{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:05:42Z","timestamp":1779840342826,"version":"3.53.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["Y2023307"],"award-info":[{"award-number":["Y2023307"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301672"],"award-info":[{"award-number":["82301672"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017577","name":"Zhejiang Province Basic Public Welfare Research Program","doi-asserted-by":"publisher","award":["LY24H010004"],"award-info":[{"award-number":["LY24H010004"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017577","name":"Zhejiang Province Basic Public Welfare Research Program","doi-asserted-by":"publisher","award":["LQ23H010002"],"award-info":[{"award-number":["LQ23H010002"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jbc.2026.111388","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T07:11:19Z","timestamp":1774249879000},"page":"111388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective role of NRF2 activation against ER Stress\u2013Mediated apoptosis in obstructive sleep apnea"],"prefix":"10.1016","volume":"302","author":[{"given":"PeiPei","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1826-9495","authenticated-orcid":false,"given":"Shurui","family":"Zhuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjia","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youliang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Tsague Mbiada Meffo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liujia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanhao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuesha","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiucui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-4506","authenticated-orcid":false,"given":"Xiaohong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.111388_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00408-020-00342-5","article-title":"Evaluation and management of children with obstructive sleep apnea syndrome","volume":"198","author":"Bitners","year":"2020","journal-title":"Lung"},{"key":"10.1016\/j.jbc.2026.111388_bib2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.acvd.2020.01.003","article-title":"Obstructive sleep apnoea and cardiovascular consequences: pathophysiological mechanisms","volume":"113","author":"Arnaud","year":"2020","journal-title":"Arch. Cardiovasc. Dis."},{"key":"10.1016\/j.jbc.2026.111388_bib3","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.3892\/etm.2017.4971","article-title":"Intermittent hypoxia simulating obstructive sleep apnea causes pulmonary inflammation and activates the Nrf2\/HO-1 pathway","volume":"14","author":"Wang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jbc.2026.111388_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3529709","article-title":"Dysfunction of Nrf2-ARE signaling pathway: potential pathogenesis in the development of neurocognitive impairment in patients with moderate to severe obstructive sleep apnea-hypopnea syndrome","volume":"2018","author":"Zhou","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jbc.2026.111388_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8520967","article-title":"Involvement of hepcidin in cognitive damage induced by chronic intermittent hypoxia in mice","volume":"2021","author":"Zhao","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jbc.2026.111388_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s40478-020-01051-z","article-title":"Mild hypoxia triggers transient blood-brain barrier disruption: a fundamental protective role for microglia","volume":"8","author":"Halder","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.jbc.2026.111388_bib7","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.33594\/000000311","article-title":"Intermittent hypoxia and its impact on Nrf2\/HIF-1alpha expression and ABC transporters: an in vitro human blood-brain barrier model study","volume":"54","author":"Zolotoff","year":"2020","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.jbc.2026.111388_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.smrv.2012.12.003","article-title":"Obstructive sleep apnea and cognitive impairment: addressing the blood-brain barrier","volume":"18","author":"Lim","year":"2014","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.jbc.2026.111388_bib9","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.3390\/cells9051160","article-title":"Role of endoplasmic reticulum stress sensor IRE1alpha in cellular physiology, calcium, ROS signaling, and metaflammation","volume":"9","author":"Riaz","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111388_bib10","first-page":"705","article-title":"Roles of endoplasmic reticulum stress in immune responses","volume":"41","author":"So","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111388_bib11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/jb\/mvr143","article-title":"CHOP is a multifunctional transcription factor in the ER stress response","volume":"151","author":"Nishitoh","year":"2012","journal-title":"J. Biochem."},{"key":"10.1016\/j.jbc.2026.111388_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111388_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114500","article-title":"Blockage of calcium-sensing receptor improves chronic intermittent hypoxia-induced cognitive impairment by PERK-ATF4-CHOP pathway","volume":"368","author":"You","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jbc.2026.111388_bib14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.55782\/ane-2010-1799","article-title":"Chronic intermittent hypoxia exposure induces memory impairment in growing rats","volume":"70","author":"Cai","year":"2010","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"key":"10.1016\/j.jbc.2026.111388_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.taap.2018.03.020","article-title":"Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling","volume":"346","author":"Dong","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jbc.2026.111388_bib16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.phrs.2019.04.023","article-title":"Neuroprotective effects of andrographolide derivative CX-10 in transient focal ischemia in rat: involvement of Nrf2\/AE and TLR\/NF-kappaB signaling","volume":"144","author":"Yang","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jbc.2026.111388_bib17","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1073\/pnas.0400282101","article-title":"Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid","volume":"101","author":"Suh","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jbc.2026.111388_bib18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mam.2008.05.005","article-title":"Regulation of