{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T23:44:54Z","timestamp":1786146294235,"version":"build-2736575974"},"reference-count":97,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-21-CE44-0010"],"award-info":[{"award-number":["ANR-21-CE44-0010"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-23-CE15-0009-01"],"award-info":[{"award-number":["ANR-23-CE15-0009-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["PlasmohostANR-25-CE11-3606"],"award-info":[{"award-number":["PlasmohostANR-25-CE11-3606"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010115","name":"R\u00e9gion Auvergne-Rh\u00f4ne-Alpes","doi-asserted-by":"publisher","award":["-40\/104\/2023-MED-DBT"],"award-info":[{"award-number":["-40\/104\/2023-MED-DBT"]}],"id":[{"id":"10.13039\/501100010115","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032196","name":"International Centre for Genetic Engineering and Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012952","name":"Universit\u00e9 Grenoble Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001852","name":"Indo-French Centre for the Promotion of Advanced Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001852","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["\/2022\/002655"],"award-info":[{"award-number":["\/2022\/002655"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010953","name":"Office of Biotechnology, Iowa State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010953","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["6003-1"],"award-info":[{"award-number":["6003-1"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["\/PR19127\/BIC\/101\/1047\/2016"],"award-info":[{"award-number":["\/PR19127\/BIC\/101\/1047\/2016"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["HRD-16016\/10\/2023-AFS-DBT"],"award-info":[{"award-number":["HRD-16016\/10\/2023-AFS-DBT"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["ANR-11-LABX-0024"],"award-info":[{"award-number":["ANR-11-LABX-0024"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FRM EQU202103012700"],"award-info":[{"award-number":["FRM EQU202103012700"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jbc.2026.113188","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T23:31:48Z","timestamp":1779838308000},"page":"113188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A prokaryotic-like cardiolipin synthase is essential to maintain mitochondrial function, lipid homeostasis, and survival of the blood stage malaria parasite Plasmodium falciparum"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8463-0530","authenticated-orcid":false,"given":"Md Muzahidul","family":"Islam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Omair","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Yamaryo-Bott\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1207-9735","authenticated-orcid":false,"given":"Pragyan P.","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madiha","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2807-053X","authenticated-orcid":false,"given":"Sumit","family":"Rathore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2245-536X","authenticated-orcid":false,"given":"Cyrille Y.","family":"Bott\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0239-1979","authenticated-orcid":false,"given":"Asif","family":"Mohmmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113188_bib1","series-title":"World Malaria Report 2024: Addressing Inequity in the Global Malaria Response","year":"2024"},{"key":"10.1016\/j.jbc.2026.113188_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002380","article-title":"Tools and strategies for malaria control and elimination: what do we need to achieve a Grand convergence in malaria?","volume":"14","author":"Hemingway","year":"2016","journal-title":"Plos Biol."},{"key":"10.1016\/j.jbc.2026.113188_bib3","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12936-016-1289-3","article-title":"Transfusion-transmitted malaria: donor prevalence of parasitaemia and a survey of healthcare workers knowledge and practices in a district hospital in Ghana","volume":"15","author":"Owusu-Ofori","year":"2016","journal-title":"Malar. J."},{"key":"10.1016\/j.jbc.2026.113188_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmaid.2025.102841","article-title":"The impact of climate change on travel-related vector-borne diseases: a case study on dengue virus transmission","volume":"65","author":"Abbasi","year":"2025","journal-title":"Trav. Med. Infect. Dis."},{"key":"10.1016\/j.jbc.2026.113188_bib5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbc.2026.113188_bib6","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/trstmh\/trac044","article-title":"Impact of climate change on West Nile virus distribution in South America","volume":"116","author":"Lorenz","year":"2022","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.jbc.2026.113188_bib7","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nature14412","article-title":"A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria","volume":"520","author":"Mbengue","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113188_bib8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1586\/14787210.2015.1031744","article-title":"Fighting fire with fire: mass antimalarial drug administrations in an era of antimalarial resistance","volume":"13","author":"von Seidlein","year":"2015","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"10.1016\/j.jbc.2026.113188_bib9","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nchembio.658","article-title":"Chemical inhibitors of monogalactosyldiacylglycerol synthases in Arabidopsis thaliana","volume":"7","author":"Botte","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2026.113188_bib10","doi-asserted-by":"crossref","first-page":"10949","DOI":"10.1073\/pnas.1003335107","article-title":"A common red algal origin of the apicomplexan, dinoflagellate, and heterokont plastids","volume":"107","author":"Janouskovec","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113188_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2174\/138945007779315632","article-title":"Mitochondrial drug targets in apicomplexan parasites","volume":"8","author":"Mather","year":"2007","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.jbc.2026.113188_bib12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/bies.950191114","article-title":"Plastids in parasites of humans","volume":"19","author":"McFadden","year":"1997","journal-title":"Bioessays"},{"key":"10.1016\/j.jbc.2026.113188_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179239","article-title":"Plasmodium falciparum mitochondrial Complex III, the target of atovaquone, is essential for progression to the transmissible sexual stages","volume":"25","author":"Sheokand","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2026.113188_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010313","article-title":"The flexibility of Apicomplexa parasites in lipid metabolism","volume":"18","author":"Shunmugam","year":"2022","journal-title":"Plos Pathog."