{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:33:11Z","timestamp":1793233991059,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jbc.2026.113666","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:45:18Z","timestamp":1792597518000},"page":"113666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["MASTL Kinase Mediates the DNA Replication Stress Response Through PP2A\/B55 Phosphatase Modulation"],"prefix":"10.1016","author":[{"given":"Odjo G.","family":"Gouttia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory G.","family":"Oakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-1949","authenticated-orcid":false,"given":"Aimin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2026.113666_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.71.110601.135425","article-title":"DNA replication in eukaryotic cells","volume":"71","author":"Bell","year":"2002","journal-title":"Annu Rev Biochem"},{"issue":"11","key":"10.1016\/j.jbc.2026.113666_bib2","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/ncb1109-1275","article-title":"Cyclin-dependent kinases: a family portrait","volume":"11","author":"Malumbres","year":"2009","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.jbc.2026.113666_bib3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0955-0674(94)90028-0","article-title":"Eukaryotic DNA replication","volume":"6","author":"Diffley","year":"1994","journal-title":"Curr Opin Cell Biol"},{"issue":"11","key":"10.1016\/j.jbc.2026.113666_bib4","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1371\/journal.pgen.0030200","article-title":"Mutations in Drosophila Greatwall\/scant reveal its roles in mitosis and meiosis and interdependence with polo kinase","volume":"3","author":"Archambault","year":"2007","journal-title":"PLoS Genet"},{"issue":"4","key":"10.1016\/j.jbc.2026.113666_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1083\/jcb.200310059","article-title":"Greatwall kinase: A nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila","volume":"164","author":"Yu","year":"2004","journal-title":"Journal of Cell Biology"},{"issue":"22","key":"10.1016\/j.jbc.2026.113666_bib6","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1091\/mbc.e09-07-0643","article-title":"The M phase kinase greatwall (Gwl) promotes inactivation of PP2A\/B55\u03b4, a phosphatase directed against CDK phosphosites","volume":"20","author":"Castilho","year":"2009","journal-title":"Mol Biol Cell"},{"issue":"45","key":"10.1016\/j.jbc.2026.113666_bib7","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1038\/onc.2010.371","article-title":"Serine\/threonine phosphatases in the DNA damage response and cancer","volume":"29","author":"Peng","year":"2010","journal-title":"Oncogene"},{"issue":"17","key":"10.1016\/j.jbc.2026.113666_bib8","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.4161\/cc.9.17.12832","article-title":"MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis","volume":"9","author":"Voets","year":"2010","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.jbc.2026.113666_bib9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.molcel.2006.02.022","article-title":"Greatwall Kinase Participates in the Cdc2 Autoregulatory Loop in Xenopus Egg Extracts","volume":"22","author":"Yu","year":"2006","journal-title":"Mol Cell"},{"issue":"11","key":"10.1016\/j.jbc.2026.113666_bib10","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1128\/MCB.00753-10","article-title":"Characterization of the Mechanisms Controlling Greatwall Activity","volume":"31","author":"Vigneron","year":"2011","journal-title":"Mol Cell Biol"},{"issue":"8","key":"10.1016\/j.jbc.2026.113666_bib11","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1128\/MCB.06525-11","article-title":"Determinants for Activation of the Atypical AGC Kinase Greatwall during M Phase Entry","volume":"32","author":"Blake-Hodek","year":"2012","journal-title":"Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.jbc.2026.113666_bib12","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1080\/15384101.2015.1127476","article-title":"Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle","volume":"15","author":"Wang","year":"2016","journal-title":"Cell Cycle"},{"issue":"6011","key":"10.1016\/j.jbc.2026.113666_bib13","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1126\/science.1197048","article-title":"The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A","volume":"330","author":"Gharbi-Ayachi","year":"2010","journal-title":"Science"},{"issue":"6011","key":"10.1016\/j.jbc.2026.113666_bib14","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1126\/science.1195689","article-title":"Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis","volume":"330","author":"Mochida","year":"2010","journal-title":"Science"},{"issue":"18","key":"10.1016\/j.jbc.2026.113666_bib15","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1038\/emboj.2009.238","article-title":"Regulated activity of PP2A\u2013B55\u03b4 is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts","volume":"28","author":"Mochida","year":"2009","journal-title":"EMBO J"},{"issue":"18","key":"10.1016\/j.jbc.2026.113666_bib16","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1038\/emboj.2009.228","article-title":"Greatwall maintains mitosis through regulation of PP2A","volume":"28","author":"Vigneron","year":"2009","journal-title":"EMBO J"},{"issue":"21","key":"10.1016\/j.jbc.2026.113666_bib17","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.4161\/cc.9.21.13632","article-title":"A novel role for greatwall kinase in recovery from DNA damage","volume":"9","author":"Peng","year":"2010","journal-title":"Cell