{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:23:31Z","timestamp":1787646211034,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K11487andJP19K10060"],"award-info":[{"award-number":["JP16K11487andJP19K10060"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005623","name":"University of Tokushima","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005623","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jbc.2026.113108","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:56:32Z","timestamp":1778108192000},"page":"113108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Geranylgeraniol promotes osteoblast differentiation and inhibits osteoclastogenesis through MAPK and nuclear receptor signaling"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4960-4679","authenticated-orcid":false,"given":"Mineko","family":"Tomomura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3020-8091","authenticated-orcid":false,"given":"Takao","family":"Tsukahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-1671","authenticated-orcid":false,"given":"Ryuichiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8001-2121","authenticated-orcid":false,"given":"Hiroshi","family":"Sakagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1362-3034","authenticated-orcid":false,"given":"Kenjiro","family":"Bandow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akito","family":"Tomomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113108_bib1","first-page":"115","article-title":"Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis","volume":"21","author":"Manolagas","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jbc.2026.113108_bib2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1186\/s13018-021-02772-0","article-title":"The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis","volume":"16","author":"Salari","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.jbc.2026.113108_bib3","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/jnci\/90.11.814","article-title":"Relationship between estrogen levels, use of hormone replacement therapy, and breast cancer","volume":"90","author":"Colditz","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.jbc.2026.113108_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.23736\/S2724-6329.20.04306-X","article-title":"Bisphosphonate-associated osteonecrosis of the jaw","volume":"70","author":"Ferreira Jr","year":"2021","journal-title":"Minerva. Dent. Oral Sci."},{"key":"10.1016\/j.jbc.2026.113108_bib5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00198-015-3386-5","article-title":"Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation","volume":"27","author":"Weaver","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.jbc.2026.113108_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.12968\/denu.2015.42.5.436","article-title":"Denosumab, an alternative to bisphosphonates but also associated with osteonecrosis of the Jaw--What is the risk?","volume":"42","author":"Sidhu","year":"2015","journal-title":"Dent. Update"},{"key":"10.1016\/j.jbc.2026.113108_bib7","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jbc.2026.113108_bib8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113108_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1749-6632.2009.05245.x","article-title":"Integrins, growth factors, and the osteoclast cytoskeleton","volume":"1192","author":"Zou","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jbc.2026.113108_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0169-6009(92)90750-8","article-title":"The role of alkaline phosphatase in cartilage mineralization","volume":"17","author":"Golub","year":"1992","journal-title":"Bone Miner"},{"key":"10.1016\/j.jbc.2026.113108_bib11","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.2741\/2296","article-title":"Signaling and transcriptional regulation in osteoblast commitment and differentiation","volume":"12","author":"Huang","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jbc.2026.113108_bib12","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1089\/ten.teb.2016.0454","article-title":"Osteoblast differentiation and bone matrix formation in vivo and in vitro","volume":"23","author":"Blair","year":"2017","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.jbc.2026.113108_bib13","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/jbmr.1961","article-title":"Positive regulation of osteogenesis by bile acid through FXR","volume":"28","author":"Cho","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jbc.2026.113108_bib14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1677\/JOE-10-0208","article-title":"Pregnane X receptor knockout mice display osteopenia with reduced bone formation and enhanced bone resorption","volume":"207","author":"Azuma","year":"2010","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jbc.2026.113108_bib15","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1172\/JCI200419900","article-title":"PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors","volume":"113","author":"Akune","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.113108_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/615486","article-title":"Mechanisms of bone resorption in periodontitis","volume":"2015","author":"Hienz","year":"2015","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.jbc.2026.113108_bib17","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.4110\/in.2019.19.e2","article-title":"Osteoclasts in the inflammatory arthritis: implications for pathologic osteolysis","volume":"19","author":"Jung","year":"2019","journal-title":"Immune Netw."