{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:36:25Z","timestamp":1793219785271,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014547","name":"Parker Institute for Cancer Immunotherapy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL145754"],"award-info":[{"award-number":["HL145754"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI082630"],"award-info":[{"award-number":["U19AI082630"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P 01AI117950"],"award-info":[{"award-number":["P 01AI117950"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI149680"],"award-info":[{"award-number":["U19AI149680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AI108545"],"award-info":[{"award-number":["P01AI108545"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001368","name":"V Foundation for Cancer Research","doi-asserted-by":"publisher","award":["V 2024-009"],"award-info":[{"award-number":["V 2024-009"]}],"id":[{"id":"10.13039\/100001368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jbc.2026.113519","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:20:07Z","timestamp":1788823207000},"page":"113519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4410-0943","authenticated-orcid":false,"given":"Helen A.","family":"Jordan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Tandurella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1078-5476","authenticated-orcid":false,"given":"Vineeth","family":"Vengayil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanay S.","family":"Parnaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swechha Mainali","family":"Pokharel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Mulka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3956-6610","authenticated-orcid":false,"given":"Sara","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. John","family":"Wherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2147-6003","authenticated-orcid":false,"given":"Caroline R.","family":"Bartman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113519_bib1","series-title":"Janeway\u2019s Immunobiology","author":"Murphy","year":"2016"},{"key":"10.1016\/j.jbc.2026.113519_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41589-024-01571-y","article-title":"Mitochondrial ATP generation is more proteome efficient than glycolysis","volume":"20","author":"Shen","year":"2024","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2026.113519_bib3","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41590-019-0397-y","article-title":"CD8+ T cells induce cachexia during chronic viral infection","volume":"20","author":"Baazim","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2026.113519_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2012.10.020","article-title":"Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling","volume":"38","author":"Sena","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2026.113519_bib5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1074-7613(02)00323-0","article-title":"The CD28 signaling pathway regulates glucose metabolism","volume":"16","author":"Frauwirth","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2026.113519_bib6","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cell.2013.05.016","article-title":"Posttranscriptional control of T cell effector function by aerobic glycolysis","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113519_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2019.01.050","article-title":"Energetic trade-offs and hypometabolic states promote disease tolerance","volume":"177","author":"Ganeshan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113519_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cmet.2014.05.004","article-title":"The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function","volume":"20","author":"Macintyre","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2026.113519_bib9","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s42255-019-0083-2","article-title":"Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-\u03b3 stimulation","volume":"1","author":"Seim","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jbc.2026.113519_bib10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41590-018-0292-y","article-title":"Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated \u2018don\u2019t-eat-me\u2019 signal","volume":"20","author":"Liu","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2026.113519_bib11","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.immuni.2019.11.009","article-title":"Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase","volume":"51","author":"Lauterbach","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2026.113519_bib12","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1074\/jbc.M113.522037","article-title":"Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-MEDIATED glucose metabolism drives a proinflammatory phenotype","volume":"289","author":"Freemerman","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113519_bib13","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.celrep.2016.09.008","article-title":"Mitochondrial dysfunction prevents repolarization of inflammatory macrophages","volume":"17","author":"Van den Bossche","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.113519_bib14","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/s44319-024-00351-y","article-title":"Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation","volume":"26","author":"Ball","year":"2025","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2026.113519_bib15","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.chembiol.2024.04.007","article-title":"One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade","volume":"31","author":"Xu","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jbc.2026.113519_bib16","doi-asserted-by":"crossref","first-page":"16386","DOI":"10.1021\/ja2070889","article-title":"Itaconic acid is a mammalian metabolite induced during macrophage activation","volume":"133","author":"Strelko","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jbc.2026.113519_bib17","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1073\/pnas.1218599110","article-title":"Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production","volume":"110","author":"Michelucci","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113519_bib18","doi-asserted-by":"crossref","first-page":"14274","DOI":"10.1074\/jbc.M115.685792","article-title":"Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels","volume":"291","author":"Cordes","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113519_bib19","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s42255-022-00565-1","article-title":"Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages","volume":"4","author":"He","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jbc.2026.113519_bib20","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1126\/science.aaz1333","article-title":"Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella","volume":"369","author":"Chen","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113519_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0006-291X(88)80015-9","article-title":"Nitric