{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:59:37Z","timestamp":1787878777376,"version":"build-2784847793"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001279","name":"Orthopedic Research and Education Foundation (OREF)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001279","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["UL1TR000135 (Mayo CTSA)"],"award-info":[{"award-number":["UL1TR000135 (Mayo CTSA)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jbiomech.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomechanics"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.jbiomech.2012.11.008","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T11:36:10Z","timestamp":1353670570000},"page":"456-461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Anterior and posterior variations in mechanical properties of human vertebrae measured by nanoindentation"],"prefix":"10.1016","volume":"46","author":[{"given":"Hugo","family":"Giambini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Nassr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Nan","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiomech.2012.11.008_bib1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.jmbbm.2011.03.026","article-title":"The effect of friction on indenter force and pile-up in numerical simulations of bone nanoindentation","volume":"4","author":"Adam","year":"2011","journal-title":"Journal of the Mechanical Behavior of Biomedical Materials"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib2","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.bone.2006.05.007","article-title":"Raloxifene enhances vertebral mechanical properties independent of bone density","volume":"39","author":"Allen","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib3","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1359\/jbmr.080517","article-title":"Microarchitecture influences microdamage accumulation in human vertebral trabecular bone","volume":"23","author":"Arlot","year":"2008","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib4","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jbiomech.2008.11.032","article-title":"Biomechanical properties across trabeculae from the proximal femur of normal and ovariectomised sheep","volume":"42","author":"Brennan","year":"2009","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00198-006-0304-x","article-title":"The vertebral fracture cascade in osteoporosis: a review of aetiopathogenesis","volume":"18","author":"Briggs","year":"2007","journal-title":"Osteoporosis International"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib6","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1007\/s00586-006-0158-0","article-title":"The effect of osteoporotic vertebral fracture on predicted spinal loads in vivo","volume":"15","author":"Briggs","year":"2006","journal-title":"European Spine Journal"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib7","first-page":"201","article-title":"Bone material properties and mineral matrix contributions to fracture risk or age in woman and men","volume":"2","author":"Burr","year":"2002","journal-title":"Journal of Musculoskeletal and Neuronal Interactions"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib8","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00198-008-0593-3","article-title":"Regional variations of vertebral trabecular bone microstructure with age and gender","volume":"19","author":"Chen","year":"2008","journal-title":"Osteoporosis International"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib9","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1016\/j.jbiomech.2007.05.004","article-title":"Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation","volume":"40","author":"Chevalier","year":"2007","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib10","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1097\/00007632-199909150-00010","article-title":"Spinal curvatures and quality of life in women with vertebral fractures secondary to osteoporosis","volume":"24","author":"Cortet","year":"1999","journal-title":"Spine"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib11","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/00007632-198311000-00003","article-title":"The three column spine and its significance in the classification of acute thoracolumbar spinal injuries","volume":"8","author":"Denis","year":"1983","journal-title":"Spine"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1592\/phco.2006.26.1.104","article-title":"Examining the relationship between bone mineral density and fracture risk reduction during pharmacologic treatment of osteoporosis","volume":"26","author":"Divittorio","year":"2006","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib13","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1259\/0007-1285-67-802-969","article-title":"The relationship between bone mineral density, vertebral body shape and spinal curvature in the elderly thoracolumbar spine: an in vitro study","volume":"67","author":"Edmondston","year":"1994","journal-title":"British Journal of Radiology"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4065\/80.3.379","article-title":"The roles of bone mineral density, bone turnover, and other properties in reducing fracture risk during antiresorptive therapy","volume":"80","author":"Epstein","year":"2005","journal-title":"Mayo Clinic Proceedings"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF02352262","article-title":"Kyphosis in older women and its relation to back pain, disability and osteopenia: the study of osteoporotic fractures","volume":"4","author":"Ettinger","year":"1994","journal-title":"Osteoporosis International"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib16","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.jbiomech.2012.05.001","article-title":"Mechanical properties of porcine femoral cortical bone measured by nanoindentation","volume":"45","author":"Feng","year":"2012","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib17","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1359\/jbmr.090317","article-title":"Role of trabecular microarchitecture in whole-vertebral body biomechanical behavior","volume":"24","author":"Fields","year":"2009","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib18","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.bone.2003.12.012","article-title":"The degree of mineralization is a determinant of bone strength: a study on human calcanei","volume":"34","author":"Follet","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jbiomech.2010.10.007","article-title":"Multiscale modeling of bone tissue with surface and permeability control","volume":"44","author":"Goncalves Coelho","year":"2011","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/01.brs.0000193939.99618.ee","article-title":"Regional variations in microstructural properties of vertebral trabeculae with structural groups","volume":"31","author":"Gong","year":"2006","journal-title":"Spine"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib21","first-page":"185","article-title":"Is trabecular bone tissue different from cortical bone tissue?","volume":"12","author":"Guo","year":"1997","journal-title":"FORMA"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/jor.1100180224","article-title":"Vertebral trabecular bone microscopic tissue elastic modulus and hardness do not change in ovariectomized rats","volume":"18","author":"Guo","year":"2000","journal-title":"Journal of Orthopaedic Research"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib23","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1016\/j.jbiomech.2008.05.014","article-title":"Heterogeneous linear elastic trabecular bone modelling using micro-CT attenuation data and experimentally measured heterogeneous tissue properties","volume":"41","author":"Harrison","year":"2008","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S8756-3282(01)00624-X","article-title":"Nanoindentation discriminates the elastic properties of individual human bone lamellae under dry and physiological conditions","volume":"30","author":"Hengsberger","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib25","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1097\/00007632-200107150-00010","article-title":"Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution","volume":"26","author":"Homminga","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib26","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1359\/JBMR.051201","article-title":"Hyperkyphotic