{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:31:28Z","timestamp":1762176688056,"version":"3.44.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR 49438","EB14351"],"award-info":[{"award-number":["AR 49438","EB14351"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011036","name":"Empire State Development&apos;s Division of Science, Technology and Innovation","doi-asserted-by":"publisher","award":["DA033485","MH083711","NS073855"],"award-info":[{"award-number":["DA033485","MH083711","NS073855"]}],"id":[{"id":"10.13039\/100011036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomechanics"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.jbiomech.2013.09.024","type":"journal-article","created":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:02:31Z","timestamp":1381276951000},"page":"162-167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Enhancement of neuromuscular dynamics and strength behavior using extremely low magnitude mechanical signals in mice"],"prefix":"10.1016","volume":"47","author":[{"given":"Gabriel","family":"Mettlach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Polo-Parada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Peca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clinton T.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Plattner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Bibb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiomech.2013.09.024_bib1","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1002\/art.24783","article-title":"Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen","volume":"60","author":"Allen","year":"2009","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib2","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.neurobiolaging.2007.04.005","article-title":"Motor and cognitive deficits in the heterozygous leaner mouse, a Cav2.1 voltage-gated Ca2+ channel mutant","volume":"29","author":"Alonso","year":"2008","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbr.2012.04.051","article-title":"Evidence of a progressive motor dysfunction in Mucopolysaccharidosis type I mice","volume":"233","author":"Baldo","year":"2012","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib4","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1111\/j.1742-4658.2005.04965.x","article-title":"Nerve influence on myosin light chain phosphorylation in slow and fast skeletal muscles","volume":"272","author":"Bozzo","year":"2005","journal-title":"The FEBS Journal"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1113\/jphysiol.1976.sp011580","article-title":"The responses of human muscle spindle endings to vibration of non-contracting muscles","volume":"261","author":"Burke","year":"1976","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0960-8966(94)00063-F","article-title":"Effect of voluntary wheel-running exercise on muscles of the mdx mouse","volume":"5","author":"Carter","year":"1995","journal-title":"Neuromuscular Disorders: NMD"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0006-8993(98)01258-X","article-title":"Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests","volume":"835","author":"Crawley","year":"1999","journal-title":"Brain Research"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0969-9961(03)00041-X","article-title":"Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatment","volume":"13","author":"Derave","year":"2003","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1113\/jphysiol.1991.sp018550","article-title":"Effects of enhanced activity on synaptic transmission in mouse extensor digitorum longus muscle","volume":"436","author":"Dorlochter","year":"1991","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0006-8993(98)00010-9","article-title":"Electrophysiology of the neuromuscular junction of the laminin-2 (merosin) deficient C57 BL\/6J dy2J\/dy2J dystrophic mouse","volume":"788","author":"Edwards","year":"1998","journal-title":"Brain Research"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib11","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.expneurol.2003.10.006","article-title":"Increased quantal size in transmission at slow but not fast neuromuscular synapses of apolipoprotein E deficient mice","volume":"185","author":"Everett","year":"2004","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/mus.20796","article-title":"Vibration sensitivity of human muscle spindles and Golgi tendon organs","volume":"36","author":"Fallon","year":"2007","journal-title":"Muscle and Nerve"},{"issue":"1","key":"10.1016\/j.jbiomech.2013.09.024_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0021-9290(91)90382-W","article-title":"The determinants of skeletal muscle force and power: their adaptability with changes in activity pattern","volume":"24","author":"Fitts","year":"1991","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neulet.2008.05.075","article-title":"High frequency tendon reflexes in the human soleus muscle","volume":"440","author":"Fornari","year":"2008","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib15","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1359\/jbmr.060612","article-title":"Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD","volume":"21","author":"Gilsanz","year":"2006","journal-title":"Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib16","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1113\/jphysiol.1988.sp017226","article-title":"Slow-to-fast transformation of denervated soleus muscles by chronic high-frequency stimulation in the