},{"key":"10.1016\/j.jbc.2026.113188_bib15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.pt.2022.06.001","article-title":"Toxoplasma metabolic flexibility in different growth conditions","volume":"38","author":"Walsh","year":"2022","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jbc.2026.113188_bib16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature05572","article-title":"Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum","volume":"446","author":"Painter","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113188_bib17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.celrep.2015.03.011","article-title":"Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle","volume":"11","author":"Ke","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.113188_bib18","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1021\/jm8001026","article-title":"Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum","volume":"51","author":"Phillips","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib19","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2210929120","article-title":"The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation","volume":"120","author":"Nair","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113188_bib20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/ddr.20347","article-title":"Targeting the lipid Metabolic pathways for the treatment of malaria","volume":"71","author":"Ben Mamoun","year":"2010","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.jbc.2026.113188_bib21","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1073\/pnas.1301251110","article-title":"Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites","volume":"110","author":"Botte","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113188_bib22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.chom.2015.08.003","article-title":"Profiling the essential Nature of lipid metabolism in asexual blood and gametocyte stages of Plasmodium falciparum","volume":"18","author":"Gulati","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2026.113188_bib23","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1194\/jlr.M085589","article-title":"Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite","volume":"59","author":"Wein","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jbc.2026.113188_bib24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12936-016-1130-z","article-title":"Changes in lipid composition during sexual development of the malaria parasite Plasmodium falciparum","volume":"15","author":"Tran","year":"2016","journal-title":"Malar. J."},{"key":"10.1016\/j.jbc.2026.113188_bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1155\/2005\/452563","article-title":"A study of archaeal enzymes involved in polar lipid synthesis linking amino acid sequence information, genomic contexts and lipid composition","volume":"1","author":"Daiyasu","year":"2005","journal-title":"Archaea"},{"key":"10.1016\/j.jbc.2026.113188_bib26","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.bpj.2011.03.031","article-title":"Cardiolipin affects the supramolecular organization of ATP synthase in mitochondria","volume":"100","author":"Acehan","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbc.2026.113188_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07739","article-title":"MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture","volume":"4","author":"Friedman","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.113188_bib28","doi-asserted-by":"crossref","first-page":"18797","DOI":"10.1016\/S0021-9258(17)30583-5","article-title":"Mitochondrial contact sites. Lipid composition and dynamics","volume":"265","author":"Ardail","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbalip.2016.08.010","article-title":"Biosynthesis, remodeling and turnover of mitochondrial cardiolipin","volume":"1862","author":"Schlame","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.jbc.2026.113188_bib30","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051015","article-title":"Respiratory supercomplexes enhance electron transport by decreasing cytochrome c diffusion distance","volume":"21","author":"Berndtsson","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2026.113188_bib31","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/S0021-9258(19)69888-1","article-title":"Cardiolipin requirement for electron transfer in complex I and III of the mitochondrial respiratory chain","volume":"256","author":"Fry","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib32","doi-asserted-by":"crossref","first-page":"11568","DOI":"10.1074\/jbc.RA119.009037","article-title":"Cardiolipin-induced activation of pyruvate dehydrogenase links mitochondrial lipid biosynthesis to TCA cycle function","volume":"294","author":"Li","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib33","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1128\/jb.170.2.775-780.1988","article-title":"Disruption of the Escherichia coli cls gene responsible for cardiolipin synthesis","volume":"170","author":"Nishijima","year":"1988","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbc.2026.113188_bib34","doi-asserted-by":"crossref","first-page":"14933","DOI":"10.1074\/jbc.273.24.14933","article-title":"Isolation and characterization of the gene (CLS1) encoding cardiolipin synthase in Saccharomyces cerevisiae","volume":"273","author":"Chang","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-5793(97)01525-1","article-title":"YDL142c