{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:52:41Z","timestamp":1789044761111,"version":"build-2803163510"},"reference-count":156,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001412","name":"CSIR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jbc.2026.111455","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:38:14Z","timestamp":1776407894000},"page":"111455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of mitochondrial translation in modulating inflammatory disease outcome: Current knowledge and future perspectives"],"prefix":"10.1016","volume":"302","author":[{"given":"Swarnali","family":"Basu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukshar","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Prajapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Ammanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Rungta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2391-1301","authenticated-orcid":false,"given":"Amit","family":"Lahiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.111455_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1114231","article-title":"Mitochondria: it is all about energy","volume":"14","author":"Casanova","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jbc.2026.111455_bib2","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.bbabio.2011.06.010","article-title":"Human diseases with impaired mitochondrial protein synthesis","volume":"1807","author":"Rotig","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2026.111455_bib3","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41580-025-00885-6","article-title":"Molecular machineries and pathways of mitochondrial protein transport","volume":"26","author":"Endo","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.80","article-title":"Mitochondrial diseases","volume":"2","author":"Gorman","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jbc.2026.111455_bib5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13045-024-01615-9","article-title":"Unraveling the roles and mechanisms of mitochondrial translation in normal and malignant hematopoiesis","volume":"17","author":"Liu","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jbc.2026.111455_bib6","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.161096","article-title":"CLUH functions as a negative regulator of inflammation in human macrophages and determines ulcerative colitis pathogenesis","volume":"8","author":"Khan","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbc.2026.111455_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107120","article-title":"ORMDL3 regulates NLRP3 inflammasome activation by maintaining ER-mitochondria contacts in human macrophages and dictates ulcerative colitis patient outcome","volume":"300","author":"Sharma","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111455_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/biom13121789","article-title":"Mitochondrial quality control via mitochondrial unfolded protein response (mtUPR) in ageing and neurodegenerative diseases","volume":"13","author":"Cilleros-Holgado","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jbc.2026.111455_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413397","article-title":"Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-I-Like receptors (RLRs) in innate immunity. TLRs, NLRs, and RLRs ligands as immunotherapeutic agents for hematopoietic diseases","volume":"22","author":"Wicherska-Pawlowska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.111455_bib10","article-title":"Mitochondrial protein translation: emerging roles and clinical significance in disease","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s43556-025-00284-5","article-title":"Role of mitochondria in physiological activities, diseases, and therapy","volume":"6","author":"Wang","year":"2025","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.jbc.2026.111455_bib12","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1172\/JCI120845","article-title":"Mitochondrial fidelity and metabolic agility control immune cell fate and function","volume":"128","author":"Sack","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111455_bib13","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/1873-3468.14024","article-title":"The diseased mitoribosome","volume":"595","author":"Ferrari","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2026.111455_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","article-title":"Sequence and organization of the human mitochondrial genome","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111455_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00441-016-2456-0","article-title":"The process of mammalian mitochondrial protein synthesis","volume":"367","author":"Mai","year":"2017","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.jbc.2026.111455_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1042\/EBC20170102","article-title":"Mitochondrial transcription and translation: overview","volume":"62","author":"D'Souza","year":"2018","journal-title":"Essays Biochem."},{"key":"10.1016\/j.jbc.2026.111455_bib17","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.1093\/nar\/gkh886","article-title":"Interaction of mitochondrial initiation factor 2 with mitochondrial fMet-tRNA","volume":"32","author":"Spencer","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111455_bib18","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2007.06.031","article-title":"mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG","volume":"27","author":"Soleimanpour-Lichaei","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111455_bib19","doi-asserted-by":"crossref","first-page":"7518","DOI":"10.1016\/S0021-9258(18)83265-3","article-title":"Interaction of bovine mitochondrial ribosomes with messenger RNA","volume":"264","author":"Liao","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111455_bib20","doi-asserted-by":"crossref","DOI":"10.1199\/tab.0176","article-title":"Mechanism of cytoplasmic mRNA translation","volume":"13","author":"Browning","year":"2015","journal-title":"Arabidopsis