR-19-0228","article-title":"Trifluridine\/Tipiracil plus oxaliplatin improves PD-1 blockade in colorectal cancer by inducing immunogenic cell death and depleting macrophages","volume":"7","author":"Limagne","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.jbc.2026.111343_bib24","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260577","article-title":"Vimentin intermediate filaments provide structural stability to the mammalian Golgi complex","volume":"136","author":"Vitali","year":"2023","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jbc.2026.111343_bib25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1158\/2326-6066.CIR-24-0103","article-title":"Selective STING activation in intratumoral myeloid cells via CCR2-directed antibody\u2013drug conjugate TAK-500","volume":"13","author":"Appleman","year":"2025","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.jbc.2026.111343_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2025.189279","article-title":"Epithelial-mesenchymal transition in cancer: a focus on itraconazole, a hedgehog inhibitor","volume":"1880","author":"Kulkarni","year":"2025","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.jbc.2026.111343_bib27","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1038\/s41467-023-40024-3","article-title":"Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer","volume":"14","author":"Babic","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111343_bib28","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1111\/cas.15569","article-title":"Pentraxin 3 is an adipose tissue-related serum marker for pancreatic cancer cachexia predicting subsequent muscle mass and visceral fat loss","volume":"113","author":"Sato","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.jbc.2026.111343_bib29","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.cell.2018.08.027","article-title":"The multifaceted role of chromosomal instability in cancer and its microenvironment","volume":"174","author":"Bakhoum","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.111343_bib30","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.immuni.2013.03.003","article-title":"Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells","volume":"38","author":"Ma","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2026.111343_bib31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41568-018-0056-x","article-title":"Stem cell fate in cancer growth, progression and therapy resistance","volume":"18","author":"Lytle","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbc.2026.111343_bib32","first-page":"3680","article-title":"Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability","volume":"351","author":"Pattabiraman","year":"2016","journal-title":"Sci. 2016"},{"key":"10.1016\/j.jbc.2026.111343_bib33","article-title":"Mapping single-cell developmental potential in health and disease with interpretable deep learning","author":"Kang","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2026.111343_bib34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.aaa8172","article-title":"The future of immune checkpoint therapy","volume":"348","author":"Sharma","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.111343_bib35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s43018-023-00521-2","article-title":"CD4+ T cells in cancer","volume":"4","author":"Speiser","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.jbc.2026.111343_bib36","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.cell.2015.10.054","article-title":"SnapShot: t cell exhaustion","volume":"163","author":"Pauken","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.111343_bib37","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2026.111343_bib38","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jconrel.2023.10.049","article-title":"Implications of biological clocks in pharmacology and pharmacokinetics of antitumor drugs","volume":"364","author":"Ohdo","year":"2023","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.jbc.2026.111343_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114045","article-title":"Circadian rhythm in pharmacokinetics and its relevance to chronotherapy","volume":"178","author":"Dong","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jbc.2026.111343_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb0738","article-title":"Clocks, cancer, and chronochemotherapy","volume":"371","author":"Sancar","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.111343_bib41","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/bioinformatics\/btw405","article-title":"MetaCycle: an integrated R package to evaluate periodicity in large scale data","volume":"32","author":"Wu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2026.111343_bib42","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cmet.2022.12.006","article-title":"Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals","volume":"35","author":"Deota","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2026.111343_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105251","article-title":"Preservation of circadian rhythm in hepatocellular cancer","volume":"299","author":"Yang","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111343_bib44","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12724","article-title":"Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model","volume":"70","author":"Hassan","year":"2021","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.jbc.2026.111343_bib45","first-page":"4777","article-title":"Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues","volume":"115","author":"Yang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111343_bib46","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1073\/pnas.0915085107","article-title":"Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase","volume":"107","author":"Kang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111343_bib47","doi-asserted-by":"crossref","first-page":"11960","DOI":"10.1074\/jbc.RA119.009579","article-title":"Long-term, genome-wide kinetic analysis of the effect of the circadian clock and transcription on the repair of cisplatin-DNA adducts in the mouse liver","volume":"294","author":"Yang","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111343_bib48","doi-asserted-by":"crossref","first-page":"11897","DOI":"10.2147\/CMAR.S278903","article-title":"Circadian clock protein period2 suppresses the pi3k\/akt pathway and promotes cisplatin sensitivity in ovarian cancer","volume":"12","author":"Wang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.jbc.2026.111343_bib49","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1074\/jbc.RA118.004942","article-title":"Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene","volume":"294","author":"Katamune","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111343_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201900667","article-title":"Periodic oxaliplatin administration in synergy with PER2-mediated PCNA transcription