{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:12:05Z","timestamp":1790107925555,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007062","name":"Yangzhou University","doi-asserted-by":"publisher","award":["137013326"],"award-info":[{"award-number":["137013326"]}],"id":[{"id":"10.13039\/501100007062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404216"],"award-info":[{"award-number":["82404216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014862","name":"YangZhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["YZ2024179"],"award-info":[{"award-number":["YZ2024179"]}],"id":[{"id":"10.13039\/501100014862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014862","name":"YangZhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["YZ2024184"],"award-info":[{"award-number":["YZ2024184"]}],"id":[{"id":"10.13039\/501100014862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752726"],"award-info":[{"award-number":["2024M752726"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jbc.2026.113400","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:02:34Z","timestamp":1786114954000},"page":"113400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bone marrow mesenchymal stem cell-derived CHI3L1 protected against Helicobacter pylori-induced gastric mucosal damage by promoting DNA damage repair via regulating CTCF\/CPT1A"],"prefix":"10.1016","volume":"302","author":[{"given":"Wang","family":"Qianqian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Xiaoxiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yongbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2246-8571","authenticated-orcid":false,"given":"Hu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113400_bib1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41575-025-01042-2","article-title":"Microbiota and gastric cancer - principles of microorganism-driven carcinogenesis","volume":"22","author":"Wizenty","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jbc.2026.113400_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.00732-23","article-title":"Testing for in an era of antimicrobial resistance","volume":"62","author":"Schuetz","year":"2024","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jbc.2026.113400_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120945","article-title":"Amelioration of induced gastric injury by folium total extract, its total flavonoids, and eupatilin through suppression of NF-\u03baB signaling and virulence factors","volume":"357","author":"Zheng","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jbc.2026.113400_bib4","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3390\/cells14211652","article-title":"Hsp60-bearing exosomes in induced gastric tumorigenesis: a pathomorphological and therapeutical overview","volume":"14","author":"Gratie","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2026.113400_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2025.157061","article-title":"Inflammation in gastric epithelium associated with infection of is induced by inhibited PPAR\u03b3 pathway: the key role of TLRs\/NF-\u03baB axis","volume":"196","author":"Mao","year":"2025","journal-title":"Cytokine"},{"key":"10.1016\/j.jbc.2026.113400_bib6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/gutjnl-2025-335103","article-title":"Gastrin-dependent expansion of Cck2r corpus progenitors accelerates ulcer healing and inhibits gastric dysplasia","volume":"75","author":"Zheng","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.jbc.2026.113400_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13045-024-01654-2","article-title":"Helicobacter pylori and gastric cancer: mechanisms and new perspectives","volume":"18","author":"Duan","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jbc.2026.113400_bib8","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2463581","article-title":"Infection induces DNA double-strand breaks through the ACVR1\/IRF3\/POLD1 signaling axis to drive gastric tumorigenesis","volume":"17","author":"Xu","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jbc.2026.113400_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13099-025-00778-1","article-title":"Extracts from and inhibit induced epithelial cell damage, DNA double-strand breaks inflammation","volume":"17","author":"Noman","year":"2025","journal-title":"Gut Pathog."},{"key":"10.1016\/j.jbc.2026.113400_bib10","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1016\/j.ymthe.2025.02.003","article-title":"Mesenchymal stromal cell therapy: progress to date and future outlook","volume":"33","author":"Lu","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jbc.2026.113400_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh0322","article-title":"Inactivation of the tumor suppressor gene synergizes with to induce DNA damage in murine gastric stem and progenitor cells","volume":"9","author":"He","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2026.113400_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41573-024-01060-w","article-title":"DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications","volume":"24","author":"Drew","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jbc.2026.113400_bib13","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1056\/NEJMoa2211807","article-title":"Homologous-recombination genes, and gastric cancer","volume":"388","author":"Usui","year":"2023","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jbc.2026.113400_bib14","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1172\/JCI125581","article-title":"Infection alters repair of DNA double-strand breaks via