{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T20:20:14Z","timestamp":1776111614235,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH\/NIAMS","award":["R01AR064216S2"],"award-info":[{"award-number":["R01AR064216S2"]}]},{"name":"NIH\/NIAMS","award":["P30AR050950"],"award-info":[{"award-number":["P30AR050950"]}]},{"name":"NSF GRFP"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomechanics"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.jbiomech.2017.06.008","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T07:00:15Z","timestamp":1498028415000},"page":"30-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Aging leads to inferior Achilles tendon mechanics and altered ankle function in rodents"],"prefix":"10.1016","volume":"60","author":[{"given":"A.M.","family":"Pardes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.M.","family":"Beach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Raja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.B.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.R.","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.J.","family":"Soslowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiomech.2017.06.008_b0005","doi-asserted-by":"crossref","first-page":"e0153568","DOI":"10.1371\/journal.pone.0153568","article-title":"Structural and ultrastructural characteristics of bone-tendon junction of the calcaneal tendon of adult and elderly wistar rats","volume":"11","author":"Cury","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jbiomech.2017.06.008_b0010","unstructured":"Danos, N., Holt, N.C., Sawicki, G.S., Azizi, E., 2016. Modeling age-related changes in muscle-tendon dynamics during cyclical contractions in the rat gastrocnemius. J. Appl. Physiol. (1985), jap 00396 02016."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0015","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1249\/MSS.0000000000000744","article-title":"The relationships between age and running biomechanics","volume":"48","author":"Devita","year":"2016","journal-title":"Med. Sci. Sports Exerc."},{"issue":"95","key":"10.1016\/j.jbiomech.2017.06.008_b0020","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1152\/japplphysiol.00347.2003","article-title":"Invited review: aging and sarcopenia","volume":"1985","author":"Doherty","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0025","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1474-9726.2007.00307.x","article-title":"Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity","volume":"6","author":"Dudhia","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.jbiomech.2017.06.008_b0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1249\/JES.0000000000000086","article-title":"The age-associated reduction in propulsive power generation in walking","volume":"44","author":"Franz","year":"2016","journal-title":"Exerc. Sport Sci. Rev."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0035","doi-asserted-by":"crossref","DOI":"10.1002\/jor.23253","article-title":"Nonsurgical treatment and early return to activity leads to improved Achilles tendon fatigue mechanics and functional outcomes during early healing in an animal model","author":"Freedman","year":"2016","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0040","unstructured":"Fryhofer, G.W., Freedman, B.R., Hillin, C.D., Salka, N.S., Pardes, A.M., Weiss, S.N., Farber, D.C., Soslowsky, L.J., 2016. Post-injury biomechanics of achilles tendon vary by sex and hormone status. J. Appl. Physiol. (1985), jap 00620 02016."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0045","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1177\/0363546514540599","article-title":"Acute achilles tendon ruptures: incidence of injury and surgery in Sweden between 2001 and 2012","volume":"42","author":"Huttunen","year":"2014","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0050","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1519\/JSC.0000000000000361","article-title":"Achilles tendon biomechanics in response to acute intense exercise","volume":"28","author":"Joseph","year":"2014","journal-title":"J. Strength Cond. Res."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0055","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jbiomech.2004.12.017","article-title":"Mechanical and morphological properties of human quadriceps femoris and triceps surae muscle-tendon unit in relation to aging and running","volume":"39","author":"Karamanidis","year":"2006","journal-title":"J. Biomech."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0060","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.archger.2012.04.004","article-title":"Age-associated gait patterns and the role of lower extremity strength - results from the Baltimore Longitudinal Study of Aging","volume":"55","author":"Ko","year":"2012","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0065","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1007\/s11357-013-9514-2","article-title":"Age-related changes in structure and extracellular matrix protein expression levels in rat tendons","volume":"35","author":"Kostrominova","year":"2013","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.jbiomech.2017.06.008_b0070","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1249\/01.mss.0000247006.24965.74","article-title":"Age-related differences in the properties of the plantar flexor muscles and tendons","volume":"39","author":"Kubo","year":"2007","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0075","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s004210170013","article-title":"Age related blood flow around the Achilles tendon during exercise in