{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:37:21Z","timestamp":1792784241877,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["HL-070262"],"award-info":[{"award-number":["HL-070262"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biomechanics"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.jbiomech.2011.03.017","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T13:58:25Z","timestamp":1301666305000},"page":"1459-1465","source":"Crossref","is-referenced-by-count":31,"title":["Regional analysis of dynamic deformation characteristics of native aortic valve leaflets"],"prefix":"10.1016","volume":"44","author":[{"given":"Michael","family":"Weiler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon","family":"Hwai Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik","family":"Balachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muralidhar","family":"Padala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit P.","family":"Yoganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jbiomech.2011.03.017_bib1","first-page":"75","article-title":"Characteristics of compressive strains in porcine aortic valves cusps","volume":"11","author":"Adamczyk","year":"2002","journal-title":"The Journal of Heart Valve Disease"},{"issue":"11","key":"10.1016\/j.jbiomech.2011.03.017_bib2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s10439-006-9167-8","article-title":"An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch","volume":"34","author":"Balachandran","year":"2006","journal-title":"Annals of Biomedical Engineering"},{"issue":"3","key":"10.1016\/j.jbiomech.2011.03.017_bib3","doi-asserted-by":"crossref","first-page":"H756","DOI":"10.1152\/ajpheart.00900.2008","article-title":"Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease","volume":"296","author":"Balachandran","year":"2009","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"issue":"1","key":"10.1016\/j.jbiomech.2011.03.017_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2353\/ajpath.2010.090631","article-title":"Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner","volume":"177","author":"Balachandran","year":"2010","journal-title":"The American Journal of Pathology"},{"issue":"1","key":"10.1016\/j.jbiomech.2011.03.017_bib5","first-page":"1","article-title":"Stress analysis of the aortic valve with and without the sinuses of Valsalva","volume":"10","author":"Beck","year":"2001","journal-title":"The Journal of Heart Valve Disease"},{"issue":"1","key":"10.1016\/j.jbiomech.2011.03.017_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1115\/1.429624","article-title":"Biaxial mechanical properties of the natural and glutaraldehyde treated aortic valve cusp\u2014part I: experimental results","volume":"122","author":"Billiar","year":"2000","journal-title":"Journal of Biomechanical Engineering"},{"issue":"2 Suppl","key":"10.1016\/j.jbiomech.2011.03.017_bib7","doi-asserted-by":"crossref","first-page":"S160","DOI":"10.1016\/0003-4975(95)00259-N","article-title":"Biaxial mechanical properties of explanted aortic allograft leaflets","volume":"60","author":"Christie","year":"1995","journal-title":"The Annals of Thoracic Surgery"},{"issue":"19 Suppl","key":"10.1016\/j.jbiomech.2011.03.017_bib8","first-page":"II54","article-title":"Deformational dynamics of the aortic root: modes and physiologic determinants","volume":"100","author":"Dagum","year":"1999","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.jbiomech.2011.03.017_bib10","first-page":"679","article-title":"Mesostructures of the aortic valve","volume":"14","author":"Doehring","year":"2005","journal-title":"The Journal of Heart Valve Disease"},{"issue":"1","key":"10.1016\/j.jbiomech.2011.03.017_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1055\/s-2007-1013982","article-title":"Haemodynamic effect of supraaortic ridge enhancement on the closure mechanism of the aortic valve and its implications in aortic valve repair","volume":"38","author":"Duran","year":"1990","journal-title":"The Thoracic and Cardiovascular Surgeon"},{"issue":"1","key":"10.1016\/j.jbiomech.2011.03.017_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1114\/1.1432690","article-title":"Bioprosthetic heart valve leaflet deformation monitored by double-pulse stereo photogrammetry","volume":"30","author":"Gao","year":"2002","journal-title":"Annals of Biomedical Engineering."},{"issue":"3","key":"10.1016\/j.jbiomech.2011.03.017_bib13","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1115\/1.1894385","article-title":"In vitro dynamic strain behavior of the mitral valve posterior leaflet","volume":"127","author":"He","year":"2005","journal-title":"Journal of Biomechanical Engineering."