},{"key":"10.1016\/j.jbc.2026.113108_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130174","article-title":"Rhinacanthin C inhibits osteoclast differentiation and bone resorption: roles of TRAF6\/TAK1\/MAPKs\/NF-kappaB\/NFATc1 signaling","volume":"10","author":"Tomomura","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2026.113108_bib19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1677\/joe.0.1760339","article-title":"Vitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell culture","volume":"176","author":"Koshihara","year":"2003","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jbc.2026.113108_bib20","first-page":"3","article-title":"Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-kappaB activation","volume":"27","author":"Yamaguchi","year":"2011","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jbc.2026.113108_bib21","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00774-022-01342-6","article-title":"Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review","volume":"40","author":"Zhou","year":"2022","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.jbc.2026.113108_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2023.100396","article-title":"Geranylgeranoic acid, a bioactive and endogenous fatty acid in mammals: a review","volume":"64","author":"Shidoji","year":"2023","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jbc.2026.113108_bib23","doi-asserted-by":"crossref","first-page":"26475","DOI":"10.1074\/jbc.M313973200","article-title":"Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos","volume":"279","author":"Matsuo","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113108_bib24","doi-asserted-by":"crossref","first-page":"17963","DOI":"10.1074\/jbc.M112.358796","article-title":"Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-kappaB ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling pathway","volume":"287","author":"Tomomura","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113108_bib25","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/cdd.2015.168","article-title":"Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?","volume":"23","author":"Chen","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jbc.2026.113108_bib26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3390\/ijms19020360","article-title":"Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment","volume":"19","author":"Hu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.113108_bib27","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1248\/bpb.b16-01020","article-title":"Underlying mechanisms and therapeutic strategies for Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ)","volume":"40","author":"Endo","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jbc.2026.113108_bib28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113108_bib29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.clinbiochem.2007.03.016","article-title":"Mevalonate pathway: a review of clinical and therapeutical implications","volume":"40","author":"Buhaescu","year":"2007","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.jbc.2026.113108_bib30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.biotechadv.2016.03.005","article-title":"The potential of the mevalonate pathway for enhanced isoprenoid production","volume":"34","author":"Liao","year":"2016","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jbc.2026.113108_bib31","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1021\/jf900612n","article-title":"Modulation of inflammatory genes by natural dietary bioactive compounds","volume":"57","author":"Pan","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jbc.2026.113108_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3164\/jcbn.10-110","article-title":"Polished rice as natural sources of cancer-preventing geranylgeranoic acid","volume":"49","author":"Muraguchi","year":"2011","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.jbc.2026.113108_bib33","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.foodchem.2016.06.048","article-title":"Characterisation of minor components in vegetable oil by comprehensive gas chromatography with dual detection","volume":"212","author":"Purcaro","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jbc.2026.113108_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nutres.2021.07.001","article-title":"Beneficial effect of dietary geranylgeraniol on glucose homeostasis and bone microstructure in obese mice is associated with suppression of proinflammation and modification of gut microbiome","volume":"93","author":"Chung","year":"2021","journal-title":"Nutr. Res."},{"key":"10.1016\/j.jbc.2026.113108_bib35","first-page":"151","article-title":"Tumor-specificity and type of cell death induced by vitamin K2 derivatives and prenylalcohols","volume":"28","author":"Sakagami","year":"2008","journal-title":"Anticancer Res."},{"key":"10.1016\/j.jbc.2026.113108_bib36","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00394-012-0429-y","article-title":"Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-kappaB activation in rats","volume":"52","author":"Giriwono","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jbc.2026.113108_bib37","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1080\/09168451.2015.1123612","article-title":"Geranylgeraniol enhances testosterone production via the cAMP\/protein kinase A pathway in testis-derived I-10 tumor cells","volume":"80","author":"Ho","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jbc.2026.113108_bib38","doi-asserted-by":"crossref","first-page":"11394","DOI":"10.1073\/pnas.0805556105","article-title":"Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation","volume":"105","author":"Kotti","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113108_bib39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1359\/jbmr.2002.17.1.91","article-title":"Effects of geranylgeranoic acid in bone: induction of osteoblast differentiation and inhibition of osteoclast formation","volume":"17","author":"Wang","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jbc.2026.113108_bib40","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.3390\/ijms19103004","article-title":"Roles of mitogen-activated protein kinases in osteoclast biology","volume":"19","author":"Lee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.113108_bib41","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1242\/jcs.00082","article-title":"JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms","volume":"115","author":"David","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jbc.2026.113108_bib42","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.3184","article-title":"c-Jun N-terminal kinases (JNKs) are critical mediators of osteoblast activity in vivo","volume":"32","author":"Xu","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jbc.2026.113108_bib43","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1359\/jbmr.081107","article-title":"JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation","volume":"24","author":"Matsuguchi","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jbc.2026.113108_bib44","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.tibs.2006.08.002","article-title":"FXR, a