{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:51:12Z","timestamp":1791661872214,"version":"4.3.4"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07207"],"award-info":[{"award-number":["22K07207"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16KK0162"],"award-info":[{"award-number":["16KK0162"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24H02274"],"award-info":[{"award-number":["24H02274"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03415"],"award-info":[{"award-number":["20H03415"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K06300"],"award-info":[{"award-number":["22K06300"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25H01101"],"award-info":[{"award-number":["25H01101"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K27351"],"award-info":[{"award-number":["23K27351"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Biological Regulation"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jbior.2026.101186","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:49:15Z","timestamp":1791416955000},"page":"101186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["BNIP3\/NIX-mediated mitophagy versus Parkin-mediated mitophagy: mechanistic differences and functional implications"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9919-7111","authenticated-orcid":false,"given":"Satoshi","family":"Waguri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8892-0765","authenticated-orcid":false,"given":"Shun-ichi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuko","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomotake","family":"Kanki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.jbior.2026.101186_bib1","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.1038\/s44318-025-00615-w","article-title":"Mechanism of autophagy initiation by transmembrane selective autophagy receptors","volume":"44","author":"Adriaenssens","year":"2025","journal-title":"Embo j"},{"issue":"8","key":"10.1016\/j.jbior.2026.101186_bib2","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/s41556-025-01712-y","article-title":"Reconstitution of BNIP3\/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery","volume":"27","author":"Adriaenssens","year":"2025","journal-title":"Nat. Cell Biol."},{"issue":"7848","key":"10.1016\/j.jbior.2026.101186_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41586-020-2992-3","article-title":"Wetting regulates autophagy of phase-separated compartments and the cytosol","volume":"591","author":"Agudo-Canalejo","year":"2021","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jbior.2026.101186_bib4","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201911659","article-title":"FBXL4 deficiency increases mitochondrial removal by autophagy","volume":"12","author":"Alsina","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jbior.2026.101186_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fgene.2019.00039","article-title":"FBXL4-Related mitochondrial DNA depletion syndrome 13 (MTDPS13): a case report with a comprehensive mutation review","volume":"10","author":"Ballout","year":"2019","journal-title":"Front. Genet."},{"issue":"39","key":"10.1016\/j.jbior.2026.101186_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh4094","article-title":"ULK1 forms distinct oligomeric states and nanoscopic structures during autophagy initiation","volume":"9","author":"Banerjee","year":"2023","journal-title":"Sci. Adv."},{"issue":"10","key":"10.1016\/j.jbior.2026.101186_bib7","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1128\/MCB.00166-09","article-title":"Hypoxia-Induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains","volume":"29","author":"Bellot","year":"2009","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.jbior.2026.101186_bib8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ajhg.2013.07.017","article-title":"Mutations in FBXL4 cause mitochondrial encephalopathy and a disorder of mitochondrial DNA maintenance","volume":"93","author":"Bonnen","year":"2013","journal-title":"Am. J. Hum. Genet."},{"issue":"16","key":"10.1016\/j.jbior.2026.101186_bib9","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1073\/pnas.97.16.9082","article-title":"Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia","volume":"97","author":"Bruick","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"22","key":"10.1016\/j.jbior.2026.101186_bib10","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2023113491","article-title":"Nix interacts with WIPI2 to induce mitophagy","volume":"42","author":"Bunker","year":"2023","journal-title":"Embo j"},{"issue":"13","key":"10.1016\/j.jbior.2026.101186_bib11","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022113033","article-title":"A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease","volume":"42","author":"Cao","year":"2023","journal-title":"Embo j"},{"issue":"10","key":"10.1016\/j.jbior.2026.101186_bib12","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41418-023-01205-1","article-title":"FBXL4 mutations cause excessive mitophagy via BNIP3\/BNIP3L accumulation leading to mitochondrial DNA depletion syndrome","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.jbior.2026.101186_bib13","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/cge.12894","article-title":"FBXL4 defects are common in patients with congenital lactic acidemia and encephalomyopathic mitochondrial DNA depletion syndrome","volume":"91","author":"Dai","year":"2017","journal-title":"Clin. Genet."