{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:27:25Z","timestamp":1784345245868,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Commission within the Horizon 2020 Framework","award":["642458"],"award-info":[{"award-number":["642458"]}]}],"content-domain":{"domain":["jbiomech.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomechanics"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jbiomech.2016.11.013","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T17:46:15Z","timestamp":1478799975000},"page":"83-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["In vitro  and in silico approaches to quantify the effects of the Mitraclip \u00ae  system on mitral valve function"],"prefix":"10.1016","volume":"50","author":[{"given":"Francesco","family":"Sturla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Vismara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Jaworek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Votta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Romitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar A.","family":"Pappalardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Lucherini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Antona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco B.","family":"Fiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Redaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiomech.2016.11.013_bib1","unstructured":"Abbott Laboratories, 2014. Electronic instructions for use for the Mitraclip(R) clip delivery system(\u3008http:\/\/www.abbottvascular.com\/static\/cms_workspace\/pdf\/ifu\/structural_heart\/eIFU_Mitraclip.pdf\u3009)."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib2","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/eurheartj\/ehq222","article-title":"Degenerative mitral valve regurgitation: best practice revolution","volume":"31","author":"Adams","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib3","first-page":"207","article-title":"Ischemic mitral regurgitation: mechanisms and echocardiographic classification","volume":"9","author":"Agricola","year":"2008","journal-title":"Eur. J. Echocardiogr."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib4","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1067\/mtc.2001.117277","article-title":"The double-orifice technique in mitral valve repair: a simple solution for complex problems","volume":"122","author":"Alfieri","year":"2001","journal-title":"J. Thorac. Cardiovasc Surg."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib5","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1177\/0954411911414803","article-title":"Functional and structural effects of percutaneous edge-to-edge double-orifice repair under cardiac cycle in comparison with suture repair","volume":"225","author":"Avanzini","year":"2011","journal-title":"Proc. Inst. Mech. Eng. H"},{"key":"10.1016\/j.jbiomech.2016.11.013_bib6","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1161\/CIRCIMAGING.113.000620","article-title":"Assessment of mitral valve area during percutaneous mitral valve repair using the Mitraclip system: comparison of different echocardiographic methods","volume":"6","author":"Biaggi","year":"2013","journal-title":"Circ. Cardiovasc Imaging"},{"key":"10.1016\/j.jbiomech.2016.11.013_bib7","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/j.jbiomech.2016.01.045","article-title":"An integrated computational approach for aortic mechanics including geometric, histological and chemico-physical data","volume":"49","author":"Bianchi","year":"2016","journal-title":"J. Biomech."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/CIRCULATIONAHA.107.758086","volume":"118","author":"Bonow","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jbiomech.2016.11.013_bib9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/ejcts\/ezs302","article-title":"Mitral valve replacement following a failed Mitraclip procedure","volume":"42","author":"Chanda","year":"2012","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib10","first-page":"8","article-title":"Dynamic phenotypes of degenerative myxomatous mitral valve disease: quantitative 3-dimensional echocardiographic study","author":"Clavel","year":"2015","journal-title":"Circ. Cardiovasc Imaging"},{"key":"10.1016\/j.jbiomech.2016.11.013_bib11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12265-014-9543-y","article-title":"Devices for mitral valve repair","volume":"7","author":"Denti","year":"2014","journal-title":"J. Cardiovasc Transl. Res."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jacc.2010.10.012","article-title":"Percutaneous leaflet repair and annuloplasty for mitral regurgitation","volume":"57","author":"Feldman","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib13","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jacc.2009.03.077","article-title":"Percutaneous mitral repair with the Mitraclip system: safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge REpair Study) cohort","volume":"54","author":"Feldman","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib14","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/j.jacc.2014.01.039","article-title":"Percutaneous approaches to valve repair for mitral regurgitation","volume":"63","author":"Feldman","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib15","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1161\/CIRCULATIONAHA.115.017519","article-title":"Intracardiac visualization of transcatheter mitral valve repair in an in vitro passive beating heart","volume":"132","author":"Gelpi","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jbiomech.2016.11.013_bib16","first-page":"M405","article-title":"Mechanical properties of basal and marginal mitral valve chordae tendineae","volume":"36","author":"Kunzelman","year":"1990","journal-title":"ASAIO Trans."