multipurpose nuclear receptor","volume":"31","author":"Lee","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2026.113108_bib45","first-page":"621","article-title":"FXR, a target for different diseases","volume":"23","author":"Wang","year":"2008","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.jbc.2026.113108_bib46","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.bone.2011.08.013","article-title":"Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblasts","volume":"49","author":"Id Boufker","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jbc.2026.113108_bib47","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1210\/me.2014-1225","article-title":"Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3","volume":"29","author":"Wang","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jbc.2026.113108_bib48","article-title":"Farnesoid X receptor agonist attenuates subchondral bone osteoclast fusion and osteochondral pathologies of osteoarthritis via suppressing JNK1\/2\/NFATc1 pathway","volume":"36","author":"Hu","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2026.113108_bib49","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/jbmr.1702","article-title":"Liver X receptors orchestrate osteoblast\/osteoclast crosstalk and counteract pathologic bone loss","volume":"27","author":"Kleyer","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jbc.2026.113108_bib50","first-page":"lb394","article-title":"Geranylgeraniol suppresses the expression of adipogenic genes and the differentiation of murine 3T3-F442A and 3T3-L1 preadipocytes","volume":"31","author":"Elfakhani","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2026.113108_bib51","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.21873\/invivo.11384","article-title":"Geranylgeraniol induces PPARgamma expression and enhances the biological effects of a PPARgamma agonist in adipocyte Lineage cells","volume":"32","author":"Matsubara","year":"2018","journal-title":"In Vivo"},{"key":"10.1016\/j.jbc.2026.113108_bib52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/joim.12718","article-title":"Clinical implications of bone marrow adiposity","volume":"283","author":"Veldhuis-Vlug","year":"2018","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jbc.2026.113108_bib53","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cytogfr.2020.02.003","article-title":"The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis","volume":"52","author":"Li","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jbc.2026.113108_bib54","first-page":"372","article-title":"Obesity, osteoporosis and bone metabolism","volume":"20","author":"Gkastaris","year":"2020","journal-title":"J. Musculoskelet. Neuronal Interact"},{"key":"10.1016\/j.jbc.2026.113108_bib55","first-page":"1353","article-title":"Geranylgeraniol application in human osteoblasts and osteoclasts for reversal of the effect of bisphosphonates","volume":"13","author":"Jung","year":"2023","journal-title":"Life (Basel)"},{"key":"10.1016\/j.jbc.2026.113108_bib56","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1359\/jbmr.2000.15.8.1467","article-title":"Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298","volume":"15","author":"Coxon","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jbc.2026.113108_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111334","article-title":"Link between microbiota and hypertension: focus on LPS\/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics","volume":"137","author":"Grylls","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jbc.2026.113108_bib58","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13024-024-00722-y","article-title":"The endotoxin hypothesis of Alzheimer's disease","volume":"19","author":"Brown","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jbc.2026.113108_bib59","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.3390\/ijms20092320","article-title":"Geranylgeraniol suppresses the expression of IRAK1 and TRAF6 to inhibit NFkappaB activation in lipopolysaccharide-induced inflammatory responses in human macrophage-like cells","volume":"20","author":"Giriwono","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.113108_bib60","doi-asserted-by":"crossref","first-page":"25448","DOI":"10.1074\/jbc.M109.068742","article-title":"Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity","volume":"285","author":"Hasegawa","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113108_bib61","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S8756-3282(99)00210-0","article-title":"Osteoblasts\/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor\/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand","volume":"25","author":"Udagawa","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.jbc.2026.113108_bib62","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3923\/jbs.2014.327.331","article-title":"Isolation and characterization of dental pulp stem cells from murine incisors","volume":"14","author":"Nur Akmal","year":"2014","journal-title":"J. Biol. Sci."},{"key":"10.1016\/j.jbc.2026.113108_bib63","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1359\/jbmr.090302","article-title":"Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling","volume":"24","author":"Koide","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jbc.2026.113108_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2210-10-1","article-title":"Antinociceptive effect of geranylgeraniol and 6alpha,7beta-dihydroxyvouacapan-17beta-oate methyl ester isolated from Pterodon pubescens Benth","volume":"10","author":"Spindola","year":"2010","journal-title":"BMC Pharmacol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826019800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826019800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:27:19Z","timestamp":1787642839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826019800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0021925826019800"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113108","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Geranylgeraniol promotes osteoblast differentiation and inhibits osteoclastogenesis through MAPK and nuclear receptor signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113108"}}