{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:31:55Z","timestamp":1787495515832,"version":"build-2736575974"},"reference-count":280,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008487","name":"Sosiaali- ja Terveysministeri\u00c3\u00b6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008487","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016375","name":"Ministerium f\u00fcr Soziales und Integration Baden-W\u00fcrttemberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Biological Regulation"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jbior.2020.100741","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T02:24:52Z","timestamp":1593829492000},"page":"100741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":195,"special_numbering":"C","title":["Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression"],"prefix":"10.1016","volume":"77","author":[{"given":"G\u00fcnther","family":"Sch\u00f6nrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Raftery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-2456","authenticated-orcid":false,"given":"Yvonne","family":"Samstag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbior.2020.100741_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41590-019-0571-2","article-title":"Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation","volume":"21","author":"Adrover","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib2","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1161\/CIRCRESAHA.120.317055","article-title":"COVID-19 and the heart","volume":"126","author":"Akhmerov","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib3","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41591-020-0820-9","article-title":"The proximal origin of SARS-CoV-2","volume":"26","author":"Andersen","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib4","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3389\/fimmu.2017.01232","article-title":"Interferon-lambdas: front-line guardians of immunity and homeostasis in the respiratory tract","volume":"8","author":"Andreakos","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib5","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1042\/BST20180169","article-title":"Vitamin C and immune cell function in inflammation and cancer","volume":"46","author":"Ang","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jbior.2020.100741_bib6","doi-asserted-by":"crossref","first-page":"9465","DOI":"10.1128\/JVI.00489-08","article-title":"Genomic analysis reveals age-dependent innate immune responses to severe acute respiratory syndrome coronavirus","volume":"82","author":"Baas","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jbior.2020.100741_bib7","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1038\/s41467-019-11909-z","article-title":"Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells","volume":"10","author":"Balta","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbior.2020.100741_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-020-2312-y","article-title":"The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice","author":"Bao","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2020.100741_bib9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.chom.2014.04.011","article-title":"The balancing act of neutrophils","volume":"15","author":"Bardoel","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbior.2020.100741_bib10","doi-asserted-by":"crossref","first-page":"e20200652","DOI":"10.1084\/jem.20200652","article-title":"Targeting potential drivers of COVID-19: neutrophil extracellular traps","volume":"217","author":"Barnes","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/ALN.0000000000002619","article-title":"Neutrophil extracellular traps are elevated in patients with pneumonia-related acute respiratory distress syndrome","volume":"130","author":"Bendib","year":"2019","journal-title":"Anesthesiology: The Journal of the American Society of Anesthesiologists"},{"key":"10.1016\/j.jbior.2020.100741_bib12","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced host response to SARS-CoV-2 drives development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2020.100741_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","article-title":"TNF and ROS crosstalk in inflammation","volume":"26","author":"Blaser","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jbior.2020.100741_bib14","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.15.1.749","article-title":"Cellular responses to interferon-gamma","volume":"15","author":"Boehm","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib15","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41418-018-0261-x","article-title":"To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps","volume":"26","author":"Boeltz","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jbior.2020.100741_bib16","doi-asserted-by":"crossref","DOI":"10.1001\/jamacardio.2020.1105","article-title":"Association of coronavirus disease 2019 (COVID-19) with myocardial injury and mortality","author":"Bonow","year":"2020","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.jbior.2020.100741_bib17","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/ATVBAHA.113.301627","article-title":"Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state","volume":"33","author":"Borissoff","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jbior.2020.100741_bib18","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3390\/nu11061363","article-title":"The role of physiological vitamin C concentrations on key functions of neutrophils isolated from healthy individuals","volume":"11","author":"Bozonet","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jbior.2020.100741_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1538-7836.2011.04544.x","article-title":"Neutrophil extracellular traps promote deep vein thrombosis in mice","volume":"10","author":"Brill","year":"2012","journal-title":"J. Thromb. Haemostas."},{"key":"10.1016\/j.jbior.2020.100741_bib20","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jbior.2020.100741_bib21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/intimm\/dxr048","article-title":"Corticosteroids shift the Toll-like receptor response pattern of primary-isolated murine liver cells from an inflammatory to an anti-inflammatory state","volume":"23","author":"Broering","year":"2011","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc3545","article-title":"Type III interferons disrupt the lung epithelial barrier upon viral recognition","author":"Broggi","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jbior.2020.100741_bib23","first-page":"137802","article-title":"Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system","author":"Cantuti-Castelvetri","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13054-020-02851-4","article-title":"A new clinical trial to test high-dose vitamin C in patients with COVID-19","volume":"24","author":"Carr","year":"2020","journal-title":"Crit. Care"},{"key":"10.1016\/j.jbior.2020.100741_bib25","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3390\/nu9111211","article-title":"Vitamin C and immune function","volume":"9","author":"Carr","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jbior.2020.100741_bib26","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1084\/jem.20181468","article-title":"Neutrophils instruct homeostatic and pathological states in naive tissues","volume":"215","author":"Casanova-Acebes","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib27","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1172\/JCI61303","article-title":"Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury","volume":"122","author":"Caudrillier","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbior.2020.100741_bib28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chom.2016.01.007","article-title":"Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice","volume":"19","author":"Channappanavar","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbior.2020.100741_bib29","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1172\/JCI126363","article-title":"IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes","volume":"130","author":"Channappanavar","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbior.2020.100741_bib30","series-title":"Oxidative Stress and Biomaterials","first-page":"35","article-title":"Chapter two - oxidative stress, inflammation, and disease","author":"Chatterjee","year":"2016"},{"key":"10.1016\/j.jbior.2020.100741_bib35","series-title":"The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Directly Decimates Human Spleens and Lymph