{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:43:09Z","timestamp":1792568589479,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM153297"],"award-info":[{"award-number":["R35GM153297"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["MCB-2424888"],"award-info":[{"award-number":["MCB-2424888"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jbc.2026.113560","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:44:02Z","timestamp":1789602242000},"page":"113560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Active-site arginines differentially control Cas12a DNA cleavage and specificity"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-2090","authenticated-orcid":false,"given":"Saadi","family":"Rostami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7033-3922","authenticated-orcid":false,"given":"Alberto M.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0185-9277","authenticated-orcid":false,"given":"Richard S.","family":"Van","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kole","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-341X","authenticated-orcid":false,"given":"Yihan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-4412","authenticated-orcid":false,"given":"Rakhi","family":"Rajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113560_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.619763","article-title":"The CRISPR-Cas mechanism for adaptive immunity and alternate bacterial functions fuels diverse biotechnologies","volume":"10","author":"Newsom","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.jbc.2026.113560_bib2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41579-022-00739-4","article-title":"Structural biology of CRISPR\u2013Cas immunity and genome editing enzymes","volume":"20","author":"Wang","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jbc.2026.113560_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1158672","article-title":"CRISPR-cas technology: a key approach for SARS-CoV-2 detection","volume":"11","author":"Fang","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jbc.2026.113560_bib4","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2022.02.015","article-title":"Spatial CRISPR genomics identifies regulators of the tumor microenvironment","volume":"185","author":"Dhainaut","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113560_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cell.2020.12.001","article-title":"Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy","volume":"184","author":"Fozouni","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113560_bib6","article-title":"Point-of-care testing for COVID-19 using SHERLOCK diagnostics","author":"Joung","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.jbc.2026.113560_bib7","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cell.2015.09.038","article-title":"Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system","volume":"163","author":"Zetsche","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113560_bib8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.aar6245","article-title":"CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity","volume":"360","author":"Chen","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113560_bib9","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1016\/j.celrep.2017.11.100","article-title":"RNA-independent DNA cleavage activities of Cas9 and Cas12a","volume":"21","author":"Sundaresan","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2026.113560_bib10","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.molcel.2017.06.035","article-title":"Structural basis for the canonical and non-canonical PAM recognition by CRISPR-Cpf1","volume":"67","author":"Yamano","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113560_bib11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.molcel.2018.11.021","article-title":"Mechanistic insights into the cis-and trans-acting DNase activities of Cas12a","volume":"73","author":"Swarts","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113560_bib12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature22398","article-title":"Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage","volume":"546","author":"Stella","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113560_bib13","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.omtn.2019.12.038","article-title":"CRISPR-Cas12a possesses unconventional DNase activity that can be inactivated by synthetic oligonucleotides","volume":"19","author":"Li","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.jbc.2026.113560_bib14","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.1225829","article-title":"A programmable dual-RNA\u2013guided DNA endonuclease in adaptive bacterial immunity","volume":"337","author":"Jinek","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113560_bib15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.molcel.2017.03.016","article-title":"Structural basis for guide RNA processing and seed-dependent DNA targeting by CRISPR-Cas12a","volume":"66","author":"Swarts","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113560_bib16","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.cell.2016.04.003","article-title":"Crystal structure of Cpf1 in complex with guide RNA and target DNA","volume":"165","author":"Yamano","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113560_bib17","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/1873-3468.14051","article-title":"The bridge helix of Cas12a imparts selectivity in cis-DNA cleavage and regulates trans-DNA cleavage","volume":"595","author":"Parameshwaran","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2026.113560_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107295","article-title":"Unity among the diverse RNA-guided CRISPR-Cas interference mechanisms","volume":"300","author":"Ganguly","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113560_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2026.153760","article-title":"Helicity of the bridge helix of Cas12a regulates on-target DNA cleavage efficiency and off-target cleavage propensity","volume":"823","author":"Martin","year":"2026","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2026.113560_bib20","doi-asserted-by":"crossref","first-page":"10153","DOI":"10.1093\/nar\/gkac767","article-title":"Allosteric activation of CRISPR-Cas12a requires the concerted movement of the bridge helix and helix 1 of the RuvC II domain","volume":"50","author":"W\u00f6rle","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.113560_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002023","article-title":"Structures of Apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage","volume":"21","author":"Jianwei","year":"2023","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2026.113560_bib22","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1038\/s41467-026-68657-0","article-title":"Bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation","volume":"17","author":"Ganguly","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113560_bib23","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nature17944","article-title":"The crystal structure of Cpf1 in complex with CRISPR RNA","volume":"532","author":"Dong","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113560_bib24","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.cell.2018.10.045","article-title":"Conformational activation promotes CRISPR-Cas12a catalysis and resetting of the endonuclease activity","volume":"175","author":"Stella","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2026.113560_bib25","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.molcel.2024.06.007","article-title":"Cas12a domain flexibility guides R-loop formation and forces RuvC resetting","volume":"84","author":"Strohkendl","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113560_bib26","doi-asserted-by":"crossref","first-page":"60a","DOI":"10.1016\/j.bpj.2023.11.432","article-title":"Folding and unfolding of an alpha-helical lid govern target double-stranded DNA break in Cas12a","volume":"123","author":"Saha","year":"2024","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbc.2026.113560_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1056\/NEJMoa2031054","article-title":"CRISPR-Cas9 gene editing for sickle cell disease and \u03b2-thalassemia","volume":"384","author":"Frangoul","year":"2021","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jbc.2026.113560_bib28","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMoa2504747","article-title":"Patient-specific in vivo gene editing to treat a rare genetic disease","volume":"392","author":"Musunuru","year":"2025","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jbc.2026.113560_bib29","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature17945","article-title":"The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA","volume":"532","author":"Fonfara","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113560_bib30","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1073\/pnas.1700557114","article-title":"High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding","volume":"114","author":"Boyle","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113560_bib31","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nbt.2647","article-title":"DNA targeting specificity of RNA-guided Cas9 nucleases","volume":"31","author":"Hsu","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2026.113560_bib32","doi-asserted-by":"crossref","first-page":"138a","DOI":"10.1016\/j.bpj.2020.11.1034","article-title":"Massively parallel kinetic profiling of natural and engineered CRISPR nucleases","volume":"120","author":"Jones","year":"2021","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbc.2026.113560_bib33","doi-asserted-by":"crossref","first-page":"12689","DOI":"10.1093\/nar\/gkac1192","article-title":"Improved genome editing by an engineered CRISPR-Cas12a","volume":"50","author":"Ma","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.113560_bib34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nbt.3481","article-title":"Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA","volume":"34","author":"Richardson","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2026.113560_bib35","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1073\/pnas.1718686115","article-title":"Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a)","volume":"115","author":"Singh","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113560_bib36","doi-asserted-by":"crossref","first-page":"13596","DOI":"10.1021\/acscatal.0c03566","article-title":"Catalytic mechanism of non-target DNA cleavage in CRISPR-Cas9 revealed by ab initio molecular dynamics","volume":"10","author":"Casalino","year":"2020","journal-title":"ACS Catal."},{"key":"10.1016\/j.jbc.2026.113560_bib37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1021\/acs.biochem.4c00651","article-title":"Exploring CRISPR-Cas9 HNH-domain-catalyzed DNA cleavage using accelerated quantum mechanical molecular mechanical free energy simulation","volume":"64","author":"Van","year":"2024","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2026.113560_bib38","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nature08473","article-title":"The role of DNA shape in protein\u2013DNA recognition","volume":"461","author":"Rohs","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113560_bib39","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1093\/nar\/29.13.2860","article-title":"Amino acid\u2013base interactions: a three-dimensional analysis of protein\u2013DNA interactions at an atomic level","volume":"29","author":"Luscombe","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.113560_bib40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/bs.mie.2022.08.048","article-title":"Optimized protocols for the characterization of Cas12a activities","volume":"679","author":"Martin","year":"2023","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jbc.2026.113560_bib41","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41589-022-01082-8","article-title":"CRISPR\u2013Cas12a-mediated DNA clamping triggers target-strand cleavage","volume":"18","author":"Naqvi","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2026.113560_bib42","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s41587-020-0513-4","article-title":"CRISPR\u2013Cas12-based detection of SARS-CoV-2","volume":"38","author":"Broughton","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2026.113560_bib43","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.1074\/jbc.RA120.012933","article-title":"CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects","volume":"295","author":"Murugan","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113560_bib44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.compbiolchem.2018.01.009","article-title":"A random version of principal component analysis in data clustering","volume":"73","author":"Palese","year":"2018","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113560_bib45","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.molcel.2018.06.043","article-title":"Kinetic basis for DNA target specificity of CRISPR-Cas12a","volume":"71","author":"Strohkendl","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2026.113560_bib46","doi-asserted-by":"crossref","first-page":"8377","DOI":"10.1093\/nar\/gkac578","article-title":"Enhancement of CRISPR\/Cas12a trans-cleavage activity using hairpin DNA reporters","volume":"50","author":"Rossetti","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2026.113560_bib47","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1089\/crispr.2023.0022","article-title":"Differential divalent metal binding by SpyCas9's RuvC active site contributes to nonspecific DNA cleavage","volume":"6","author":"Newsom","year":"2023","journal-title":"CRISPR J."},{"key":"10.1016\/j.jbc.2026.113560_bib48","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1021\/ct200133y","article-title":"Improved treatment of ligands and coupling effects in empirical calculation and rationalization of p K a values","volume":"7","author":"S\u00f8ndergaard","year":"2011","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2026.113560_bib49","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/ct100578z","article-title":"PROPKA3: consistent treatment of internal and surface residues in empirical pKa predictions","volume":"7","author":"Olsson","year":"2011","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2026.113560_bib50","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jbc.2026.113560_bib51","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","article-title":"Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes","volume":"23","author":"Ryckaert","year":"1977","journal-title":"J. Comput. Phys."},{"key":"10.1016\/j.jbc.2026.113560_bib52","series-title":"AMBER 2020","author":"Case","year":"2020"},{"key":"10.1016\/j.jbc.2026.113560_bib53","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2026.113560_bib54","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1021\/acs.jctc.5b00716","article-title":"Refinement of the sugar\u2013phosphate backbone torsion beta for AMBER force fields improves the description of Z-and B-DNA","volume":"11","author":"Zgarbov\u00e1","year":"2015","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2026.113560_bib55","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1021\/ct200162x","article-title":"Refinement of the Cornell et al. nucleic acids force field based on reference quantum chemical calculations of glycosidic torsion profiles","volume":"7","author":"Zgarbov\u00e1","year":"2011","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2026.113560_bib56","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","article-title":"PTRAJ and CPPTRAJ: software for processing and analysis of molecular dynamics trajectory data","volume":"9","author":"Roe","year":"2013","journal-title":"J. Chem. Theor. Comput."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826024324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925826024324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:22:53Z","timestamp":1792567373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925826024324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":56,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0021925826024324"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113560","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Active-site arginines differentially control Cas12a DNA cleavage and specificity","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113560","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113560"}}