Book"},{"key":"10.1016\/j.jbc.2026.111455_bib21","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.molcel.2009.06.028","article-title":"EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis","volume":"35","author":"Tsuboi","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111455_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.aaa1193","article-title":"Ribosome. The structure of the human mitochondrial ribosome","volume":"348","author":"Amunts","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.111455_bib23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nature12890","article-title":"Architecture of the large subunit of the mammalian mitochondrial ribosome","volume":"505","author":"Greber","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111455_bib24","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/emboj\/20.6.1281","article-title":"Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA","volume":"20","author":"Hell","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2026.111455_bib25","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/j.celrep.2018.01.066","article-title":"Kinetics and mechanism of Mammalian mitochondrial ribosome assembly","volume":"22","author":"Bogenhagen","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111455_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/genes15060694","article-title":"Knockout mouse studies show that mitochondrial CLPP peptidase and CLPX Unfoldase Act in matrix condensates near IMM, as fast stress response in protein assemblies for transcript processing, translation, and heme production","volume":"15","author":"Key","year":"2024","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.jbc.2026.111455_bib27","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1002\/pro.3688","article-title":"Mechanisms of mammalian mitochondrial transcription","volume":"28","author":"Bouda","year":"2019","journal-title":"Protein Sci."},{"key":"10.1016\/j.jbc.2026.111455_bib28","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10545-015-9859-z","article-title":"Mitochondrial transcript maturation and its disorders","volume":"38","author":"Van Haute","year":"2015","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.jbc.2026.111455_bib29","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1017\/S1355838200001047","article-title":"Search for characteristic structural features of mammalian mitochondrial tRNAs","volume":"6","author":"Helm","year":"2000","journal-title":"RNA"},{"key":"10.1016\/j.jbc.2026.111455_bib30","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1080\/15384101.2015.1053672","article-title":"Mitochondrial ribosome assembly in health and disease","volume":"14","author":"De Silva","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jbc.2026.111455_bib31","article-title":"Fever supports CD8(+) effector T cell responses by promoting mitochondrial translation","volume":"118","author":"O'Sullivan","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.111455_bib32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.redox.2016.09.005","article-title":"Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production","volume":"10","author":"Baseler","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1126\/science.aal3535","article-title":"Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages","volume":"356","author":"Ip","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.111455_bib34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ajhg.2010.06.004","article-title":"Mutations in C12orf65 in patients with encephalomyopathy and a mitochondrial translation defect","volume":"87","author":"Antonicka","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2026.111455_bib35","doi-asserted-by":"crossref","first-page":"eaay2118","DOI":"10.1126\/sciadv.aay2118","article-title":"Fidelity of translation initiation is required for coordinated respiratory complex assembly","volume":"5","author":"Rudler","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2026.111455_bib36","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tibs.2025.03.007","article-title":"Emerging mechanisms of human mitochondrial translation regulation","volume":"50","author":"Brischigliaro","year":"2025","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2026.111455_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.84168","article-title":"Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function","volume":"12","author":"Huang","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.111455_bib38","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s13059-022-02732-9","article-title":"Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes","volume":"23","author":"Soto","year":"2022","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib39","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1186\/s12967-023-04373-3","article-title":"RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors","volume":"21","author":"Ma","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jbc.2026.111455_bib40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1042\/BJ20040469","article-title":"The role of the LRPPRC (leucine-rich pentatricopeptide repeat cassette) gene in cytochrome oxidase assembly: mutation causes lowered levels of COX (cytochrome c oxidase) I and COX III mRNA","volume":"382","author":"Xu","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2026.111455_bib41","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1128\/MCB.23.14.4972-4982.2003","article-title":"LRP130, a pentatricopeptide motif protein with a noncanonical RNA-binding domain, is bound in vivo to mitochondrial and nuclear RNAs","volume":"23","author":"Mili","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib42","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/ng.390","article-title":"Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome","volume":"41","author":"Weraarpachai","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2026.111455_bib43","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2016.09.003","article-title":"Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein","volume":"167","author":"Richter-Dennerlein","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.111455_bib44","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.cell.2012.11.053","article-title":"MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation","volume":"151","author":"Mick","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.111455_bib45","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ajhg.2011.11.027","article-title":"Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis","volume":"90","author":"Weraarpachai","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2026.111455_bib46","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13796","article-title":"Mitonuclear communication in stem cell function","volume":"58","author":"Peng","year":"2025","journal-title":"Cell Prolif."