Cycle"},{"issue":"33","key":"10.1016\/j.jbc.2026.113666_bib18","doi-asserted-by":"crossref","first-page":"28996","DOI":"10.1074\/jbc.M111.257121","article-title":"Greatwall and Polo-like Kinase 1 Coordinate to Promote Checkpoint Recovery","volume":"286","author":"Peng","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jbc.2026.113666_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.904719","article-title":"The MASTL-ENSA-PP2A\/B55 axis modulates cisplatin resistance in oral squamous cell carcinoma","volume":"10","author":"Gouttia","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jbc.2026.113666_bib20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.7554\/eLife.86976","article-title":"The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery","volume":"12","author":"Li","year":"2023","journal-title":"Elife"},{"issue":"NOVEMBER2015","key":"10.1016\/j.jbc.2026.113666_bib21","article-title":"Greatwall promotes cell transformation by hyperactivating AKT in human malignancies","volume":"4","author":"Vera","year":"2015","journal-title":"Elife"},{"issue":"20","key":"10.1016\/j.jbc.2026.113666_bib22","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.222364","article-title":"Greatwall kinase at a glance","volume":"131","author":"Castro","year":"2018","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jbc.2026.113666_bib23","first-page":"6","article-title":"The Oncogenic Functions of MASTL Kinase","volume":"23","author":"Marzec","year":"2018","journal-title":"Front Cell Dev Biol"},{"issue":"10","key":"10.1016\/j.jbc.2026.113666_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00366-18","article-title":"AKT Regulates Mitotic Progression of Mammalian Cells by Phosphorylating MASTL, Leading to Protein Phosphatase 2A Inactivation","volume":"40","author":"Reshi","year":"2020","journal-title":"Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.jbc.2026.113666_bib25","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201906204","article-title":"MASTL promotes cell contractility and motility through kinase-independent signaling","volume":"219","author":"Taskinen","year":"2020","journal-title":"Journal of Cell Biology"},{"issue":"38","key":"10.1016\/j.jbc.2026.113666_bib26","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1038\/s41388-021-01951-x","article-title":"MASTL Regulates EGFR Signaling to Impact Pancreatic Cancer Progression","volume":"40","author":"Fatima","year":"2021","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.jbc.2026.113666_bib27","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022110833","article-title":"The MASTL\/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner","volume":"42","author":"Sanz\u2010Castillo","year":"2023","journal-title":"EMBO J"},{"issue":"22","key":"10.1016\/j.jbc.2026.113666_bib28","doi-asserted-by":"crossref","first-page":"11479","DOI":"10.18632\/oncotarget.2565","article-title":"Mastl kinase, a promising therapeutic target, promotes cancer recurrence","volume":"5","author":"Wang","year":"2014","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.jbc.2026.113666_bib29","first-page":"2413","article-title":"MASTL is a potential poor prognostic indicator in ER+ breast cancer","volume":"21","author":"Zhuge","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.jbc.2026.113666_bib30","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.biopha.2017.05.118","article-title":"E2F8 confers cisplatin resistance to ER+ breast cancer cells via transcriptionally activating MASTL","volume":"92","author":"Tian","year":"2017","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"6","key":"10.1016\/j.jbc.2026.113666_bib31","first-page":"7283","article-title":"Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer","volume":"14","author":"Sun","year":"2017","journal-title":"Oncol Lett"},{"issue":"5","key":"10.1016\/j.jbc.2026.113666_bib32","first-page":"828","article-title":"Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL\/Greatwall in breast cancer","volume":"25","author":"\u00c1lvarez-Fern\u00e1ndez","year":"2018","journal-title":"Cell Death Differ"},{"issue":"33","key":"10.1016\/j.jbc.2026.113666_bib33","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1038\/s41388-018-0295-z","article-title":"MASTL overexpression promotes chromosome instability and metastasis in breast cancer","volume":"37","author":"Rogers","year":"2018","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.jbc.2026.113666_bib34","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-018-0848-3","article-title":"MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt\/\u03b2-catenin signaling","volume":"17","author":"Uppada","year":"2018","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jbc.2026.113666_bib35","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-012414-040424","article-title":"DNA replication stress as a hallmark of cancer","volume":"10","author":"Macheret","year":"2015","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jbc.2026.113666_bib36","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.semcdb.2014.04.035","article-title":"The causes of replication stress and their consequences on genome stability and cell fate","volume":"30","author":"Magdalou","year":"2014","journal-title":"Semin Cell Dev Biol"},{"issue":"8","key":"10.1016\/j.jbc.2026.113666_bib37","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1158\/0008-5472.CAN-09-3422","article-title":"Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function","volume":"70","author":"Shuck","year":"2010","journal-title":"Cancer