},{"issue":"16","key":"10.1016\/j.jbior.2026.101186_bib14","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1073\/pnas.0610666104","article-title":"Unrestrained erythroblast development in Nix-\/- mice reveals a mechanism for apoptotic modulation of erythropoiesis","volume":"104","author":"Diwan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"13","key":"10.1016\/j.jbior.2026.101186_bib15","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112799","article-title":"FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels","volume":"42","author":"Elcocks","year":"2023","journal-title":"Embo j"},{"issue":"1","key":"10.1016\/j.jbior.2026.101186_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"Epstein","year":"2001","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.jbior.2026.101186_bib17","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.15252\/embj.201695916","article-title":"Programmed mitophagy is essential for the glycolytic switch during cell differentiation","volume":"36","author":"Esteban-Mart\u00ednez","year":"2017","journal-title":"Embo j"},{"issue":"11","key":"10.1016\/j.jbior.2026.101186_bib18","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1091\/mbc.e08-03-0312","article-title":"An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure","volume":"19","author":"Fujita","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"12","key":"10.1016\/j.jbior.2026.101186_bib19","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.molcel.2023.04.022","article-title":"The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy","volume":"83","author":"Fukuda","year":"2023","journal-title":"Mol Cell"},{"issue":"3","key":"10.1016\/j.jbior.2026.101186_bib20","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ajhg.2013.07.016","article-title":"Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy","volume":"93","author":"Gai","year":"2013","journal-title":"Am. J. Hum. Genet."},{"issue":"16","key":"10.1016\/j.jbior.2026.101186_bib21","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2101562118","article-title":"A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis","volume":"118","author":"Ghanbarpour","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbior.2026.101186_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/jb\/mvag048","article-title":"BNIP3\/NIX-dependent mitophagy: molecular mechanisms and physiological roles","author":"Ginevskaia","year":"2026","journal-title":"J. Biochem."},{"issue":"13","key":"10.1016\/j.jbior.2026.101186_bib23","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1128\/MCB.00167-12","article-title":"BNip3 regulates mitochondrial function and lipid metabolism in the liver","volume":"32","author":"Glick","year":"2012","journal-title":"Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.jbior.2026.101186_bib24","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202204021","article-title":"The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3\/BNIP3L-mediated mitophagy","volume":"222","author":"Gok","year":"2023","journal-title":"J. Cell Biol."},{"issue":"44","key":"10.1016\/j.jbior.2026.101186_bib25","doi-asserted-by":"crossref","first-page":"43628","DOI":"10.1074\/jbc.M308947200","article-title":"Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons","volume":"278","author":"Goldberg","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"7926","key":"10.1016\/j.jbior.2026.101186_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41586-022-05138-6","article-title":"Capillary forces generated by biomolecular condensates","volume":"609","author":"Gouveia","year":"2022","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jbior.2026.101186_bib27","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.cmet.2021.05.006","article-title":"TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis","volume":"33","author":"Huang","year":"2021","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.jbior.2026.101186_bib28","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0006-291X(03)00050-0","article-title":"Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells","volume":"301","author":"Ishihara","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.jbior.2026.101186_bib29","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.cell.2012.11.001","article-title":"The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes\/lysosomes","volume":"151","author":"Itakura","year":"2012","journal-title":"Cell"},{"issue":"18","key":"10.1016\/j.jbior.2026.101186_bib30","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1093\/hmg\/ddg239","article-title":"Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse","volume":"12","author":"Itier","year":"2003","journal-title":"Hum. Mol. Genet."},{"issue":"5516","key":"10.1016\/j.jbior.2026.101186_bib31","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"issue":"5516","key":"10.1016\/j.jbior.2026.101186_bib32","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.jbior.2026.101186_bib33","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol Cell"},{"issue":"15","key":"10.1016\/j.jbior.2026.101186_bib34","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.neuron.2023.05.011","article-title":"Profiling of purified autophagic vesicle degradome in the maturing and aging brain","volume":"111","author":"Kallergi","year":"2023","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.jbior.2026.101186_bib35","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.cell.2020.04.025","article-title":"Visualizing and modulating mitophagy for therapeutic studies of