{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:39:52Z","timestamp":1793176792911,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008224","name":"Foundation of the Federal University of Parana","doi-asserted-by":"publisher","award":["03 \/2023"],"award-info":[{"award-number":["03 \/2023"]}],"id":[{"id":"10.13039\/501100008224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["406816 \/2022\\u20130"],"award-info":[{"award-number":["406816 \/2022\\u20130"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["403593\/2023\\u20139"],"award-info":[{"award-number":["403593\/2023\\u20139"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["303150\/2021\\u20131"],"award-info":[{"award-number":["303150\/2021\\u20131"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008223","name":"Universidade Federal do Paran\u00e1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008223","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Biological Regulation"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jbior.2026.101160","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:37:01Z","timestamp":1770507421000},"page":"101160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Modulation of skin inflammation by a recombinant Brown spider venom phospholipase D: In silico and in vitro approaches"],"prefix":"10.1016","volume":"100","author":[{"given":"Pedro Henrique de Caires","family":"Schluga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Boia-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Lucas","family":"Theodoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eduarda","family":"de Fraga-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelinda","family":"Schemczssen-Graeff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Senff-Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eduardo","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Sanches Veiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3347-4571","authenticated-orcid":false,"given":"Luiza Helena","family":"Gremski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbior.2026.101160_bib1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.bbalip.2013.07.003","article-title":"Imaging local sphingomyelin-rich domains in the plasma membrane using specific probes and advanced microscopy","volume":"1841","author":"Abe","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.jbior.2026.101160_bib2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41577-022-00694-4","article-title":"Immunomodulation by endothelial cells \u2014 partnering up with the immune system?","volume":"22","author":"Amersfoort","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbior.2026.101160_bib3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.bbalip.2008.06.005","article-title":"Two pathways for lysophosphatidic acid production","volume":"1781","author":"Aoki","year":"2008","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.jbior.2026.101160_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0005-2744(78)90101-8","article-title":"Isolation procedure and some properties of myeloperoxidase from human leukocytes","volume":"524","author":"Bakkenist","year":"1978","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbior.2026.101160_bib5","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1172\/JCI112200","article-title":"Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines","volume":"76","author":"Bevilacqua","year":"1985","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jbior.2026.101160_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jbior.2026.101160_bib7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/jcb.22148","article-title":"Identification of a direct hemolytic effect dependent on the catalytic activity induced by phospholipase-D (dermonecrotic toxin) from brown spider venom","volume":"107","author":"Chaves-Moreira","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jbior.2026.101160_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11060355","article-title":"Brown spider (loxosceles) venom toxins as potential biotools for the development of novel therapeutics","volume":"11","author":"Chaves-Moreira","year":"2019","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.jbior.2026.101160_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2022.984045","article-title":"Dermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytes","volume":"13","author":"Cordier-Dirikoc","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2026.101160_bib10","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.biochi.2006.02.008","article-title":"Molecular cloning and functional characterization of two isoforms of dermonecrotic toxin from Loxosceles intermedia (brown spider) venom gland","volume":"88","author":"Da Silveira","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.jbior.2026.101160_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-018-1235-0","article-title":"Necroptosis: a regulated inflammatory mode of cell death","volume":"15","author":"Dhuriya","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jbior.2026.101160_bib12","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/sj.jid.5700644","article-title":"Upregulation of IL-6, IL-8, CXCL1, and CXCL2 dominates gene expression in human fibroblast cells exposed to Loxosceles reclusa sphingomyelinase D: insights into spider venom dermonecrosis [2]","volume":"127","author":"Dragulev","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jbior.2026.101160_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-017-1559-2","article-title":"Reactome pathway analysis: a high-performance in-memory approach","volume":"18","author":"Fabregat","year":"2017","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jbior.2026.101160_bib14","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1152\/japplphysiol.01269.2011","article-title":"Sphingomyelinase depresses force and calcium sensitivity of the contractile apparatus in mouse diaphragm muscle fibers","volume":"112","author":"Ferreira","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jbior.2026.101160_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00000441-199210000-00008","article-title":"Loxoscelism","volume":"304","author":"Futrell","year":"1992","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.jbior.2026.101160_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/j.1524-475X.2007.00225.x","article-title":"Role of keratinocyte-fibroblast cross-talk in development of hypertrophic scar","volume":"15","author":"Ghahary","year":"2007","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.jbior.2026.101160_bib17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/toxins12030164","article-title":"Forty years of the description of brown spider venom phospholipases-D","volume":"12","author":"Gremski","year":"2020","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.jbior.2026.101160_bib18","article-title":"Systemic loxoscelism, less frequent but more deadly: the involvement of phospholipases D in the pathophysiology of envenomation","volume":"15","author":"Gremski","year":"2023","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.jbior.2026.101160_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxicon.2014.02.023","article-title":"Recent advances in the understanding of brown spider venoms: from the biology of spiders to the molecular mechanisms of toxins","volume":"83","author":"Gremski","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.jbior.2026.101160_bib20","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1038\/jid.2013.40","article-title":"Lysophosphatidic acid mediates the release of cytokines and chemokines by human fibroblasts treated with loxosceles spider venom","volume":"133","author":"Horta","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jbior.2026.101160_bib21","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1038\/jid.2013.40","article-title":"Lysophosphatidic acid mediates the release of cytokines and chemokines by human fibroblasts treated with loxosceles spider venom","volume":"133","author":"Horta","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jbior.2026.101160_bib22","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(10)62230-1","article-title":"Spider bite","volume":"378","author":"Isbister","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jbior.2026.101160_bib23","article-title":"Inflammation-related signaling pathways in tendinopathy","volume":"18","author":"Jiang","year":"2023","journal-title":"Open Life Sci."