{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:32:43Z","timestamp":1793223163273,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2023\/00109"],"award-info":[{"award-number":["CRG\/2023\/00109"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022012","name":"CSIR-Institute of Microbial Technology","doi-asserted-by":"publisher","award":["OLP-0170"],"award-info":[{"award-number":["OLP-0170"]}],"id":[{"id":"10.13039\/501100022012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022012","name":"CSIR-Institute of Microbial Technology","doi-asserted-by":"publisher","award":["FBR070308"],"award-info":[{"award-number":["FBR070308"]}],"id":[{"id":"10.13039\/501100022012","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jbc.2026.113445","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:22:09Z","timestamp":1786663329000},"page":"113445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptional control of asparagine utilization regulates mycobacterial pH-driven adaptation at the host\u2013pathogen crossroads"],"prefix":"10.1016","volume":"302","author":[{"given":"Bhanwar","family":"Bamniya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Kajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushboo","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6499-177X","authenticated-orcid":false,"given":"Dibyendu","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113445_bib1","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.micinf.2005.10.027","article-title":"Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another","volume":"8","author":"Schnappinger","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.jbc.2026.113445_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0065-2911(09)05502-7","article-title":"Physiology of mycobacteria","volume":"55","author":"Cook","year":"2009","journal-title":"Adv. Microb. Physiol."},{"key":"10.1016\/j.jbc.2026.113445_bib3","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cell.2013.10.045","article-title":"Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing","volume":"155","author":"Zhang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113445_bib4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.imbio.2008.12.005","article-title":"The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages","volume":"214","author":"de Chastellier","year":"2009","journal-title":"Immunobiology"},{"key":"10.1016\/j.jbc.2026.113445_bib5","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/j.1462-5822.2009.01335.x","article-title":"Mycobacterial survival strategies in the phagosome: defence against host stresses","volume":"11","author":"Ehrt","year":"2009","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/35085034","article-title":"Mycobacterium tuberculosis: here today, and here tomorrow","volume":"2","author":"Russell","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.113445_bib7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-065X.2010.00984.x","article-title":"Mycobacterium tuberculosis and the intimate discourse of a chronic infection","volume":"240","author":"Russell","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jbc.2026.113445_bib8","doi-asserted-by":"crossref","first-page":"6554","DOI":"10.1073\/pnas.1219375110","article-title":"Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis","volume":"110","author":"Eoh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113445_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/nmicrobiol.2017.84","article-title":"Metabolic anticipation in Mycobacterium tuberculosis","volume":"2","author":"Eoh","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.chom.2007.09.006","article-title":"Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues","volume":"2","author":"Rohde","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2026.113445_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002769","article-title":"Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection","volume":"8","author":"Rohde","year":"2012","journal-title":"Plos Pathog."},{"key":"10.1016\/j.jbc.2026.113445_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000988","article-title":"Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival","volume":"6","author":"Homolka","year":"2010","journal-title":"Plos Pathog."},{"key":"10.1016\/j.jbc.2026.113445_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00705-19","article-title":"Metabolic switching of Mycobacterium tuberculosis during hypoxia is controlled by the virulence regulator PhoP","volume":"202","author":"Singh","year":"2020","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbc.2026.113445_bib14","doi-asserted-by":"crossref","first-page":"10008","DOI":"10.1073\/pnas.1513033112","article-title":"Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis","volume":"112","author":"Berney","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113445_bib15","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1128\/IAI.68.5.2888-2898.2000","article-title":"Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis","volume":"68","author":"Hondalus","year":"2000","journal-title":"Infect Immun."},{"key":"10.1016\/j.jbc.2026.113445_bib16","doi-asserted-by":"crossref","first-page":"e41129","DOI":"10.7554\/eLife.41129","article-title":"Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis","volume":"8","author":"Agapova","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.113445_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003928","article-title":"Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection","volume":"10","author":"Gouzy","year":"2014","journal-title":"Plos Pathog."