neurodegeneration","volume":"181","author":"Katayama","year":"2020","journal-title":"Cell"},{"issue":"27","key":"10.1016\/j.jbior.2026.101186_bib36","doi-asserted-by":"crossref","first-page":"11441","DOI":"10.1073\/pnas.0702717104","article-title":"Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice","volume":"104","author":"Kitada","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7859","key":"10.1016\/j.jbior.2026.101186_bib37","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41586-021-03510-6","article-title":"Distinct fission signatures predict mitochondrial degradation or biogenesis","volume":"593","author":"Kleele","year":"2021","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jbior.2026.101186_bib38","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41594-026-01752-4","article-title":"Core principles of autophagy initiation mechanisms","volume":"33","author":"Kotani","year":"2026","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"31","key":"10.1016\/j.jbior.2026.101186_bib39","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2606606123","article-title":"Spatiotemporal control of Atg2 association with the ER during autophagosome formation","volume":"123","author":"Kotani","year":"2026","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"30","key":"10.1016\/j.jbior.2026.101186_bib40","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1038\/sj.onc.1206666","article-title":"BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF","volume":"22","author":"Kothari","year":"2003","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.jbior.2026.101186_bib41","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1091\/mbc.e02-06-0330","article-title":"Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins","volume":"13","author":"Legros","year":"2002","journal-title":"Mol. Biol. Cell"},{"issue":"6","key":"10.1016\/j.jbior.2026.101186_bib42","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202103105","article-title":"TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine","volume":"220","author":"Li","year":"2021","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.jbior.2026.101186_bib43","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1080\/15548627.2021.1896924","article-title":"Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC","volume":"17","author":"Liu","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.jbior.2026.101186_bib44","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45777","article-title":"The autophagic membrane tether ATG2A transfers lipids between membranes","volume":"8","author":"Maeda","year":"2019","journal-title":"eLife"},{"issue":"12","key":"10.1016\/j.jbior.2026.101186_bib45","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/s41594-020-00520-2","article-title":"Structure, lipid scrambling activity and role in autophagosome formation of ATG9A","volume":"27","author":"Maeda","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"9","key":"10.1016\/j.jbior.2026.101186_bib46","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/sj.embor.7400488","article-title":"Separate fusion of outer and inner mitochondrial membranes","volume":"6","author":"Malka","year":"2005","journal-title":"EMBO Rep."},{"issue":"8","key":"10.1016\/j.jbior.2026.101186_bib47","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1083\/jcb.201712058","article-title":"Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17","volume":"217","author":"Matsui","year":"2018","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.jbior.2026.101186_bib48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.molcel.2014.11.006","article-title":"PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3\/GABARAP proteins","volume":"57","author":"McEwan","year":"2015","journal-title":"Mol Cell"},{"issue":"2","key":"10.1016\/j.jbior.2026.101186_bib49","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cmet.2017.12.008","article-title":"Basal mitophagy occurs independently of PINK1 in mouse tissues of high metabolic demand","volume":"27","author":"McWilliams","year":"2018","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.jbior.2026.101186_bib50","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1038\/s41467-020-17163-y","article-title":"Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes","volume":"11","author":"Mochida","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jbior.2026.101186_bib51","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1038\/s41467-021-26331-7","article-title":"GAK and PRKCD are positive regulators of PRKN-independent mitophagy","volume":"12","author":"Munson","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jbior.2026.101186_bib52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cell.2007.05.021","article-title":"Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion","volume":"130","author":"Nakatogawa","year":"2007","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.jbior.2026.101186_bib53","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.jbior.2026.101186_bib55","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.201607039","article-title":"Atg8 family LC3\/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1\/Parkin mitophagy and starvation","volume":"215","author":"Nguyen","year":"2016","journal-title":"J. Cell Biol."