Res"},{"issue":"21","key":"10.1016\/j.jbc.2026.113666_bib38","doi-asserted-by":"crossref","first-page":"10780","DOI":"10.1093\/nar\/gks849","article-title":"Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress","volume":"40","author":"Liu","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"8\u20139","key":"10.1016\/j.jbc.2026.113666_bib39","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.dnarep.2004.03.028","article-title":"Replication Protein A phosphorylation and the cellular response to DNA damage","volume":"3","author":"Binz","year":"2004","journal-title":"DNA Repair (Amst)"},{"issue":"Pt 22","key":"10.1016\/j.jbc.2026.113666_bib40","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1242\/jcs.053702","article-title":"Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress","volume":"122","author":"Vassin","year":"2009","journal-title":"J Cell Sci"},{"issue":"4","key":"10.1016\/j.jbc.2026.113666_bib41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.201404111","article-title":"Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery","volume":"206","author":"Murphy","year":"2014","journal-title":"J Cell Biol"},{"issue":"1","key":"10.1016\/j.jbc.2026.113666_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-70589-y","article-title":"The effect of replication protein A inhibition and post-translational modification on ATR kinase signaling","volume":"14","author":"Jordan","year":"2024","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jbc.2026.113666_bib43","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrd4553","article-title":"Exploiting replicative stress to treat cancer","volume":"14","author":"Dobbelstein","year":"2015","journal-title":"Nature Reviews Drug Discovery 2015"},{"issue":"3","key":"10.1016\/j.jbc.2026.113666_bib44","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/embor.2011.263","article-title":"Protein phosphatases and their regulation in the control of mitosis","volume":"13","author":"Mochida","year":"2012","journal-title":"EMBO Rep"},{"issue":"3","key":"10.1016\/j.jbc.2026.113666_bib45","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.molcel.2011.10.007","article-title":"Protein phosphatase 2A controls the order and dynamics of cell-cycle transitions","volume":"44","author":"Krasinska","year":"2011","journal-title":"Mol Cell"},{"issue":"41","key":"10.1016\/j.jbc.2026.113666_bib46","doi-asserted-by":"crossref","first-page":"29382","DOI":"10.1074\/jbc.M113.499012","article-title":"Control of DNA replication by the nucleus\/cytoplasm ratio in Xenopus","volume":"288","author":"Murphy","year":"2013","journal-title":"Journal of Biological Chemistry"},{"issue":"44","key":"10.1016\/j.jbc.2026.113666_bib47","doi-asserted-by":"crossref","first-page":"71182","DOI":"10.18632\/oncotarget.11511","article-title":"A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct","volume":"7","author":"Ocasio","year":"2016","journal-title":"Oncotarget"},{"issue":"21","key":"10.1016\/j.jbc.2026.113666_bib48","doi-asserted-by":"crossref","first-page":"19234","DOI":"10.1021\/acs.jmedchem.4c01659","article-title":"Discovery of Highly Selective Inhibitors of Microtubule-Associated Serine\/Threonine Kinase-like (MASTL)","volume":"67","author":"Gallego","year":"2024","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.jbc.2026.113666_bib49","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1038\/s41598-018-21040-6","article-title":"Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress","volume":"8","author":"Wang","year":"2018","journal-title":"Sci Rep"},{"issue":"13","key":"10.1016\/j.jbc.2026.113666_bib50","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1093\/nar\/gks256","article-title":"Role of SUMO modification of human PCNA at stalled replication fork","volume":"40","author":"Gali","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jbc.2026.113666_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/srep22230","article-title":"MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC\/C activation","volume":"6","author":"Wong","year":"2016","journal-title":"Sci Rep"},{"issue":"7209","key":"10.1016\/j.jbc.2026.113666_bib52","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature07185","article-title":"Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery","volume":"455","author":"Mac\u016frek","year":"2008","journal-title":"Nature"},{"issue":"5883","key":"10.1016\/j.jbc.2026.113666_bib53","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.1157425","article-title":"Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry","volume":"320","author":"Seki","year":"2008","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jbc.2026.113666_bib54","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/carcin\/bgq035","article-title":"The role of RPA2 phosphorylation in homologous recombination in response to replication arrest","volume":"31","author":"Shi","year":"2010","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.jbc.2026.113666_bib55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/cr.2014.147","article-title":"RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response","volume":"25","author":"Mar\u00e9chal","year":"2015","journal-title":"Cell Res"},{"issue":"2","key":"10.1016\/j.jbc.2026.113666_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/genes15020167","article-title":"The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break Repair","volume":"15","author":"Fousek-Schuller","year":"2024","journal-title":"Genes (Basel)"},{"issue":"2","key":"10.1016\/j.jbc.2026.113666_bib57","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1083\/jcb.200702034","article-title":"An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells","volume":"178","author":"Hochegger","year":"2007","journal-title":"J Cell Biol"},{"issue":"4","key":"10.1016\/j.jbc.2026.113666_bib58","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.devcel.2016.07.023","article-title":"Waves