{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:09:04Z","timestamp":1790406544005,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1-GM20501-40"],"award-info":[{"award-number":["RO1-GM20501-40"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Biological Regulation"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jbior.2015.11.011","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T10:00:49Z","timestamp":1450519249000},"page":"17-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Membrane and inhibitor interactions of intracellular phospholipases A2"],"prefix":"10.1016","volume":"61","author":[{"given":"Varnavas D.","family":"Mouchlis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbior.2015.11.011_bib1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.4049\/jimmunol.0901219","article-title":"Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils","volume":"184","author":"Ayilavarapu","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbior.2015.11.011_bib2","doi-asserted-by":"crossref","first-page":"29317","DOI":"10.1074\/jbc.272.46.29317","article-title":"Antisense inhibition of group VI Ca2+-independent phospholipase A2 blocks phospholipid fatty acid remodeling in murine P388D1 macrophages","volume":"272","author":"Balsinde","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib3","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.4049\/jimmunol.164.10.5398","article-title":"Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels","volume":"164","author":"Balsinde","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbior.2015.11.011_bib4","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.1021\/jm800649q","article-title":"Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes","volume":"51","author":"Baskakis","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib5","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1126\/science.1071702","article-title":"Biomedicine. Back to an aspirin a day?","volume":"296","author":"Vane","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jbior.2015.11.011_bib6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2337\/db14-0097","article-title":"Inhibition of Ca2+-independent phospholipase A2\u03b2 (iPLA2\u03b2) ameliorates islet infiltration and incidence of diabetes in NOD mice","volume":"64","author":"Bone","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.jbior.2015.11.011_bib7","doi-asserted-by":"crossref","first-page":"e1003156","DOI":"10.1371\/journal.pcbi.1003156","article-title":"Insertion of the Ca2+-independent phospholipase A2 into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulations","volume":"9","author":"Bucher","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jbior.2015.11.011_bib8","doi-asserted-by":"crossref","first-page":"22834","DOI":"10.1074\/jbc.M701831200","article-title":"TLR-4 and sustained calcium agonists synergistically produce eicosanoids independent of protein synthesis in RAW264. 7 cells","volume":"282","author":"Buczynski","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib9","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1194\/jlr.R900004-JLR200","article-title":"Thematic review Series: proteomics. An integrated omics analysis of eicosanoid biology","volume":"50","author":"Buczynski","year":"2009","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jbior.2015.11.011_bib10","doi-asserted-by":"crossref","first-page":"31227","DOI":"10.1074\/jbc.M804492200","article-title":"A\u00a0phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2","volume":"283","author":"Burke","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib11","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1021\/ja900098y","article-title":"Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry","volume":"131","author":"Burke","year":"2009","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.jbior.2015.11.011_bib12","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1074\/jbc.R112.421909","article-title":"Using hydrogen\/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes","volume":"288","author":"Cao","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib13","doi-asserted-by":"crossref","first-page":"18711","DOI":"10.1074\/jbc.270.32.18711","article-title":"Lipid signaling enzymes and surface dilution kinetics","volume":"270","author":"Carman","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib14","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1242\/jcs.02637","article-title":"Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling","volume":"118","author":"Chalfant","year":"2005","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.jbior.2015.11.011_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pharmtox.010909.105741","article-title":"Allosteric receptors: from electric organ to cognition","volume":"50","author":"Changeux","year":"2009","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jbior.2015.11.011_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-biophys-050511-102222","article-title":"Allostery and the Monod-Wyman-Changeux model after 50 years","volume":"41","author":"Changeux","year":"2012","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.jbior.2015.11.011_bib17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0092-8674(91)90556-E","article-title":"A\u00a0novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP","volume":"65","author":"Clark","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2015.11.011_bib18","doi-asserted-by":"crossref","first-page":"23838","DOI":"10.1074\/jbc.M202322200","article-title":"Roles of catalytic domain residues in interfacial binding and activation of group IV cytosolic phospholipase A2","volume":"277","author":"Das","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib19","doi-asserted-by":"crossref","first-page":"9013","DOI":"10.1016\/S0021-9258(19)40687-X","article-title":"Kinetic analysis of phospholipase A2 activity toward mixed micelles and its implications for the study of lipolytic enzymes","volume":"250","author":"Deems","year":"1975","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nri3859","article-title":"Eicosanoid storm in infection and inflammation","volume":"15","author":"Dennis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2015.11.011_bib21","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.1021\/cr200085w","article-title":"Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention","volume":"111","author":"Dennis","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jbior.2015.11.011_bib22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0092-8674(00)80744-8","article-title":"Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism","volume":"97","author":"Dessen","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2015.11.011_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1741-7007-9-71","article-title":"Molecular dynamics simulations and drug discovery","volume":"9","author":"Durrant","year":"2011","journal-title":"BMC Biol."