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib17","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1098\/rstb.2007.2123","article-title":"Fluid-structure interaction models of the mitral valve: function in normal and pathological states","volume":"362","author":"Kunzelman","year":"2007","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib18","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.jacc.2011.07.035","article-title":"Valvular heart disease. The value of 3-dimensional echocardiography","volume":"58","author":"Lang","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib19","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/j.jbiomech.2013.10.058","article-title":"An inverse modeling approach for stress estimation in mitral valve anterior leaflet valvuloplasty for in-vivo valvular biomaterial assessment","volume":"47","author":"Lee","year":"2014","journal-title":"J. Biomech."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib20","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jbiomech.2012.02.007","article-title":"In vitro hemodynamics and valve imaging in passive beating hearts","volume":"45","author":"Leopaldi","year":"2012","journal-title":"J. Biomech."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1115\/1.2834305","article-title":"A constitutive law for mitral valve tissue","volume":"120","author":"May-Newman","year":"1998","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib22","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/eurheartj\/ehm001","article-title":"What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery?","volume":"28","author":"Mirabel","year":"2007","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib23","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jbiomech.2016.11.013_bib24","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.4244\/EIJV9I12A238","article-title":"Failure of acute procedural success predicts adverse outcome after percutaneous edge-to-edge mitral valve repair with Mitraclip","volume":"9","author":"Puls","year":"2014","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jbiomech.2016.11.013_bib25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s13239-010-0032-4","article-title":"Mitral valve patient-specific finite element modeling from cardiac MRI: application to an annuloplasty procedure","volume":"2","author":"Stevanella","year":"2011","journal-title":"Cardiovasc Eng. Tech."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib26","doi-asserted-by":"crossref","first-page":"4000107","DOI":"10.1115\/1.4000107","article-title":"Mitral valve finite element modeling: implications of tissues\u05f3 nonlinear response and annular motion","volume":"131","author":"Stevanella","year":"2009","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib27","series-title":"Biomedical Technology","first-page":"117","article-title":"Repair of mitral valve prolapse through ePTFE neochordae: a finite element approach from CMR","author":"Sturla","year":"2015"},{"key":"10.1016\/j.jbiomech.2016.11.013_bib28","first-page":"1","article-title":"Functional and biomechanical effects of the edge-to-edge repair in the setting of mitral regurgitation: consolidated knowledge and novel tools to gain insight into its percutaneous implementation","author":"Sturla","year":"2014","journal-title":"Cardiovasc. Eng. Tech."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib29","first-page":"167","article-title":"Guidelines on the management of valvular heart disease (version 2012)","volume":"14","author":"Vahanian","year":"2013","journal-title":"Jt. Task. Force Manag. Valvular Heart Dis. Eur. Soc. Cardiol. (ESC) Eur. Assoc. Cardio-Thorac. Surg. (EACTS)]. G Ital. Cardiol."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib30","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.jacc.2016.06.022","article-title":"Transcatheter edge-to-edge treatment of functional tricuspid regurgitation in an ex vivo pulsatile heart model","volume":"68","author":"Vismara","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.medengphy.2016.01.007","article-title":"In vitro assessment of mitral valve function in cyclically pressurized porcine hearts","volume":"38","author":"Vismara","year":"2016","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.athoracsur.2007.03.040","article-title":"The Geoform disease-specific annuloplasty system: a finite element study","volume":"84","author":"Votta","year":"2007","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jacc.2011.08.067","article-title":"Acute and 12-month results with catheter-based mitral valve leaflet repair: the EVEREST II (Endovascular Valve Edge-to-Edge Repair) high risk study","volume":"59","author":"Whitlow","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jbiomech.2016.11.013_bib34","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/ehjci\/jet060","article-title":"Peri-interventional echo assessment for the Mitraclip procedure","volume":"14","author":"Wunderlich","year":"2013","journal-title":"Eur. Heart J. - Cardiovasc. Imaging"},{"key":"10.1016\/j.jbiomech.2016.11.013_bib35","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.actbio.2015.12.001","article-title":"A meso-scale layer-specific structural constitutive model of the mitral heart valve leaflets","volume":"32","author":"Zhang","year":"2016","journal-title":"Acta Biomater."}],"container-title":["Journal of Biomechanics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192901631171X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192901631171X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T18:30:46Z","timestamp":1531420246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192901631171X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":35,"alternative-id":["S002192901631171X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiomech.2016.11.013","relation":{},"ISSN":["0021-9290"],"issn-type":[{"value":"0021-9290","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro and in silico approaches to quantify the effects of the Mitraclip\u00ae system on mitral valve function","name":"articletitle","label":"Article Title"},{"value":"Journal of Biomechanics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiomech.2016.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}