},{"issue":"10","key":"10.1016\/j.jbior.2026.101186_bib56","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.molcel.2023.04.021","article-title":"Unconventional initiation of PINK1\/Parkin mitophagy by Optineurin","volume":"83","author":"Nguyen","year":"2023","journal-title":"Mol Cell"},{"issue":"8","key":"10.1016\/j.jbior.2026.101186_bib54","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1038\/s44319-024-00181-y","article-title":"PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF(FBXL4)","volume":"25","author":"Nguyen-Dien","year":"2024","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.jbior.2026.101186_bib57","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1042\/BST20221364","article-title":"Coordinating BNIP3\/NIX-mediated mitophagy in space and time","volume":"52","author":"Niemi","year":"2024","journal-title":"Biochem. Soc. Trans."},{"issue":"1","key":"10.1016\/j.jbior.2026.101186_bib58","doi-asserted-by":"crossref","first-page":"6431","DOI":"10.1038\/s41467-023-42069-w","article-title":"PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy","volume":"14","author":"Niemi","year":"2023","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.jbior.2026.101186_bib59","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104705","article-title":"Molecular mechanisms and physiological functions of mitophagy","volume":"40","author":"Onishi","year":"2021","journal-title":"EMBO J."},{"issue":"24","key":"10.1016\/j.jbior.2026.101186_bib60","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1016\/j.molcel.2021.10.001","article-title":"Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy","volume":"81","author":"Ordureau","year":"2021","journal-title":"Mol. Cell"},{"issue":"25","key":"10.1016\/j.jbior.2026.101186_bib61","doi-asserted-by":"crossref","first-page":"10190","DOI":"10.1073\/pnas.1107402108","article-title":"Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation","volume":"108","author":"Rambold","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbior.2026.101186_bib62","doi-asserted-by":"crossref","DOI":"10.1080\/15548627.2026.2711596","article-title":"Mitophagy in neurodegeneration: crosstalk between PRKN\/parkin-dependent and PRKN-independent pathways","author":"Rasmussen","year":"2026","journal-title":"Autophagy"},{"issue":"7201","key":"10.1016\/j.jbior.2026.101186_bib63","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature07006","article-title":"Essential role for Nix in autophagic maturation of erythroid cells","volume":"454","author":"Sandoval","year":"2008","journal-title":"Nature"},{"issue":"49","key":"10.1016\/j.jbior.2026.101186_bib64","doi-asserted-by":"crossref","first-page":"19500","DOI":"10.1073\/pnas.0708818104","article-title":"NIX is required for programmed mitochondrial clearance during reticulocyte maturation","volume":"104","author":"Schweers","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.jbior.2026.101186_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2007044","article-title":"CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor","volume":"17","author":"Shoemaker","year":"2019","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.jbior.2026.101186_bib66","article-title":"PINK1 regulated mitophagy is evident in skeletal muscles","volume":"3","author":"Singh","year":"2024","journal-title":"Autophagy Rep"},{"issue":"11","key":"10.1016\/j.jbior.2026.101186_bib67","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1091\/mbc.e08-03-0309","article-title":"The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice","volume":"19","author":"Sou","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"18","key":"10.1016\/j.jbior.2026.101186_bib68","first-page":"6669","article-title":"HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors","volume":"61","author":"Sowter","year":"2001","journal-title":"Cancer Res."},{"issue":"31","key":"10.1016\/j.jbior.2026.101186_bib69","doi-asserted-by":"crossref","first-page":"12937","DOI":"10.1073\/pnas.1103295108","article-title":"Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo","volume":"108","author":"Sterky","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.jbior.2026.101186_bib70","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ncb2979","article-title":"Cargo recognition and trafficking in selective autophagy","volume":"16","author":"Stolz","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.jbior.2026.101186_bib71","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.molcel.2023.11.038","article-title":"A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass","volume":"84","author":"Sun","year":"2024","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.jbior.2026.101186_bib72","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1038\/s41467-018-05254-w","article-title":"An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure","volume":"9","author":"Takahashi","year":"2018","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.jbior.2026.101186_bib73","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1083\/jcb.201007013","article-title":"Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.jbior.2026.101186_bib74","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1161\/CIRCRESAHA.118.314607","article-title":"Mitophagy is essential for maintaining cardiac function during high fat diet-induced diabetic Cardiomyopathy","volume":"124","author":"Tong","year":"2019","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.jbior.2026.101186_bib75","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J."