repression promotes chronochemotherapeutic efficacy of OSCC","volume":"6","author":"Tang","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jbc.2026.111343_bib51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-3-642-25950-0_11","article-title":"Cancer chronotherapeutics: experimental, theoretical, and clinical aspects","volume":"217","author":"Ortiz-Tudela","year":"2013","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.jbc.2026.111343_bib52","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.molmed.2016.03.004","article-title":"Dosing-time makes the poison: circadian regulation and pharmacotherapy","volume":"22","author":"Dallmann","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jbc.2026.111343_bib53","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1158\/1078-0432.CCR-13-2781","article-title":"Combinatorial immunotherapy of polyinosinic-polycytidylic acid and blockade of programmed death-ligand 1 induce effective CD8 t-cell responses against established tumors","volume":"20","author":"Nagato","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2026.111343_bib54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cellsig.2018.03.010","article-title":"A novel regulatory function of CDKN1A\/p21 in TNF\u03b1-induced matrix metalloproteinase 9-dependent migration and invasion of triple-negative breast cancer cells","volume":"47","author":"Zaremba-Czogalla","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.jbc.2026.111343_bib55","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1515\/med-2022-0597","article-title":"EphA3 targeted by miR-3666 contributes to melanoma malignancy via activating ERK1\/2 and p38 MAPK pathways","volume":"17","author":"Ming","year":"2022","journal-title":"Open Med."},{"key":"10.1016\/j.jbc.2026.111343_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1464852","article-title":"Transcription factor MEF2D regulates aberrant expression of ACSL3 and enhances sorafenib resistance by inhibiting ferroptosis in HCC","volume":"15","author":"Li","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jbc.2026.111343_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113586","article-title":"Sphingolipid paracrine signaling impairs keratinocyte adhesion to promote melanoma invasion","volume":"42","author":"Noujar\u00e8de","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.jbc.2026.111343_bib58","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1002\/1878-0261.12828","article-title":"TGFBI modulates tumour hypoxia and promotes breast cancer metastasis","volume":"14","author":"Fico","year":"2020","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.jbc.2026.111343_bib59","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/fsn3.1439","article-title":"Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9","volume":"8","author":"Pai","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.jbc.2026.111343_bib60","first-page":"2791","article-title":"Expression of MMP-10 in lung cancer","volume":"27","author":"Zhang","year":"2007","journal-title":"Anticancer Res."},{"key":"10.1016\/j.jbc.2026.111343_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100907","article-title":"Research progress of therapeutic effects and drug resistance of immunotherapy based on PD-1\/PD-L1 blockade","volume":"66","author":"Pang","year":"2023","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.jbc.2026.111343_bib62","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.colsurfa.2018.11.055","article-title":"Phase-transfer method synthesis hydroxyethyl cellulose lauryl ether","volume":"562","author":"Wang","year":"2019","journal-title":"Colloid Surf. A"},{"key":"10.1016\/j.jbc.2026.111343_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.enzmictec.2016.04.004","article-title":"Enzymatic modification of polysaccharides: mechanisms, properties, and potential applications: a review","volume":"90","author":"Karaki","year":"2016","journal-title":"Enzyme Microb. Technol."},{"key":"10.1016\/j.jbc.2026.111343_bib64","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.tips.2018.06.003","article-title":"MMP-responsive 'smart' drug delivery and tumor targeting","volume":"39","author":"Yao","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jbc.2026.111343_bib65","doi-asserted-by":"crossref","first-page":"979","DOI":"10.12688\/f1000research.73600.1","article-title":"Doublet identification in single-cell sequencing data using scDblFinder","volume":"10","author":"Germain","year":"2021","journal-title":"F1000Res"},{"key":"10.1016\/j.jbc.2026.111343_bib66","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal, and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2026.111343_bib67","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","article-title":"The single-cell transcriptional landscape of Mammalian organogenesis","volume":"566","author":"Cao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111343_bib68","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111343_bib69","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13062-023-00382-w","article-title":"Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM\/p53 signaling pathway","volume":"18","author":"Wei","year":"2023","journal-title":"Biol. Direct."},{"key":"10.1016\/j.jbc.2026.111343_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108611","article-title":"Morinda citrifolia protective effects on paclitaxel-induced testis parenchyma toxicity: an experimental study","volume":"127","author":"Genc","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.jbc.2026.111343_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116121","article-title":"An overview of the functions of p53 and drugs acting either on wild- or mutant-type p53","volume":"265","author":"Huang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jbc.2026.111343_bib72","article-title":"Unraveling the guardian: p53\u2019s multifaceted role in the DNA damage response and tumor treatment strategies","volume":"25","author":"Zhang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.111343_bib73","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1093\/nar\/gkaa006","article-title":"SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair","volume":"48","author":"Hou","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111343_bib74","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5425612","article-title":"Chromodomain helicase DNA-binding protein 5 inhibits renal cell carcinoma tumorigenesis by activation of the p53 and RB pathways","volume":"2020","author":"Huang","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jbc.2026.111343_bib75","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-3-030-94804-7_4","article-title":"Gadd45 in DNA demethylation and DNA repair","volume":"130","author":"Chandramouly","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jbc.2026.111343_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-94804-7_1","article-title":"GADD45 in stress signaling, cell cycle control, and