oxide: a cytotoxic activated macrophage effector molecule","volume":"157","author":"Hibbs","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2026.113519_bib22","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/s42255-025-01337-3","article-title":"Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide","volume":"7","author":"John","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jbc.2026.113519_bib23","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1172\/JCI43157","article-title":"Repeated TLR9 stimulation results in macrophage activation syndrome\u2013like disease in mice","volume":"121","author":"Behrens","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.113519_bib24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nm987","article-title":"Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration","volume":"10","author":"Heikenwalder","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2026.113519_bib25","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1084\/jem.160.2.521","article-title":"Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence","volume":"160","author":"Ahmed","year":"1984","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2026.113519_bib26","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1126\/science.272.5270.1947","article-title":"Induction of bystander T cell proliferation by viruses and type I interferon in vivo","volume":"272","author":"Tough","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113519_bib27","series-title":"Essentials of Glycobiology","year":"2022"},{"key":"10.1016\/j.jbc.2026.113519_bib28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of toll-like receptors - redefining innate immunity","volume":"13","author":"O\u2019Neill","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2026.113519_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF01884255","article-title":"Serum sialic acid in malignant tumors, bacterial infections, and chronic liver diseases","volume":"109","author":"Stefenelli","year":"1985","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.jbc.2026.113519_bib30","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00296-013-2921-y","article-title":"Sialic acid level reflects the disturbances of glycosylation and acute-phase reaction in rheumatic diseases","volume":"34","author":"Chrostek","year":"2014","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.jbc.2026.113519_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/09674845.2014.11669959","article-title":"Elevated levels of serum sialic acid and high-sensitivity C-Reactive protein: markers of systemic inflammation in patients with chronic heart failure","volume":"71","author":"Rajendiran","year":"2014","journal-title":"Br. J. Biomed. Sci."},{"key":"10.1016\/j.jbc.2026.113519_bib32","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/000456329202900603","article-title":"Measurement of sialic acid in serum and urine: clinical applications and limitations","volume":"29","author":"Waters","year":"1992","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.jbc.2026.113519_bib33","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/S0959-8049(97)00318-3","article-title":"Plasma sialic acid as a marker of the effect of the treatment on metastatic colorectal cancer","volume":"33","author":"Painbeni","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jbc.2026.113519_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0090-8258(89)90558-1","article-title":"Management of patients with gynecologic cancer by serum sialic acid determination","volume":"33","author":"Shimizu","year":"1989","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.jbc.2026.113519_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3835(89)90207-3","article-title":"Serum and tissue total sialic acid as a marker for human thyroid cancer","volume":"46","author":"K\u00f6ko\u011flu","year":"1989","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jbc.2026.113519_bib36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0009-8981(93)90204-H","article-title":"Serum sialic acid and acute phase proteins in type 1 and type 2 diabetes mellitus","volume":"219","author":"Crook","year":"1993","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jbc.2026.113519_bib37","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1365-2362.1999.00485.x","article-title":"J\u00e4\u00e4skel\u00e4inen. Occurrence of sialic acids in healthy humans and different disorders","volume":"29","author":"Sillanaukee","year":"1999","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.jbc.2026.113519_bib38","doi-asserted-by":"crossref","first-page":"D809","DOI":"10.1093\/nar\/gkr1170","article-title":"MMMDB: Mouse multiple tissue metabolome database","volume":"40","author":"Sugimoto","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.113519_bib39","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature24271","article-title":"Inflammatory memory sensitizes skin epithelial stem cells to tissue damage","volume":"550","author":"Naik","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113519_bib40","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11306-024-02089-z","article-title":"Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock","volume":"20","author":"Rogers","year":"2024","journal-title":"Metabolomics"},{"key":"10.1016\/j.jbc.2026.113519_bib41","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140327","article-title":"COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status","volume":"5","author":"Thomas","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbc.2026.113519_bib42","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jhep.2019.11.009","article-title":"Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF","volume":"72","author":"Moreau","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jbc.2026.113519_bib43","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.molmed.2008.06.002","article-title":"Sialic acids in human health and disease","volume":"14","author":"Varki","year":"2008","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jbc.2026.113519_bib44","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/hmg\/11.12.1455","article-title":"Systemic and neurologic abnormalities distinguish the lysosomal disorders sialidosis and galactosialidosis in mice","volume":"11","author":"de