of Cdk1 activity in S-phase synchronize the cell cycle in Drosophila embryos","volume":"38","author":"Deneke","year":"2016","journal-title":"Dev Cell"},{"issue":"48","key":"10.1016\/j.jbc.2026.113666_bib59","doi-asserted-by":"crossref","first-page":"23891","DOI":"10.1073\/pnas.1915108116","article-title":"WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells","volume":"116","author":"Moiseeva","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.jbc.2026.113666_bib60","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1073\/pnas.0712063105","article-title":"Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing","volume":"105","author":"Wu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.jbc.2026.113666_bib61","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/emboj.2008.29","article-title":"Plx1 is required for chromosomal DNA replication under stressful conditions","volume":"27","author":"Trenz","year":"2008","journal-title":"EMBO journal"},{"issue":"10","key":"10.1016\/j.jbc.2026.113666_bib62","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1128\/MCB.01277-08","article-title":"Polo-Like Kinase 1 Depletion Induces DNA Damage in Early S Prior to Caspase Activation","volume":"29","author":"Yim","year":"2009","journal-title":"Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.jbc.2026.113666_bib63","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jbior.2013.04.001","article-title":"On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis","volume":"53","author":"Hunt","year":"2013","journal-title":"Adv Biol Regul"},{"issue":"1","key":"10.1016\/j.jbc.2026.113666_bib64","first-page":"1","article-title":"Ensa controls S-phase length by modulating Treslin levels","volume":"8","author":"Charrasse","year":"2017","journal-title":"Nature Communications 2017"},{"issue":"6","key":"10.1016\/j.jbc.2026.113666_bib65","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ccr.2010.10.028","article-title":"Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A\/B55\u03b1,\u03b4 Phosphatase","volume":"18","author":"Manchado","year":"2010","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.jbc.2026.113666_bib66","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1158\/1535-7163.MCT-14-0846","article-title":"Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC","volume":"14","author":"Nagel","year":"2015","journal-title":"Mol Cancer Ther"},{"issue":"33","key":"10.1016\/j.jbc.2026.113666_bib67","doi-asserted-by":"crossref","first-page":"34629","DOI":"10.18632\/oncotarget.5282","article-title":"Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening","volume":"6","author":"Anania","year":"2015","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.jbc.2026.113666_bib68","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.drudis.2019.02.011","article-title":"CRISPR\/Cas9: a powerful tool for identification of new targets for cancer treatment","volume":"24","author":"Liu","year":"2019","journal-title":"Drug Discov Today"},{"issue":"4","key":"10.1016\/j.jbc.2026.113666_bib69","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/hed.21198","article-title":"Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines","volume":"32","author":"Brenner","year":"2010","journal-title":"Head Neck"},{"issue":"11","key":"10.1016\/j.jbc.2026.113666_bib70","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1158\/1535-7163.MCT-12-0448","article-title":"Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer","volume":"11","author":"Wang","year":"2012","journal-title":"Mol Cancer Ther"},{"issue":"6","key":"10.1016\/j.jbc.2026.113666_bib71","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.molcel.2015.07.029","article-title":"Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase","volume":"59","author":"Buisson","year":"2015","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.jbc.2026.113666_bib72","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1158\/1541-7786.MCR-17-0670","article-title":"Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression","volume":"17","author":"Wang","year":"2019","journal-title":"Mol Cancer Res"},{"issue":"18","key":"10.1016\/j.jbc.2026.113666_bib73","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1158\/0008-5472.CAN-14-0306","article-title":"RPA inhibition increases replication stress and suppresses tumor growth","volume":"74","author":"Glanzer","year":"2014","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.jbc.2026.113666_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00494-8","article-title":"Improved split fluorescent proteins for endogenous protein labeling","volume":"8","author":"Feng","year":"2017","journal-title":"Nat Commun"},{"issue":"17","key":"10.1016\/j.jbc.2026.113666_bib75","doi-asserted-by":"crossref","first-page":"23383","DOI":"10.18632\/oncotarget.8110","article-title":"Cell fate determination in cisplatin resistance and chemosensitization","volume":"7","author":"Luong","year":"2016","journal-title":"Oncotarget"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582602538X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582602538X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:14:22Z","timestamp":1793232862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582602538X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":75,"alternative-id":["S002192582602538X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113666","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MASTL Kinase Mediates the DNA Replication Stress Response Through PP2A\/B55 Phosphatase Modulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2026.113666","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"113666"}}