humans","volume":"84","author":"Langberg","year":"2001","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0080","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1111\/sms.12253","article-title":"Epidemiology of Achilles tendon ruptures: increasing incidence over a 33-year period","volume":"25","author":"Lantto","year":"2015","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"10.1016\/j.jbiomech.2017.06.008_b0085","first-page":"451","article-title":"Muscle strength and speed of movement in relation to age and muscle morphology","volume":"46","author":"Larsson","year":"1979","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0090","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/sms.12143","article-title":"The influence of physical activity during youth on structural and functional properties of the Achilles tendon","volume":"25","author":"Lenskjold","year":"2015","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"10.1016\/j.jbiomech.2017.06.008_b0095","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/17453679608994688","article-title":"Incidence of Achilles tendon rupture","volume":"67","author":"Leppilahti","year":"1996","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0100","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1177\/03635465000280040901","article-title":"Tenocytes from ruptured and tendinopathic achilles tendons produce greater quantities of type III collagen than tenocytes from normal achilles tendons. An in vitro model of human tendon healing","volume":"28","author":"Maffulli","year":"2000","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0105","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.2106\/JBJS.J.00184","article-title":"Evaluation of in vivo rotator cuff muscle function after acute and chronic detachment of the supraspinatus tendon: an experimental study in an animal model","volume":"93","author":"Mannava","year":"2011","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0110","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1159\/000368357","article-title":"Biomechanics of the ageing foot and ankle: a mini-review","volume":"61","author":"Menz","year":"2015","journal-title":"Gerontology"},{"key":"10.1016\/j.jbiomech.2017.06.008_b0115","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/gerona\/60.12.1546","article-title":"Foot and ankle characteristics associated with impaired balance and functional ability in older people","volume":"60","author":"Menz","year":"2005","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1748-1716.2006.01634.x","article-title":"Gastrocnemius muscle-tendon behaviour during walking in young and older adults","volume":"189","author":"Mian","year":"2007","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.jbiomech.2017.06.008_b0125","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1748-1716.2006.01522.x","article-title":"Metabolic cost, mechanical work, and efficiency during walking in young and older men","volume":"186","author":"Mian","year":"2006","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.jbiomech.2017.06.008_b0130","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.3402\/gha.v4i0.6347","article-title":"Increasing physical activity, but persisting social gaps among middle-aged people: trends in Northern Sweden from 1990 to 2007","volume":"4","author":"Ng","year":"2011","journal-title":"Glob. Health Action"},{"issue":"100","key":"10.1016\/j.jbiomech.2017.06.008_b0135","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1152\/japplphysiol.01442.2005","article-title":"Calf muscle-tendon properties and postural balance in old age","volume":"1985","author":"Onambele","year":"2006","journal-title":"J. Appl. Physiol."},{"issue":"10","key":"10.1016\/j.jbiomech.2017.06.008_b0140","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1007\/s10439-016-1635-1","article-title":"Males have inferior Achilles tendon material properties compared to females in a rodent model","volume":"\u200b44","author":"Pardes","year":"2016","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13075-015-0544-2","article-title":"Transcriptome analysis of ageing in uninjured human Achilles tendon","volume":"17","author":"Peffers","year":"2015","journal-title":"Arthritis. Res. Ther."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0155","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jbiomech.2012.11.007","article-title":"Normal aging alters in vivo passive biomechanical response of the rat gastrocnemius-Achilles muscle-tendon unit","volume":"46","author":"Plate","year":"2013","journal-title":"J. Biomech."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0160","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.nut.2005.04.002","article-title":"Comparing rat's to human's age: how old is my rat in people years?","volume":"21","author":"Quinn","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.jbiomech.2017.06.008_b0165","doi-asserted-by":"crossref","first-page":"021029","DOI":"10.1115\/1.4026285","article-title":"Analysis of collagen organization in mouse achilles tendon using high-frequency ultrasound imaging","volume":"136","author":"Riggin","year":"2014","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0170","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1177\/0363546516646377","article-title":"Ibuprofen differentially affects supraspinatus muscle and tendon adaptations to exercise in a rat model","volume":"44","author":"Rooney","year":"2016","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0175","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.jelekin.2008.10.008","article-title":"Differences in lower-extremity muscular activation during walking between healthy older and young adults","volume":"19","author":"Schmitz","year":"2009","journal-title":"J. Electromyogr. Kinesiol."