},{"key":"10.1016\/j.jbior.2015.11.011_bib24","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","article-title":"Prostaglandins and leukotrienes: advances in eicosanoid biology","volume":"294","author":"Funk","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jbior.2015.11.011_bib25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.plipres.2006.05.003","article-title":"Properties of the group IV phospholipase A2 family","volume":"45","author":"Ghosh","year":"2006","journal-title":"Prog. Lipid Res."},{"issue":"Pt 3","key":"10.1016\/j.jbior.2015.11.011_bib26","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1042\/bj2800581","article-title":"Human myocardial cytosolic Ca2+-independent phospholipase A2 is modulated by ATP. Concordant ATP-induced alterations in enzyme kinetics and mechanism-based inhibition","volume":"280","author":"Hazen","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbior.2015.11.011_bib27","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1084\/jem.20030016","article-title":"Cytosolic phospholipase A2\u03b1-deficient mice are resistant to collagen-induced arthritis","volume":"197","author":"Hegen","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jbior.2015.11.011_bib28","doi-asserted-by":"crossref","first-page":"9820","DOI":"10.1074\/jbc.M708143200","article-title":"Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen\/deuterium exchange mass spectrometry","volume":"283","author":"Hsu","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib29","doi-asserted-by":"crossref","first-page":"23652","DOI":"10.1074\/jbc.M109.021857","article-title":"Localizing the membrane binding region of group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen\/deuterium exchange mass spectrometry","volume":"284","author":"Hsu","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib30","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1021\/ja306490g","article-title":"Fluoroketone inhibition of Ca2+-independent phospholipase A2 through binding pocket association defined by Hydrogen\/Deuterium exchange and molecular dynamics","volume":"135","author":"Hsu","year":"2013","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.jbior.2015.11.011_bib31","doi-asserted-by":"crossref","first-page":"15615","DOI":"10.1074\/jbc.M511623200","article-title":"Highly selective hydrolysis of fatty acyl-CoAs by calcium-independent phospholipase A2beta. Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity","volume":"281","author":"Jenkins","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib32","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.biochi.2010.02.002","article-title":"Extracellular phospholipases in atherosclerosis","volume":"92","author":"Karabina","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.jbior.2015.11.011_bib33","doi-asserted-by":"crossref","first-page":"H153","DOI":"10.1152\/ajpheart.01057.2009","article-title":"Resolvin E1 protects the rat heart against reperfusion injury","volume":"299","author":"Keyes","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jbior.2015.11.011_bib34","doi-asserted-by":"crossref","first-page":"28912893","DOI":"10.1021\/jm025538p","article-title":"Novel 2-Oxoamide inhibitors of human group IVA phospholipase A2","volume":"45","author":"Kokotos","year":"2002","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib35","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1021\/jm901872v","article-title":"Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2","volume":"53","author":"Kokotos","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib36","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1016\/S0021-9258(19)67782-3","article-title":"The Ca2+-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells","volume":"266","author":"Kramer","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1074\/jbc.273.1.207","article-title":"Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity","volume":"273","author":"Larsson","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib38","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1046\/j.1432-1327.1999.00418.x","article-title":"The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene","volume":"262","author":"Larsson Forsell","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jbior.2015.11.011_bib39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0005-2760(90)90129-L","article-title":"Anionic phospholipids stimulate an arachidonoyl-hydrolyzing phospholipase A2 from macrophages and reduce the calcium requirement for activity","volume":"1045","author":"Leslie","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbior.2015.11.011_bib40","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0005-2760(98)00049-6","article-title":"Interfacial activation, lysophospholipase and transacylase activity of group VI Ca2+-independent phospholipase A2","volume":"1392","author":"Lio","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbior.2015.11.011_bib41","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1529\/biophysj.105.061515","article-title":"X-ray reflectivity studies of cPLA2\u03b1-C2 domains adsorbed onto langmuir monolayers of SOPC","volume":"89","author":"M\u00e1lkov\u00e1","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbior.2015.11.011_bib42","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1742-4658.2004.04489.x","article-title":"Various secretory phospholipase A2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells","volume":"272","author":"Masuda","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.jbior.2015.11.011_bib43","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1093\/emboj\/cdf651","article-title":"Crystal structure of a 12 ANK repeat stack from human ankyrinR","volume":"21","author":"Michaely","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.jbior.2015.11.011_bib44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-2836(65)80285-6","article-title":"On the nature of allosteric transitions: a plausible model","volume":"12","author":"Monod","year":"1965","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.jbior.2015.11.011_bib45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10822-010-9319-7","article-title":"Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor","volume":"24","author":"Mouchlis","year":"2010","journal-title":"J.