rat","volume":"402","author":"Gorza","year":"1988","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib17","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0014-4886(03)00290-5","article-title":"Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia","volume":"184","author":"Hamann","year":"2003","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib18","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.spinee.2009.02.009","article-title":"Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest","volume":"9","author":"Holguin","year":"2009","journal-title":"The Spine Journal: Official Journal of the North American Spine Society"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib19","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/jn.1977.40.5.1113","article-title":"Responses of primary and secondary endings of isolated mammalian muscle spindles to sinusoidal length changes","volume":"40","author":"Hunt","year":"1977","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib20","doi-asserted-by":"crossref","first-page":"C365","DOI":"10.1152\/ajpcell.1998.274.2.C365","article-title":"Changes in myosin heavy chain mRNA and protein isoforms of rat muscle during forced contractile activity","volume":"274","author":"Jaschinski","year":"1998","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib21","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1748-1716.2007.01680.x","article-title":"Treadmill but not wheel running improves fatigue resistance of isolated extensor digitorum longus muscle in mice","volume":"190","author":"Jeneson","year":"2007","journal-title":"Acta Physiologica"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF00202900","article-title":"Superimposing noise linearizes the responses of primary muscle spindle afferents to sinusoidal muscle stretch","volume":"60","author":"Kroller","year":"1988","journal-title":"Biological Cybernetics"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib23","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1097\/WNR.0b013e32833037ae","article-title":"The primary locus of motor neuron death in an ALS\u2013PDC mouse model","volume":"20","author":"Lee","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1152\/physiolgenomics.90207.2008","article-title":"Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study","volume":"34","author":"Mandillo","year":"2008","journal-title":"Physiological Genomics"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib25","doi-asserted-by":"crossref","first-page":"11246","DOI":"10.1523\/JNEUROSCI.3260-09.2009","article-title":"Fast kinetics, high-frequency oscillations, and subprimary firing range in adult mouse spinal motoneurons","volume":"29","author":"Manuel","year":"2009","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib26","article-title":"Adaptations of mouse skeletal muscle to low-intensity vibration training","author":"McKeehen","year":"2012","journal-title":"Medicine and Science in Sports and Exercise"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib28","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.gaitpost.2010.12.019","article-title":"Postural instability caused by extended bed rest is alleviated by brief daily exposure to low magnitude mechanical signals","volume":"33","author":"Muir","year":"2011","journal-title":"Gait and Posture"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib29","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1152\/japplphysiol.01135.2004","article-title":"High-frequency, low-magnitude vibrations suppress the number of blood vessels per muscle fiber in mouse soleus muscle","volume":"98","author":"Murfee","year":"2005","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib30","doi-asserted-by":"crossref","first-page":"34918","DOI":"10.1074\/jbc.M109.022442","article-title":"Triadin deletion induces impaired skeletal muscle function","volume":"284","author":"Oddoux","year":"2009","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/1050-6411(92)90002-Z","article-title":"Tonic vibration reflex of human limb muscles: discharge pattern of motor units","volume":"2","author":"Person","year":"1992","journal-title":"Journal of Electromyography and Kinesiology: Official Journal of the International Society of Electrophysiological Kinesiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib32","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1152\/jn.00313.2012","article-title":"Frequency-dependent amplification of stretch-evoked excitatory input in spinal motoneurons","volume":"108","author":"Powers","year":"2012","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1152\/jn.1985.53.1.76","article-title":"Action potential patterns of isolated frog muscle spindle in response to sinusoidal stimulation","volume":"53","author":"Querfurth","year":"1985","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib34","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.1523\/JNEUROSCI.20-17-06529.2000","article-title":"Structural and functional alterations of neuromuscular junctions in NCAM-deficient mice","volume":"20","author":"Rafuse","year":"2000","journal-title":"The Journal of neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1123\/japa.15.4.367","article-title":"Effects of vibration exercise on muscle performance and mobility in an older population","volume":"15","author":"Rees","year":"2007","journal-title":"Journal of Aging and Physical Activity"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib36","doi-asserted-by":"crossref","first-page":"462","DOI":"10.2522\/ptj.20070027","article-title":"Effects of whole-body vibration exercise on lower-extremity muscle strength and power in an older population: a randomized clinical trial","volume":"88","author":"Rees","year":"2008","journal-title":"Physical