Geest","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2026.113519_bib45","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62644","article-title":"Glutamine deprivation triggers NAGK-dependent hexosamine salvage","volume":"10","author":"Campbell","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.jbc.2026.113519_bib46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nchembio.999","article-title":"Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome","volume":"8","author":"Rillahan","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2026.113519_bib47","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20241207","article-title":"Early transcriptional effects of inflammatory cytokines reveal highly redundant cytokine networks","volume":"222","author":"Lee","year":"2025","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2026.113519_bib48","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1111\/j.1742-4658.2005.04679.x","article-title":"Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages","volume":"272","author":"Stamatos","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.jbc.2026.113519_bib49","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s10719-009-9239-8","article-title":"Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase","volume":"26","author":"Amith","year":"2009","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.jbc.2026.113519_bib50","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/170662a0","article-title":"Carbohydrate residue of a urine mucoprotein inhibiting influenza virus h\u00e6magglutination","volume":"170","author":"Gottschalk","year":"1952","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113519_bib51","article-title":"Systemic metabolic changes in acute and chronic lymphocytic choriomeningitis virus infection","volume":"99","author":"Bartman","year":"2025","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jbc.2026.113519_bib52","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2308511120","article-title":"The total mass, number, and distribution of immune cells in the human body","volume":"120","author":"Sender","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113519_bib53","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1008-1091","article-title":"The Immunological genome project: networks of gene expression in immune cells","volume":"9","author":"Heng","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2026.113519_bib54","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1021\/acs.analchem.5b04071","article-title":"Metabolite profiling and stable isotope tracing in sorted subpopulations of mammalian cells","volume":"88","author":"Roci","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jbc.2026.113519_bib55","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56782","article-title":"Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma","volume":"9","author":"Lau","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.113519_bib56","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.166470","article-title":"Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption","volume":"8","author":"Kho","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbc.2026.113519_bib57","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/s42255-023-00881-0","article-title":"Spatial metabolomics: from a niche field towards a driver of innovation","volume":"5","author":"Alexandrov","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jbc.2026.113519_bib58","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41573-020-00093-1","article-title":"The clinical impact of glycobiology: targeting selectins, siglecs and mammalian glycans","volume":"20","author":"Smith","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jbc.2026.113519_bib59","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41590-025-02352-y","article-title":"Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and role in disease","volume":"27","author":"Park","year":"2026","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2026.113519_bib60","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1128\/JVI.77.8.4911-4927.2003","article-title":"Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment","volume":"77","author":"Wherry","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2026.113519_bib61","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.immuni.2007.09.006","article-title":"Molecular signature of CD8+ T cell exhaustion during chronic viral infection","volume":"27","author":"Wherry","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2026.113519_bib62","doi-asserted-by":"crossref","first-page":"35149","DOI":"10.1074\/jbc.M114.606517","article-title":"Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases","volume":"289","author":"Macauley","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113519_bib63","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41586-022-05661-6","article-title":"Slow TCA flux and ATP production in primary solid tumours but not metastases","volume":"614","author":"Bartman","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113519_bib64","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0021-9258(18)51740-3","article-title":"Effect of ischemia ON KNOWN substrates and cofactors of the glycolytic pathway in brain","volume":"239","author":"Lowry","year":"1964","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113519_bib65","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/ars.2017.7014","article-title":"Extraction and quantitation of nicotinamide adenine dinucleotide redox cofactors","volume":"28","author":"Lu","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jbc.2026.113519_bib66","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1021\/acs.analchem.7b00396","article-title":"Metabolite spectral accuracy on orbitraps","volume":"89","author":"Su","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jbc.2026.113519_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-48009-6","article-title":"MetaboAnalystR 4.0: a unified LC-MS workflow for global metabolomics","volume":"15","author":"Pang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113519_bib68","series-title":"Ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826023914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826023914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:28:52Z","timestamp":1793219332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826023914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":68,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0021925826023914"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113519","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113519","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113519"}}