SNHG17","volume":"130","author":"Han","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.113400_bib15","article-title":"Inhibition of CCCTC binding factor-programmed cell death ligand 1 axis suppresses emergence of chemoresistance induced by gastric cancer-derived mesenchymal stem cells","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2026.113400_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.103002","article-title":"miR-6722-3p Improves sepsis-induced Acute Kidney Injury by Targeting CHI3L1","volume":"96","author":"Zhang","year":"2025","journal-title":"Tissue Cell"},{"key":"10.1016\/j.jbc.2026.113400_bib17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3164\/jcbn.20-151","article-title":"Therapeutic effects of placenta derived-, umbilical cord derived-, and adipose tissue derived-mesenchymal stem cells in chronic infection: comparison and novel mechanisms","volume":"69","author":"Park","year":"2021","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.jbc.2026.113400_bib18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41419-021-03524-y","article-title":"Mesenchymal stem cells alleviate experimental immune-mediated liver injury via chitinase 3-like protein 1-mediated T cell suppression","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2026.113400_bib19","doi-asserted-by":"crossref","first-page":"11950","DOI":"10.7150\/thno.49717","article-title":"Gastric cancer mesenchymal stem cells regulate PD-L1-CTCF enhancing cancer stem cell-like properties and tumorigenesis","volume":"10","author":"Sun","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jbc.2026.113400_bib20","doi-asserted-by":"crossref","first-page":"4.2","DOI":"10.1212\/WNL.92.15_supplement.P4.2-050","article-title":"Intrathecal MSC-NP treatment in patients with progressive multiple sclerosis is associated with modulation of cerebrospinal fluid biomarkers","volume":"92","author":"Zanker","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.jbc.2026.113400_bib21","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41419-020-02909-9","article-title":"The different role of YKL-40 in glioblastoma is a function of MGMT promoter methylation status","volume":"11","author":"Chen","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2026.113400_bib22","first-page":"442","article-title":"Gastric cancer-derived exosomes induce PD-L1 expression on human bone marrow mesenchymal stem cells through the AKT-c-Myc signal axis","volume":"15","author":"Gao","year":"2022","journal-title":"J. Biochem. Cell Mol. Biol."},{"key":"10.1016\/j.jbc.2026.113400_bib23","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41586-023-05961-5","article-title":"CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion","volume":"616","author":"Davidson","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113400_bib24","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/s41467-025-56781-2","article-title":"D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming","volume":"16","author":"Lang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113400_bib25","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.abi6378","article-title":"Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress","volume":"376","author":"Larsen","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113400_bib26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.cell.2023.11.022","article-title":"Metabolic regulation of homologous recombination repair by MRE11 lactylation","volume":"187","author":"Chen","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113400_bib27","doi-asserted-by":"crossref","first-page":"10373","DOI":"10.1007\/s11033-012-1916-1","article-title":"Toxicogenomic activity of gemcitabine in two mutated bladder cancer cell lines: special focus on cell cycle-related genes","volume":"39","author":"da Silva","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jbc.2026.113400_bib28","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/emboj.2010.330","article-title":"ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA Repair","volume":"30","author":"Cosentino","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2026.113400_bib29","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccr.2013.02.024","article-title":"SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism","volume":"23","author":"Jeong","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbc.2026.113400_bib30","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.7150\/thno.74770","article-title":"Plasma lipids signify the progression of precancerous gastric lesions to gastric cancer: a prospective targeted lipidomics study","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.jbc.2026.113400_bib31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41419-023-05968-w","article-title":"Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation","volume":"14","author":"Yang","year":"2023","journal-title":"Cell Death Dis."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826022726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826022726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:57:45Z","timestamp":1790107065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826022726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0021925826022726"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113400","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone marrow mesenchymal stem cell-derived CHI3L1 protected against Helicobacter pylori-induced gastric mucosal damage by promoting DNA damage repair via regulating CTCF\/CPT1A","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113400"}}