{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:43:53Z","timestamp":1792446233289,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["No.LQ24H160034"],"award-info":[{"award-number":["No.LQ24H160034"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["ZCLQN25H1609"],"award-info":[{"award-number":["ZCLQN25H1609"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ24H160034"],"award-info":[{"award-number":["LQ24H160034"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ23H160047"],"award-info":[{"award-number":["LQ23H160047"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304628,82472352"],"award-info":[{"award-number":["82304628,82472352"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472352"],"award-info":[{"award-number":["82472352"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82505091"],"award-info":[{"award-number":["82505091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304628"],"award-info":[{"award-number":["82304628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jbc.2026.113162","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:12:54Z","timestamp":1778825574000},"page":"113162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolinderalactone suppresses the progression of cholangiocarcinoma by modulating the CARMA1-BCL10-MALT1 signalosome"],"prefix":"10.1016","volume":"302","author":[{"given":"Wangyang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenshan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanling","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-2862","authenticated-orcid":false,"given":"Hongzhang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113162_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jbc.2026.113162_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-022-00741-4","article-title":"Immunology and immunotherapy of cholangiocarcinoma","volume":"20","author":"Greten","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jbc.2026.113162_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrclinonc.2017.157","article-title":"Cholangiocarcinoma - evolving concepts and therapeutic strategies","volume":"15","author":"Ilyas","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jbc.2026.113162_bib4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13045-022-01253-z","article-title":"Immune cell atlas of cholangiocarcinomas reveals distinct tumor microenvironments and associated prognoses","volume":"15","author":"Xia","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jbc.2026.113162_bib5","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1136\/gutjnl-2024-333359","article-title":"Guidelines development group for the British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma","volume":"74","author":"Khan","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.jbc.2026.113162_bib6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jbc.2026.113162_bib7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.semcancer.2022.06.009","article-title":"Natural products and their derivatives as immune check point inhibitors: targeting cytokine\/chemokine signalling in cancer","volume":"86","author":"Gupta","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jbc.2026.113162_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106357","article-title":"Inhibiting STAT3 signaling pathway by natural products for cancer prevention and therapy: in vitro and in vivo activity and mechanisms of action","volume":"182","author":"Yang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jbc.2026.113162_bib9","doi-asserted-by":"crossref","first-page":"36101","DOI":"10.1039\/D4RA05643D","article-title":"Characterization and quantification of the phytochemical constituents and anti-inflammatory properties of Lindera aggregata","volume":"14","author":"Wen","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.jbc.2026.113162_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110965","article-title":"A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-\u03baB pathway and activation Nrf2 pathway in macrophages","volume":"124","author":"Shen","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jbc.2026.113162_bib11","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1021\/acs.jnatprod.3c00894","article-title":"Isolinderalactone ameliorates the pathology of Alzheimer's disease by inhibiting the JNK signaling pathway","volume":"86","author":"Xiong","year":"2023","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jbc.2026.113162_bib12","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1021\/np100874f","article-title":"Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity","volume":"74","author":"Wong","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jbc.2026.113162_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.canlet.2020.03.009","article-title":"Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models","volume":"478","author":"Park","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jbc.2026.113162_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154383","article-title":"Isolinderalactone sensitizes oxaliplatin-resistance colorectal cancer cells through JNK\/p38 MAPK signaling pathways","volume":"105","author":"Kwak","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jbc.2026.113162_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113497","article-title":"Isolinderalactone suppresses pancreatic ductal adenocarcinoma by activating p38 MAPK to promote DDIT3 expression and trigger endoplasmic reticulum stress","volume":"143","author":"Xu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jbc.2026.113162_bib16","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.3892\/mmr.2014.2015","article-title":"Isolinderalactone inhibits proliferation of A549 human non-small cell lung cancer cells by arresting the cell cycle at the G0\/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway","volume":"9","author":"Chang","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jbc.2026.113162_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.jbc.2026.113162_bib18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41423-025-01310-w","article-title":"NF-\u03baB in inflammation and cancer","volume":"22","author":"Mao","year":"2025","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.jbc.2026.113162_bib19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nri1352","article-title":"CARMA1, BCL-10 and MALT1 in lymphocyte development and activation","volume":"4","author":"Thome","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2026.113162_bib20","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.molcel.2013.08.032","article-title":"Structural architecture of the CARMA1\/Bcl10\/MALT1 signalosome: nucleation-induced filamentous assembly","volume":"51","author":"Qiao","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113162_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nature02273","article-title":"Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO","volume":"427","author":"Zhou","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113162_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/cr.2010.182","article-title":"NF-\u03baB signaling pathways regulated by CARMA family of scaffold proteins","volume":"21","author":"Blonska","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.jbc.2026.113162_bib23","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003004","article-title":"Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1","volume":"2","author":"Thome","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jbc.2026.113162_bib24","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jhep.2016.09.010","article-title":"Epithelial-mesenchymal transition in cholangiocarcinoma: from clinical evidence to regulatory networks","volume":"66","author":"Vaquero","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jbc.2026.113162_bib25","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.1158\/0008-5472.CAN-21-1538","article-title":"A PLCB1-PI3K-AKT signaling axis activates EMT to promote cholangiocarcinoma progression","volume":"81","author":"Liang","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2026.113162_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41392-024-01761-z","article-title":"Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis","volume":"9","author":"Fu","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.jbc.2026.113162_bib27","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/S0140-6736(13)61903-0","article-title":"Cholangiocarcinoma","volume":"383","author":"Razumilava","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jbc.2026.113162_bib28","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1097\/HEP.0000000000000322","article-title":"Aberrant fucosylation sustains the NOTCH and EGFR\/NF-\u03baB pathways and has a prognostic value in human intrahepatic cholangiocarcinoma","volume":"78","author":"Ament","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jbc.2026.113162_bib29","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/hep.32317","article-title":"TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-\u03baB-inducing kinase-mediated hepatocyte transdifferentiation","volume":"77","author":"Shiode","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jbc.2026.113162_bib30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1233606","article-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","volume":"341","author":"Martinez Molina","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113162_bib31","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2026.113162_bib32","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1007\/s13238-017-0441-3","article-title":"The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-\u03baB activation and cell survival","volume":"8","author":"Zhang","year":"2017","journal-title":"Protein Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582602034X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582602034X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T23:33:13Z","timestamp":1786145593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582602034X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S002192582602034X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113162","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolinderalactone suppresses the progression of cholangiocarcinoma by modulating the CARMA1-BCL10-MALT1 signalosome","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113162"}}