{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:32:22Z","timestamp":1786991542539,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370438"],"award-info":[{"award-number":["81370438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SJTU Medical-Engineering Cross-cutting Research Project","award":["YG2016MS09"],"award-info":[{"award-number":["YG2016MS09"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomechanics"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.jbiomech.2017.09.023","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T22:01:32Z","timestamp":1507759292000},"page":"23-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["A computational model of the hepatic circulation applied to analyze the sensitivity of hepatic venous pressure gradient (HVPG) in liver cirrhosis"],"prefix":"10.1016","volume":"65","author":[{"given":"Tianqi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyou","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunqiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiomech.2017.09.023_b0005","series-title":"Anatomy and Physiology of the Hepatic Circulation","first-page":"3607","author":"Abshagen","year":"2015"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0010","first-page":"317","article-title":"Lumped parameter outflow models for 1-D blood flow simulations: effect on pulse waves and parameter estimation","volume":"4","author":"Alastruey","year":"2008","journal-title":"Commun. Comput. Phys."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0015","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jbiomech.2016.11.037","article-title":"Partial hepatectomy hemodynamics changes: experimental data explained by closed-loop lumped modeling","volume":"50","author":"Audebert","year":"2017","journal-title":"J. Biomech."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cma.2016.07.009","article-title":"Kinetic scheme for arterial and venous blood flow, and application to partial hepatectomy modeling","volume":"314","author":"Audebert","year":"2017","journal-title":"Comput. Meth. Appl. Mech. Eng."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1586\/egh.12.83","article-title":"Assessing portal hypertension in liver diseases","volume":"7","author":"Berzigotti","year":"2013","journal-title":"Exp. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF01656368","article-title":"Surgical anatomy and anatomical surgery of the liver","volume":"6","author":"Bismuth","year":"1982","journal-title":"World J. Surg."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0035","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrgastro.2009.149","article-title":"The clinical use of HVPG measurements in chronic liver disease","volume":"6","author":"Bosch","year":"2009","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0040","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1115\/1.2891375","article-title":"A lumped parameter mathematical model of the splanchnic circulation","volume":"114","author":"Chu","year":"1992","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0045","series-title":"Multi-Level Modelling of Hepatic Perfusion in Support of Liver Transplantation Strategies","author":"Debbaut","year":"2013"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1109\/TBME.2010.2065229","article-title":"From vascular corrosion cast to electrical analog model for the study of human liver hemodynamics and perfusion","volume":"58","author":"Debbaut","year":"2011","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0055","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/A:1026622721389","article-title":"Portohepatic gradient and portal hemodynamics in patients with cirrhosis due to hepatitis C virus infection","volume":"44","author":"Deplano","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0060","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.3748\/wjg.v16.i48.6046","article-title":"Regulation of hepatic blood flow: the hepatic arterial buffer response revisited","volume":"16","author":"Eipel","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0065","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJMra1504367","article-title":"Treatment of patients with cirrhosis","volume":"375","author":"Ge","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0070","first-page":"177","article-title":"The pathophysiology of portal hypertension","volume":"2","author":"Groszmann","year":"1982","journal-title":"Gastroenterol. Clin. North Am."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0075","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/hep.20062","article-title":"The hepatic venous pressure gradient: anything worth doing should be done right","volume":"39","author":"Groszmann","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3109\/08037051.2011.585808","article-title":"Systolic and diastolic blood pressure, mean arterial pressure and pulse pressure for prediction of cardiovascular events and mortality in a Middle Eastern population","volume":"21","author":"Hadaegh","year":"2012","journal-title":"Blood Press."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0085","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1109\/TMI.2012.2219882","article-title":"Hemodynamic analysis for transjugular intrahepatic portosystemic shunt (TIPS) in the liver based on a CT-image","volume":"32","author":"Ho","year":"2013","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0090","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.gie.2016.09.026","article-title":"EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study","volume":"85","author":"Huang","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0095","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s002610000014","article-title":"Portosystemic collaterals of the upper abdomen: review of anatomy and demonstration on MR imaging","volume":"25","author":"Kim","year":"2000","journal-title":"Abdom. Imag."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0100","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1161\/01.CIR.96.12.4415","article-title":"Regulation of hepatic vascular volume","volume":"96","author":"Kjekshus","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0105","first-page":"74","article-title":"Hepatic venous pressure gradient measurement: time to learn!","volume":"27","author":"Kumar","year":"2008","journal-title":"Ind. J. Gastroenterol. Off. J. Ind. Soc. Gastroenterol."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0110","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1148\/radiology.181.2.1924786","article-title":"Segmental anatomy of the liver: a sonographic approach to the Couinaud nomenclature","volume":"181","author":"Lafortune","year":"1991","journal-title":"Radiology"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0115","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0950-3528(97)90037-3","article-title":"Evaluation of patients with portal hypertension","volume":"11","author":"Lebrec","year":"1997","journal-title":"Bailli\u00e8res Clin. Gastroenterol."