encodes cardiolipin synthase (Cls1p) and is non-essential for aerobic growth of Saccharomyces cerevisiae","volume":"421","author":"Tuller","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2026.113188_bib36","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1194\/jlr.R700018-JLR200","article-title":"Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes","volume":"49","author":"Schlame","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jbc.2026.113188_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.plipres.2007.03.003","article-title":"Comparative genomics and evolution of eukaryotic phospholipid biosynthesis","volume":"46","author":"Lykidis","year":"2007","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jbc.2026.113188_bib38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2148-12-32","article-title":"The evolution of cardiolipin biosynthesis and maturation pathways and its implications for the evolution of eukaryotes","volume":"12","author":"Tian","year":"2012","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.jbc.2026.113188_bib39","doi-asserted-by":"crossref","first-page":"E954","DOI":"10.1073\/pnas.1121528109","article-title":"An essential bacterial-type cardiolipin synthase mediates cardiolipin formation in a eukaryote","volume":"109","author":"Serricchio","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113188_bib40","doi-asserted-by":"crossref","first-page":"32294","DOI":"10.1074\/jbc.M403275200","article-title":"Absence of cardiolipin results in temperature sensitivity, respiratory defects, and mitochondrial DNA instability independent of pet56","volume":"279","author":"Zhong","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib41","doi-asserted-by":"crossref","first-page":"16504","DOI":"10.1073\/pnas.1212797109","article-title":"Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates","volume":"109","author":"Tan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113188_bib42","doi-asserted-by":"crossref","first-page":"13161","DOI":"10.1096\/fj.201901184RR","article-title":"Cardiolipin depletion-induced changes in the Trypanosoma brucei proteome","volume":"33","author":"Schadeli","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2026.113188_bib43","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202001579RR","article-title":"Depletion of cardiolipin induces major changes in energy metabolism in Trypanosoma brucei bloodstream forms","volume":"35","author":"Serricchio","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2026.113188_bib44","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0968-0004(96)30024-8","article-title":"A duplicated catalytic motif in a new superfamily of phosphohydrolases and phospholipid synthases that includes poxvirus envelope proteins","volume":"21","author":"Koonin","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2026.113188_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1042\/BJ20060303","article-title":"Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria","volume":"398","author":"Chen","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2026.113188_bib46","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1105\/tpc.113.118018","article-title":"The importance of cardiolipin synthase for mitochondrial ultrastructure, respiratory function, plant development, and stress responses in Arabidopsis","volume":"25","author":"Pineau","year":"2013","journal-title":"Plant Cell"},{"key":"10.1016\/j.jbc.2026.113188_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.38131","article-title":"Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase","volume":"7","author":"Seidi","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.113188_bib48","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1038\/s41467-021-23919-x","article-title":"Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum","volume":"12","author":"Evers","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113188_bib49","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/mmi.14357","article-title":"Identification of the Toxoplasma gondii mitochondrial ribosome, and characterisation of a protein essential for mitochondrial translation","volume":"112","author":"Lacombe","year":"2019","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2026.113188_bib50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbrc.2020.12.004","article-title":"Revisiting the mode of action of the antimalarial proguanil using the yeast model","volume":"534","author":"Mounkoro","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2026.113188_bib51","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1073\/pnas.0307742101","article-title":"A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation","volume":"101","author":"Pessi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113188_bib52","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S1286-4579(03)00070-4","article-title":"Lipid metabolism in Plasmodium falciparum-infected erythrocytes: possible new targets for malaria chemotherapy","volume":"5","author":"Mitamura","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.jbc.2026.113188_bib53","doi-asserted-by":"crossref","first-page":"17308","DOI":"10.1074\/jbc.R118.003213","article-title":"Role of phospholipid synthesis in the development and differentiation of malaria parasites in the blood","volume":"293","author":"Kilian","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib54","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.mito.2022.05.005","article-title":"Defining ER-mitochondria contact dynamics in Plasmodium falciparum by targeting component of phospholipid synthesis pathway, phosphatidylserine synthase (PfPSS)","volume":"65","author":"Anwar","year":"2022","journal-title":"Mitochondrion"},{"key":"10.1016\/j.jbc.2026.113188_bib55","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bbalip.2013.11.014","article-title":"MAM (Mitochondria-associated membranes) in mammalian cells: lipids and beyond","volume":"1841","author":"Vance","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2026.113188_bib56","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3390\/cells8070728","article-title":"Role of cardiolipin in mitochondrial function and dynamics in health and disease: molecular and pharmacological aspects","volume":"8","author":"Paradies","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.113188_bib57","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12915-021-01042-z","article-title":"An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum","volume":"19","author":"Asad","year":"2021","journal-title":"BMC Biol."