{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:08:51Z","timestamp":1788869331655,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR047838"],"award-info":[{"award-number":["R01 AR047838"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR51555"],"award-info":[{"award-number":["R01 AR51555"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AR007581"],"award-info":[{"award-number":["T32 AR007581"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomechanics"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.jbiomech.2008.07.039","type":"journal-article","created":{"date-parts":[[2009,3,13]],"date-time":"2009-03-13T04:08:22Z","timestamp":1236917302000},"page":"938-944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Theoretical analysis of alendronate and risedronate effects on canine vertebral remodeling and microdamage"],"prefix":"10.1016","volume":"42","author":[{"given":"Xiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia M.","family":"Erickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Burr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Bruce","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Hazelwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jbiomech.2008.07.039_bib1","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1359\/jbmr.070720","article-title":"Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment","volume":"22","author":"Allen","year":"2007","journal-title":"Journal of Bone and Mineral Research"},{"issue":"4","key":"10.1016\/j.jbiomech.2008.07.039_bib2","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.bone.2006.04.028","article-title":"Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate and alendronate","volume":"39","author":"Allen","year":"2006","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.jbiomech.2008.07.039_bib3","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jor.1100080507","article-title":"An approach for time-dependent bone modeling and remodeling-application: a preliminary remodeling simulation","volume":"8","author":"Beaupre","year":"1990","journal-title":"Journal of Orthopaedic Research"},{"issue":"5","key":"10.1016\/j.jbiomech.2008.07.039_bib4","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S8756-3282(00)00376-8","article-title":"Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women","volume":"27","author":"Boivin","year":"2000","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.jbiomech.2008.07.039_bib5","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJMoa030897","article-title":"Ten years\u2019 experience with alendronate for osteoporosis in postmenopausal women","volume":"350","author":"Bone","year":"2004","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1016\/j.jbiomech.2008.07.039_bib6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bone.2006.01.161","article-title":"Long-term risedronate treatment normalizes mineralization and continues to preserve trabecular architecture: sequential triple biopsy studies with micro-computed tomography","volume":"39","author":"Borah","year":"2006","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.jbiomech.2008.07.039_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/jbmr.5650100207","article-title":"The effects of risedronate on canine cancellous bone remodeling: three-dimensional kinetic reconstruction of the remodeling site","volume":"10","author":"Boyce","year":"1995","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0021-9290(85)90204-0","article-title":"Bone remodeling in response to in vivo fatigue microdamage","volume":"18","author":"Burr","year":"1985","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib9","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1172\/JCI119668","article-title":"Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis","volume":"100","author":"Chavassieux","year":"1997","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib10","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1359\/jbmr.2000.15.4.754","article-title":"Effects of alendronate on bone quality and remodeling in glucocorticoid-induced osteoporosis: a histomorphometric analysis of transiliac biopsies","volume":"15","author":"Chavassieux","year":"2000","journal-title":"Journal of Bone and Mineral Research"},{"issue":"3","key":"10.1016\/j.jbiomech.2008.07.039_bib11","first-page":"465","article-title":"Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties","volume":"22","author":"Day","year":"2004","journal-title":"Journal of Orthopaedic Research"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S8756-3282(00)00301-X","article-title":"How does antiresorptive therapy decrease the risk of fracture in women with osteoporosis?","volume":"27","author":"Delmas","year":"2000","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.jbiomech.2008.07.039_bib13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00223-002-2066-6","article-title":"Canine cancellous bone microarchitecture after one year of high-dose bisphosphonates","volume":"72","author":"Ding","year":"2003","journal-title":"Calcified Tissue International"},{"issue":"5","key":"10.1016\/j.jbiomech.2008.07.039_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00223-002-2104-4","article-title":"Risedronate preserves bone architecture in early postmenopausal women in 1 year as measured by three-dimensional microcomputed tomography","volume":"73","author":"Dufresne","year":"2003","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib15","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S8756-3282(02)00869-4","article-title":"Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis","volume":"31","author":"Eriksen","year":"2002","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.jbiomech.2008.07.039_bib16","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/8756-3282(95)00120-3","article-title":"Risedronate treatment does not increase microdamage in the canine femoral neck","volume":"16","author":"Forwood","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF02058664","article-title":"Tetracycline-based histological analysis of bone remodeling","volume":"3","author":"Frost","year":"1969","journal-title":"Calcified Tissue International"},{"issue":"2","key":"10.1016\/j.jbiomech.2008.07.039_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s002239900399","article-title":"Osteoporoses: a rationale for further definitions?","volume":"62","author":"Frost","year":"1998","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0021-9290(00)00221-9","article-title":"A mechanistic model for internal bone remodeling exhibits different dynamic responses in disuse and overload","volume":"34","author":"Hazelwood","year":"2001","journal-title":"Journal of Biomechanics"},{"issue":"1","key":"10.1016\/j.jbiomech.2008.07.039_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S8756-3282(00)00284-2","article-title":"Does suppression of bone turnover impair mechanical properties by allowing microdamage accumulation?","volume":"27","author":"Hirano","year":"2000","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jbiomech.2008.07.039_bib21","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1359\/jbmr.2003.18.3.512","article-title":"Long-term treatment of incadronate disodium accumulates microdamage but improves the trabecular bone microarchitecture