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2170\/physiolsci.RP001305","article-title":"Simulation of hemodynamic responses to the Valsalva maneuver: an integrative computational model of the cardiovascular system and the autonomic nervous system","volume":"56","author":"Liang","year":"2006","journal-title":"J. Physiol. Sci. JPS"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0125","doi-asserted-by":"crossref","first-page":"101011","DOI":"10.1115\/1.4031457","article-title":"Numerical study of cerebroarterial hemodynamic changes following carotid artery operation: a comparison between multiscale modeling and stand-alone three-dimensional modeling","volume":"137","author":"Liang","year":"2015","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0130","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s11517-009-0449-9","article-title":"Multi-scale modeling of the human cardiovascular system with applications to aortic valvular and arterial stenoses","volume":"47","author":"Liang","year":"2009","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0135","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jbiomech.2009.01.010","article-title":"Biomechanical characterization of ventricular-arterial coupling during aging: a multi-scale model study","volume":"42","author":"Liang","year":"2009","journal-title":"J. Biomech."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0140","article-title":"Anatomy of the liver","author":"Mahadevan","year":"2014","journal-title":"Surgery"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0145","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/apt.13571","article-title":"Differential visceral blood flow in the hyperdynamic circulation of patients with liver cirrhosis","volume":"43","author":"Mcavoy","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0150","first-page":"762","article-title":"Hepatic venous pressure gradient measurement in clinical hepatology","volume":"43","author":"Merkel","year":"2011","journal-title":"Digest. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0155","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/hpb.12157","article-title":"Three-dimensional volumetry in 107 normal livers reveals clinically relevant inter-segment variation in size","volume":"16","author":"Mise","year":"2014","journal-title":"HPB: Off. J. Int. Hepato Pancreato Biliary Assoc."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0160","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1172\/JCI105545","article-title":"Portal blood flow in cirrhosis of the liver","volume":"46","author":"Moreno","year":"1967","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0165","series-title":"Computer Modelling and Wave Intensity Analysis of Perinatal Cardiovascular Function and Dysfunction","author":"Mynard","year":"2011"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0170","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s10439-015-1313-8","article-title":"One-dimensional haemodynamic modeling and wave dynamics in the entire adult circulation","volume":"43","author":"Mynard","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0175","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.3934\/mbe.2004.1.61","article-title":"On deriving lumped models for blood flow and pressure in the systemic arteries","volume":"1","author":"Olufsen","year":"2004","journal-title":"Math. Biosci. Eng."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0180","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/0016-5085(81)90018-4","article-title":"Correlation of the intrahepatic pressure with collagen in the Disse space and hepatomegaly in humans and rats","volume":"80","author":"Orrego","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0185","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/hep.510300628","article-title":"Wedged hepatic venous pressure adequately reflects portal pressure in hepatitis C virus-related cirrhosis","volume":"30","author":"Perello","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0190","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/hep.1840050312","article-title":"Presinusoidal portal hypertension in non-alcoholic cirrhosis","volume":"5","author":"Pomier-Layrargues","year":"1985","journal-title":"Hepatology"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0195","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1365-2559.2003.01464.x","article-title":"Histopathology of portal hypertension: a practical guideline","volume":"42","author":"Roskams","year":"2003","journal-title":"Histopathology"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0200","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/0022-4804(87)90169-7","article-title":"Computer analysis of portal hemodynamics after small-diameter portacaval H-grafts: the theoretical basis for partial shunting","volume":"42","author":"Rypins","year":"1987","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0205","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1053\/j.gastro.2008.03.007","article-title":"Portal hypertension and its complications","volume":"134","author":"Sanyal","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0210","first-page":"546","article-title":"Sildenafil has no effect on portal pressure but lowers arterial pressure in patients with compensated cirrhosis","volume":"8","author":"Tandon","year":"2010","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"10.1016\/j.jbiomech.2017.09.023_b0215","first-page":"601","article-title":"Assessment of the agreement between wedge hepatic vein pressure and portal vein pressure in cirrhotic patients","volume":"37","author":"Thalheimer","year":"2005","journal-title":"Digest. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0220","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/gut.31.3.339","article-title":"Portal hypertension in chronic hepatitis: relationship to morphological changes","volume":"31","author":"van Leeuwen","year":"1990","journal-title":"Gut"},{"key":"10.1016\/j.jbiomech.2017.09.023_b0225","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1053\/bega.2000.0136","article-title":"Diagnosing portal hypertension","volume":"14","author":"Wongcharatrawee","year":"2000","journal-title":"Bailli\u00e8res Best Pract. Res. Clin. Gastroenterol."}],"container-title":["Journal of Biomechanics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929017304967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021929017304967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T18:05:16Z","timestamp":1574964316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021929017304967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":45,"alternative-id":["S0021929017304967"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiomech.2017.09.023","relation":{},"ISSN":["0021-9290"],"issn-type":[{"value":"0021-9290","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A computational model of the hepatic circulation applied to analyze the sensitivity of hepatic venous pressure gradient (HVPG) in liver cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Biomechanics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiomech.2017.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}