Nodes","author":"Chen","year":"2020"},{"key":"10.1016\/j.jbior.2020.100741_bib32","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fmicb.2019.00050","article-title":"Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jbior.2020.100741_bib31","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1172\/JCI137244","article-title":"Clinical and immunological features of severe and moderate coronavirus disease 2019","volume":"130","author":"Chen","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbior.2020.100741_bib34","article-title":"Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients","author":"Chen","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib33","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jbior.2020.100741_bib36","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0140-6736(04)16255-7","article-title":"Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome","volume":"363","author":"Cheng","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jbior.2020.100741_bib37","doi-asserted-by":"crossref","first-page":"7819","DOI":"10.1128\/JVI.79.12.7819-7826.2005","article-title":"Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis","volume":"79","author":"Cheung","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.jbior.2020.100741_bib38","article-title":"Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases","author":"Chirivi","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib39","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/s10753-017-0542-4","article-title":"Quercetin and ascorbic acid suppress fructose-induced NLRP3 inflammasome activation by blocking intracellular shuttling of TXNIP in human macrophage cell lines","volume":"40","author":"Choe","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.jbior.2020.100741_bib40","article-title":"Usefulness of cellular analysis of bronchoalveolar lavage fluid for predicting the etiology of pneumonia in critically ill patients","volume":"9","author":"Choi","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jbior.2020.100741_bib41","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1146\/annurev-immunol-042617-053309","article-title":"RIG-I and other RNA sensors in antiviral immunity","volume":"36","author":"Chow","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib42","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciaa410","article-title":"Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19","author":"Chu","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib43","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/infdis\/jiv380","article-title":"Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways","volume":"213","author":"Chu","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib44","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.17683","article-title":"Suppression of LPS-induced inflammatory responses by the hydroxyl groups of dexamethasone","volume":"8","author":"Chuang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbior.2020.100741_bib45","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1089\/ars.2006.8.572","article-title":"The molecular inflammatory process in aging","volume":"8","author":"Chung","year":"2006","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jbior.2020.100741_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(20)30264-3","article-title":"Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study","author":"Clark","year":"2020","journal-title":"The Lancet Global Health"},{"key":"10.1016\/j.jbior.2020.100741_bib47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib48","series-title":"Advances in Virus Research","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/bs.aivir.2018.01.001","article-title":"Chapter eight - hosts and sources of endemic human coronaviruses","author":"Corman","year":"2018"},{"key":"10.1016\/j.jbior.2020.100741_bib49","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2","volume":"5","year":"2020","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jbior.2020.100741_bib50","doi-asserted-by":"crossref","first-page":"104742","DOI":"10.1016\/j.antiviral.2020.104742","article-title":"The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade","volume":"176","author":"Coutard","year":"2020","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib51","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/eji.201747044","article-title":"Glucocorticoids downregulate TLR4 signaling activity via its direct targeting by miR-511-5p","volume":"47","author":"Curtale","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib52","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1172\/JCI36498","article-title":"CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury","volume":"119","author":"D'alessio","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbior.2020.100741_bib53","article-title":"Neuropilin-1 is a host factor for SARS-CoV-2 infection","author":"Daly","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib54","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1172\/JCI108517","article-title":"Neutrophil kinetics in man","volume":"58","author":"Dancey","year":"1976","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbior.2020.100741_bib55","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1183\/09031936.97.10071535","article-title":"Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment","volume":"10","author":"De Flora","year":"1997","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jbior.2020.100741_bib56","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1128\/JVI.02576-13","article-title":"Inhibition of NF-kappaB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival","volume":"88","author":"Dediego","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.jbior.2020.100741_bib57","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1084\/jem.20130056","article-title":"Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow","volume":"210","author":"Devi","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib58","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fimmu.2020.00827","article-title":"Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19)","volume":"11","author":"Diao","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib59","article-title":"A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures","author":"Dinnon","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib60","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An interactive web-based dashboard to track COVID-19 in real time","volume":"20","author":"Dong","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib61","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1161\/CIRCRESAHA.120.315931","article-title":"Neutrophil extracellular traps participate in cardiovascular diseases: recent experimental and clinical insights","volume":"126","author":"Doring","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virusres.2009.01.005","article-title":"SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-\u03baB pathway in human monocyte macrophages in vitro","volume":"142","author":"Dosch","year":"2009","journal-title":"Virus Res."},{"key":"10.1016\/j.jbior.2020.100741_bib63","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1056\/NEJMoa030747","article-title":"Identification of a novel coronavirus in patients with severe acute respiratory syndrome","volume":"348","author":"Drosten","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib64","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib65","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s10753-019-01020-2","article-title":"The protection potential of antioxidant vitamins against acute respiratory distress syndrome: a rat trial","volume":"42","author":"Erol","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.jbior.2020.100741_bib66","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1182\/blood-2015-01-624023","article-title":"P-selectin promotes neutrophil extracellular trap formation in mice","volume":"126","author":"Etulain","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jbior.2020.100741_bib67","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.2020040432","article-title":"Ultrastructural evidence for direct renal infection with