{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T20:23:59Z","timestamp":1787257439944,"version":"build-2736575974"},"reference-count":62,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES103361"],"award-info":[{"award-number":["ES103361"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001463","name":"American Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001463","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jbc.2026.113305","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:02:43Z","timestamp":1782774163000},"page":"113305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["PAX8 controls proximal tubule epithelial identity and stress response through epigenetic modification of distal regulatory elements"],"prefix":"10.1016","volume":"302","author":[{"given":"Asha C.","family":"Telang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"Orban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Stahlecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna T.","family":"Ference-Salo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don A.","family":"Delker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-7174","authenticated-orcid":false,"given":"Jonathan M.","family":"Shillingford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison C.","family":"McElliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Laszczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan N.","family":"Vashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Parolia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin L.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-8470","authenticated-orcid":false,"given":"Ryan J.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R.","family":"Dressler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4851-3481","authenticated-orcid":false,"given":"Jeffrey A.","family":"Beamish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113305_bib1","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1681\/ASN.2004090740","article-title":"Acute kidney injury, mortality, length of stay, and costs in hospitalized patients","volume":"16","author":"Chertow","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jbc.2026.113305_bib2","doi-asserted-by":"crossref","first-page":"15874","DOI":"10.1073\/pnas.2005477117","article-title":"Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury","volume":"117","author":"Kirita","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113305_bib3","doi-asserted-by":"crossref","first-page":"7567","DOI":"10.1038\/s41467-025-62599-9","article-title":"Multimodal spatial transcriptomic characterization of mouse kidney injury and repair","volume":"16","author":"Xuanyuan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113305_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1681\/ASN.2016070748","article-title":"Does renal repair recapitulate kidney development?","volume":"28","author":"Little","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jbc.2026.113305_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s40139-015-0069-z","article-title":"Kidney regeneration: lessons from development","volume":"3","author":"Chiba","year":"2015","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.jbc.2026.113305_bib6","first-page":"711","article-title":"Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development","volume":"119","author":"Rothenpieler","year":"1993","journal-title":"Dev. Camb Engl."},{"key":"10.1016\/j.jbc.2026.113305_bib7","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1101\/gad.240102","article-title":"Nephric lineage specification by Pax2 and Pax8","volume":"16","author":"Bouchard","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2026.113305_bib8","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1681\/ASN.2019090962","article-title":"Pax2 and Pax8 proteins regulate urea transporters and aquaporins to control urine concentration in the adult kidney","volume":"31","author":"Laszczyk","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jbc.2026.113305_bib9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.kint.2023.10.022","article-title":"Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease","volume":"105","author":"Beamish","year":"2024","journal-title":"Kidney Int."},{"key":"10.1016\/j.jbc.2026.113305_bib10","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.celrep.2015.12.071","article-title":"Sox9-Positive Progenitor cells play a key role in renal tubule epithelial regeneration in mice","volume":"14","author":"Kang","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.113305_bib11","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2026684118","article-title":"Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury","volume":"118","author":"Gerhardt","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113305_bib12","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/s41467-024-45706-0","article-title":"Predicting proximal tubule failed repair drivers through regularized regression analysis of single cell multiomic sequencing","volume":"15","author":"Ledru","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113305_bib13","doi-asserted-by":"crossref","first-page":"F95","DOI":"10.1152\/ajprenal.00289.2024","article-title":"Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury","volume":"328","author":"McElliott","year":"2025","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.jbc.2026.113305_bib14","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1038\/s41467-019-11672-1","article-title":"PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma","volume":"10","author":"Bleu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113305_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddaf205","article-title":"PAX gene expression in autosomal dominant polycystic kidney disease contributes to cyst expansion and regulates a gene network associated with cyst growth","volume":"35","author":"Zheng","year":"2026","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2026.113305_bib16","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.devcel.2007.09.004","article-title":"The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex","volume":"13","author":"Patel","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jbc.2026.113305_bib17","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1074\/jbc.M109663200","article-title":"Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation","volume":"277","author":"Cai","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113305_bib18","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1093\/nar\/28.14.2741","article-title":"PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin","volume":"28","author":"Lechner","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.113305_bib19","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1093\/emboj\/19.10.2292","article-title":"Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family","volume":"19","author":"Eberhard","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2026.113305_bib20","doi-asserted-by":"crossref","first-page":"7185","DOI":"10.1074\/jbc.M114.607424","article-title":"The Groucho-associated phosphatase PPM1B displaces pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor","volume":"290","author":"Abraham","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113305_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molcel.2011.11.007","article-title":"Epigenetic mechanisms of Groucho\/Grg\/TLE mediated transcriptional repression","volume":"45","author":"Patel","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113305_bib22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.chembiol.2021.11.003","article-title":"Identification of pax protein inhibitors that suppress target gene expression and cancer cell proliferation","volume":"29","author":"Bradford","year":"2022","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jbc.2026.113305_bib23","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1093\/emboj\/cdg536","article-title":"Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation","volume":"22","author":"Cai","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2026.113305_bib24","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00467-013-2603-8","article-title":"Mechanisms of gene activation and repression by pax proteins in the developing kidney","volume":"29","author":"Patel","year":"2014","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.jbc.2026.113305_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73861-3","article-title":"Sustained alterations in proximal tubule gene expression in primary culture associate with HNF4A loss","volume":"14","author":"Telang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2026.113305_bib26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.jbc.2026.113305_bib27","doi-asserted-by":"crossref","first-page":"F1210","DOI":"10.1152\/ajprenal.00660.2011","article-title":"PTEN