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Rep."},{"key":"10.1016\/j.jbc.2026.113618_bib79","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2024.2399970","article-title":"Experimental infection of chickens, Pekin ducks, Eurasian wigeons and Barnacle geese with two recent highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses","volume":"13","author":"Bordes","year":"2024","journal-title":"Emerg. 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A."},{"key":"10.1016\/j.jbc.2026.113618_bib85","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.chom.2015.02.014","article-title":"RIG-I works double duty","volume":"17","author":"Chan","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2026.113618_bib86","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.4049\/jimmunol.1003712","article-title":"Characterization of Chicken Mda5 Activity: Regulation of IFN-\u03b2 in the Absence of RIG-I Functionality","volume":"186","author":"Karpala","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2026.113618_bib87","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1297-9716-45-66","article-title":"Duck MDA5 functions in innate immunity against H5N1 highly pathogenic avian influenza virus infections","volume":"45","author":"Wei","year":"2014","journal-title":"Vet. Res."},{"issue":"3","key":"10.1016\/j.jbc.2026.113618_bib88","article-title":"Dynamic evolution of avian RNA virus sensors: Repeated loss of RIG-I and RIPLET","volume":"15","author":"Krchl\u00edkov\u00e1","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.jbc.2026.113618_bib89","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1680791","article-title":"Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction","volume":"16","author":"Sid","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2026.113618_bib90","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1099\/vir.0.055921-0","article-title":"Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity","volume":"94","author":"Smith","year":"2013","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jbc.2026.113618_bib91","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/sj.icb.7100033","article-title":"Immunopathogenesis of poxvirus infections: forecasting the impending storm","volume":"85","author":"Stanford","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jbc.2026.113618_bib92","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/MCB.20.4.1278-1290.2000","article-title":"NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase","volume":"20","author":"Zamanian-Daryoush","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2026.113618_bib93","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2115354119","article-title":"Maladaptation after a virus host switch leads to increased activation of the pro-inflammatory NF-\u03baB pathway","volume":"119","author":"Yu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113618_bib94","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3201\/eid3006.231280","article-title":"Effect of Myxoma Virus Species Jump on Iberian Hare Populations","volume":"30","author":"Cardoso","year":"2024","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jbc.2026.113618_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/v11060530","article-title":"Genetic Characterization of a Recombinant Myxoma Virus in the Iberian Hare ( )","author":"\u00c1gueda-Pinto","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.jbc.2026.113618_bib96","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03461-21","article-title":"Identification of a Novel Myxoma Virus C7-Like Host Range Factor That Enabled a Species Leap from Rabbits to Hares","volume":"13","author":"\u00c1gueda-Pinto","year":"2022","journal-title":"MBio"},{"key":"10.1016\/j.jbc.2026.113618_bib97","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1128\/JVI.06166-11","article-title":"The vaccinia virus O1 protein is required for sustained activation of extracellular signal-regulated kinase 1\/2 and promotes viral virulence","volume":"86","author":"Schweneker","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2026.113618_bib98","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nm757","article-title":"Lethal H5N1 influenza viruses escape host anti-viral cytokine responses","volume":"8","author":"Seo","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2026.113618_bib99","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1099\/vir.0.069542-0","article-title":"Influenza virus non-structural protein NS1: interferon antagonism and beyond","volume":"95","author":"Marc","year":"2014","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jbc.2026.113618_bib100","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chom.2009.04.006","article-title":"Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I","volume":"5","author":"Gack","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2026.113618_bib101","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05732","article-title":"TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity","volume":"446","author":"Gack","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2026.113618_bib102","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003059","article-title":"Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein","volume":"8","author":"Rajsbaum","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jbc.2026.113618_bib103","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1099\/vir.0.063776-0","article-title":"Shortening the unstructured, interdomain region of the non-structural protein NS1 of an avian H1N1 influenza virus increases its replication and pathogenicity in chickens","volume":"95","author":"Trapp","year":"2014","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jbc.2026.113618_bib104","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s11262-007-0187-8","article-title":"Virulence of H5N1 avian influenza virus enhanced by a 15-nucleotide deletion in the viral nonstructural gene","volume":"36","author":"Long","year":"2008","journal-title":"Virus Genes"},{"key":"10.1016\/j.jbc.2026.113618_bib105","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1128\/JVI.01667-06","article-title":"Amelioration of influenza virus pathogenesis in chickens attributed to the enhanced interferon-inducing capacity of a virus with a truncated NS1 gene","volume":"81","author":"Cauthen","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2026.113618_bib106","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003265","article-title":"Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling","volume":"9","author":"Morrison","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jbc.2026.113618_bib107","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling","volume":"19","author":"Grant","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2026.113618_bib108","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1038\/s41467-024-49758-0","article-title":"Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints","volume":"15","author":"Veit","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2026.113618_bib109","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000429","article-title":"Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin\/BST2","volume":"5","author":"Jia","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jbc.2026.113618_bib110","doi-asserted-by":"crossref","first-page":"14049","DOI":"10.1073\/pnas.96.24.14049","article-title":"Emergence