SARS-CoV-2","author":"Farkash","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jbior.2020.100741_bib68","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0140-6736(20)30858-8","article-title":"Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed","volume":"395","author":"Feldmann","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jbior.2020.100741_bib69","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/CIRCULATIONAHA.104.510461","article-title":"Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2","volume":"111","author":"Ferrario","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jbior.2020.100741_bib70","doi-asserted-by":"crossref","first-page":"L20","DOI":"10.1152\/ajplung.00300.2011","article-title":"Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid","volume":"303","author":"Fisher","year":"2012","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.jbior.2020.100741_bib71","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1097\/CCM.0b013e3182120cb8","article-title":"Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury*","volume":"39","author":"Fisher","year":"2011","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jbior.2020.100741_bib72","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/jama.2019.11825","article-title":"Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial","volume":"322","author":"Fowler","year":"2019","journal-title":"Jama"},{"key":"10.1016\/j.jbior.2020.100741_bib73","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1479-5876-12-32","article-title":"Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis","volume":"12","author":"Fowler","year":"2014","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib74","series-title":"Pulmonary and Cardiac Pathology in Covid-19: the First Autopsy Series from New Orleans","author":"Fox","year":"2020"},{"key":"10.1016\/j.jbior.2020.100741_bib75","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/MMBR.00015-08","article-title":"Mechanisms of severe acute respiratory syndrome pathogenesis and innate immunomodulation","volume":"72","author":"Frieman","year":"2008","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.jbior.2020.100741_bib76","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"Fuchs","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbior.2020.100741_bib77","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1073\/pnas.1005743107","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","author":"Fuchs","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbior.2020.100741_bib78","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1146\/annurev-micro-020518-115759","article-title":"Human coronavirus: host-pathogen interaction","volume":"73","author":"Fung","year":"2019","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jbior.2020.100741_bib79","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.smim.2016.10.010","article-title":"Blood coagulation in immunothrombosis\u2014at the frontline of intravascular immunity","volume":"28","author":"Gaertner","year":"2016","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib80","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1038\/s41598-020-61253-2","article-title":"Plasma neutrophil extracellular trap level is modified by disease severity and inhaled corticosteroids in chronic inflammatory lung diseases","volume":"10","author":"G\u00e1l","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbior.2020.100741_bib81","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.immuni.2017.04.025","article-title":"Interferon-lambda mediates non-redundant front-line antiviral protection against influenza virus infection without compromising host fitness","volume":"46","author":"Galani","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.jbior.2020.100741_bib82","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1056\/NEJMe2009758","article-title":"Asymptomatic transmission, the Achilles\u2019 heel of current strategies to control covid-19","volume":"382","author":"Gandhi","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib83","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.thromres.2020.03.023","article-title":"The significance of disseminated intravascular coagulation on multiple organ dysfunction during the early stage of acute respiratory distress syndrome","volume":"191","author":"Gando","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib84","doi-asserted-by":"crossref","first-page":"458","DOI":"10.15585\/mmwr.mm6915e3","article-title":"Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019 - COVID-NET, 14 states, march 1-30, 2020","volume":"69","author":"Garg","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.jbior.2020.100741_bib85","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.freeradbiomed.2010.01.006","article-title":"Linking oxidative stress to inflammation: Toll-like receptors","volume":"48","author":"Gill","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib86","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2","volume":"5","author":"Gorbalenya","year":"2020","journal-title":"Nature Microbiology"},{"key":"10.1016\/j.jbior.2020.100741_bib87","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1001\/jama.2020.5394","article-title":"Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the lombardy region, Italy","volume":"323","author":"Grasselli","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.jbior.2020.100741_bib88","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib89","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1084\/jem.20050828","article-title":"Multiple organ infection and the pathogenesis of SARS","volume":"202","author":"Gu","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib90","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib91","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib92","article-title":"Diabetes is a risk factor for the progression and prognosis of COVID-19 (2020)","volume":"3319","author":"Guo","year":"2020","journal-title":"Diabetes Metabol. Res. Rev."},{"key":"10.1016\/j.jbior.2020.100741_bib93","article-title":"Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients","author":"Hadjadj","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib94","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/path.1570","article-title":"Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis","volume":"203","author":"Hamming","year":"2004","journal-title":"J. Pathol."},{"key":"10.1016\/j.jbior.2020.100741_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.06.011","article-title":"A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies","author":"Hassan","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2020.100741_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/nu9040339","article-title":"Vitamin C and infections","volume":"9","author":"Hemil\u00e4","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jbior.2020.100741_bib97","article-title":"Vitamin C for preventing and treating pneumonia","author":"Hemila","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jbior.2020.100741_bib98","article-title":"The protein expression profile of ACE2 in human tissues","author":"Hikmet","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib99","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2020.100741_bib100","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jbior.2020.100741_bib101","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/1521-4141(200109)31:9<2566::AID-IMMU2566>3.0.CO;2-L","article-title":"Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology","volume":"31","author":"Hussell","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib102","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2008.02.043","article-title":"Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury","volume":"133","author":"Imai","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2020.100741_bib103","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature03712","article-title":"Angiotensin-converting enzyme 2 protects from severe acute lung failure","volume":"436","author":"Imai","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2020.100741_bib104","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nri.2016.117","article-title":"Early local immune defences in the respiratory tract","volume":"17","author":"Iwasaki","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib105","doi-asserted-by":"crossref","first-page":"15748","DOI":"10.1073\/pnas.0403812101","article-title":"CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus","volume":"101","author":"Jeffers","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jbior.2020.100741_bib106","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.chom.2013.01.005","article-title":"Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps","volume":"13","author":"Jenne","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbior.2020.100741_bib107","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.imbio.2014.03.006","article-title":"Vitamin C treatment of mouse bone marrow-derived dendritic cells enhanced CD8(+) memory T cell production capacity of these cells in vivo","volume":"219","author":"Jeong","year":"2014","journal-title":"Immunobiology"},{"key":"10.1016\/j.jbior.2020.100741_bib108","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiaa206","article-title":"Transmission potential of asymptomatic and paucisymptomatic SARS-CoV-2 infections: a three-family cluster study in China","author":"Jiang","year":"2020","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib109","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1126\/science.aam8897","article-title":"Host DNases prevent vascular occlusion by neutrophil extracellular traps","volume":"358","author":"Jimenez-Alcazar","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jbior.2020.100741_bib110","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1542\/hpeds.2020-0123","article-title":"COVID-19 and Kawasaki disease: novel virus and novel case","volume":"10","author":"Jones","year":"2020","journal-title":"Hosp. Pediatr."