},{"key":"10.1016\/j.jbior.2026.101160_bib24","article-title":"Induction of ectosome formation by binding of phospholipases D from loxosceles venoms to endothelial cell surface: mechanism of interaction","volume":"1870","author":"Justa","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.jbior.2026.101160_bib25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.immuni.2015.09.005","article-title":"Interleukin-4 receptor \u03b1 signaling in myeloid cells controls collagen fibril assembly in skin repair","volume":"43","author":"Knipper","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jbior.2026.101160_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0072372","article-title":"Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates","volume":"8","author":"Lajoie","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jbior.2026.101160_bib27","first-page":"1","article-title":"Src family kinases: a potential therapeutic target for acute kidney injury","volume":"12","author":"Li","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jbior.2026.101160_bib28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2016","journal-title":"Cell Syst."},{"key":"10.1016\/j.jbior.2026.101160_bib29","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00204-020-02719-0","article-title":"Clinical aspects, diagnosis and management of loxosceles spider envenomation: literature and case review","volume":"94","author":"Lopes","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jbior.2026.101160_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2022.1035497","article-title":"Editorial: endothelial cells as innate immune cells","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbior.2026.101160_bib31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"MacEyka","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jbior.2026.101160_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molimm.2017.12.009","article-title":"Loxosceles venom sphingomyelinase D activates human blood leukocytes: role of the complement system","volume":"94","author":"Manzoni-de-Almeida","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jbior.2026.101160_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2133.1991.tb04942.x","article-title":"Epidermal cytokines and their roles in cutaneous wound healing","volume":"124","author":"McKay","year":"1991","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jbior.2026.101160_bib34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biochi.2016.06.003","article-title":"Expression and immunological cross-reactivity of LALP3, a novel astacin-like metalloprotease from brown spider (Loxosceles intermedia) venom","volume":"128\u2013129","author":"Morgon","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.jbior.2026.101160_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4091278","article-title":"Loxoscelism: cutaneous and hematologic manifestations","volume":"2019","author":"Nguyen","year":"2019","journal-title":"Adv. Hematol."},{"key":"10.1016\/j.jbior.2026.101160_bib36","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.toxicon.2006.02.006","article-title":"The effect of brown spider venom on endothelial cell morphology and adhesive structures","volume":"47","author":"Paludo","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.jbior.2026.101160_bib37","series-title":"A-Z of Quantitative PCR","first-page":"87","article-title":"Quantification strategies in real-time PCR","author":"Pfaffl","year":"2004"},{"key":"10.1016\/j.jbior.2026.101160_bib38","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1007\/s00204-023-03602-4","article-title":"Role of ErbB and IL-1 signaling pathways in the dermonecrotic lesion induced by loxosceles sphingomyelinases D","volume":"97","author":"Pinto","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jbior.2026.101160_bib39","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.4049\/jimmunol.136.5.1680","article-title":"Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells","volume":"136","author":"Pober","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbior.2026.101160_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/toxins9040125","article-title":"Phospholipase d from Loxosceles laeta spider venom induces IL-6, IL-8, CXCL1\/GRO-\u03b1, and CCL2\/MCP-1 production in human skin fibroblasts and stimulates monocytes migration","volume":"9","author":"Rojas","year":"2017","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.jbior.2026.101160_bib41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.12688\/f1000research.4477.1","article-title":"Biological network analysis with CentiScaPe: centralities and experimental dataset integration","volume":"3","author":"Scardoni","year":"2014","journal-title":"F1000Research"},{"key":"10.1016\/j.jbior.2026.101160_bib42","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/nar\/gkh081","article-title":"BRENDA, the enzyme database: updates and major new developments","volume":"32","author":"Schomburg","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbior.2026.101160_bib43","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/nar\/gkp1005","article-title":"PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification","volume":"38","author":"Spandidos","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbior.2026.101160_bib44","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jbior.2026.101160_bib45","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbior.2026.101160_bib46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2567.2006.02321.x","article-title":"Mechanisms of immune suppression by interleukin-10 and transforming growth factor-\u03b2: the role of T regulatory cells","volume":"117","author":"Taylor","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.jbior.2026.101160_bib47","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.toxicon.2013.01.027","article-title":"Modulation of membrane phospholipids, the cytosolic calcium influx and cell proliferation following treatment of B16-F10 cells with recombinant phospholipase-D from Loxosceles intermedia (brown spider) venom","volume":"67","author":"Wille","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.jbior.2026.101160_bib48","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.bjc.6605530","article-title":"TNF-\u03b1\/NF\u03ba-B\/Snail pathway in cancer cell migration and invasion","volume":"102","author":"Wu","year":"2010","journal-title":"Br. J. Cancer"},{"issue":"STATs","key":"10.1016\/j.jbior.2026.101160_bib49","first-page":"139","article-title":"STATs in cancer inflammation and immunity: a leading role for STAT3","volume":"176","author":"Yu","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jbior.2026.101160_bib50","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/0962935021000051548","article-title":"Cell adhesion molecules involved in the leukocyte recruitment induced by venom of the snake Bothrops jararaca","volume":"11","author":"Zamuner","year":"2002","journal-title":"Mediat. Inflamm."}],"container-title":["Advances in Biological Regulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212492626000175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212492626000175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:27:58Z","timestamp":1793176078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212492626000175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":50,"alternative-id":["S2212492626000175"],"URL":"https:\/\/doi.org\/10.1016\/j.jbior.2026.101160","relation":{},"ISSN":["2212-4926"],"issn-type":[{"value":"2212-4926","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of skin inflammation by a recombinant Brown spider venom phospholipase D: In silico and in vitro approaches","name":"articletitle","label":"Article Title"},{"value":"Advances in Biological Regulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbior.2026.101160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101160"}}