{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:12:41Z","timestamp":1778850761244,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["ECS00000041"],"award-info":[{"award-number":["ECS00000041"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["C43C22000380007"],"award-info":[{"award-number":["C43C22000380007"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Biological Regulation"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jbior.2023.100976","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T03:04:37Z","timestamp":1691463877000},"page":"100976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A possible role for G-quadruplexes formation and DNA methylation at IMOOD gene promoter in Obsessive Compulsive Disorder"],"prefix":"10.1016","volume":"89","author":[{"given":"Annalaura","family":"Sabatucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Girella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Di Bartolomeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Pucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Vismara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Benatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isobel Alice","family":"Blacksell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Dainese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvio","family":"D'Acquisto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Dell\u2019Osso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-098X","authenticated-orcid":false,"given":"Claudio","family":"D'Addario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbior.2023.100976_bib1","article-title":"DSM-5 diagnostic classification","year":"2013","journal-title":"Diagn. Stat. Manual Mental. Disord."},{"key":"10.1016\/j.jbior.2023.100976_bib2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nchem.1548","article-title":"Quantitative visualization of DNA G-quadruplex structures in human cells","volume":"5","author":"Biffi","year":"2013","journal-title":"Nat. Chem."},{"key":"10.1016\/j.jbior.2023.100976_bib3","first-page":"586","article-title":"Polymorphisms falling within putative miRNA target sites in the 3\u2032UTR region of SIRT2 and DRD2 genes are correlated with human longevity","volume":"71","author":"Crocco","year":"2016","journal-title":"J. Gerontol. - Series Biol.l Sci. Med.Sci."},{"key":"10.1016\/j.jbior.2023.100976_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jpsychires.2019.04.006","article-title":"Exploring the role of BDNF DNA methylation and hydroxymethylation in patients with obsessive compulsive disorder","volume":"114","author":"D'Addario","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jbior.2023.100976_bib5","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.2174\/0929867328666211208115536","article-title":"In search for biomarkers in obsessive-compulsive disorder: new evidence on saliva as a practical source of DNA to assess epigenetic regulation","volume":"29","author":"D'Addario","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jbior.2023.100976_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13148-022-01264-0","article-title":"Regulation of oxytocin receptor gene expression in obsessive\u2013compulsive disorder: a possible role for the microbiota-host epigenetic axis","volume":"14","author":"D'Addario","year":"2022","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.jbior.2023.100976_bib7","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1017\/S0033291709991012","article-title":"Subthreshold symptoms and obsessive-compulsive disorder: evaluating the diagnostic threshold","volume":"40","author":"De Bruijn","year":"2010","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jbior.2023.100976_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/j.1742-1241.2006.01167.x","article-title":"Diagnosis and treatment of obsessive-compulsive disorder and related disorders","author":"Dell'Osso","year":"2007","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.jbior.2023.100976_bib9","doi-asserted-by":"crossref","first-page":"10205","DOI":"10.1021\/jacs.8b12753","article-title":"Interplay of three G-quadruplex units in the KIT promoter","volume":"141","author":"Ducani","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jbior.2023.100976_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.970448","article-title":"Case Report: possible autoimmune obsessive-compulsive disorder with postpartum onset","volume":"13","author":"Endres","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2023.100976_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.957023","article-title":"Decoding regulatory associations of G-quadruplex with epigenetic and transcriptomic functional components","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.jbior.2023.100976_bib12","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1093\/nar\/gkg605","article-title":"Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN","volume":"31","author":"Farr\u00e9","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbior.2023.100976_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.jbior.2023.100976_bib14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/wps.20189","article-title":"The development of the ICD-11 clinical descriptions and diagnostic guidelines for mental and behavioural disorders","volume":"14","author":"First","year":"2015","journal-title":"World Psychiatr."