glutathione synthesis","volume":"30","author":"Lu","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jbc.2026.111388_bib19","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jbc.2026.111388_bib20","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jbc.2026.111388_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101342","article-title":"Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2\/HO-1 pathway","volume":"28","author":"Xu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jbc.2026.111388_bib22","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/MCB.00677-14","volume":"34","author":"Meakin","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111388_bib23","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1128\/MCB.23.20.7198-7209.2003","article-title":"Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival","volume":"23","author":"Cullinan","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111388_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001945","article-title":"De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling","volume":"12","author":"Del Vecchio","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2026.111388_bib25","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1073\/pnas.89.11.4820","article-title":"Molecular cloning of human CREB-2: an ATF\/CREB transcription factor that can negatively regulate transcription from the cAMP response element","volume":"89","author":"Karpinski","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jbc.2026.111388_bib26","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1136\/gutjnl-2020-321548","article-title":"ATF4 activation promotes hepatic mitochondrial dysfunction by repressing NRF1-TFAM signalling in alcoholic steatohepatitis","volume":"70","author":"Hao","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jbc.2026.111388_bib27","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.ajpath.2015.03.009","article-title":"Multiple mechanisms of unfolded protein response-induced cell death","volume":"185","author":"Hiramatsu","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jbc.2026.111388_bib28","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3389\/fgene.2018.00429","article-title":"Investigation of Nrf2, AhR and ATF4 activation in toxicogenomic databases","volume":"9","author":"Zgheib","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.jbc.2026.111388_bib29","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.3390\/ijms20071706","article-title":"Concomitant Nrf2- and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes","volume":"20","author":"Mimura","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.111388_bib30","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1021\/tx0502138","article-title":"Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane","volume":"18","author":"Hong","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jbc.2026.111388_bib31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/128_2012_339","article-title":"Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane","volume":"329","author":"Kensler","year":"2013","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.jbc.2026.111388_bib32","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1007\/s12672-025-03580-2","article-title":"Sulforaphane from broccoli, an epigenetic modulator in cancer cells","volume":"16","author":"Dabre","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.jbc.2026.111388_bib33","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1038\/s41380-025-02967-5","article-title":"Sulforaphane protects developing neural networks from VPA-induced synaptic alterations","volume":"30","author":"Bessetti","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jbc.2026.111388_bib34","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2416937","article-title":"Sulforaphane regulates AngII-induced podocyte oxidative stress injury through the Nrf2-Keap1\/ho-1\/ROS pathway","volume":"46","author":"Lu","year":"2024","journal-title":"Ren. Fail."},{"key":"10.1016\/j.jbc.2026.111388_bib35","first-page":"692","article-title":"The protective effect of sulforaphane against oxidative stress through activation of NRF2\/ARE pathway in human granulosa cells","volume":"23","author":"Esfandyari","year":"2021","journal-title":"Cell J."},{"key":"10.1016\/j.jbc.2026.111388_bib36","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1021\/acschembio.6b00651","article-title":"Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-Deficient NSCLC tumors","volume":"11","author":"Singh","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jbc.2026.111388_bib37","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/jpp\/rgae017","article-title":"Brusatol's anticancer activity and its molecular mechanism: a research update","volume":"76","author":"Xi","year":"2024","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jbc.2026.111388_bib38","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.1014275108","article-title":"Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism","volume":"108","author":"Ren","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jbc.2026.111388_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109813","article-title":"The protective role of Nrf2 on cognitive impairment in chronic intermittent hypoxia and sleep fragmentation mice","volume":"116","author":"Qiu","year":"2023","journal-title":"Int. Immunopharmacol"},{"key":"10.1016\/j.jbc.2026.111388_bib40","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/hipo.22472","article-title":"From synaptic plasticity to spatial maps and sequence learning","volume":"25","author":"Mehta","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.jbc.2026.111388_bib41","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3390\/cells9040958","article-title":"PC12 cell line: cell types, coating of culture vessels, differentiation and other culture conditions","volume":"9","author":"Wiatrak","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111388_bib42","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1007\/s12035-022-03189-4","article-title":"Inhibition of calcium-sensing receptor alleviates chronic intermittent hypoxia-induced cognitive dysfunction via CaSR-PKC-ERK1\/2 pathway","volume":"60","author":"Ying","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jbc.2026.111388_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117020","article-title":"HMGB1\/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA","volume":"239","author":"Guo","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.jbc.2026.111388_bib44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/s12974-020-02014-w","article-title":"Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea","volume":"17","author":"Gong","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jbc.2026.111388_bib45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","article-title":"UPR, autophagy, and