},{"key":"10.1016\/j.jbc.2026.113188_bib58","doi-asserted-by":"crossref","first-page":"35204","DOI":"10.1074\/jbc.M306729200","article-title":"Cardiolipin is not required to maintain mitochondrial DNA stability or cell viability for Saccharomyces cerevisiae grown at elevated temperatures","volume":"278","author":"Zhang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib59","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nmeth.3063","article-title":"Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum","volume":"11","author":"Wagner","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2026.113188_bib60","doi-asserted-by":"crossref","first-page":"9555","DOI":"10.1074\/jbc.RA118.007121","article-title":"Ribozyme-mediated, multiplex CRISPR gene editing and CRISPR interference (CRISPRi) in rodent-infectious Plasmodium yoelii","volume":"294","author":"Walker","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib61","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nbt.2925","article-title":"Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system","volume":"32","author":"Ghorbal","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2026.113188_bib62","doi-asserted-by":"crossref","DOI":"10.1126\/science.aap7847","article-title":"Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis","volume":"360","author":"Zhang","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113188_bib63","article-title":"Metabolism of host lysophosphatidylcholine in Plasmodium falciparum-infected erythrocytes","volume":"121","author":"Liu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113188_bib64","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1462-5822.2005.00518.x","article-title":"Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma","volume":"7","author":"Nishikawa","year":"2005","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.jbc.2026.113188_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112251","article-title":"A Plasmodium falciparum lysophospholipase regulates host fatty acid flux via parasite lipid storage to enable controlled asexual schizogony","volume":"42","author":"Sheokand","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.113188_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100645","article-title":"Toxoplasma acyl-CoA synthetase TgACS3 is crucial to channel host fatty acids in lipid droplets and for parasite propagation","volume":"65","author":"Dass","year":"2024","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jbc.2026.113188_bib67","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.cell.2017.10.020","article-title":"Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum","volume":"171","author":"Brancucci","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113188_bib68","doi-asserted-by":"crossref","first-page":"11190","DOI":"10.1074\/jbc.270.19.11190","article-title":"Evidence that phosphatidylserine is imported into mitochondria via a mitochondria-associated membrane and that the majority of mitochondrial phosphatidylethanolamine is derived from decarboxylation of phosphatidylserine","volume":"270","author":"Shiao","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib69","doi-asserted-by":"crossref","first-page":"34534","DOI":"10.1074\/jbc.M002865200","article-title":"Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes","volume":"275","author":"Stone","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib70","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051323","article-title":"Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes","volume":"22","author":"Yeo","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2026.113188_bib71","first-page":"1","article-title":"Structure and functional properties of diacylglycerols in membranes","volume":"38","author":"Goni","year":"1999","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jbc.2026.113188_bib72","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s00018-006-6016-8","article-title":"The life cycle of neutral lipids: synthesis, storage and degradation","volume":"63","author":"Athenstaedt","year":"2006","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jbc.2026.113188_bib73","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.bbrc.2004.07.070","article-title":"Evidence that Plasmodium falciparum diacylglycerol acyltransferase is essential for intraerythrocytic proliferation","volume":"321","author":"Palacpac","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2026.113188_bib74","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1128\/EC.05049-11","article-title":"Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function","volume":"10","author":"Ke","year":"2011","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.jbc.2026.113188_bib75","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1741-7007-11-67","article-title":"Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum","volume":"11","author":"MacRae","year":"2013","journal-title":"BMC Biol."},{"key":"10.1016\/j.jbc.2026.113188_bib76","doi-asserted-by":"crossref","first-page":"10216","DOI":"10.1073\/pnas.1423959112","article-title":"Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase","volume":"112","author":"Sturm","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113188_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101897","article-title":"Metabolic changes accompanying the loss of fumarate hydratase and malate-quinone oxidoreductase in the asexual blood stage of Plasmodium falciparum","volume":"298","author":"Rajaram","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib78","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2301047120","article-title":"Direct tests of cytochrome c and c(1) functions in the electron transport chain of malaria parasites","volume":"120","author":"Espino-Sanchez","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113188_bib79","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/mmi.15211","article-title":"Disruption of