{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:50Z","timestamp":1790108030839,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011541","name":"National Cancer Institute Division of Cancer Epidemiology and Genetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jbc.2026.113364","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:01:18Z","timestamp":1784934078000},"page":"113364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human length telomeres restrict the regenerative potential of hematopoietic stem cells in mice"],"prefix":"10.1016","volume":"302","author":[{"given":"Melissa M.","family":"Rowe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-5879","authenticated-orcid":false,"given":"Joanna","family":"Tober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riham","family":"Smoom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Tzfati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Speck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1228-021X","authenticated-orcid":false,"given":"Klaus H.","family":"Kaestner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113364_bib1","article-title":"How shelterin orchestrates the replication and protection of telomeres","volume":"18","author":"de Lange","year":"2026","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jbc.2026.113364_bib2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/bjh.13442","article-title":"Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder","volume":"170","author":"Glousker","year":"2015","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jbc.2026.113364_bib3","doi-asserted-by":"crossref","first-page":"15960","DOI":"10.1073\/pnas.0508124102","article-title":"Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita","volume":"102","author":"Armanios","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.jbc.2026.113364_bib4","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1182\/blood-2006-12-062851","article-title":"Telomerase reverse-transcriptase homozygous mutations in autosomal recessive dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome","volume":"110","author":"Marrone","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2026.113364_bib5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ajhg.2013.02.001","article-title":"Constitutional mutations in RTEL1 cause severe dyskeratosis congenita","volume":"92","author":"Walne","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2026.113364_bib6","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1399-0004.2011.01658.x","article-title":"Three novel truncating TINF2 mutations causing severe dyskeratosis congenita in early childhood","volume":"81","author":"Sasa","year":"2012","journal-title":"Clin. Genet."},{"key":"10.1016\/j.jbc.2026.113364_bib7","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ajhg.2007.10.004","article-title":"TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita","volume":"82","author":"Savage","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2026.113364_bib8","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1182\/blood-2008-05-153445","article-title":"TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes","volume":"112","author":"Walne","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2026.113364_bib9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00439-013-1265-8","article-title":"Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita","volume":"132","author":"Ballew","year":"2013","journal-title":"Hum. Genet."},{"key":"10.1016\/j.jbc.2026.113364_bib10","doi-asserted-by":"crossref","first-page":"E3408","DOI":"10.1073\/pnas.1300600110","article-title":"Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome","volume":"110","author":"Deng","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113364_bib11","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1093\/hmg\/ddt178","article-title":"Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability","volume":"22","author":"Le Guen","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2026.113364_bib12","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1182\/blood-2010-08-303537","article-title":"The replication rate of human hematopoietic stem cells in vivo","volume":"117","author":"Catlin","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2026.113364_bib13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nbt.1517","article-title":"Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells","volume":"27","author":"Foudi","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2026.113364_bib14","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1073\/pnas.96.6.3120","article-title":"In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells","volume":"96","author":"Cheshier","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113364_bib15","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0959-8049(97)00059-2","article-title":"Telomeres and telomerase in normal and malignant haematopoietic cells","volume":"33","author":"Norrback","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jbc.2026.113364_bib16","doi-asserted-by":"crossref","first-page":"6708","DOI":"10.1038\/s41467-023-42534-6","article-title":"Telomouse-a mouse model with human-length telomeres generated by a single amino acid change in RTEL1","volume":"14","author":"Smoom","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113364_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0092-8674(01)80006-4","article-title":"Telomere shortening and tumor formation by mouse cells lacking telomerase RNA","volume":"91","author":"Blasco","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113364_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2025.101655","article-title":"Human-length telomeres limit regeneration of liver epithelial cells in mice","volume":"20","author":"Hu","year":"2026","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jbc.2026.113364_bib19","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","article-title":"SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells","volume":"121","author":"Kiel","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113364_bib20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1365-2141.1979.tb03761.x","article-title":"Effects of 5-fluorouracil on mouse bone marrow","volume":"43","author":"Radley","year":"1979","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jbc.2026.113364_bib21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.stem.2013.05.014","article-title":"SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors","volume":"13","author":"Oguro","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jbc.2026.113364_bib22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.genet.41.110306.130350","article-title":"How shelterin protects mammalian telomeres","volume":"42","author":"Palm","year":"2008","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.jbc.2026.113364_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf830","article-title":"The house mouse maintains constant telomere length throughout life","volume":"53","author":"Smoom","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.113364_bib24","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1056\/NEJMra0903373","article-title":"Telomere diseases","volume":"361","author":"Calado","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbc.2026.113364_bib25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/ng1346","article-title":"Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC","volume":"36","author":"Vulliamy","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2026.113364_bib26","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.exphem.2004.07.023","article-title":"Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths","volume":"32","author":"Shepherd","year":"2004","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.jbc.2026.113364_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.27779","article-title":"Severe therapy-related toxicities after treatment for Hodgkin lymphoma due to a pathogenic TERT variant and shortened telomeres","volume":"66","author":"Agrusa","year":"2019","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.jbc.2026.113364_bib28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/GIM.0b013e3181f415b5","article-title":"The genetics and clinical manifestations of telomere biology disorders","volume":"12","author":"Savage","year":"2010","journal-title":"Genet. Med."},{"key":"10.1016\/j.jbc.2026.113364_bib29","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa066157","article-title":"Telomerase mutations in families with idiopathic pulmonary fibrosis","volume":"356","author":"Armanios","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbc.2026.113364_bib30","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/hep.24173","article-title":"Constitutional telomerase mutations are genetic risk factors for cirrhosis","volume":"53","author":"Calado","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jbc.2026.113364_bib31","article-title":"Placental growth factor expression is required for bone marrow endothelial cell support of primitive murine hematopoietic cells","volume":"8","author":"Zhou","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2026.113364_bib32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.stem.2019.06.007","article-title":"Remodeling of bone marrow hematopoietic stem cell niches promotes myeloid cell expansion during premature or physiological aging","volume":"25","author":"Ho","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jbc.2026.113364_bib33","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/jbmr.3142","article-title":"PTHrP(12-48) modulates the bone marrow microenvironment and suppresses human osteoclast differentiation and lifespan","volume":"32","author":"Kamalakar","year":"2017","journal-title":"J Bone Miner Res"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826022362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826022362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:58:19Z","timestamp":1790107099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826022362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0021925826022362"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113364","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human length telomeres restrict the regenerative potential of hematopoietic stem cells in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113364","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113364"}}