{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:36:32Z","timestamp":1777635392025,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biomechanics"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.jbiomech.2008.09.028","type":"journal-article","created":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T16:19:02Z","timestamp":1227197942000},"page":"3371-3376","source":"Crossref","is-referenced-by-count":30,"title":["Bisphosphonate treatment in the oim mouse model alters bone modeling during growth"],"prefix":"10.1016","volume":"41","author":[{"given":"S.H.","family":"Rao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.D.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Oberbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.B.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jbiomech.2008.09.028_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/jor.1100050118","article-title":"Fracture failure mechanisms in patients with osteogenesis imperfecta","volume":"5","author":"Alman","year":"1987","journal-title":"Journal of Orthopaedic Research"},{"issue":"5","key":"10.1016\/j.jbiomech.2008.09.028_bib2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/adc.86.5.356","article-title":"Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta","volume":"86","author":"Astrom","year":"2002","journal-title":"Archives of Disease in Childhood"},{"issue":"1","key":"10.1016\/j.jbiomech.2008.09.028_bib3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bone.2005.07.028","article-title":"The use of micro-CT to evaluate cortical bone geometry and strength in nude rats: correlation with mechanical testing, pQCT and DXA","volume":"38","author":"Bagi","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib4","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0022-3476(97)70074-X","article-title":"Intravenous pamidronate treatment in osteogenesis imperfecta","volume":"131","author":"Bembi","year":"1997","journal-title":"Journal of Pediatrics"},{"issue":"4","key":"10.1016\/j.jbiomech.2008.09.028_bib5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S8756-3282(95)00241-3","article-title":"Alterations to the en bloc basic fuchsin staining protocol for the demonstration of microdamage produced in vivo","volume":"17","author":"Burr","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib6","series-title":"Connective Tissue and Its Heritable Disorders","first-page":"317","article-title":"Osteogenesis imperfecta","author":"Byers","year":"1993"},{"issue":"2","key":"10.1016\/j.jbiomech.2008.09.028_bib7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1359\/jbmr.1999.14.2.264","article-title":"The material basis for reduced mechanical properties in oim mice bones","volume":"14","author":"Camacho","year":"1999","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s002230010045","article-title":"A controlled study of the effects of alendronate in a growing mouse model of osteogenesis imperfecta","volume":"69","author":"Camacho","year":"2001","journal-title":"Calcified Tissue International"},{"issue":"2","key":"10.1016\/j.jbiomech.2008.09.028_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1297-319X(01)00256-1","article-title":"Osteogenesis imperfecta: lifelong management is imperative and feasible","volume":"68","author":"Chevrel","year":"2001","journal-title":"Joint Bone Spine"},{"issue":"2","key":"10.1016\/j.jbiomech.2008.09.028_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-3565(24)38786-5","article-title":"Structure\u2013activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates","volume":"296","author":"Dunford","year":"2001","journal-title":"JPET"},{"issue":"2","key":"10.1016\/j.jbiomech.2008.09.028_bib11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1172\/JCI118428","article-title":"Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle X-ray scattering","volume":"97","author":"Fratzl","year":"1996","journal-title":"Journal of Clinical Investigation"},{"issue":"2","key":"10.1016\/j.jbiomech.2008.09.028_bib12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1359\/jbmr.2003.18.2.204","article-title":"Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro","volume":"18","author":"Frith","year":"2003","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib13","unstructured":"Garn, S., 1970. The Earlier Gain and the Later Loss of Cortical Bone in Nutritional Perspective.Charles C. Thomas, Springfield."},{"issue":"14","key":"10.1016\/j.jbiomech.2008.09.028_bib14","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1056\/NEJM199810013391402","article-title":"Cyclic administration of pamidronate in children with severe osteogenesis imperfecta","volume":"339","author":"Glorieux","year":"1998","journal-title":"The New England Journal of Medicine"},{"issue":"3","key":"10.1016\/j.jbiomech.2008.09.028_bib15","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1359\/JBMR.051207","article-title":"Cyclical intravenous pamidronate treatment affects metaphyseal modeling in growing patients with osteogenesis imperfecta","volume":"21","author":"Land","year":"2006","journal-title":"Journal of Bone and Mineral Research"},{"issue":"12","key":"10.1016\/j.jbiomech.2008.09.028_bib16","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1210\/jc.80.12.3465","article-title":"Skeletal metabolism in patients with osteoporosis after discontiuation of long term treatment with oral pamidronate","volume":"80","author":"Landman","year":"1995","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib17","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s004310050715","article-title":"Treatment of osteogenesis imperfecta with the bisphosphonate olpadronate (dimethylaminohydrosypropylidene bisphosphonate)","volume":"156","author":"Landsmeer-Beker","year":"1997","journal-title":"European Journal of Pediatrics"},{"issue":"4","key":"10.1016\/j.jbiomech.2008.09.028_bib18","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1345\/aph.1E357","article-title":"Discovery, clinical development, and therapeutic uses of bisphosphonates","volume":"39","author":"Licata","year":"2005","journal-title":"The Annals of Pharmacotherapy"},{"issue":"2","key":"10.1016\/j.jbiomech.2008.09.028_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/8756-3282(95)00445-9","article-title":"Bisphosphonates: a review of their pharmacokinetic properties","volume":"18","author":"Lin","year":"1996","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.jbiomech.2008.09.028_bib20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0090-9556(25)08706-9","article-title":"Effects of dose, sex, and age on the disposition of alendronate, a potent antiosteolytic bisphosphonate, in rats","volume":"20","author":"Lin","year":"1992","journal-title":"Drug Metabolism and Disposition"},{"issue":"9","key":"10.1016\/j.jbiomech.2008.09.028_bib21","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1172\/JCI0217051","article-title":"Modeling the benefits of pamidronate in children