},{"issue":"11","key":"10.1016\/j.jbiomech.2011.03.017_bib15","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1114\/1.1415523","article-title":"Dynamic in vitro quantification of bioprosthetic heart valve leaflet motion using structured light projection","volume":"29","author":"Iyengar","year":"2001","journal-title":"Annals of Biomedical Engineering"},{"issue":"5","key":"10.1016\/j.jbiomech.2011.03.017_bib16","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2353\/ajpath.2007.070251","article-title":"The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology","volume":"171","author":"Liu","year":"2007","journal-title":"The American Journal of Pathology"},{"issue":"5","key":"10.1016\/j.jbiomech.2011.03.017_bib17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.carpath.2007.03.006","article-title":"Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast","volume":"16","author":"Merryman","year":"2007","journal-title":"Cardiovascular Pathology: The Official Journal of the Society for Cardiovascular Pathology"},{"issue":"3-4","key":"10.1016\/j.jbiomech.2011.03.017_bib18","first-page":"287","article-title":"Aortic valve mechanics\u2014part I: material properties of natural porcine aortic valves","volume":"2","author":"Missirlis","year":"1978","journal-title":"Journal of Bioengineering"},{"issue":"13","key":"10.1016\/j.jbiomech.2011.03.017_bib19","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMe0807001","article-title":"Calcific aortic stenosis\u2014time to look more closely at the valve","volume":"359","author":"Otto","year":"2008","journal-title":"The New England Journal of Medicine"},{"issue":"8","key":"10.1016\/j.jbiomech.2011.03.017_bib20","doi-asserted-by":"crossref","first-page":"081004","DOI":"10.1115\/1.4001682","article-title":"Mechanics of the mitral valve strut chordae insertion region","volume":"132","author":"Padala","year":"2010","journal-title":"Journal of Biomechanical Engineering."},{"issue":"4","key":"10.1016\/j.jbiomech.2011.03.017_bib21","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0003-4975(01)03001-6","article-title":"Cause of degenerative disease of the trileaflet aortic valve: review of subject and presentation of a new theory","volume":"73","author":"Robicsek","year":"2002","journal-title":"The Annals of Thoracic Surgery"},{"issue":"12","key":"10.1016\/j.jbiomech.2011.03.017_bib22","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.jbiomech.2009.05.015","article-title":"On the biomechanics of heart valve function","volume":"42","author":"Sacks","year":"2009","journal-title":"Journal of Biomechanics"},{"issue":"4","key":"10.1016\/j.jbiomech.2011.03.017_bib23","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.athoracsur.2006.03.117","article-title":"In-vivo dynamic deformation of the mitral valve anterior leaflet","volume":"82","author":"Sacks","year":"2006","journal-title":"The Annals of Thoracic Surgery"},{"issue":"10","key":"10.1016\/j.jbiomech.2011.03.017_bib24","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1114\/1.1529194","article-title":"Surface strains in the anterior leaflet of the functioning mitral valve","volume":"30","author":"Sacks","year":"2002","journal-title":"Annals of Biomedical Engineering"},{"issue":"1","key":"10.1016\/j.jbiomech.2011.03.017_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/(SICI)1097-4636(199807)41:1<131::AID-JBM16>3.0.CO;2-Q","article-title":"The aortic valve microstructure: effects of transvalvular pressure","volume":"41","author":"Sacks","year":"1998","journal-title":"Journal of Biomedical Materials Research"},{"issue":"1484","key":"10.1016\/j.jbiomech.2011.03.017_bib26","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1098\/rstb.2007.2122","article-title":"Heart valve function: a biomechanical perspective","volume":"362","author":"Sacks","year":"2007","journal-title":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences"},{"issue":"14","key":"10.1016\/j.jbiomech.2011.03.017_bib27","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1016\/j.jbiomech.2007.04.001","article-title":"Time-dependent biaxial mechanical behavior of the aortic heart valve leaflet","volume":"40","author":"Stella","year":"2007","journal-title":"Journal of Biomechanics"},{"issue":"5","key":"10.1016\/j.jbiomech.2011.03.017_bib28","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1115\/1.2768111","article-title":"On the biaxial mechanical properties of the layers of the aortic valve leaflet","volume":"129","author":"Stella","year":"2007","journal-title":"Journal of Biomechanical Engineering"},{"key":"10.1016\/j.jbiomech.2011.03.017_bib29","series-title":"The Aortic Valve","author":"Thubrikar","year":"1990"},{"issue":"3","key":"10.1016\/j.jbiomech.2011.03.017_bib30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0002-9149(86)90067-6","article-title":"Patterns of calcific deposits in operatively excised stenotic or purely regurgitant aortic valves and their relation to mechanical stress","volume":"58","author":"Thubrikar","year":"1986","journal-title":"The American Journal of Cardiology"},{"issue":"1","key":"10.1016\/j.jbiomech.2011.03.017_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0021-9290(92)90249-Z","article-title":"Micromechanics of the fibrosa and the ventricularis in aortic valve leaflets","volume":"25","author":"Vesely","year":"1992","journal-title":"Journal of Biomechanics"},{"issue":"2","key":"10.1016\/j.jbiomech.2011.03.017_bib32","doi-asserted-by":"crossref","first-page":"H395","DOI":"10.1152\/ajpheart.00040.2009","article-title":"Dynamic deformation characteristics of porcine aortic valve leaflet under normal and hypertensive conditions","volume":"298","author":"Yap","year":"2010","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"}],"container-title":["Journal of Biomechanics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929011002673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929011002673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T15:56:09Z","timestamp":1543852569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021929011002673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0021929011002673"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiomech.2011.03.017","relation":{},"ISSN":["0021-9290"],"issn-type":[{"value":"0021-9290","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}