},{"key":"10.1016\/j.jbior.2020.100741_bib111","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/jcmm.13038","article-title":"Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases","volume":"21","author":"Kander","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib112","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1542\/peds.54.3.271","article-title":"A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan","volume":"54","author":"Kawasaki","year":"1974","journal-title":"Pediatrics"},{"key":"10.1016\/j.jbior.2020.100741_bib113","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-319-63245-2_8","article-title":"ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)","volume":"967","author":"Kellner","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jbior.2020.100741_bib114","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048111","article-title":"Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition","volume":"7","author":"Keshari","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jbior.2020.100741_bib115","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3390\/v10080392","article-title":"Redox biology of respiratory viral infections","volume":"10","author":"Khomich","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.jbior.2020.100741_bib116","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.smim.2016.10.013","article-title":"Role of platelets in neutrophil extracellular trap (NET) production and tissue injury","volume":"28","author":"Kim","year":"2016","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib117","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/bs.aivir.2016.08.006","article-title":"Interaction of SARS and MERS coronaviruses with the antiviral interferon response","volume":"96","author":"Kindler","year":"2016","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.jbior.2020.100741_bib118","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1681\/ASN.2008111160","article-title":"Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury","volume":"20","author":"Kinsey","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jbior.2020.100741_bib119","doi-asserted-by":"crossref","first-page":"710239","DOI":"10.1155\/2013\/710239","article-title":"Flavonoids and 5-aminosalicylic acid inhibit the formation of neutrophil extracellular traps","volume":"2013","author":"Kirchner","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jbior.2020.100741_bib120","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.immuni.2008.06.016","article-title":"Oxidation of cofilin mediates T cell hyporesponsiveness under oxidative stress conditions","volume":"29","author":"Klemke","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jbior.2020.100741_bib121","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib122","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1038\/ncomms7673","article-title":"Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature","volume":"6","author":"Kolaczkowska","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbior.2020.100741_bib283","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41423-019-0247-8","article-title":"Vitamin C promotes the proliferation and effector functions of \u03b3\u03b4 T cells","volume":"17","author":"Kouakanou","year":"2020","journal-title":"Cellular and Molecular Immunology"},{"key":"10.1016\/j.jbior.2020.100741_bib123","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(03)13967-0","article-title":"Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome","volume":"362","author":"Kuiken","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jbior.2020.100741_bib124","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.immuni.2019.11.013","article-title":"Immune sensing of cell death through recognition of histone sequences by C-type lectin-receptor-2d causes inflammation and tissue injury","volume":"52","author":"Lai","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jbior.2020.100741_bib125","doi-asserted-by":"crossref","first-page":"687","DOI":"10.7326\/0003-4819-152-10-201005180-00017","article-title":"High-dose N-acetylcysteine therapy for novel H1N1 influenza pneumonia","volume":"152","author":"Lai","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib126","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-0038-1677040","article-title":"Neutrophil extracellular traps in arterial and venous thrombosis","volume":"45","author":"Laridan","year":"2019","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.jbior.2020.100741_bib127","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1182\/blood-2004-10-4166","article-title":"Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells","volume":"106","author":"Law","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jbior.2020.100741_bib128","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.immuni.2019.03.025","article-title":"Shared and distinct functions of type I and type III interferons","volume":"50","author":"Lazear","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jbior.2020.100741_bib129","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/d41586-020-01824-5","article-title":"Coronavirus breakthrough: dexamethasone is first drug shown to save lives","volume":"582","author":"Ledford","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2020.100741_bib130","first-page":"1","article-title":"Neutrophil activation and acute lung injury","volume":"7","author":"Lee","year":"2001","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.jbior.2020.100741_bib131","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1152\/physiol.00017.2019","article-title":"Platelet biogenesis in the lung circulation","volume":"34","author":"Lefrancais","year":"2019","journal-title":"Physiology"},{"key":"10.1016\/j.jbior.2020.100741_bib132","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98178","article-title":"Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury","volume":"3","author":"Lefran\u00e7ais","year":"2018","journal-title":"JCI insight"},{"key":"10.1016\/j.jbior.2020.100741_bib133","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature21706","article-title":"The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors","volume":"544","author":"Lefrancais","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2020.100741_bib134","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1034\/j.1399-3003.1999.13a31.x","article-title":"Oxidatively modified proteins in bronchoalveolar lavage fluid of patients with ARDS and patients at-risk for ARDS","volume":"13","author":"Lenz","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jbior.2020.100741_bib135","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.imbio.2012.05.029","article-title":"Neutrophil--CD4+CD25+ T regulatory cell interactions: a possible new mechanism of infectious tolerance","volume":"218","author":"Lewkowicz","year":"2013","journal-title":"Immunobiology"},{"key":"10.1016\/j.jbior.2020.100741_bib136","doi-asserted-by":"crossref","first-page":"eaat4579","DOI":"10.1126\/sciimmunol.aat4579","article-title":"Neutrophils: new insights and open questions","volume":"3","author":"Ley","year":"2018","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jbior.2020.100741_bib138","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s13054-018-2191-x","article-title":"Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis","volume":"22","author":"Li","year":"2018","journal-title":"Crit. Care"},{"key":"10.1016\/j.jbior.2020.100741_bib141","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/science.abb3221","article-title":"Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)","volume":"368","author":"Li","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jbior.2020.100741_bib139","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fimmu.2018.00585","article-title":"Regulatory