},{"key":"10.1016\/j.jbc.2026.111455_bib47","doi-asserted-by":"crossref","first-page":"11935","DOI":"10.1074\/jbc.M707389200","article-title":"Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits","volume":"283","author":"Ramachandran","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.111455_bib48","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202101034","article-title":"High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo","volume":"4","author":"Bonekamp","year":"2021","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.jbc.2026.111455_bib49","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Canto","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111455_bib50","article-title":"PGC-1alpha is a master regulator of mitochondrial lifecycle and ROS stress response","volume":"12","author":"Abu Shelbayeh","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jbc.2026.111455_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073474","article-title":"Types and functions of mitoribosome-specific ribosomal proteins across eukaryotes","volume":"23","author":"Scaltsoyiannes","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.111455_bib52","article-title":"Mitochondrial ribosomal proteins: potential targets for cancer prognosis and therapy","volume":"15","author":"Zhu","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jbc.2026.111455_bib53","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1093\/nar\/gks257","article-title":"Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit","volume":"40","author":"He","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111455_bib54","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.celrep.2016.07.031","article-title":"Hierarchical RNA processing is required for mitochondrial ribosome assembly","volume":"16","author":"Rackham","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111455_bib55","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/s41467-023-37291-5","article-title":"A defect in mitochondrial protein translation influences mitonuclear communication in the heart","volume":"14","author":"Gao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111455_bib56","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nsmb.3206","article-title":"Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis","volume":"23","author":"Gao","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib57","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41586-020-2076-4","article-title":"A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol","volume":"579","author":"Fessler","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111455_bib58","article-title":"Mitochondrial unfolded protein response (mtUPR) activation improves pathological alterations in cellular models of ethylmalonic encephalopathy","volume":"14","author":"Romero-Dominguez","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jbc.2026.111455_bib59","doi-asserted-by":"crossref","DOI":"10.1172\/JCI157504","article-title":"OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy","volume":"132","author":"Shammas","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.111455_bib60","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1016\/j.molcel.2025.10.012","article-title":"Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis","volume":"85","author":"Zheng","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111455_bib61","doi-asserted-by":"crossref","first-page":"9710","DOI":"10.1093\/nar\/gkae645","article-title":"The human mitochondrial translation factor TACO1 alleviates mitoribosome stalling at polyproline stretches","volume":"52","author":"Brischigliaro","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111455_bib62","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13046-022-02304-6","article-title":"Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth","volume":"41","author":"Zamberlan","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2026.111455_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.626117","article-title":"Mitochondrial OMA1 and OPA1 as gatekeepers of organellar structure\/function and cellular stress response","volume":"9","author":"Gilkerson","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib64","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1038\/s41467-022-29945-7","article-title":"Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis","volume":"13","author":"Sidarala","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111455_bib65","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1007\/s10753-025-02302-8","article-title":"TFAM deficiency triggers mtDNA Leakage and cGAS-STING-Mediated intestinal ischemia-reperfusion injury","volume":"48","author":"Ding","year":"2025","journal-title":"Inflammation"},{"key":"10.1016\/j.jbc.2026.111455_bib66","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41590-020-00859-0","article-title":"IRGM1 links mitochondrial quality control to autoimmunity","volume":"22","author":"Rai","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2026.111455_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010003","article-title":"IL-25 induced ROS-Mediated M2 macrophage polarization via AMPK-associated mitophagy","volume":"23","author":"Tsai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.111455_bib68","first-page":"397","article-title":"Tetracyclines