loss defines a TGF-\u03b2-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis","volume":"302","author":"Lan","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol"},{"key":"10.1016\/j.jbc.2026.113305_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1523-1755.2002.00401.x","article-title":"Interleukin-1\u03b2 induces human proximal tubule cell injury, \u03b1-smooth muscle actin expression and fibronectin production 1","volume":"62","author":"Vesey","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.jbc.2026.113305_bib29","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.68603","article-title":"Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair","volume":"10","author":"Ide","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.jbc.2026.113305_bib30","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1681\/ASN.2020101406","article-title":"A comprehensive map of mRNAs and their isoforms across all 14 renal tubule segments of mouse","volume":"32","author":"Chen","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jbc.2026.113305_bib31","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1681\/ASN.2020010009","article-title":"Transcriptomes of major proximal tubule cell culture models","volume":"32","author":"Khundmiri","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jbc.2026.113305_bib32","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1681\/ASN.2014111067","article-title":"Deep sequencing in microdissected renal tubules identifies nephron segment-specific transcriptomes","volume":"26","author":"Lee","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jbc.2026.113305_bib33","doi-asserted-by":"crossref","first-page":"F563","DOI":"10.1152\/ajprenal.00232.2024","article-title":"Assays to enhance metabolic phenotyping in the kidney","volume":"328","author":"Hammoud","year":"2025","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.jbc.2026.113305_bib34","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","article-title":"ChIPseeker: an R\/Bioconductor package for ChIP peak annotation, comparison and visualization","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2026.113305_bib35","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1101\/gad.339762.120","article-title":"A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4\/COMPASS and is sufficient to rescue loss of viability in null animals","volume":"34","author":"Rickels","year":"2020","journal-title":"Gene Dev"},{"key":"10.1016\/j.jbc.2026.113305_bib36","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.molcel.2017.04.018","article-title":"Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation","volume":"66","author":"Dorighi","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113305_bib37","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1038\/ng.3965","article-title":"Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability","volume":"49","author":"Rickels","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2026.113305_bib38","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1128\/MCB.00990-10","article-title":"Role of PTIP in class switch recombination and long-range chromatin interactions at the Immunoglobulin heavy chain locus","volume":"31","author":"Schwab","year":"2011","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.113305_bib39","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1242\/dev.127.17.3703","article-title":"Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development","volume":"127","author":"Bouchard","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.jbc.2026.113305_bib40","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/s41590-024-01933-7","article-title":"Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development","volume":"25","author":"Fedl","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2026.113305_bib41","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20230260","article-title":"Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development","volume":"220","author":"Gruenbacher","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2026.113305_bib42","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/s41590-018-0234-8","article-title":"Transcription-factor-mediated supervision of global genome architecture maintains B cell identity","volume":"19","author":"Johanson","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2026.113305_bib43","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD","volume":"11","author":"Ferenbach","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jbc.2026.113305_bib44","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1038\/emboj.2012.155","article-title":"The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis","volume":"31","author":"Revilla-i-Domingo","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2026.113305_bib45","doi-asserted-by":"crossref","first-page":"7978","DOI":"10.1074\/jbc.271.14.7978","article-title":"Identification of novel Pax-2 binding sites by chromatin precipitation (\u2217)","volume":"271","author":"Phelps","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113305_bib46","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1101\/gad.7.10.2048","article-title":"DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site","volume":"7","author":"Czerny","year":"1993","journal-title":"Gene Dev."},{"key":"10.1016\/j.jbc.2026.113305_bib47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1152\/ajpcell.1995.268.4.C1053","article-title":"Improved culture conditions stimulate gluconeogenesis in primary cultures of renal proximal tubule cells","volume":"268","author":"Nowak","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jbc.2026.113305_bib48","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.molcel.2024.10.021","article-title":"Long-range regulation of transcription scales with genomic distance in a gene-specific manner","volume":"85","author":"Jensen","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113305_bib49","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.aau0320","article-title":"Developmental enhancers and chromosome topology","volume":"361","author":"Furlong","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113305_bib50","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1073\/pnas.1605085113","article-title":"Syntax compensates for poor binding sites to encode tissue specificity of developmental enhancers","volume":"113","author":"Farley","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113305_bib51","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/s41588-019-0538-0","article-title":"Activity-by-contact model of enhancer\u2013promoter regulation from thousands of CRISPR perturbations","volume":"51","author":"Fulco","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2026.113305_bib52","doi-asserted-by":"crossref","first-page":"F488","DOI":"10.1152\/ajprenal.00172.2002","article-title":"Chemical anoxia of tubular cells induces activation of c-Src and its translocation to the zonula adherens","volume":"284","author":"Sinha","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.jbc.2026.113305_bib53","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbc.2026.113305_bib54","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2026.113305_bib55","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbc.2026.113305_bib56","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.113305_bib57","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2026.113305_bib58","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1038\/s41596-020-0373-x","article-title":"Efficient low-cost chromatin profiling with CUT&Tag","volume":"15","author":"Kaya-Okur","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2026.113305_bib59","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2026.113305_bib60","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2026.113305_bib61","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-021-04246-z","article-title":"Targeting SWI\/SNF ATPases in enhancer-addicted prostate cancer","volume":"601","author":"Xiao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113305_bib62","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors Prime cis-Regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826021770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826021770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T19:36:58Z","timestamp":1787254618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826021770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0021925826021770"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113305","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PAX8 controls proximal tubule epithelial identity and stress response through epigenetic modification of distal regulatory elements","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113305","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113305"}}