{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:32:51Z","timestamp":1793223171728,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002661","name":"FRS-FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jbc.2026.113547","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:40:45Z","timestamp":1789195245000},"page":"113547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The phosphate exporter XPR1 promotes gasdermin D\u2013independent mature IL-1\u03b2 secretion"],"prefix":"10.1016","volume":"302","author":[{"given":"Nathalie","family":"Remy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Six","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-734X","authenticated-orcid":false,"given":"Sandrine","family":"Tury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-7647","authenticated-orcid":false,"given":"Emile","family":"Van Schaftingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Battini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre G.","family":"Coulie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2483-2730","authenticated-orcid":false,"given":"Tiphanie","family":"Gomard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113547_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12621","article-title":"Overview of the IL-1 family in innate inflammation and acquired immunity","volume":"281","author":"Dinarello","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jbc.2026.113547_bib2","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/eji.201141550","article-title":"A clinical perspective of IL-1\u03b2 as the gatekeeper of inflammation","volume":"41","author":"Dinarello","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbc.2026.113547_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113547_bib4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113547_bib5","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2026.113547_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2026.113547_bib7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41421-020-0167-x","article-title":"Inflammasome activation and regulation: toward a better understanding of complex mechanisms","volume":"6","author":"Zheng","year":"2020","journal-title":"Cell Discov."},{"key":"10.1016\/j.jbc.2026.113547_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113547_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113547_bib10","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41586-021-03478-3","article-title":"Gasdermin D pore structure reveals preferential release of mature interleukin-1","volume":"593","author":"Xia","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113547_bib11","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.jbc.2026.113547_bib12","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113547_bib13","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113547_bib14","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.celrep.2018.07.027","article-title":"Interleukin-1\u03b2 maturation triggers its relocation to the plasma membrane for Gasdermin-D-Dependent and -Independent secretion","volume":"24","author":"Monteleone","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.113547_bib15","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.celrep.2014.06.028","article-title":"The neutrophil NLRC4 inflammasome selectively promotes IL-1\u03b2 maturation without pyroptosis during acute Salmonella challenge","volume":"8","author":"Chen","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.113547_bib16","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.cell.2016.05.076","article-title":"Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan","volume":"166","author":"Wolf","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113547_bib17","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.aaf3036","article-title":"An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells","volume":"352","author":"Zanoni","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113547_bib18","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2016.01.012","article-title":"Human monocytes engage an alternative inflammasome pathway","volume":"44","author":"Gaidt","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2026.113547_bib19","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41419-018-1121-9","article-title":"Progressive waves of IL-1\u03b2 release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways","volume":"9","author":"Semino","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2026.113547_bib20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.semcdb.2018.03.011","article-title":"The unconventional secretion of IL-1\u03b2: handling a dangerous weapon to optimize inflammatory responses","volume":"83","author":"Sitia","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2026.113547_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.immuni.2017.11.013","article-title":"The pore-forming protein gasdermin D regulates Interleukin-1 secretion from living macrophages","volume":"48","author":"Evavold","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2026.113547_bib22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ijc.2910260208","article-title":"Establishment and characterization of a human acute monocytic leukemia cell line (THP-1)","volume":"26","author":"Tsuchiya","year":"1980","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jbc.2026.113547_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00011-007-6115-5","article-title":"Optimized THP-1 differentiation is required for the detection of responses to weak stimuli","volume":"56","author":"Park","year":"2007","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jbc.2026.113547_bib24","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1038\/sj.bjp.0702732","article-title":"Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes","volume":"127","author":"Grahames","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jbc.2026.113547_bib25","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.1038\/ncomms9761","article-title":"Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes","volume":"6","author":"Vigano","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113547_bib26","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1073\/pnas.96.4.1385","article-title":"A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction","volume":"96","author":"Battini","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113547_bib27","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1073\/pnas.96.3.927","article-title":"Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses","volume":"96","author":"Tailor","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113547_bib28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/6005","article-title":"Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1","volume":"21","author":"Yang","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2026.113547_bib29","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.celrep.2013.05.035","article-title":"Inorganic phosphate export by the retrovirus receptor XPR1 in metazoans","volume":"3","author":"Giovannini","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.113547_bib30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s43018-022-00360-7","article-title":"Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer","volume":"3","author":"Bondeson","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.jbc.2026.113547_bib31","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1016\/j.molcel.2025.08.003","article-title":"KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1","volume":"85","author":"Wang","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113547_bib32","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ng.3289","article-title":"Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export","volume":"47","author":"Legati","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2026.113547_bib33","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1126\/science.aad9858","article-title":"Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains","volume":"352","author":"Wild","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113547_bib34","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1073\/pnas.1908830117","article-title":"Control of XPR1-dependent cellular phosphate efflux by InsP(8) is an exemplar