posture and risk of future osteoporotic fractures: the Rancho Bernardo study","volume":"21","author":"Huang","year":"2006","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00198-007-0432-y","article-title":"Flattening of sagittal spinal curvature as a predictor of vertebral fracture","volume":"19","author":"Kobayashi","year":"2008","journal-title":"Osteoporosis International"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib28","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1097\/00007632-199712151-00002","article-title":"Epidemiology of spinal osteoporosis","volume":"22","author":"Melton","year":"1997","journal-title":"Spine"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib29","doi-asserted-by":"crossref","unstructured":"Mosekilde, L., 1993. Vertebral structure and strength in vivo and in vitro. Calcified Tissue International 53 Suppl 1, S121\u2013125, discussion S125\u2013126.","DOI":"10.1007\/BF01673420"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib30","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/jbm.a.31474","article-title":"Relationship between tissue stiffness and degree of mineralization of developing trabecular bone","volume":"84","author":"Mulder","year":"2008","journal-title":"Journal of Biomedical Materials Research Part A"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib31","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00223-008-9174-x","article-title":"Bone volume fraction explains the variation in strength and stiffness of cancellous bone affected by metastatic cancer and osteoporosis","volume":"83","author":"Nazarian","year":"2008","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib32","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jbm.a.31766","article-title":"Micromechanical properties of human trabecular bone: a hierarchical investigation using nanoindentation","volume":"87","author":"Norman","year":"2008","journal-title":"Journal of Biomedical Materials Research"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib33","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1557\/JMR.1992.1564","article-title":"An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments","volume":"7","author":"Oliver","year":"1992","journal-title":"Journal of Materials Research"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib34","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/(SICI)1097-4636(199904)45:1<48::AID-JBM7>3.0.CO;2-5","article-title":"Elastic properties of microstructural components of human bone tissue as measured by nanoindentation","volume":"45","author":"Rho","year":"1999","journal-title":"Journal of Biomedical Materials Research"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib35","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0142-9612(97)00073-2","article-title":"Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation","volume":"18","author":"Rho","year":"1997","journal-title":"Biomaterials"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib36","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1007\/s00198-005-1951-z","article-title":"The relationship between bone mineral density and biomechanics in patients with osteoporosis and scoliosis","volume":"16","author":"Routh","year":"2005","journal-title":"Osteoporosis International"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib37","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1359\/jbmr.060513","article-title":"Incidence and risk factors for vertebral fracture in women and men: 25-year follow-up results from the population-based Framingham study","volume":"21","author":"Samelson","year":"2006","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib38","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00198-009-1008-9","article-title":"Cortical and trabecular architecture are altered in postmenopausal women with fractures","volume":"20","author":"Sornay-Rendu","year":"2009","journal-title":"Osteoporosis International"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib39","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1359\/jbmr.060102","article-title":"Importance of individual rods and plates in the assessment of bone quality and their contribution to bone stiffness","volume":"21","author":"Stauber","year":"2006","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib40","first-page":"947","article-title":"Effect of mineral content on the nanoindentation properties and nanoscale deformation mechanisms of bovine tibial cortical bone","volume":"16","author":"Tai","year":"2005","journal-title":"Journal of Materials Science: Materials in Medicine"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib41","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/00007632-198710000-00005","article-title":"Relationship between kyphosis, scoliosis, and osteoporosis in the elderly population","volume":"12","author":"Thevenon","year":"1987","journal-title":"Spine"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib42","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0021-9290(75)90025-1","article-title":"Buckling studies of single human trabeculae","volume":"8","author":"Townsend","year":"1975","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib43","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0021-9290(98)00177-8","article-title":"The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques","volume":"32","author":"Turner","year":"1999","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib44","doi-asserted-by":"crossref","first-page":"e38560","DOI":"10.1371\/journal.pone.0038560","article-title":"A modified sagittal spine postural classification and its relationship to deformities and spinal mobility in a Chinese osteoporotic population","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1385\/JCD:7:3:255","article-title":"Relationship between changes in bone mineral density and vertebral fracture risk associated with risedronate: greater increases in bone mineral density do not relate to greater decreases in fracture risk","volume":"7","author":"Watts","year":"2004","journal-title":"Journal of Clinical Densitometry"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib46","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jbiomech.2010.02.026","article-title":"Valid micro finite element models of vertebral trabecular bone can be obtained using tissue properties measured with nanoindentation under wet conditions","volume":"43","author":"Wolfram","year":"2010","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00002517-199604000-00014","article-title":"Effect of patient position on the sagittal-plane profile of the thoracolumbar spine","volume":"9","author":"Wood","year":"1996","journal-title":"Journal of Spinal Disorders"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib48","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.jbiomech.2011.01.039","article-title":"The effect of holding time on nanoindentation measurements of creep in bone","volume":"44","author":"Wu","year":"2011","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib49","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.bone.2011.02.023","article-title":"Differences in the degree of bone tissue mineralization account for little of the differences in tissue elastic properties","volume":"48","author":"Zebaze","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jbiomech.2012.11.008_bib50","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0021-9290(99)00111-6","article-title":"Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur","volume":"32","author":"Zysset","year":"1999","journal-title":"Journal of Biomechanics"}],"container-title":["Journal of Biomechanics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929012006604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929012006604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T01:12:05Z","timestamp":1562375525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021929012006604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0021929012006604"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiomech.2012.11.008","relation":{},"ISSN":["0021-9290"],"issn-type":[{"value":"0021-9290","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anterior and posterior variations in mechanical properties of human vertebrae measured by nanoindentation","name":"articletitle","label":"Article Title"},{"value":"Journal of Biomechanics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiomech.2012.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}