in dog vertebra","volume":"18","author":"Komatsubara","year":"2003","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib22","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1359\/JBMR.040126","article-title":"Suppressed bone turnover by long-term bisphosphonate treatment accumulates microdamage but maintains intrinsic material properties in cortical bone of dog rib","volume":"19","author":"Komatsubara","year":"2004","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ajpa.1330280512","article-title":"The usefulness of mathematical models for bone remodeling","volume":"28","author":"Martin","year":"1985","journal-title":"Yearbook of Physical Anthropology"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib24","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jor.1100130303","article-title":"Mathematical model for repair of fatigue damage and stress fracture in osteonal bone","volume":"13","author":"Martin","year":"1995","journal-title":"Journal of Orthopaedic Research"},{"issue":"4","key":"10.1016\/j.jbiomech.2008.07.039_bib25","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1359\/jbmr.2000.15.4.613","article-title":"Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib","volume":"15","author":"Mashiba","year":"2000","journal-title":"Journal of Bone and Mineral Research"},{"issue":"Supplement","key":"10.1016\/j.jbiomech.2008.07.039_bib26","first-page":"36","article-title":"The effects of suppressed bone remodeling by bisphosphonates on microdamage accumulation and degree of mineralization in the cortical bone of dog rib","volume":"23","author":"Mashiba","year":"2005","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib27","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S8756-3282(01)00414-8","article-title":"Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles","volume":"28","author":"Mashiba","year":"2001","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.jbiomech.2008.07.039_bib28","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0002-9343(97)00278-7","article-title":"Cyclical etidronate in the treatment of postmenopausal osteoporosis: efficacy and safety after seven years of treatment","volume":"103","author":"Miller","year":"1997","journal-title":"American Journal of Medicine"},{"issue":"1","key":"10.1016\/j.jbiomech.2008.07.039_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1115\/1.1428745","article-title":"Microdamage accumulation in bovine trabecular bone in uniaxial compression","volume":"124","author":"Moore","year":"2002","journal-title":"Journal of Biomechanical Engineering\u2014Transactions of the ASME"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/8756-3282(93)90235-3","article-title":"Increased intracortical remodeling following fatigue damage","volume":"14","author":"Mori","year":"1993","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.jbiomech.2008.07.039_bib31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.arth.2005.02.014","article-title":"Predictions on preserving bone mass in knee arthroplasty with bisphosphonates","volume":"21","author":"Nyman","year":"2006","journal-title":"Journal of Arthroplasty"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bone.2004.03.007","article-title":"A theoretical analysis of long-term bisphosphonate effects on trabecular bone volume and microdamage","volume":"35","author":"Nyman","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2165\/00003088-199936050-00002","article-title":"Pharmacokinetics of alendronate","volume":"36","author":"Porras","year":"1999","journal-title":"Clinical Pharmacokinetics"},{"issue":"7","key":"10.1016\/j.jbiomech.2008.07.039_bib34","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4065\/80.7.856","article-title":"Effect of dosing frequency on bisphosphonate medication adherence in a large longitudinal cohort of women","volume":"80","author":"Recker","year":"2005","journal-title":"Mayo Clinic Proceedings"},{"issue":"12","key":"10.1016\/j.jbiomech.2008.07.039_bib35","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1172\/JCI118722","article-title":"Bisphosphonates: mechanisms of action","volume":"97","author":"Rodan","year":"1996","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib36","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/8756-3282(95)00370-3","article-title":"Aging and matrix microdamage accumulation in human compact bone","volume":"17","author":"Schaffler","year":"1995","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.jbiomech.2008.07.039_bib37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00223-004-0039-7","article-title":"Five years of treatment with risedronate and its effects on bone safety in women with postmenopausal osteoporosis","volume":"75","author":"Ste-Marie","year":"2004","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/jbmr.5650080211","article-title":"Changes in bone histomorphometry after long-term treatment with intermittent, cyclic etidronate for postmenopausal osteoporosis","volume":"8","author":"Storm","year":"1993","journal-title":"Journal of Bone and Mineral Research"},{"issue":"9","key":"10.1016\/j.jbiomech.2008.07.039_bib39","first-page":"3109","article-title":"Skeletal benefits of alendronate: 7-year treatment of postmenopausal osteoporotic women. Phase III osteoporosis treatment study group","volume":"85","author":"Tonino","year":"2000","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jbiomech.2008.07.039_bib40","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jbiomech.2005.02.007","article-title":"Microdamage propagation in trabecular bone due to changes in loading mode","volume":"39","author":"Wang","year":"2006","journal-title":"Journal of Biomechanics"},{"issue":"10","key":"10.1016\/j.jbiomech.2008.07.039_bib41","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0021-9290(88)90015-2","article-title":"Influence of physical activity on the regulation of bone density","volume":"21","author":"Whalen","year":"1988","journal-title":"Journal of Biomechanics"},{"issue":"7","key":"10.1016\/j.jbiomech.2008.07.039_bib42","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1359\/jbmr.060401","article-title":"Effects of 3- and 5-year treatment with risedronate on bone mineralization density distribution in triple biopsies of the iliac crest in postmenopausal women","volume":"21","author":"Zoehrer","year":"2006","journal-title":"Journal of Bone and Mineral Research"}],"container-title":["Journal of Biomechanics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929009000554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929009000554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T01:05:08Z","timestamp":1758243908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021929009000554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0021929009000554"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiomech.2008.07.039","relation":{},"ISSN":["0021-9290"],"issn-type":[{"value":"0021-9290","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Theoretical analysis of alendronate and risedronate effects on canine vertebral remodeling and microdamage","name":"articletitle","label":"Article Title"},{"value":"Journal of Biomechanics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiomech.2008.07.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}