mitochondria crosstalk underlies the ER stress response","volume":"40","author":"Senft","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2026.111388_bib46","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111388_bib47","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(03)00105-9","article-title":"An integrated stress response regulates amino acid metabolism and resistance to oxidative stress","volume":"11","author":"Harding","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111388_bib48","first-page":"4163","article-title":"Roles of endoplasmic reticulum stress and autophagy on H2O2-induced oxidative stress injury in HepG2 cells","volume":"18","author":"Wu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jbc.2026.111388_bib49","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/sj.emboj.7600596","article-title":"TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death","volume":"24","author":"Ohoka","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2026.111388_bib50","doi-asserted-by":"crossref","first-page":"16938","DOI":"10.1523\/JNEUROSCI.1598-10.2010","article-title":"Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA","volume":"30","author":"Galehdar","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2026.111388_bib51","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ncb2738","article-title":"ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death","volume":"15","author":"Han","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111388_bib52","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.3389\/fimmu.2018.03083","article-title":"The C\/EBP homologous protein (CHOP) transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2026.111388_bib53","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41419-022-04574-6","article-title":"cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells","volume":"13","author":"Mora-Molina","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2026.111388_bib54","doi-asserted-by":"crossref","first-page":"45495","DOI":"10.1074\/jbc.M406933200","article-title":"CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells","volume":"279","author":"Yamaguchi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111388_bib55","doi-asserted-by":"crossref","first-page":"12254","DOI":"10.18632\/oncotarget.7601","article-title":"Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival","volume":"7","author":"Saveljeva","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2026.111388_bib56","article-title":"Sulforaphane attenuates chronic intermittent hypoxia-induced brain damage in mice via augmenting Nrf2 nuclear translocation and autophagy","volume":"16","author":"Li","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.jbc.2026.111388_bib57","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.freeradbiomed.2021.12.258","article-title":"SESN2\/NRF2 signaling activates as a direct downstream regulator of the PERK pathway against endoplasmic reticulum stress to improve the in vitro maturation of porcine oocytes","volume":"178","author":"Park","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jbc.2026.111388_bib58","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13046-020-01565-3","article-title":"PERK\/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells","volume":"39","author":"Jang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2026.111388_bib59","doi-asserted-by":"crossref","first-page":"20858","DOI":"10.1074\/jbc.M101198200","article-title":"Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation","volume":"276","author":"He","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111388_bib60","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.bbamcr.2012.06.001","article-title":"Implication of Nrf2 and ATF4 in differential induction of CHOP by proteasome inhibition in thyroid cancer cells","volume":"1823","author":"Zong","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2026.111388_bib61","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3390\/cancers12030569","article-title":"ATF4-dependent NRF2 transcriptional regulation promotes antioxidant protection during endoplasmic reticulum stress","volume":"12","author":"Sarcinelli","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jbc.2026.111388_bib62","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.00011.2005","article-title":"Heme oxygenase-1\/carbon monoxide: from basic science to therapeutic applications","volume":"86","author":"Ryter","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jbc.2026.111388_bib63","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3892\/ijmm.2015.2199","article-title":"Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells","volume":"36","author":"Li","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jbc.2026.111388_bib64","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","article-title":"Glutathione synthesis","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2026.111388_bib65","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.jbc.2026.111388_bib66","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2360427","article-title":"Brusatol enhances the chemotherapy efficacy of gemcitabine in pancreatic cancer via the Nrf2 signalling pathway","volume":"2018","author":"Xiang","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jbc.2026.111388_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102632","article-title":"Association of NRF2 with HIF-2alpha-induced cancer stem cell phenotypes in chronic hypoxic condition","volume":"60","author":"Hallis","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.jbc.2026.111388_bib68","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.expneurol.2014.04.029","article-title":"Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats","volume":"257","author":"Cai","year":"2014","journal-title":"Exp. Neurol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826002589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826002589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T23:41:49Z","timestamp":1779838909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826002589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0021925826002589"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111388","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective role of NRF2 activation against ER Stress\u2013Mediated apoptosis in obstructive sleep apnea","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111388","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"111388"}}