},{"key":"10.1016\/j.jbior.2023.100976_bib15","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.psychres.2009.04.005","article-title":"Quality of life and symptom dimensions of patients with obsessive\u2013compulsive disorder","volume":"179","author":"Fontenelle","year":"2010","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.jbior.2023.100976_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005053-200003000-00005","article-title":"Compulsivity and obsessionality in opioid addiction","volume":"188","author":"Friedman","year":"2000","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jbior.2023.100976_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psychres.2014.07.009","article-title":"Factors associated with non-treatment or delayed treatment seeking in OCD sufferers: a review of the literature","volume":"220","author":"Garc\u00eda-Soriano","year":"2014","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.jbior.2023.100976_bib18","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"The Yale-Brown obsessive compulsive scale: I. Development, use, and reliability","volume":"46","author":"Goodman","year":"1989","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.jbior.2023.100976_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ymeth.2012.04.006","article-title":"Isothermal folding of G-quadruplexes","volume":"57","author":"Gray","year":"2012","journal-title":"Methods"},{"key":"10.1016\/j.jbior.2023.100976_bib20","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/ng.3662","article-title":"G-quadruplex structures mark human regulatory chromatin","volume":"48","author":"H\u00e4nsel-Hertsch","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbior.2023.100976_bib21","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/jcpp.13161","article-title":"From man to fly \u2013 convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes","volume":"61","author":"Harich","year":"2020","journal-title":"JCPP (J. Child Psychol. Psychiatry)"},{"key":"10.1016\/j.jbior.2023.100976_bib22","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1101\/gad.250746.114","article-title":"Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence","volume":"28","author":"Hashimoto","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbior.2023.100976_bib23","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/nar\/gkl1057","article-title":"G-quadruplexes in promoters throughout the human genome","volume":"35","author":"Huppert","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbior.2023.100976_bib24","doi-asserted-by":"crossref","first-page":"10645","DOI":"10.1002\/anie.201105193","article-title":"Topological characterization of nucleic acid G-quadruplexes by UV absorption and circular dichroism","volume":"50","author":"Karsisiotis","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jbior.2023.100976_bib25","doi-asserted-by":"crossref","first-page":"w676","DOI":"10.1093\/nar\/gkl253","article-title":"QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences","volume":"34","author":"Kikin","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbior.2023.100976_bib26","series-title":"Guideline Watch (March 2013): Practice Guideline for the Treatment of Patients with Obsessive-Compulsive Disorder","author":"Koran","year":"2013"},{"key":"10.1016\/j.jbior.2023.100976_bib27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12917-022-03290-9","article-title":"Four novel genes associated with longevity found in Cane corso purebred dogs","volume":"18","author":"Korec","year":"2022","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.jbior.2023.100976_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/nrg1125","article-title":"The power of the 3\u2032 UTR: translational control and development","author":"Kuersten","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jbior.2023.100976_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadva.2021.100007","article-title":"Effects of CpG methylation on the thermal stability of c-kit2, c-kit*, and c-kit1 G-quadruplex structures","volume":"1","author":"Laddachote","year":"2021","journal-title":"BBA Adv."},{"key":"10.1016\/j.jbior.2023.100976_bib30","first-page":"1479","article-title":"Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis","author":"Lee","year":"2023","journal-title":"Epigenomics"},{"key":"10.1016\/j.jbior.2023.100976_bib31","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.beth.2013.03.007","article-title":"Characteristics of individuals seeking treatment for obsessive-compulsive disorder","volume":"44","author":"Levy","year":"2013","journal-title":"Behav. Ther."},{"key":"10.1016\/j.jbior.2023.100976_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/18.11.1427","article-title":"MethPrimer: designing primers for methylation PCRs","author":"Li","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbior.2023.100976_bib33","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41594-018-0131-8","article-title":"DNA G-quadruplex structures mold the DNA methylome","volume":"25","author":"Mao","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbior.2023.100976_bib34","article-title":"A Model for qualitative research design","volume":"62","author":"Maxwell","year":"2013","journal-title":"Qualitative Research Design: An Interactive Approach"},{"key":"10.1016\/j.jbior.2023.100976_bib35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/bioinformatics\/18.2.333","article-title":"PROMO: detection of known transcription regulatory elements using species-tailored searches","volume":"18","author":"Messeguer","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbior.2023.100976_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/hgv.2017.32","article-title":"Deep sequencing reveals variations in somatic cell mosaic mutations between monozygotic twins with discordant psychiatric disease","volume":"4","author":"Morimoto","year":"2017","journal-title":"Hum. Genome Var."