with osteogenesis imperfecta","volume":"110","author":"Lindsay","year":"2002","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib22","series-title":"Mechanical Testing of Bone and the Bone\u2013Implant Interface","first-page":"207","article-title":"Bending Tests of Bone","author":"Lopez","year":"2000"},{"issue":"3","key":"10.1016\/j.jbiomech.2008.09.028_bib23","first-page":"209","article-title":"Size, structure, and gender: lessons about fracture risk","volume":"2","author":"Martin","year":"2002","journal-title":"Journal of Musculoskeletal and Neuronal Interactions"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib24","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s002239900412","article-title":"Bone geometry and strength measurements in aging mice with the oim mutation","volume":"62","author":"McBride","year":"1998","journal-title":"Calcified Tissue International"},{"issue":"5","key":"10.1016\/j.jbiomech.2008.09.028_bib25","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1203\/00006450-200211000-00010","article-title":"Alendronate treatment for infants with osteogenesis imperfecta: demonstration of efficacy in a mouse model","volume":"52","author":"McCarthy","year":"2002","journal-title":"Pediatric Research"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00223-007-9045-x","article-title":"Abnormal mineral\u2013matrix interactions are a significant contributor to fragility in oim\/oim bone","volume":"81","author":"Miller","year":"2007","journal-title":"Calcified Tissue International"},{"issue":"1","key":"10.1016\/j.jbiomech.2008.09.028_bib27","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bone.2004.10.006","article-title":"Differential effects of alendronate treatment on bone from growing osteogenesis imperfecta and wild-type mouse","volume":"36","author":"Misof","year":"2005","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.jbiomech.2008.09.028_bib28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0950-351X(97)80601-5","article-title":"Osteogenesis imperfecta and other heritable disorders of bone","volume":"11","author":"Paterson","year":"1997","journal-title":"Baillieres Clinical Endocrinology and Metabolism"},{"issue":"5","key":"10.1016\/j.jbiomech.2008.09.028_bib29","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1210\/jc.85.5.1846","article-title":"Pamidronate treatment of severe osteogenesis imperfecta in children under 3 years of age","volume":"85","author":"Plotkin","year":"2000","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib30","first-page":"279","article-title":"Single day detection of transgenic mice by PCR of toe-clips","volume":"89","author":"Pomp","year":"1991","journal-title":"Mouse Genome"},{"issue":"4","key":"10.1016\/j.jbiomech.2008.09.028_bib31","first-page":"393","article-title":"Osteogenesis imperfecta at the beginning of bone and joint decade","volume":"42","author":"Primorac","year":"2001","journal-title":"Croatian Medical Journal"},{"issue":"3","key":"10.1016\/j.jbiomech.2008.09.028_bib33","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1210\/jc.2002-021371","article-title":"Osteogenesis imperfecta types I, III, and IV: effect of pamidronate therapy on bone and mineral metabolism","volume":"88","author":"Rauch","year":"2003","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"4","key":"10.1016\/j.jbiomech.2008.09.028_bib32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.bone.2006.11.020","article-title":"Long-bone changes after pamidronate discontinuation in children and adolescents with osteogenesis imperfecta","volume":"40","author":"Rauch","year":"2007","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.jbiomech.2008.09.028_bib34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00223-004-0024-1","article-title":"From molds and macrophages to mevalonate: a decade of progress in understanding the molecular mode of action of bisphosphonates","volume":"75","author":"Rogers","year":"2004","journal-title":"Calcified Tissue International"},{"issue":"6","key":"10.1016\/j.jbiomech.2008.09.028_bib35","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S8756-3282(96)00305-5","article-title":"Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta","volume":"19","author":"Saban","year":"1996","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.jbiomech.2008.09.028_bib36","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1172\/JCI115539","article-title":"Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure","volume":"88","author":"Sato","year":"1991","journal-title":"The Journal of Clinical Investigation"},{"issue":"6","key":"10.1016\/j.jbiomech.2008.09.028_bib37","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1001\/archpedi.1975.02120430019007","article-title":"Osteogenesis imperfecta. Review of the literature with presentation of 29 cases","volume":"129","author":"Shoenfeld","year":"1975","journal-title":"American Journal of Diseases of Children"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence","year":"1979","journal-title":"Journal of Medical Genetics"},{"issue":"3","key":"10.1016\/j.jbiomech.2008.09.028_bib39","doi-asserted-by":"crossref","first-page":"E456","DOI":"10.1152\/ajpendo.00311.2005","article-title":"Perinatal testosterone surge is required for normal adult bone size but not for normal bone remodeling","volume":"290","author":"Sims","year":"2006","journal-title":"American Journal of Physiology\u2014Endocrinology and Metabolism"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib40","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.bbrc.2004.11.097","article-title":"Mechanisms of sex steriod effects on bone","volume":"328","author":"Syed","year":"2005","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.jbiomech.2008.09.028_bib41","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bone.2003.07.007","article-title":"Differentiation the mechanisms of antiresorptive action of nitrogen containing bisphosphonates","volume":"33","author":"Van Beek","year":"2003","journal-title":"Bone"},{"issue":"371","key":"10.1016\/j.jbiomech.2008.09.028_bib42","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00003086-200002000-00027","article-title":"Effect of collagen denaturation on the toughness of bone","author":"Wang","year":"2000","journal-title":"Clinical Orthopaedics"}],"container-title":["Journal of Biomechanics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929008004909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929008004909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T01:08:41Z","timestamp":1738544921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021929008004909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":42,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0021929008004909"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiomech.2008.09.028","relation":{},"ISSN":["0021-9290"],"issn-type":[{"value":"0021-9290","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}