apoptosis","volume":"1360","author":"Humayun","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jbc.2026.111343_bib77","article-title":"The down-regulation of GADD45B leads to a conversion of cellular oxidative phosphorylation to glycolysis and promotes the progression of bladder cancer","volume":"10","author":"Wang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jbc.2026.111343_bib78","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41419-022-04766-0","article-title":"HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells","volume":"13","author":"Youn","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2026.111343_bib79","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41388-019-1016-y","article-title":"Heat-shock proteins: chaperoning DNA repair","volume":"39","author":"Dubrez","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2026.111343_bib80","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1038\/s41388-017-0022-1","article-title":"The Tumor suppressor Hic1 maintains chromosomal stability independent of Tp53","volume":"37","author":"Szczepny","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2026.111343_bib81","article-title":"The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53","volume":"824","author":"Zhao","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.jbc.2026.111343_bib82","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41418-023-01205-1","article-title":"FBXL4 mutations cause excessive mitophagy via BNIP3\/BNIP3L accumulation leading to mitochondrial DNA depletion syndrome","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jbc.2026.111343_bib83","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20210110","article-title":"Glucose oxidase-instructed biomineralization of calcium-based biomaterials for biomedical applications","volume":"3","author":"Fu","year":"2023","journal-title":"Exploration"},{"key":"10.1016\/j.jbc.2026.111343_bib84","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10565-024-09974-2","article-title":"NFKB1 as a key player in tumor biology: from mechanisms to therapeutic implications","volume":"41","author":"Song","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.jbc.2026.111343_bib85","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2024.2360230","article-title":"Immunogenic oncolysis by tigilanol tiglate","volume":"13","author":"Pol","year":"2024","journal-title":"OncoImmunology"},{"key":"10.1016\/j.jbc.2026.111343_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113940","article-title":"Co-imaging of RelA and c-Rel reveals features of NF-\u03baB signaling for ligand discrimination","volume":"43","author":"Rahman","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.jbc.2026.111343_bib87","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2147\/JIR.S439315","article-title":"Use of machine learning for the identification and validation of immunogenic cell death biomarkers and immunophenotypes in coronary artery disease","volume":"17","author":"Zhang","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jbc.2026.111343_bib88","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12950-024-00427-5","article-title":"Progress of CCL20-CCR6 in the airways: a promising new therapeutic target","volume":"21","author":"Li","year":"2024","journal-title":"J. Inflamm."},{"key":"10.1016\/j.jbc.2026.111343_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103035","article-title":"DNAJC12 causes breast cancer chemotherapy resistance by repressing doxorubicin-induced ferroptosis and apoptosis via activation of AKT","volume":"70","author":"Shen","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.jbc.2026.111343_bib90","doi-asserted-by":"crossref","first-page":"D1302","DOI":"10.1093\/nar\/gkaa1027","article-title":"Open targets platform: supporting systematic drug-target identification and prioritisation","volume":"49","author":"Ochoa","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111343_bib91","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1158\/0008-5472.CAN-23-2812","article-title":"Targeting TACC3 induces immunogenic cell death and enhances T-DM1 response in HER2-positive breast cancer","volume":"84","author":"Gedik","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2026.111343_bib92","doi-asserted-by":"crossref","first-page":"537","DOI":"10.4254\/wjh.v16.i4.537","article-title":"Multifaceted roles of lymphatic and blood endothelial cells in the tumor microenvironment of hepatocellular carcinoma: a comprehensive review","volume":"16","author":"Li","year":"2024","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.jbc.2026.111343_bib93","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1600-065X.1998.tb01576.x","article-title":"Carboxypeptidase M as a marker of macrophage maturation Autbors\u2019 addresses immunological reviews","volume":"161","author":"Krause","year":"1998","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jbc.2026.111343_bib94","article-title":"CCL20 and CD8A as potential diagnostic biomarkers for HBV-induced liver fibrosis in chronic hepatitis B","volume":"10","author":"Song","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jbc.2026.111343_bib95","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2314426121","article-title":"Aflatoxin B1 and Epstein\u2013Barr virus-induced CCL22 expression stimulates B cell infection","volume":"121","author":"Maroui","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111343_bib96","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00262-024-03794-3","article-title":"Preclinical development of a novel CCR8\/CTLA-4 bispecific antibody for cancer treatment by disrupting CTLA-4 signaling on CD8 T cells and specifically depleting tumor-resident Tregs","volume":"73","author":"Guo","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.jbc.2026.111343_bib97","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13045-024-01634-6","article-title":"Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition","volume":"18","author":"Glaviano","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jbc.2026.111343_bib98","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/1471-2164-10-233","article-title":"Transcriptional signatures of Itk-Deficient CD3+, CD4+ and CD8+ T-Cells","volume":"10","author":"Blomberg","year":"2009","journal-title":"BMC Genomics"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826002139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826002139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:32:02Z","timestamp":1777455122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826002139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":98,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0021925826002139"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111343","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the Golgi apparatus enhances PD-L1 blockade and synergizes with oxaliplatin to improve immunotherapy efficacy","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111343","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"111343"}}