T-cells: potential regulator of tissue repair and regeneration","volume":"9","author":"Li","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib137","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.3201\/eid2607.200718","article-title":"Asymptomatic and human-to-human transmission of SARS-CoV-2 in a 2-family cluster, xuzhou, China","volume":"26","author":"Li","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib142","doi-asserted-by":"crossref","first-page":"25754","DOI":"10.1038\/srep25754","article-title":"SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-beta1 via ROS\/p38 MAPK\/STAT3 pathway","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbior.2020.100741_bib140","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40249-020-00662-x","article-title":"Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues","volume":"9","author":"Li","year":"2020","journal-title":"Infectious Diseases of Poverty"},{"key":"10.1016\/j.jbior.2020.100741_bib143","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/22221751.2020.1741327","article-title":"Clinical observation and management of COVID-19 patients","volume":"9","author":"Li","year":"2020","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.jbior.2020.100741_bib144","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2020.100741_bib145","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.3389\/fimmu.2018.02584","article-title":"Sulforaphane inhibits inflammatory responses of primary human T-cells by increasing ROS and depleting glutathione","volume":"9","author":"Liang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib146","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.3389\/fimmu.2020.01172","article-title":"Piperlongumine acts as an immunosuppressant by exerting prooxidative effects in human T cells resulting in diminished TH17 but enhanced Treg differentiation","volume":"11","author":"Liang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib147","article-title":"The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing","author":"Liao","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib148","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1055\/s-0040-1709650","article-title":"D-Dimer is associated with severity of coronavirus disease 2019: a pooled analysis","volume":"120","author":"Lippi","year":"2020","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.jbior.2020.100741_bib149","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cca.2020.03.022","article-title":"Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis","volume":"506","author":"Lippi","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jbior.2020.100741_bib152","first-page":"e6","article-title":"Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19","volume":"81","author":"Liu","year":"2020","journal-title":"J. Infect."},{"key":"10.1016\/j.jbior.2020.100741_bib150","doi-asserted-by":"crossref","first-page":"102763","DOI":"10.1016\/j.ebiom.2020.102763","article-title":"Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients","volume":"55","author":"Liu","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jbior.2020.100741_bib151","doi-asserted-by":"crossref","first-page":"37252","DOI":"10.1038\/srep37252","article-title":"Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbior.2020.100741_bib153","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2020.100741_bib154","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.3201\/eid2607.200764","article-title":"COVID-19 outbreak associated with air conditioning in restaurant, guangzhou, China, 2020","volume":"26","author":"Lu","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib155","doi-asserted-by":"crossref","DOI":"10.1001\/jamacardio.2020.1286","article-title":"Potential effects of coronaviruses on the cardiovascular system: a review","author":"Madjid","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jbior.2020.100741_bib156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2020.04.007","article-title":"Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases","volume":"220","author":"Magro","year":"2020","journal-title":"Transl. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib157","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/SHK.0000000000000396","article-title":"Delayed but not early treatment with DNase reduces organ damage and improves outcome in a murine model of sepsis","volume":"44","author":"Mai","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.jbior.2020.100741_bib158","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1089\/ars.2012.4988","article-title":"Vitamin C promotes maturation of T-cells","volume":"19","author":"Manning","year":"2013","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jbior.2020.100741_bib159","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1182\/blood-2013-10-463646","article-title":"Thrombosis: tangled up in NETs","volume":"123","author":"Martinod","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jbior.2020.100741_bib160","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.2184","article-title":"Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases","volume":"16","author":"Massberg","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib161","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048037","article-title":"Respiratory syncytial virus inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of N-acetylcysteine","volume":"7","author":"Mata","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jbior.2020.100741_bib162","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1161\/ATVBAHA.117.309897","article-title":"Novel role of IL (Interleukin)-1beta in neutrophil extracellular trap formation and abdominal aortic aneurysms","volume":"38","author":"Meher","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jbior.2020.100741_bib164","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.jbior.2020.100741_bib165","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib166","doi-asserted-by":"crossref","DOI":"10.1111\/jth.14888","article-title":"Incidence of venous thromboembolism in hospitalized patients with COVID-19","author":"Middeldorp","year":"2020","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.jbior.2020.100741_bib167","doi-asserted-by":"crossref","first-page":"25359","DOI":"10.1038\/srep25359","article-title":"Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity","volume":"6","author":"Min","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbior.2020.100741_bib168","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1128\/IAI.00856-07","article-title":"Mechanisms of dexamethasone-mediated inhibition of Toll-like receptor signaling induced by Neisseria meningitidis and Streptococcus pneumoniae","volume":"76","author":"Mogensen","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbior.2020.100741_bib169","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.cell.2020.04.004","article-title":"Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2","volume":"181","author":"Monteil","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2020.100741_bib170","doi-asserted-by":"crossref","first-page":"14166","DOI":"10.1038\/s41598-018-32576-y","article-title":"Respiratory Syncytial Virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation","volume":"8","author":"Muraro","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbior.2020.100741_bib171","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.aac7801","article-title":"Neutrophil-macrophage communication in inflammation and atherosclerosis","volume":"349","author":"Nahrendorf","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jbior.2020.100741_bib172","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3389\/fphar.2020.00870","article-title":"Neutrophilia and NETopathy as key pathologic drivers of progressive lung impairment in patients with COVID-19","volume":"11","author":"Narasaraju","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jbior.2020.100741_bib173","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ajpath.2011.03.013","article-title":"Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis","volume":"179","author":"Narasaraju","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jbior.2020.100741_bib174","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00441-017-2763-0","article-title":"Neutrophils in viral infection","volume":"371","author":"Naumenko","year":"2018","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.jbior.2020.100741_bib175","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41573-019-0054-z","article-title":"Neutrophils as emerging therapeutic targets","volume":"19","author":"Nemeth","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jbior.2020.100741_bib176","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1182\/blood-2018-10-862243","article-title":"Neutrophils: back in the thrombosis spotlight","volume":"133","author":"Noubouossie","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jbior.2020.100741_bib177","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2019.03.020","article-title":"IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation","volume":"50","author":"Ouyang","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jbior.2020.100741_bib178","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib179","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41577-020-0317-2","article-title":"Macrophages: a trojan horse in COVID-19?","volume":"20","author":"Park","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib180","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.3346\/jkms.2020.35.e84","article-title":"Virus isolation from the first patient with SARS-CoV-2 in Korea","volume":"35","author":"Park","year":"2020","journal-title":"J. Kor. Med. Sci."