},{"key":"10.1016\/j.jbc.2026.113445_bib18","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/mmi.13091","article-title":"Deciphering the metabolic response of Mycobacterium tuberculosis to nitrogen stress","volume":"97","author":"Williams","year":"2015","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib19","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1365-2958.2011.07601.x","article-title":"aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome","volume":"80","author":"Abramovitch","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib20","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/mmi.13635","article-title":"Mycobacterium tuberculosis virulence-regulator PhoP interacts with alternative sigma factor SigE during acid-stress response","volume":"104","author":"Bansal","year":"2017","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib21","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2024571118","article-title":"Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity","volume":"118","author":"Gouzy","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113445_bib22","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.8303277","article-title":"Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase","volume":"263","author":"Sturgill-Koszycki","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113445_bib23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1600-0854.2005.00284.x","article-title":"The kinetics of phagosome maturation as a function of phagosome\/lysosome fusion and acquisition of hydrolytic activity","volume":"6","author":"Yates","year":"2005","journal-title":"Traffic"},{"key":"10.1016\/j.jbc.2026.113445_bib24","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.4049\/jimmunol.160.3.1290","article-title":"Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages","volume":"160","author":"Schaible","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2026.113445_bib25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2217\/fmb.14.28","article-title":"Amino acid capture and utilization within the Mycobacterium tuberculosis phagosome","volume":"9","author":"Gouzy","year":"2014","journal-title":"Future Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011070","article-title":"Dual functioning by the PhoR sensor is a key determinant to Mycobacterium tuberculosis virulence","volume":"19","author":"Singh","year":"2023","journal-title":"Plos Genet."},{"key":"10.1016\/j.jbc.2026.113445_bib27","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.tim.2019.06.005","article-title":"Acid fasting: Modulation of Mycobacterium tuberculosis metabolism at acidic pH","volume":"27","author":"Baker","year":"2019","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw625","article-title":"Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system","volume":"44","author":"Singh","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.113445_bib29","doi-asserted-by":"crossref","first-page":"RP92136","DOI":"10.7554\/eLife.92136","article-title":"Mycobacterium tuberculosis PhoP integrates stress response to intracellular survival by regulating cAMP level","volume":"13","author":"Khan","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.113445_bib30","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nm.1795","article-title":"A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis","volume":"14","author":"Vandal","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2026.113445_bib31","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1074\/jbc.M115.684597","article-title":"Mycobacterium tuberculosis WhiB3 responds to vacuolar pH-induced changes in mycothiol Redox potential to modulate phagosomal maturation and virulence","volume":"291","author":"Mehta","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113445_bib32","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1084\/jem.20030846","article-title":"Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment","volume":"198","author":"Schnappinger","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2026.113445_bib33","doi-asserted-by":"crossref","first-page":"34309","DOI":"10.1074\/jbc.M110.135822","article-title":"Domain structure of virulence-associated response regulator PhoP of Mycobacterium tuberculosis: role of the linker region in regulator-promoter interaction(s)","volume":"285","author":"Pathak","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113445_bib34","doi-asserted-by":"crossref","first-page":"45197","DOI":"10.1074\/jbc.M111.307447","article-title":"Phosphorylation of PhoP protein plays direct regulatory role in lipid biosynthesis of Mycobacterium tuberculosis","volume":"286","author":"Goyal","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113445_bib35","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1128\/JB.181.11.3402-3408.1999","article-title":"Transcriptional control of the iron-responsive fxbA gene by the mycobacterial regulator IdeR","volume":"181","author":"Dussurget","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbc.2026.113445_bib36","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1093\/nar\/gni013","article-title":"Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor","volume":"33","author":"Ehrt","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"Pt 11","key":"10.1016\/j.jbc.2026.113445_bib37","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1099\/00221287-145-11-3177","article-title":"Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosis","volume":"145","author":"De Smet","year":"1999","journal-title":"Microbiology (Reading)"},{"key":"10.1016\/j.jbc.2026.113445_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004183","article-title":"The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis","volume":"10","author":"Solans","year":"2014","journal-title":"Plos Pathog."},{"key":"10.1016\/j.jbc.2026.113445_bib39","doi-asserted-by":"crossref","first-page":"17707","DOI":"10.1016\/S0021-9258(19)47429-2","article-title":"Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells","volume":"266","author":"Yoshimori","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113445_bib40","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nchembio.1355","article-title":"Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate","volume":"9","author":"Gouzy","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2026.113445_bib41","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrmicro3349","article-title":"Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence","volume":"12","author":"Gouzy","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib42","first-page":"929","article-title":"Evaluation of L-asparagine metabolism in animals and man","volume":"30","author":"Cooney","year":"1970","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2026.113445_bib43","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/ndt\/17.3.413","article-title":"Free amino acids in plasma, red blood cells, polymorphonuclear leukocytes, and muscle in normal and uraemic children","volume":"17","author":"Canepa","year":"2002","journal-title":"Nephrol. Dial Transpl."