},{"issue":"19","key":"10.1016\/j.jbior.2026.101186_bib76","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1016\/j.molcel.2023.08.021","article-title":"Mitochondrial degradation: mitophagy and beyond","volume":"83","author":"Uoselis","year":"2023","journal-title":"Mol Cell"},{"issue":"6","key":"10.1016\/j.jbior.2026.101186_bib77","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1083\/jcb.201811139","article-title":"ATG2 transports lipids to promote autophagosome biogenesis","volume":"218","author":"Valverde","year":"2019","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.jbior.2026.101186_bib78","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/hmg\/ddq531","article-title":"Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization","volume":"20","author":"Van Laar","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.jbior.2026.101186_bib79","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.molcel.2019.02.010","article-title":"Spatiotemporal control of ULK1 activation by NDP52 and TBK1 during selective autophagy","volume":"74","author":"Vargas","year":"2019","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.jbior.2026.101186_bib80","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.molcel.2016.08.021","article-title":"The Vici syndrome protein EPG5 is a Rab7 effector that determines the fusion specificity of autophagosomes with late Endosomes\/Lysosomes","volume":"63","author":"Wang","year":"2016","journal-title":"Mol Cell"},{"issue":"9","key":"10.1016\/j.jbior.2026.101186_bib81","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202402765","article-title":"Dual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX","volume":"7","author":"Wei","year":"2024","journal-title":"Life Sci. Alliance"},{"issue":"6","key":"10.1016\/j.jbior.2026.101186_bib82","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41576-022-00562-w","article-title":"Autophagy genes in biology and disease","volume":"24","author":"Yamamoto","year":"2023","journal-title":"Nat. Rev. Genet."},{"issue":"9","key":"10.1016\/j.jbior.2026.101186_bib83","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201912144","article-title":"Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy","volume":"219","author":"Yamano","year":"2020","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.jbior.2026.101186_bib84","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s44318-024-00036-1","article-title":"Optineurin provides a mitophagy contact site for TBK1 activation","volume":"43","author":"Yamano","year":"2024","journal-title":"Embo j"},{"issue":"7","key":"10.1016\/j.jbior.2026.101186_bib85","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202408166","article-title":"The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria","volume":"224","author":"Yamashita","year":"2025","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.jbior.2026.101186_bib86","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1083\/jcb.201605093","article-title":"Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy","volume":"215","author":"Yamashita","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbior.2026.101186_bib87","doi-asserted-by":"crossref","DOI":"10.1038\/s41418-024-01280-y","article-title":"Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species","author":"Yamashita","year":"2024","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jbior.2026.101186_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2025.1665315","article-title":"Receptor-mediated mitophagy: a new target of neurodegenerative diseases","volume":"16","author":"Yang","year":"2025","journal-title":"Front. Neurol."},{"issue":"22","key":"10.1016\/j.jbior.2026.101186_bib89","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1038\/s44318-024-00272-5","article-title":"Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates","volume":"43","author":"Yang","year":"2024","journal-title":"Embo j"},{"issue":"3","key":"10.1016\/j.jbior.2026.101186_bib90","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.201810099","article-title":"Autophagosome maturation: an epic journey from the ER to lysosomes","volume":"218","author":"Zhao","year":"2019","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.jbior.2026.101186_bib91","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1080\/15548627.2019.1639301","article-title":"ESCRT-mediated phagophore sealing during mitophagy","volume":"16","author":"Zhen","year":"2020","journal-title":"Autophagy"},{"issue":"22","key":"10.1016\/j.jbior.2026.101186_bib92","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1016\/j.cell.2022.09.001","article-title":"Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites","volume":"185","author":"Zheng","year":"2022","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jbior.2026.101186_bib93","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.molcel.2024.12.005","article-title":"Ca(2+)\/calmodulin-dependent protein kinase II \u03b2 decodes ER Ca(2+) transients to trigger autophagosome formation","volume":"85","author":"Zheng","year":"2025","journal-title":"Mol Cell"}],"container-title":["Advances in Biological Regulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212492626000436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212492626000436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:29:26Z","timestamp":1791660566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212492626000436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":93,"alternative-id":["S2212492626000436"],"URL":"https:\/\/doi.org\/10.1016\/j.jbior.2026.101186","relation":{},"ISSN":["2212-4926"],"issn-type":[{"value":"2212-4926","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BNIP3\/NIX-mediated mitophagy versus Parkin-mediated mitophagy: mechanistic differences and functional implications","name":"articletitle","label":"Article Title"},{"value":"Advances in Biological Regulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbior.2026.101186","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101186"}}