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0180","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1088\/0967-3334\/36\/7\/1485","article-title":"Middle-aged adults exhibit altered spatial variations in Achilles tendon wave speed","volume":"36","author":"Slane","year":"2015","journal-title":"Physiol. Meas."},{"issue":"2","key":"10.1016\/j.jbiomech.2017.06.008_b0185","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s00330-016-4409-0","article-title":"Quantitative ultrasound mapping of regional variations in shear wave speeds of the aging Achilles tendon","volume":"27","author":"Slane","year":"2017","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0190","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.medengphy.2015.04.004","article-title":"Achilles tendon displacement patterns during passive stretch and eccentric loading are altered in middle-aged adults","volume":"37","author":"Slane","year":"2015","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0195","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2044-5040-4-21","article-title":"SMASH - semi-automatic muscle analysis using segmentation of histology: a MATLAB application","volume":"4","author":"Smith","year":"2014","journal-title":"Skelet Muscle"},{"key":"10.1016\/j.jbiomech.2017.06.008_b0200","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S1095-6433(02)00148-4","article-title":"The influence of ageing and exercise on tendon growth and degeneration\u2013hypotheses for the initiation and prevention of strain-induced tendinopathies","volume":"133","author":"Smith","year":"2002","journal-title":"Comp. Biochem. Physiol. A. Mol. Integr. Physiol."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0205","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.apmr.2010.09.024","article-title":"Foot and ankle strength, range of motion, posture, and deformity are associated with balance and functional ability in older adults","volume":"92","author":"Spink","year":"2011","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"113","key":"10.1016\/j.jbiomech.2017.06.008_b0210","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1152\/japplphysiol.00782.2012","article-title":"Age-related differences in Achilles tendon properties and triceps surae muscle architecture in vivo","volume":"1985","author":"Stenroth","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0215","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1177\/107110070502601106","article-title":"The incidence of Achilles tendon ruptures in Edmonton, Canada","volume":"26","author":"Suchak","year":"2005","journal-title":"Foot Ankle Int."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0220","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1007\/s00167-013-2512-1","article-title":"Compensatory muscle activation caused by tendon lengthening post-Achilles tendon rupture","volume":"23","author":"Suydam","year":"2015","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0225","unstructured":"Svensson, R.B., Heinemeier, K.M., Couppe, C., Kjaer, M., Magnusson, S.P., 2016. The effect of aging and exercise on the tendon. J. Appl. Physiol. (1985), jap 00328 02016."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0230","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1016\/j.jbiomech.2015.06.005","article-title":"Aging affects mechanical properties and lubricin\/PRG4 gene expression in normal ligaments","volume":"48","author":"Thornton","year":"2015","journal-title":"J. Biomech."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0235","doi-asserted-by":"crossref","first-page":"20455","DOI":"10.1038\/srep20455","article-title":"Anatomical heterogeneity of tendon: fascicular and interfascicular tendon compartments have distinct proteomic composition","volume":"6","author":"Thorpe","year":"2016","journal-title":"Sci. Rep."},{"issue":"111","key":"10.1016\/j.jbiomech.2017.06.008_b0240","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1152\/japplphysiol.00460.2011","article-title":"Regional stiffening with aging in tibialis anterior tendons of mice occurs independent of changes in collagen fibril morphology","volume":"1985","author":"Wood","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0245","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2474-14-2","article-title":"Aging is associated with increased activities of matrix metalloproteinase-2 and -9 in tenocytes","volume":"14","author":"Yu","year":"2013","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.jbiomech.2017.06.008_b0250","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/gerona\/glv307","article-title":"Rapamycin attenuates age-associated changes in tibialis anterior tendon viscoelastic properties","volume":"71","author":"Zaseck","year":"2016","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."}],"container-title":["Journal of Biomechanics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929017303056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929017303056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T18:02:45Z","timestamp":1574964165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021929017303056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":49,"alternative-id":["S0021929017303056"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiomech.2017.06.008","relation":{},"ISSN":["0021-9290"],"issn-type":[{"value":"0021-9290","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging leads to inferior Achilles tendon mechanics and altered ankle function in rodents","name":"articletitle","label":"Article Title"},{"value":"Journal of Biomechanics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiomech.2017.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}