{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:20:04Z","timestamp":1769185204102,"version":"3.49.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"NRF-Technion-NTU-NUS"},{"name":"Arcie Micay"},{"name":"Montreal Biomedical Research Funds"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomechanics"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.jbiomech.2015.05.009","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T06:47:56Z","timestamp":1432190876000},"page":"1777-1781","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Embryonic stem cells growing in 3-dimensions shift from reliance on the substrate to each other for mechanical support"],"prefix":"10.1016","volume":"48","author":[{"given":"Ailing","family":"Teo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayasari","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9670-3418","authenticated-orcid":false,"given":"Daphne","family":"Weihs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiomech.2015.05.009_bib1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1745-6150-5-20","article-title":"Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells","volume":"5","author":"Agur","year":"2010","journal-title":"Biol. Direct"},{"key":"10.1016\/j.jbiomech.2015.05.009_bib2","doi-asserted-by":"crossref","first-page":"C595","DOI":"10.1152\/ajpcell.00270.2001","article-title":"Traction fields, moments, and strain energy that cells exert on their surroundings","volume":"282","author":"Butler","year":"2002","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib3","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/S0006-3495(99)77386-8","article-title":"Stresses at the cell-to-substrate interface during locomotion of fibroblasts","volume":"76","author":"Dembo","year":"1999","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib4","first-page":"27","article-title":"The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium","volume":"87","author":"Doetschman","year":"1985","journal-title":"J. Embryol. Exp. Morphol."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jbiomech.2015.05.009_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12013-012-9356-z","article-title":"Intracellular mechanics and activity of breast cancer cells correlate with metastatic potential","volume":"63","author":"Gal","year":"2012","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib7","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1529\/biophysj.104.045476","article-title":"Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence","volume":"88","author":"Guck","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.6987736","article-title":"Silicone rubber substrata: a new wrinkle in the study of cell locomotion","volume":"208","author":"Harris","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.jbiomech.2015.05.009_bib9","article-title":"Elasticity of human embryonic stem cells as determined by atomic force microscopy","volume":"133","author":"Kiss","year":"2011"},{"key":"10.1016\/j.jbiomech.2015.05.009_bib10","doi-asserted-by":"crossref","first-page":"C146","DOI":"10.1152\/ajpcell.00195.2010","article-title":"Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces","volume":"300","author":"Krishnan","year":"2011","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib11","doi-asserted-by":"crossref","first-page":"035022","DOI":"10.1088\/1367-2630\/15\/3\/035022","article-title":"Metastatic cancer cells tenaciously indent impenetrable, soft substrates","volume":"15","author":"Kristal-Muscal","year":"2013","journal-title":"New. J. Phys."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4161\/cam.19583","article-title":"Role of E-cadherin and other cell adhesion molecules in survival and differentiation of human pluripotent stem cells","volume":"6","author":"Li","year":"2012","journal-title":"Cell Adhes. Migr."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib13","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1073\/pnas.1217279110","article-title":"Cadherin-based intercellular adhesions organize epithelial cell\u2013matrix traction forces","volume":"110","author":"Mertz","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib14","doi-asserted-by":"crossref","first-page":"13661","DOI":"10.1073\/pnas.94.25.13661","article-title":"Cell locomotion and focal adhesions are regulated by substrate flexibility","volume":"94","author":"Pelham","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib15","doi-asserted-by":"crossref","first-page":"L19","DOI":"10.1016\/j.bpj.2010.04.057","article-title":"Embryonic stem cells do not stiffen on rigid substrates","volume":"99","author":"Poh","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib16","doi-asserted-by":"crossref","first-page":"011918","DOI":"10.1103\/PhysRevE.76.011918","article-title":"Stress fluctuations and motion of cytoskeletal-bound markers","volume":"76","author":"Raupach","year":"2007","journal-title":"Phys. Rev. E"},{"key":"10.1016\/j.jbiomech.2015.05.009_bib17","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1242\/jcs.045112","article-title":"Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions","volume":"123","author":"Schaller","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbiomech.2011.10.023","article-title":"Mechanotransduction in adipocytes","volume":"45","author":"Shoham","year":"2012","journal-title":"J. Biomech."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib19","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1089\/ten.tea.2014.0505","article-title":"Multiscale modeling of tissue-engineered fat: is there a deformation-driven positive feedback loop in adipogenesis?","volume":"21","author":"Shoham","year":"2015","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.jbiomech.2015.05.009_bib20","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1016\/j.biomaterials.2008.04.027","article-title":"The benefit of human embryonic stem cell encapsulation for prolonged feeder-free maintenance","volume":"29","author":"Siti-Ismail","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.jbiomech.2015.05.009_bib21","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s10529-014-1456-y","article-title":"A novel perfused rotary bioreactor for cardiomyogenesis of embryonic stem cells","volume":"36","author":"Teo","year":"2014","journal-title":"Biotechnol. lett."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib22","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","article-title":"The cell\u2013cell adhesion molecule E-cadherin","volume":"65","author":"Van Roy","year":"2008","journal-title":"Cell. mol. life sci."},{"key":"10.1016\/j.jbiomech.2015.05.009_bib23","doi-asserted-by":"crossref","first-page":"054003","DOI":"10.1088\/0960-1317\/21\/5\/054003","article-title":"Microsystems for cellular force measurement: a review","volume":"21","author":"Zheng","year":"2011","journal-title":"J. Micromech. Microeng."}],"container-title":["Journal of Biomechanics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929015002869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929015002869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:02:35Z","timestamp":1762189355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021929015002869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0021929015002869"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiomech.2015.05.009","relation":{},"ISSN":["0021-9290"],"issn-type":[{"value":"0021-9290","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Embryonic stem cells growing in 3-dimensions shift from reliance on the substrate to each other for mechanical support","name":"articletitle","label":"Article Title"},{"value":"Journal of Biomechanics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiomech.2015.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}