a Plasmodium falciparum patatin-like phospholipase delays male gametocyte exflagellation","volume":"121","author":"Pietsch","year":"2024","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2026.113188_bib80","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01718-23","article-title":"A patatin-like phospholipase is important for mitochondrial function in malaria parasites","volume":"14","author":"Pietsch","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2026.113188_bib81","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.4269\/ajtmh.14-0553","article-title":"Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy","volume":"92","author":"Stickles","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jbc.2026.113188_bib82","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92752-5","article-title":"Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells","volume":"11","author":"Di Carlo","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2026.113188_bib83","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.1021\/jp8002195","article-title":"Ion\/electron coupled transport through polyaniline membrane: fast transmembrane redox reactions at neutral pH","volume":"112","author":"Kocherginsky","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jbc.2026.113188_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073783","article-title":"Inducible knockdown of Plasmodium gene expression using the glmS ribozyme","volume":"8","author":"Prommana","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2026.113188_bib85","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0020-7519(97)00080-5","article-title":"Continuous culture of Plasmodium falciparum: its impact on malaria research","volume":"27","author":"Trager","year":"1997","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.jbc.2026.113188_bib86","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","article-title":"Synchronization of Plasmodium falciparum erythrocytic stages in culture","volume":"65","author":"Lambros","year":"1979","journal-title":"J. Parasitol."},{"key":"10.1016\/j.jbc.2026.113188_bib87","first-page":"263","article-title":"Transfection of the human malaria parasite Plasmodium falciparum","volume":"270","author":"Crabb","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jbc.2026.113188_bib88","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12748","article-title":"Plasmodium falciparum OTU-like cysteine protease (PfOTU) is essential for apicoplast homeostasis and associates with noncanonical role of Atg8","volume":"19","author":"Datta","year":"2017","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.jbc.2026.113188_bib89","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001732","article-title":"Identification and characterization of a novel Plasmodium falciparum merozoite apical protein involved in erythrocyte binding and invasion","volume":"3","author":"Wickramarachchi","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2026.113188_bib90","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010932","article-title":"Dual role of an essential HtrA2\/Omi protease in the human malaria parasite: maintenance of mitochondrial homeostasis and induction of apoptosis-like cell death under cellular stress","volume":"18","author":"Singh","year":"2022","journal-title":"Plos Pathog."},{"key":"10.1016\/j.jbc.2026.113188_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2025.119940","article-title":"A dynamin-like protein in Plasmodium falciparum plays an essential role in parasite growth, mitochondrial development and homeostasis during asexual blood stages","volume":"1872","author":"Thakur","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.jbc.2026.113188_bib92","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005765","article-title":"Apicoplast-Localized lysophosphatidic acid precursor assembly is required for bulk phospholipid synthesis in Toxoplasma gondii and relies on an Algal\/Plant-Like glycerol 3-Phosphate acyltransferase","volume":"12","author":"Amiar","year":"2016","journal-title":"Plos Pathog."},{"key":"10.1016\/j.jbc.2026.113188_bib93","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.chembiol.2018.10.008","article-title":"High-Throughput plasma lipidomics: detailed mapping of the associations with cardiometabolic risk factors","volume":"26","author":"Huynh","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jbc.2026.113188_bib94","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1074\/jbc.RA120.012646","article-title":"Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions","volume":"295","author":"Ling","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113188_bib95","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1365-313X.2005.02577.x","article-title":"Histochemical staining and quantification of plant mitochondrial respiratory chain complexes using blue-native polyacrylamide gel electrophoresis","volume":"44","author":"Sabar","year":"2005","journal-title":"Plant J."},{"key":"10.1016\/j.jbc.2026.113188_bib96","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202010023","article-title":"Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics","volume":"17","author":"Cobbold","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.jbc.2026.113188_bib97","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: Molecular evolutionary genetics analysis version 11","volume":"38","author":"Tamura","year":"2021","journal-title":"Mol. Biol. Evol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826020600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826020600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T23:34:47Z","timestamp":1786145687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826020600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":97,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0021925826020600"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113188","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A prokaryotic-like cardiolipin synthase is essential to maintain mitochondrial function, lipid homeostasis, and survival of the blood stage malaria parasite Plasmodium falciparum","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113188","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113188"}}