},{"key":"10.1016\/j.jbior.2020.100741_bib181","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000196","article-title":"Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression","volume":"4","author":"Pauli","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbior.2020.100741_bib182","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nri1732","article-title":"Immunopathogenesis of coronavirus infections: implications for SARS","volume":"5","author":"Perlman","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib183","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/CIRCULATIONAHA.120.047430","article-title":"Pulmonary embolism in COVID-19 patients: awareness of an increased prevalence","volume":"142","author":"Poissy","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jbior.2020.100741_bib184","doi-asserted-by":"crossref","first-page":"e20200653","DOI":"10.1084\/jem.20200653","article-title":"COVID-19 and emerging viral infections: the case for interferon lambda","volume":"217","author":"Prokunina-Olsson","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib185","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMc2011400","article-title":"Multiorgan and renal tropism of SARS-CoV-2","author":"Puelles","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib186","series-title":"Indoor Transmission of SARS-CoV-2","author":"Qian","year":"2020"},{"key":"10.1016\/j.jbior.2020.100741_bib187","article-title":"Dysregulation of immune response in patients with COVID-19 in Wuhan, China","author":"Qin","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib188","doi-asserted-by":"crossref","first-page":"10724","DOI":"10.1128\/JVI.76.21.10724-10733.2002","article-title":"Hantavirus infection of dendritic cells","volume":"76","author":"Raftery","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.jbior.2020.100741_bib189","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1084\/jem.20131092","article-title":"beta2 integrin mediates hantavirus-induced release of neutrophil extracellular traps","volume":"211","author":"Raftery","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib190","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.00281","article-title":"Replication in the mononuclear phagocyte system (MPS) as a determinant of hantavirus pathogenicity","volume":"10","author":"Raftery","year":"2020","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"10.1016\/j.jbior.2020.100741_bib191","doi-asserted-by":"crossref","first-page":"10443","DOI":"10.1096\/fj.201900627R","article-title":"Heparinoid sevuparin inhibits Streptococcus-induced vascular leak through neutralizing neutrophil-derived proteins","volume":"33","author":"Rasmuson","year":"2019","journal-title":"Faseb. J."},{"key":"10.1016\/j.jbior.2020.100741_bib192","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41467-020-14626-0","article-title":"Influenza A viruses are transmitted via the air from the nasal respiratory epithelium of ferrets","volume":"11","author":"Richard","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbior.2020.100741_bib193","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1001\/jama.2020.6775","article-title":"Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area","volume":"323","author":"Richardson","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.jbior.2020.100741_bib194","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.1128\/JVI.00127-09","article-title":"Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection","volume":"83","author":"Rockx","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.jbior.2020.100741_bib195","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1126\/science.abb7314","article-title":"Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model","volume":"368","author":"Rockx","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jbior.2020.100741_bib196","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41581-020-0284-7","article-title":"Kidney involvement in COVID-19 and rationale for extracorporeal therapies","volume":"16","author":"Ronco","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jbior.2020.100741_bib197","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.chom.2012.05.015","article-title":"Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1","volume":"12","author":"Saitoh","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbior.2020.100741_bib198","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/imr.12115","article-title":"Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration","volume":"256","author":"Samstag","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jbior.2020.100741_bib199","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00065","article-title":"TNF-\u03b1 increases production of reactive oxygen species through Cdk5 activation in nociceptive neurons","volume":"9","author":"Sandoval","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jbior.2020.100741_bib200","doi-asserted-by":"crossref","first-page":"35237","DOI":"10.1074\/jbc.R114.619304","article-title":"Complexity of danger: the diverse nature of damage-associated molecular patterns","volume":"289","author":"Schaefer","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbior.2020.100741_bib201","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41577-020-0312-7","article-title":"COVID-19: risk for cytokine targeting in chronic inflammatory diseases?","volume":"20","author":"Schett","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib202","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3389\/fimmu.2016.00366","article-title":"Neutrophil extracellular traps go viral","volume":"7","author":"Sch\u00f6nrich","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib203","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fcimb.2019.00207","article-title":"The PD-1\/PD-L1 Axis and virus infections: a delicate balance","volume":"9","author":"Sch\u00f6nrich","year":"2019","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"10.1016\/j.jbior.2020.100741_bib204","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/j.1460-2075.1991.tb07761.x","article-title":"Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1","volume":"10","author":"Schreck","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/j.jbior.2020.100741_bib205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2019.11.010","article-title":"Detrimental role of neutrophil extracellular traps during dengue virus infection","volume":"41","author":"Schulz","year":"2020","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib206","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","article-title":"Physiological roles of mitochondrial reactive oxygen species","volume":"48","author":"Sena","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbior.2020.100741_bib207","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1161\/CIRCRESAHA.116.306923","article-title":"Molecular and cellular mechanisms of cardiovascular disorders in diabetes","volume":"118","author":"Shah","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib208","doi-asserted-by":"crossref","DOI":"10.1001\/jamacardio.2020.0950","article-title":"Association of cardiac injury with mortality in hospitalized patients with COVID-19 in wuhan, China","author":"Shi","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jbior.2020.100741_bib209","series-title":"Immunopathological Characteristics of Coronavirus Disease 2019 Cases in