downregulate the production of LPS-induced cytokines and chemokines in THP-1 cells via ERK, p38, and nuclear factor-kappaB signaling pathways","volume":"4","author":"Sun","year":"2015","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.jbc.2026.111455_bib69","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/175062","article-title":"Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease","volume":"2014","author":"Hroudova","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jbc.2026.111455_bib70","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/s41467-019-08983-8","article-title":"ZEB1 protects skeletal muscle from damage and is required for its regeneration","volume":"10","author":"Siles","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111455_bib71","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1067\/mai.2002.121145","article-title":"Histone deacetylation inhibits IL4 gene expression in T cells","volume":"109","author":"Valapour","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jbc.2026.111455_bib72","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02935","article-title":"Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer","volume":"3","author":"Ju","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.111455_bib73","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF03194602","article-title":"Mitochondrial DNA mutations in human neoplasia","volume":"47","author":"Czarnecka","year":"2006","journal-title":"J. Appl. Genet."},{"key":"10.1016\/j.jbc.2026.111455_bib74","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/humu.20338","article-title":"m.6267G>A: a recurrent mutation in the human mitochondrial DNA that reduces cytochrome c oxidase activity and is associated with tumors","volume":"27","author":"Gallardo","year":"2006","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.jbc.2026.111455_bib75","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.1156906","article-title":"ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis","volume":"320","author":"Ishikawa","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.111455_bib76","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201949799","article-title":"Mitochondrial DNA in inflammation and immunity","volume":"21","author":"Riley","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2026.111455_bib77","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1042\/BJ20140620","article-title":"Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria","volume":"462","author":"Bridges","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2026.111455_bib78","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210571","article-title":"Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma","volume":"218","author":"Vendramin","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2026.111455_bib79","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax2863","article-title":"Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response","volume":"11","author":"Sharon","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jbc.2026.111455_bib80","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01858-16","article-title":"Ribosome profiling reveals translational upregulation of cellular oxidative phosphorylation mRNAs during Vaccinia virus-induced host shutoff","volume":"91","author":"Dai","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2026.111455_bib81","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/262414a0","article-title":"Human cytomegalovirus infection of WI-38 cells stimulates mitochondrial DNA synthesis","volume":"262","author":"Furukawa","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111455_bib82","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00029-16","article-title":"Human cytomegalovirus infection upregulates the mitochondrial transcription and translation machineries","volume":"7","author":"Karniely","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2026.111455_bib83","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s13365-015-0320-8","article-title":"Rabies virus phosphoprotein interacts with mitochondrial complex I and induces mitochondrial dysfunction and oxidative stress","volume":"21","author":"Kammouni","year":"2015","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.jbc.2026.111455_bib84","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s13365-013-0214-6","article-title":"Mitochondrial dysfunction in rabies virus infection of neurons","volume":"19","author":"Alandijany","year":"2013","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.jbc.2026.111455_bib85","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.3390\/v15122380","article-title":"Mitochondrial oxidative phosphorylation in viral infections","volume":"15","author":"Purandare","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.jbc.2026.111455_bib86","doi-asserted-by":"crossref","first-page":"eabq1533","DOI":"10.1126\/scitranslmed.abq1533","article-title":"Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts","volume":"15","author":"Guarnieri","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jbc.2026.111455_bib87","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41586-018-0363-0","article-title":"Mitochondrial double-stranded RNA triggers antiviral signalling in humans","volume":"560","author":"Dhir","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.111455_bib88","doi-asserted-by":"crossref","first-page":"e1009841","DOI":"10.1371\/journal.ppat.1009841","article-title":"Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase","volume":"17","author":"Sato","year":"2021","journal-title":"Plos Pathog."