\u00a0Comput-Aided Mol. Des."},{"key":"10.1016\/j.jbior.2015.11.011_bib46","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1021\/ci100217k","article-title":"Molecular docking and 3D-QSAR CoMFA studies on indole inhibitors of GIIA secreted phospholipase A2","volume":"50","author":"Mouchlis","year":"2010","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.jbior.2015.11.011_bib47","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.2174\/092986711795933678","article-title":"The application of rational design on phospholipase A2 inhibitors","volume":"18","author":"Mouchlis","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib48","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.bmc.2010.12.030","article-title":"Inhibition of secreted phospholipases A2 by 2-oxoamides based on alpha-amino acids: synthesis, in\u00a0vitro evaluation and molecular docking calculations","volume":"19","author":"Mouchlis","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1021\/ci2005093","article-title":"Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics","volume":"52","author":"Mouchlis","year":"2012","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.jbior.2015.11.011_bib50","doi-asserted-by":"crossref","first-page":"E516","DOI":"10.1073\/pnas.1424651112","article-title":"Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates","volume":"112","author":"Mouchlis","year":"2015","journal-title":"PNAS"},{"key":"10.1016\/j.jbior.2015.11.011_bib51","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.bbalip.2006.09.005","article-title":"Roles of cPLA2\u03b1 and arachidonic acid in cancer","volume":"1761","author":"Nakanishi","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbior.2015.11.011_bib52","doi-asserted-by":"crossref","first-page":"8517","DOI":"10.1073\/pnas.1200189109","article-title":"Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling","volume":"109","author":"Norris","year":"2012","journal-title":"PNAS"},{"key":"10.1016\/j.jbior.2015.11.011_bib53","doi-asserted-by":"crossref","first-page":"12746","DOI":"10.1073\/pnas.1404372111","article-title":"Phospholipase A2 regulates eicosanoid class switching during inflammasome activation","volume":"111","author":"Norris","year":"2014","journal-title":"PNAS"},{"key":"10.1016\/j.jbior.2015.11.011_bib54","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/nrc3379","article-title":"Phospholipase signalling networks in cancer","volume":"12","author":"Park","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbior.2015.11.011_bib55","doi-asserted-by":"crossref","first-page":"14979","DOI":"10.1074\/jbc.274.21.14979","article-title":"Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2","volume":"274","author":"Perisic","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib56","doi-asserted-by":"crossref","first-page":"11320","DOI":"10.1074\/jbc.M309262200","article-title":"Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2","volume":"279","author":"Pettus","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib57","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1093\/eurheartj\/ehs148","article-title":"Phospholipase A2 enzymes and the risk of atherosclerosis","volume":"33","author":"Rosenson","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jbior.2015.11.011_bib58","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1476-5381.2010.00930.x","article-title":"The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages","volume":"161","author":"Rossi","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jbior.2015.11.011_bib59","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1021\/bi027156r","article-title":"The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad","volume":"42","author":"Rydel","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbior.2015.11.011_bib60","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.biochi.2010.03.019","article-title":"Emerging roles for phospholipase A2 enzymes in cancer","volume":"92","author":"Scott","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.jbior.2015.11.011_bib61","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0960-894X(01)00003-8","article-title":"Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'","volume":"11","author":"Seno","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jbior.2015.11.011_bib62","doi-asserted-by":"crossref","first-page":"14850","DOI":"10.1016\/S0021-9258(18)98550-9","article-title":"Molecular cloning and expression of human Ca2+-sensitive cytosolic phospholipase A2","volume":"266","author":"Sharp","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib63","doi-asserted-by":"crossref","first-page":"23842","DOI":"10.1074\/jbc.M301386200","article-title":"Essential Ca2+-independent role of the group IVA cytosolic phospholipase A2 C2 Domain for interfacial activity","volume":"278","author":"Six","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbior.2015.11.011_bib64","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1124\/pr.112.007336","article-title":"Computational methods in drug discovery","volume":"66","author":"Sliwoski","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jbior.2015.11.011_bib65","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1388-1981(00)00107-4","article-title":"Calcium-independent phospholipase A2: structure and function","volume":"1488","author":"Winstead","year":"2000","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Advances in Biological Regulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212492615300415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212492615300415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:21:54Z","timestamp":1761949314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212492615300415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":65,"alternative-id":["S2212492615300415"],"URL":"https:\/\/doi.org\/10.1016\/j.jbior.2015.11.011","relation":{},"ISSN":["2212-4926"],"issn-type":[{"value":"2212-4926","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Membrane and inhibitor interactions of intracellular phospholipases A2","name":"articletitle","label":"Article Title"},{"value":"Advances in Biological Regulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbior.2015.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}