Guangzhou","author":"Shi","year":"2020"},{"key":"10.1016\/j.jbior.2020.100741_bib210","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jbior.2020.100741_bib211","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2217\/imt.10.67","article-title":"Anti-TNF-alpha agents in the treatment of immune-mediated inflammatory diseases: mechanisms of action and pitfalls","volume":"2","author":"Silva","year":"2010","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jbior.2020.100741_bib212","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41569-019-0326-7","article-title":"Neutrophils as regulators of cardiovascular inflammation","volume":"17","author":"Silvestre-Roig","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jbior.2020.100741_bib213","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41586-019-1167-6","article-title":"Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death","volume":"569","author":"Silvestre-Roig","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2020.100741_bib214","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000756","article-title":"Exacerbated innate host response to SARS-CoV in aged non-human primates","volume":"6","author":"Smits","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbior.2020.100741_bib215","article-title":"COVID-19 early warning score: a multi-parameter screening tool to identify highly suspected patients","author":"Song","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib216","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1126\/science.1256478","article-title":"Neutrophils scan for activated platelets to initiate inflammation","volume":"346","author":"Sreeramkumar","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jbior.2020.100741_bib217","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.06.010","article-title":"Generation of a broadly useful model for COVID-19 pathogenesis vaccination, and treatment","author":"Sun","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2020.100741_bib218","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib219","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1099\/jgv.0.001024","article-title":"How myeloid cells contribute to the pathogenesis of prominent emerging zoonotic diseases","volume":"99","author":"Supramaniam","year":"2018","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jbior.2020.100741_bib220","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jlb.59.2.229","article-title":"Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis","volume":"59","author":"Takei","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jbior.2020.100741_bib221","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/jth.14768","article-title":"Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia","volume":"18","author":"Tang","year":"2020","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.jbior.2020.100741_bib222","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib223","doi-asserted-by":"crossref","first-page":"422","DOI":"10.15585\/mmwr.mm6914e4","article-title":"Coronavirus disease 2019 in children - United States, february 12-april 2, 2020","volume":"69","author":"Team","year":"2020","journal-title":"MMWR. Morbidity and mortality weekly report"},{"key":"10.1016\/j.jbior.2020.100741_bib224","article-title":"Does the newly observed inflammatory syndrome in children demonstrate a link between uncontrolled neutrophil extracellular traps formation and COVID-19?","author":"Thierry","year":"2020","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib225","article-title":"Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2","author":"Thoms","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib226","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood.V79.1.45.45","article-title":"Glucocorticoids downregulate gene expression of GM-CSF, NAP-1\/IL-8, and IL-6, but not of M-CSF in human fibroblasts","volume":"79","author":"Tobler","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.jbior.2020.100741_bib227","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201800605","article-title":"Oxidant sensor cation channel TRPM2 regulates neutrophil extracellular trap formation and protects against pneumoseptic bacterial infection","author":"Tripathi","year":"2018","journal-title":"Faseb. J."},{"key":"10.1016\/j.jbior.2020.100741_bib228","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.4049\/jimmunol.174.12.7977","article-title":"Severe acute respiratory syndrome and the innate immune responses: modulation of effector cell function without productive infection","volume":"174","author":"Tseng","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib229","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/1348-0421.12771","article-title":"Inflammasome-associated cell death: pyroptosis, apoptosis, and physiological implications","volume":"64","author":"Tsuchiya","year":"2020","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib230","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.chest.2019.06.012","article-title":"The emerging role of neutrophil extracellular traps in respiratory disease","volume":"156","author":"Twaddell","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.jbior.2020.100741_bib231","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1055\/s-0039-1678664","article-title":"Therapeutic targeting of neutrophil extracellular traps in atherogenic inflammation","volume":"119","author":"Van Avondt","year":"2019","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.jbior.2020.100741_bib232","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJMc2004973","article-title":"Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1","volume":"382","author":"Van Doremalen","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib233","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/antiox7030041","article-title":"Influence of vitamin C on lymphocytes: an overview","volume":"7","author":"Van Gorkom","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.jbior.2020.100741_bib234","doi-asserted-by":"crossref","first-page":"e20200678","DOI":"10.1084\/jem.20200678","article-title":"The many faces of the anti-COVID immune response","volume":"217","author":"Vardhana","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib235","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jbior.2020.100741_bib236","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12931-017-0689-4","article-title":"Neutrophil extracellular traps are downregulated by glucocorticosteroids in lungs in an equine model of asthma","volume":"18","author":"Vargas","year":"2017","journal-title":"Respir. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib237","article-title":"SARS-CoV-2 triggered neutrophil extracellular traps (NETs) mediate COVID-19 pathology","author":"Veras","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib238","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo","volume":"209","author":"Von Br\u00fchl","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib239","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1038\/cddis.2010.36","article-title":"Mitochondrial translocation of oxidized cofilin induces caspase-independent necrotic-like programmed cell death of T cells","volume":"1","author":"Wabnitz","year":"2010","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib240","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/ni.3212","article-title":"Guarding the frontiers: the biology of type III interferons","volume":"16","author":"Wack","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib241","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein","volume":"181","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2020.100741_bib242","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fimmu.2017.00060","article-title":"Dexamethasone inhibits S. Aureus-induced neutrophil extracellular pathogen-killing mechanism, possibly through toll-like receptor regulation","volume":"8","author":"Wan","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib243","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.jbior.2020.100741_bib244","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/infdis\/jiaa150","article-title":"Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia","volume":"221","author":"Wang","year":"2020","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib245","doi-asserted-by":"crossref","first-page":"17788","DOI":"10.1038\/s41598-018-36198-2","article-title":"DNase-1 treatment exerts protective effects in a rat model of intestinal ischemia-reperfusion injury","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbior.2020.100741_bib247","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/bjh.16315","article-title":"Platelet biology of the rapidly failing