},{"key":"10.1016\/j.jbior.2023.100976_bib37","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12863-020-00894-8","article-title":"CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity","volume":"21","author":"Patel","year":"2020","journal-title":"BMC Genet."},{"key":"10.1016\/j.jbior.2023.100976_bib38","doi-asserted-by":"crossref","first-page":"8947","DOI":"10.1093\/nar\/gkab659","article-title":"C-kit2 G-quadruplex stabilized via a covalent probe: exploring G-quartet asymmetry","volume":"49","author":"Peterkov\u00e1","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbior.2023.100976_bib39","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bbi.2020.02.015","article-title":"Immuno-moodulin: a new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells","volume":"87","author":"Piras","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jbior.2023.100976_bib40","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3389\/fgene.2019.00523","article-title":"Preclinical and clinical evidence for a distinct regulation of mu opioid and type 1 cannabinoid receptor genes expression in obesity","volume":"10","author":"Pucci","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.jbior.2023.100976_bib41","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz1097","article-title":"A guide to computational methods for G-quadruplex prediction","author":"Puig Lombardi","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbior.2023.100976_bib42","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.3390\/genes13091665","article-title":"G-Quadruplexes mark sites of methylation instability associated with ageing and cancer","volume":"13","author":"Rauchhaus","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.jbior.2023.100976_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2020.108720","article-title":"A new methodological approach for in vitro determination of the role of DNA methylation on transcription factor binding using AlphaScreen\u00ae analysis: focus on CREB1 binding at hBDNF promoter IV","author":"Sabatucci","year":"2020","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jbior.2023.100976_bib44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41398-022-01996-w","article-title":"Epigenome-wide DNA methylation in obsessive-compulsive disorder","volume":"12","author":"Schiele","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jbior.2023.100976_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.trechm.2019.07.002","article-title":"The structure and function of DNA G-quadruplexes","author":"Spiegel","year":"2020","journal-title":"Trends Chem."},{"key":"10.1016\/j.jbior.2023.100976_bib46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13059-021-02324-z","article-title":"G-quadruplexes are transcription factor binding hubs in human chromatin","volume":"22","author":"Spiegel","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbior.2023.100976_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052407","article-title":"The dynamic regulation of G-quadruplex DNA structures by cytosine methylation","author":"Stevens","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbior.2023.100976_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbior.2020.100753","article-title":"Cross-correlations between motifs in the 5\u2032-UTR of DAT1 gene: findings from Parkinson's disease","volume":"78","author":"Tafani","year":"2020","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.jbior.2023.100976_bib49","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3390\/molecules23040944","article-title":"CpG methylation changes G-Quadruplex structures derived from gene promoters and interaction with VEGF and SP1","volume":"23","author":"Tsukakoshi","year":"2018","journal-title":"Molecules"},{"issue":"356","key":"10.1016\/j.jbior.2023.100976_bib50","article-title":"Impact of cytosine methylation on DNA binding specificities of human transcription factors","volume":"1979","author":"Yin","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jbior.2023.100976_bib51","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.febslet.2007.04.017","article-title":"Extensive selection for the enrichment of G4 DNA motifs in transcriptional regulatory regions of warm blooded animals","volume":"581","author":"Zhao","year":"2007","journal-title":"FEBS Lett."}],"container-title":["Advances in Biological Regulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212492623000222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212492623000222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:56:56Z","timestamp":1778849816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212492623000222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":51,"alternative-id":["S2212492623000222"],"URL":"https:\/\/doi.org\/10.1016\/j.jbior.2023.100976","relation":{},"ISSN":["2212-4926"],"issn-type":[{"value":"2212-4926","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A possible role for G-quadruplexes formation and DNA methylation at IMOOD gene promoter in Obsessive Compulsive Disorder","name":"articletitle","label":"Article Title"},{"value":"Advances in Biological Regulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbior.2023.100976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100976"}}