},{"key":"10.1016\/j.jbc.2026.111455_bib89","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.4049\/jimmunol.1501612","article-title":"Cutting edge: mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication","volume":"196","author":"Gleeson","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2026.111455_bib90","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3390\/biom13010126","article-title":"Insulin resistance in mitochondrial diabetes","volume":"13","author":"Takano","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jbc.2026.111455_bib91","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1038\/s41467-024-51109-y","article-title":"Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver","volume":"15","author":"Aich","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111455_bib92","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/s41467-020-16423-1","article-title":"Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death","volume":"11","author":"Balsa","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111455_bib93","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.2337\/db14-1937","article-title":"Impaired mitochondrial biogenesis in adipose tissue in acquired obesity","volume":"64","author":"Heinonen","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.jbc.2026.111455_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102630","article-title":"Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle","volume":"61","author":"Lopez-Soldado","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101222","article-title":"A diet induced maladaptive increase in hepatic mitochondrial DNA precedes OXPHOS defects and may contribute to non-alcoholic fatty liver disease","volume":"8","author":"Malik","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.111455_bib96","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.7150\/ijbs.73493","article-title":"AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease","volume":"18","author":"Feng","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jbc.2026.111455_bib97","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1038\/s41598-025-85460-x","article-title":"Regulation of reactive oxygen species and the role of mitochondrial apoptotic-related genes in rheumatoid arthritis","volume":"15","author":"Gao","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2026.111455_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/diseases12090226","article-title":"Mitochondrial dysfunction in systemic lupus erythematosus: insights and therapeutic potential","volume":"12","author":"Poznyak","year":"2024","journal-title":"Diseases"},{"key":"10.1016\/j.jbc.2026.111455_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2024.103583","article-title":"Remodeling of T-cell mitochondrial metabolism to treat autoimmune diseases","volume":"23","author":"Lin","year":"2024","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jbc.2026.111455_bib100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41467-018-07841-3","article-title":"Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response","volume":"10","author":"Haberman","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111455_bib101","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1167\/tvst.14.6.37","article-title":"Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of primary open-angle glaucoma","volume":"14","author":"Chen","year":"2025","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.jbc.2026.111455_bib102","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jid.2017.08.019","article-title":"Imbalance of mitochondrial respiratory chain complexes in the epidermis induces severe skin inflammation","volume":"138","author":"Weiland","year":"2018","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jbc.2026.111455_bib103","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jid.2023.09.275","article-title":"Inhibition of mitochondrial translation ameliorates imiquimod-induced psoriasis-like skin inflammation by targeting Vgamma4+ gammadelta T cells","volume":"144","author":"Dhillon-LaBrooy","year":"2024","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jbc.2026.111455_bib104","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13062-025-00593-3","article-title":"An integrated investigation of mitochondrial genes in COPD reveals the causal effect of NDUFS2 by regulating pulmonary macrophages","volume":"20","author":"Zou","year":"2025","journal-title":"Biol. Direct"},{"key":"10.1016\/j.jbc.2026.111455_bib105","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1056\/NEJMra022567","article-title":"Mitochondrial respiratory-chain diseases","volume":"348","author":"DiMauro","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbc.2026.111455_bib106","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/cvr\/cvr015","article-title":"Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy","volume":"90","author":"Abel","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jbc.2026.111455_bib107","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1161\/CIRCULATIONAHA.122.061192","article-title":"Reduced mitochondrial protein translation promotes cardiomyocyte proliferation and heart regeneration","volume":"148","author":"Gao","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2026.111455_bib108","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-0404.2006.00671.x","article-title":"Central nervous system manifestations of mitochondrial disorders","volume":"114","author":"Finsterer","year":"2006","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jbc.2026.111455_bib109","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ymgme.2020.11.006","article-title":"A novel acceptor stem variant in mitochondrial tRNA(Tyr) impairs mitochondrial translation and is associated with a severe phenotype","volume":"131","author":"Kripps","year":"2020","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.jbc.2026.111455_bib110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41531-017-0032-2","article-title":"Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease","volume":"3","author":"Sarkar","year":"2017","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.jbc.2026.111455_bib111","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.cmet.2013.09.010","article-title":"Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging","volume":"18","author":"Youm","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2026.111455_bib112","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202302423","article-title":"Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3beta-Srebp2 