},{"key":"10.1016\/j.jbc.2026.113445_bib44","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1128\/IAI.71.7.3927-3936.2003","article-title":"Glutamine synthetase GlnA1 is essential for growth of Mycobacterium tuberculosis in human THP-1 macrophages and Guinea pigs","volume":"71","author":"Tullius","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2026.113445_bib45","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/mmi.12688","article-title":"Slow growth of Mycobacterium tuberculosis at acidic pH is regulated by phoPR and host-associated carbon sources","volume":"94","author":"Baker","year":"2014","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2958.2001.02500.x","article-title":"An essential role for phoP in Mycobacterium tuberculosis virulence","volume":"41","author":"P\u00e9rez","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib47","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1365-2958.2006.05102.x","article-title":"The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis","volume":"60","author":"Walters","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2026.113445_bib48","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1074\/jbc.C500388200","article-title":"The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis","volume":"281","author":"Gonzalo Asensio","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113445_bib49","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1016\/j.vaccine.2006.03.017","article-title":"The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and Guinea pigs","volume":"24","author":"Martin","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.jbc.2026.113445_bib50","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1371\/journal.ppat.0040033","article-title":"Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP","volume":"4","author":"Frigui","year":"2008","journal-title":"Plos Pathog."},{"key":"10.1016\/j.jbc.2026.113445_bib51","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.1128\/JB.00712-08","article-title":"The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv","volume":"190","author":"Gonzalo-Asensio","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbc.2026.113445_bib52","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/31159","article-title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence","volume":"393","author":"Cole","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113445_bib53","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1099\/00221287-148-10-3029","article-title":"Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structure","volume":"148","author":"Ludwiczak","year":"2002","journal-title":"Microbiology (Reading)"},{"key":"10.1016\/j.jbc.2026.113445_bib54","article-title":"Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages","volume":"5","author":"Li","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2026.113445_bib55","doi-asserted-by":"crossref","first-page":"19018","DOI":"10.1074\/jbc.M116.746289","article-title":"EspR-dependent ESAT-6 protein secretion of Mycobacterium tuberculosis requires the presence of virulence regulator PhoP","volume":"291","author":"Anil Kumar","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113445_bib56","doi-asserted-by":"crossref","first-page":"8008","DOI":"10.1021\/bi501019u","article-title":"DNA consensus sequence motif for binding response regulator PhoP, a virulence regulator of Mycobacterium tuberculosis","volume":"53","author":"He","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2026.113445_bib57","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1128\/JB.00669-09","article-title":"Mycobacterium tuberculosis PhoP recognizes two adjacent direct-repeat sequences to form head-to-head dimers","volume":"191","author":"Gupta","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbc.2026.113445_bib58","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1021\/bi2005575","article-title":"Structure of the response regulator PhoP from Mycobacterium tuberculosis reveals a dimer through the receiver domain","volume":"50","author":"Menon","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2026.113445_bib59","article-title":"Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tuberculosis","volume":"6","author":"He","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2026.113445_bib60","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0076-6879(91)04027-L","article-title":"Genetic systems for mycobacteria","volume":"204","author":"Jacobs","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jbc.2026.113445_bib61","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1038\/s41467-025-64404-z","article-title":"Fundamental role of spatial positioning of Mycobacterium tuberculosis in mycobacterial survival in macrophages","volume":"16","author":"Sahu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113445_bib62","doi-asserted-by":"crossref","first-page":"e80965","DOI":"10.7554\/eLife.80965","article-title":"Convergence of two global regulators to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis","volume":"11","author":"Khan","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.113445_bib63","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2026.113445_bib64","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1046\/j.1365-2958.2001.02684.x","article-title":"The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages","volume":"42","author":"Gold","year":"2001","journal-title":"Mol. Microbiol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826023173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826023173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:40:37Z","timestamp":1793220037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826023173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":64,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0021925826023173"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113445","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional control of asparagine utilization regulates mycobacterial pH-driven adaptation at the host\u2013pathogen crossroads","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113445","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113445"}}