for functionally-exclusive inositol pyrophosphate signaling","volume":"117","author":"Li","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113547_bib35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tibs.2016.10.008","article-title":"Eukaryotic phosphate homeostasis: the inositol pyrophosphate perspective","volume":"42","author":"Azevedo","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2026.113547_bib36","doi-asserted-by":"crossref","first-page":"9366","DOI":"10.1074\/jbc.RA119.011376","article-title":"Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis","volume":"295","author":"L\u00f3pez-S\u00e1nchez","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113547_bib37","article-title":"Electrostatic influence on IL-1 transport through the GSDMD pore","volume":"119","author":"Xie","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113547_bib38","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.aar7607","article-title":"ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation","volume":"362","author":"R\u00fchl","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113547_bib39","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.immuni.2023.10.004","article-title":"Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis","volume":"56","author":"Miao","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2026.113547_bib40","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/s41586-024-07852-9","article-title":"Human XPR1 structures reveal phosphate export mechanism","volume":"633","author":"Yan","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113547_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/science.adp3252","article-title":"Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1","volume":"386","author":"Lu","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113547_bib42","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41467-024-55471-9","article-title":"Structural insights into the mechanism of phosphate recognition and transport by XPR1","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113547_bib43","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41467-025-55995-8","article-title":"Structural basis of phosphate export by human XPR1","volume":"16","author":"He","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113547_bib44","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1038\/s41467-025-58076-y","article-title":"Transport and InsP(8) gating mechanisms of the human inorganic phosphate exporter XPR1","volume":"16","author":"Zhu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113547_bib45","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1038\/s41467-025-58200-y","article-title":"Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate","volume":"16","author":"Zuo","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113547_bib46","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1038\/s41467-025-59678-2","article-title":"The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable ion channel","volume":"16","author":"Wu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113547_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1163442","article-title":"Role of transporters in regulating mammalian intracellular inorganic phosphate","volume":"14","author":"Jennings","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jbc.2026.113547_bib48","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1074\/jbc.M116.765743","article-title":"The significance of the bifunctional kinase\/phosphatase activities of diphosphoinositol pentakisphosphate kinases (PPIP5Ks) for coupling inositol pyrophosphate cell signaling to cellular phosphate homeostasis","volume":"292","author":"Gu","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113547_bib49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12265-023-10427-0","article-title":"Functions, mechanisms, and therapeutic applications of the inositol pyrophosphates 5PP-InsP(5) and InsP(8) in mammalian cells","volume":"17","author":"Qi","year":"2024","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.jbc.2026.113547_bib50","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.cellsig.2005.03.021","article-title":"Signal transduction during environmental stress: InsP8 operates within highly restricted contexts","volume":"17","author":"Choi","year":"2005","journal-title":"Cell Signal."},{"key":"10.1016\/j.jbc.2026.113547_bib51","doi-asserted-by":"crossref","first-page":"43378","DOI":"10.1074\/jbc.C400286200","article-title":"Signaling by higher inositol polyphosphates. Synthesis of bisdiphosphoinositol tetrakisphosphate (\"InsP8\") is selectively activated by hyperosmotic stress","volume":"279","author":"Pesesse","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113547_bib52","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.biocel.2010.09.013","article-title":"Inositol hexakisphosphate kinases promote autophagy","volume":"42","author":"Nagata","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jbc.2026.113547_bib53","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.4161\/auto.20681","article-title":"KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formation","volume":"8","author":"Taylor","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.jbc.2026.113547_bib54","doi-asserted-by":"crossref","first-page":"8314","DOI":"10.1073\/pnas.1521600113","article-title":"Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis","volume":"113","author":"Lee","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113547_bib55","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1126\/science.1146824","article-title":"Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells","volume":"318","author":"Illies","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113547_bib56","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/s42255-021-00468-7","article-title":"5-IP(7) is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis","volume":"3","author":"Zhang","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jbc.2026.113547_bib57","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1039\/C8SC03479F","article-title":"Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a \u03b2-cell line","volume":"10","author":"Hauke","year":"2019","journal-title":"Chem. Sci."},{"key":"10.1016\/j.jbc.2026.113547_bib58","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11205","article-title":"Translocation of interleukin-1\u03b2 into a vesicle intermediate in autophagy-mediated secretion","volume":"4","author":"Zhang","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2026.113547_bib59","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1091\/mbc.10.5.1463","article-title":"The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles","volume":"10","author":"Andrei","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jbc.2026.113547_bib60","doi-asserted-by":"crossref","first-page":"9745","DOI":"10.1073\/pnas.0308558101","article-title":"Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes","volume":"101","author":"Andrei","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113547_bib61","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2026.113547_bib62","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s13059-014-0554-4","article-title":"MAGeCK enables robust identification of essential genes from genome-scale CRISPR\/Cas9 knockout screens","volume":"15","author":"Li","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbc.2026.113547_bib63","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41596-018-0113-7","article-title":"Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute","volume":"14","author":"Wang","year":"2019","journal-title":"Nat. Protoc."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826024191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826024191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:42:21Z","timestamp":1793220141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826024191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":63,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0021925826024191"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113547","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The phosphate exporter XPR1 promotes gasdermin D\u2013independent mature IL-1\u03b2 secretion","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113547"}}