axis","volume":"7","author":"Toshima","year":"2024","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.jbc.2026.111455_bib113","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.lfs.2016.09.021","article-title":"Disrupted mitochondrial genes and inflammation following stroke","volume":"166","author":"Gibbs","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.jbc.2026.111455_bib114","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.molcel.2011.03.021","article-title":"Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing","volume":"42","author":"Caballero","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111455_bib115","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s10439-022-03051-7","article-title":"Modulating mitochondrial DNA heteroplasmy with mitochondrially targeted endonucleases","volume":"52","author":"Mikhailov","year":"2024","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.jbc.2026.111455_bib116","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molcel.2015.02.008","article-title":"Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt)","volume":"58","author":"Nargund","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.111455_bib117","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2026.111455_bib118","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.jbc.2026.111455_bib119","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2022.900028","article-title":"Immune senescence, immunosenescence and aging","volume":"3","author":"Lee","year":"2022","journal-title":"Front. Aging"},{"key":"10.1016\/j.jbc.2026.111455_bib120","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cmet.2014.05.006","article-title":"Mitochondrial proteostasis in the control of aging and longevity","volume":"20","author":"Jensen","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2026.111455_bib121","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jbc.2026.111455_bib122","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01599-17","article-title":"Mitochondrial alterations (inhibition of mitochondrial protein expression, oxidative metabolism, and ultrastructure) induced by linezolid and tedizolid at clinically relevant concentrations in cultured human HL-60 promyelocytes and THP-1 monocytes","volume":"62","author":"Milosevic","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2026.111455_bib123","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1086\/501356","article-title":"Linezolid-induced inhibition of mitochondrial protein synthesis","volume":"42","author":"De Vriese","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jbc.2026.111455_bib124","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1128\/AAC.03684-14","article-title":"Nonclinical and pharmacokinetic assessments to evaluate the potential of tedizolid and linezolid to affect mitochondrial function","volume":"59","author":"Flanagan","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2026.111455_bib125","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1039\/C6MB00154H","article-title":"Halofuginone reduces the inflammatory responses of DSS-induced colitis through metabolic reprogramming","volume":"12","author":"Liu","year":"2016","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.jbc.2026.111455_bib126","article-title":"Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells","author":"Perea","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2026.111455_bib127","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.18632\/aging.101319","article-title":"Towards natural mimetics of metformin and rapamycin","volume":"9","author":"Aliper","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jbc.2026.111455_bib128","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.celrep.2018.03.033","article-title":"PTCD1 is required for 16S rRNA maturation complex stability and mitochondrial ribosome assembly","volume":"23","author":"Perks","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.111455_bib129","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.tins.2019.08.003","article-title":"Mitochondria and alzheimer's: is PTCD1 the smoking Gun?","volume":"42","author":"Pa","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jbc.2026.111455_bib130","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1093\/hmg\/ddu747","article-title":"Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia","volume":"24","author":"Menezes","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2026.111455_bib131","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/ana.20282","article-title":"Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutation","volume":"56","author":"Miller","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jbc.2026.111455_bib132","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/jmg.2007.053116","article-title":"Antenatal mitochondrial disease caused by mitochondrial ribosomal protein (MRPS22) mutation","volume":"44","author":"Saada","year":"2007","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.jbc.2026.111455_bib133","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/nar\/gkaa1131","article-title":"Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly","volume":"49","author":"Cipullo","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111455_bib134","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1038\/s41467-023-43599-z","article-title":"Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome","volume":"14","author":"Nguyen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.111455_bib135","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ajhg.2013.06.006","article-title":"ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy","volume":"93","author":"Haack","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2026.111455_bib136","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/787956","article-title":"The mitochondrial aminoacyl tRNA synthetases: genes and syndromes","volume":"2014","author":"Diodato","year":"2014","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib137","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.7150\/jca.98555","article-title":"TRMT10C gene polymorphisms confer hepatoblastoma susceptibility: evidence from a seven-center case-control study","volume":"15","author":"Liu","year":"2024","journal-title":"J. Cancer"},{"key":"10.1016\/j.jbc.2026.111455_bib138","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41418-022-01044-6","article-title":"Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers","volume":"30","author":"Martin","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jbc.2026.111455_bib139","first-page":"337","article-title":"PUS1 may be a potential prognostic biomarker and therapeutic target for hepatocellular carcinoma","volume":"16","author":"Lan","year":"2023","journal-title":"Pharmgenomics Pers Med."