Therapy"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib37","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1002\/jbmr.402","article-title":"High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children","volume":"26","author":"Reyes","year":"2011","journal-title":"Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib38","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/mus.22343","article-title":"Oxidative capacity and fatigability in run-trained malignant hyperthermia-susceptible mice","volume":"45","author":"Rouviere","year":"2012","journal-title":"Muscle and Nerve"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib39","doi-asserted-by":"crossref","first-page":"17879","DOI":"10.1073\/pnas.0708467104","article-title":"Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals","volume":"104","author":"Rubin","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib40","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/S0003-9993(03)00357-5","article-title":"High-frequency vibration training increases muscle power in postmenopausal women","volume":"84","author":"Russo","year":"2003","journal-title":"Archives of Physical Medicine and Rehabilitation"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib41","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng1196-348","article-title":"Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis","volume":"14","author":"Sango","year":"1996","journal-title":"Nature Genetics"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib43","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s00198-010-1228-z","article-title":"Effect of whole-body vibration on BMD: a systematic review and meta-analysis","volume":"21","author":"Slatkovska","year":"2010","journal-title":"Osteoporosis International: A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib44","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2009.05.016","article-title":"Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice","volume":"1279","author":"Takahashi","year":"2009","journal-title":"Brain Research"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib45","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1152\/jappl.1993.74.2.934","article-title":"Chronic stimulation-induced changes in mitochondria and performance in rat skeletal muscle","volume":"74","author":"Takahashi","year":"1993","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib46","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1292\/jvms.61.513","article-title":"Influence of motor activities on the release of transmitter quanta from motor nerve terminals in mice","volume":"61","author":"Taquahashi","year":"1999","journal-title":"The Journal of Veterinary Medical Science\/The Japanese Society of Veterinary Science"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib47","doi-asserted-by":"crossref","unstructured":"Tsang, K., de Bruin, H., Archambeault, M., 2008. A novel approach using tendon vibration of the human flexor carpi radialis muscle to study spinal reflexes. In: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2008, pp. 5089\u20135092.","DOI":"10.1109\/IEMBS.2008.4650358"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib48","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1152\/japplphysiol.00115.2010","article-title":"Low-magnitude vertical vibration enhances myotube formation in C2C12 myoblasts","volume":"109","author":"Wang","year":"2010","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib49","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1523\/JNEUROSCI.08-12-04415.1988","article-title":"Control of contractile properties within adaptive ranges by patterns of impulse activity in the rat","volume":"8","author":"Westgaard","year":"1988","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib50","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0006-291X(02)02953-4","article-title":"Inhibition of myostatin in adult mice increases skeletal muscle mass and strength","volume":"300","author":"Whittemore","year":"2003","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib51","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1469-7793.1998.623bk.x","article-title":"Fast to slow transformation of denervated and electrically stimulated rat muscle","volume":"510","author":"Windisch","year":"1998","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib52","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.bone.2006.05.012","article-title":"Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton","volume":"39","author":"Xie","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jbiomech.2013.09.024_bib53","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1152\/japplphysiol.00764.2007","article-title":"Enhancement of the adolescent murine musculoskeletal system using low-level mechanical vibrations","volume":"104","author":"Xie","year":"2008","journal-title":"Journal of Applied Physiology"}],"container-title":["Journal of Biomechanics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929013004478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929013004478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T01:12:38Z","timestamp":1758244358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021929013004478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0021929013004478"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiomech.2013.09.024","relation":{},"ISSN":["0021-9290"],"issn-type":[{"type":"print","value":"0021-9290"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancement of neuromuscular dynamics and strength behavior using extremely low magnitude mechanical signals in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Biomechanics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiomech.2013.09.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}