lung","volume":"188","author":"Washington","year":"2020","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jbior.2020.100741_bib248","doi-asserted-by":"crossref","first-page":"11678","DOI":"10.1074\/jbc.M513286200","article-title":"NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity","volume":"281","author":"Wei","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbior.2020.100741_bib249","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCRESAHA.115.303895","article-title":"Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte\/macrophage differentiation","volume":"115","author":"Weirather","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib250","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1182\/blood-2013-07-514984","article-title":"Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis","volume":"123","author":"Wildhagen","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jbior.2020.100741_bib251","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/d41586-020-01403-8","article-title":"Coronavirus blood-clot mystery intensifies","volume":"581","author":"Willyard","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2020.100741_bib252","article-title":"Covid-19 and thrombosis: what do we know about the risks and treatment?","volume":"369","author":"Wise","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.jbior.2020.100741_bib253","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-020-2196-x","article-title":"Virological assessment of hospitalized patients with COVID-2019","volume":"58","author":"Wolfel","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2020.100741_bib254","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-2249.2004.02415.x","article-title":"Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome","volume":"136","author":"Wong","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib255","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2020.100741_bib256","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1164\/rccm.201604-0712OC","article-title":"Antihistone properties of C1 esterase inhibitor protect against lung injury","volume":"196","author":"Wygrecka","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jbior.2020.100741_bib257","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular histones are major mediators of death in sepsis","volume":"15","author":"Xu","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib258","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00277-020-04019-0","article-title":"Mechanism of thrombocytopenia in COVID-19 patients","volume":"99","author":"Xu","year":"2020","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.jbior.2020.100741_bib261","doi-asserted-by":"crossref","first-page":"5642","DOI":"10.1128\/JVI.78.11.5642-5650.2004","article-title":"pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN","volume":"78","author":"Yang","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.jbior.2020.100741_bib260","article-title":"Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome","author":"Yang","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib259","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijid.2020.03.017","article-title":"Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis","volume":"94","author":"Yang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.jbior.2020.100741_bib262","doi-asserted-by":"crossref","first-page":"109906","DOI":"10.1016\/j.mehy.2020.109906","article-title":"Novel therapeutic targets for SARS-CoV-2-induced acute lung injury: targeting a potential IL-1\u03b2\/neutrophil extracellular traps feedback loop","volume":"143","author":"Yaqinuddin","year":"2020","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jbior.2020.100741_bib263","first-page":"202","article-title":"Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review","volume":"295","author":"Ye","year":"2020","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.jbior.2020.100741_bib264","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.virusres.2004.09.004","article-title":"SARS-coronavirus replication in human peripheral monocytes\/macrophages","volume":"107","author":"Yilla","year":"2005","journal-title":"Virus Res."},{"key":"10.1016\/j.jbior.2020.100741_bib265","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nm.2847","article-title":"Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo","volume":"18","author":"Yipp","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib266","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/s41390-019-0710-3","article-title":"Enhanced formation of neutrophil extracellular traps in Kawasaki disease","volume":"87","author":"Yoshida","year":"2020","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jbior.2020.100741_bib267","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJMoa1211721","article-title":"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia","volume":"367","author":"Zaki","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib271","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1056\/NEJMc2007575","article-title":"Coagulopathy and antiphospholipid antibodies in patients with covid-19","volume":"382","author":"Zhang","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib269","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/jth.14859","article-title":"D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19","volume":"18","author":"Zhang","year":"2020","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.jbior.2020.100741_bib270","article-title":"N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia: a randomized controlled trial","volume":"97","author":"Zhang","year":"2018","journal-title":"Medicine"},{"key":"10.1016\/j.jbior.2020.100741_bib268","article-title":"Immune phenotyping based on neutrophil-to-lymphocyte ratio and IgG predicts disease severity and outcome for patients with COVID-19","author":"Zhang","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.jbior.2020.100741_bib272","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fimmu.2020.00211","article-title":"NLRP3 inflammasome-A key player in antiviral responses","volume":"11","author":"Zhao","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2020.100741_bib273","series-title":"Single-cell RNA Expression Profiling of ACE2, the Putative Receptor of Wuhan 2019-nCov","author":"Zhao","year":"2020"},{"key":"10.1016\/j.jbior.2020.100741_bib276","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.chom.2020.04.017","article-title":"Heightened innate immune responses in the respiratory tract of COVID-19 patients","volume":"27","author":"Zhou","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbior.2020.100741_bib275","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2020.100741_bib274","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jbior.2020.100741_bib277","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2020.04.035","article-title":"SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues","volume":"181","author":"Ziegler","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbior.2020.100741_bib279","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11684-020-0754-0","article-title":"Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection","volume":"14","author":"Zou","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.jbior.2020.100741_bib278","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1056\/NEJMc2001737","article-title":"SARS-CoV-2 viral load in upper respiratory specimens of infected patients","volume":"382","author":"Zou","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.jbior.2020.100741_bib280","article-title":"Neutrophil extracellular traps in COVID-19","volume":"5","author":"Zuo","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbior.2020.100741_bib281","series-title":"Neutrophil Extracellular Traps and Thrombosis in COVID-19","author":"Zuo","year":"2020"}],"container-title":["Advances in Biological Regulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221249262030052X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221249262030052X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:27:27Z","timestamp":1761949647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221249262030052X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":280,"alternative-id":["S221249262030052X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbior.2020.100741","relation":{},"ISSN":["2212-4926"],"issn-type":[{"value":"2212-4926","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression","name":"articletitle","label":"Article Title"},{"value":"Advances in Biological Regulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbior.2020.100741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100741"}}