of a highly pathogenic simian\/human immunodeficiency virus in a rhesus macaque treated with anti-CD8 mAb during a primary infection with a nonpathogenic virus","volume":"96","author":"Igarashi","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2026.113618_bib111","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010718","article-title":"Viral-mediated activation and inhibition of programmed cell death","volume":"18","author":"Verburg","year":"2022","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jbc.2026.113618_bib112","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1074\/jbc.272.12.7797","article-title":"Target protease specificity of the viral serpin CrmA","volume":"272","author":"Zhou","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2026.113618_bib113","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12985-016-0528-0","article-title":"The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways","volume":"13","author":"Yu","year":"2016","journal-title":"Virol J"},{"key":"10.1016\/j.jbc.2026.113618_bib114","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/icb.2016.117","article-title":"Controlled detonation: evolution of necroptosis in pathogen defense","volume":"95","author":"Brault","year":"2017","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jbc.2026.113618_bib115","doi-asserted-by":"crossref","first-page":"E2786","DOI":"10.1073\/pnas.1616829114","article-title":"Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways","volume":"114","author":"Daley-Bauer","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jbc.2026.113618_bib116","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.chom.2015.01.003","article-title":"Herpes simplex virus suppresses necroptosis in human cells","volume":"17","author":"Guo","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2026.113618_bib117","doi-asserted-by":"crossref","first-page":"15438","DOI":"10.1073\/pnas.1412767111","article-title":"Direct activation of RIP3\/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense","volume":"111","author":"Wang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jbc.2026.113618_bib118","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.1128\/JVI.01603-05","article-title":"Activation of NF-\u03baB by the latent vFLIP gene of Kaposi\u2019s sarcoma-associated Herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype","volume":"80","author":"Grossmann","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2026.113618_bib119","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ni.1861","article-title":"Influenza virus activates inflammasomes via its intracellular M2 ion channel","volume":"11","author":"Ichinohe","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2026.113618_bib120","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nri3665","article-title":"Innate immunity to influenza virus infection","volume":"14","author":"Iwasaki","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2026.113618_bib121","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/s41564-019-0444-3","article-title":"Leukotriene B4\u2013type I interferon axis regulates macrophage-mediated disease tolerance to influenza infection","volume":"4","author":"Pernet","year":"2019","journal-title":"Nature Microbiology"},{"key":"10.1016\/j.jbc.2026.113618_bib122","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114045","article-title":"Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2","volume":"13","author":"Chan","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jbc.2026.113618_bib123","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012471","article-title":"Disease tolerance as immune defense strategy in bats: One size fits all?","volume":"20","author":"Pei","year":"2024","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jbc.2026.113618_bib124","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1001\/jama.1975.03240240018017","article-title":"Increased virus shedding with aspirin treatment of rhinovirus infection","volume":"231","author":"Stanley","year":"1975","journal-title":"JAMA"},{"key":"10.1016\/j.jbc.2026.113618_bib125","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/infdis\/162.6.1277","article-title":"Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers","volume":"162","author":"Graham","year":"1990","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jbc.2026.113618_bib126","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1006119","article-title":"Assessing the public health impact of tolerance-based therapies with mathematical models","volume":"14","author":"Hoz\u00e9","year":"2018","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jbc.2026.113618_bib127","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/icb\/icz065","article-title":"What Does Tolerance Mean for Animal Disease Dynamics When Pathology Enhances Transmission?","volume":"59","author":"Henschen","year":"2019","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.jbc.2026.113618_bib128","article-title":"Virulence-mediated infectiousness and activity trade-offs and their impact on transmission potential of influenza patients","volume":"287","author":"McKay","year":"2020","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.jbc.2026.113618_bib129","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.ecolsys.31.1.565","article-title":"The Evolutionary Ecology of Tolerance to Consumer Damage","volume":"31","author":"Stowe","year":"2000","journal-title":"Annu. Rev. Ecol. Evol. Syst."},{"key":"10.1016\/j.jbc.2026.113618_bib130","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.1148526","article-title":"Disentangling genetic variation for resistance and tolerance to infectious diseases in animals","volume":"318","author":"R\u00e5berg","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jbc.2026.113618_bib131","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1098\/rstb.2008.0184","article-title":"Decomposing health: tolerance and resistance to parasites in animals","volume":"364","author":"R\u00e5berg","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.jbc.2026.113618_bib132","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001951","article-title":"Disentangling human tolerance and resistance against HIV","volume":"12","author":"Regoes","year":"2014","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jbc.2026.113618_bib133","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3389\/fgene.2012.00266","article-title":"Novel methods for quantifying individual host response to infectious pathogens for genetic analyses","volume":"3","author":"Doeschl-Wilson","year":"2012","journal-title":"Front. 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