},{"key":"10.1016\/j.jbc.2026.111455_bib140","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/humu.24471","article-title":"Destabilization of mutated human PUS3 protein causes intellectual disability","volume":"43","author":"Lin","year":"2022","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.jbc.2026.111455_bib141","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.neulet.2010.09.059","article-title":"Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease","volume":"486","author":"Behrouz","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jbc.2026.111455_bib142","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1093\/nar\/gkn576","article-title":"The human mitochondrial ribosome recycling factor is essential for cell viability","volume":"36","author":"Rorbach","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.111455_bib143","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1007\/s12035-023-03841-7","article-title":"The protective mechanism of TFAM on mitochondrial DNA and its role in neurodegenerative diseases","volume":"61","author":"Song","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jbc.2026.111455_bib144","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1001\/archneurol.2008.588","article-title":"PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia","volume":"66","author":"Qin","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jbc.2026.111455_bib145","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/hmg\/ddy080","article-title":"Defective mitochondrial protease LonP1 can cause classical mitochondrial disease","volume":"27","author":"Peter","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2026.111455_bib146","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1021\/acschembio.8b00124","article-title":"The role of ClpP protease in bacterial pathogenesis and human diseases","volume":"13","author":"Bhandari","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib147","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1128\/iai.64.3.825-828.1996","article-title":"Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion","volume":"64","author":"Shapira","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2026.111455_bib148","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1128\/AAC.47.11.3630-3633.2003","article-title":"Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines","volume":"47","author":"Krakauer","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2026.111455_bib149","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.3390\/ijms22084100","article-title":"The antibiotic doxycycline impairs cardiac mitochondrial and contractile function","volume":"22","author":"Wust","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.111455_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2017.08.018","article-title":"Tigecycline-induced inhibition of mitochondrial DNA translation may cause lethal mitochondrial dysfunction in humans","volume":"24","author":"Vandecasteele","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.jbc.2026.111455_bib151","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.49","article-title":"Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity","volume":"6","author":"Halliday","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2026.111455_bib152","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nchembio.613","article-title":"Chemical genetics identify eIF2alpha kinase heme-regulated inhibitor as an anticancer target","volume":"7","author":"Chen","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2026.111455_bib153","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-065X.2012.01152.x","article-title":"mTOR, metabolism, and the regulation of T-cell differentiation and function","volume":"249","author":"Waickman","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jbc.2026.111455_bib154","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.immuni.2010.09.002","article-title":"The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism","volume":"33","author":"Powell","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2026.111455_bib155","doi-asserted-by":"crossref","first-page":"e8799","DOI":"10.15252\/emmm.201708799","article-title":"Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis","volume":"10","author":"Civiletto","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jbc.2026.111455_bib156","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.immuni.2021.05.004","article-title":"Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation","volume":"54","author":"Xian","year":"2021","journal-title":"Immunity"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826003273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826003273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:35:31Z","timestamp":1787643331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826003273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":156,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0021925826003273"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111455","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of mitochondrial translation in modulating inflammatory disease outcome: Current knowledge and future perspectives","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.111455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"111455"}}