{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:47:55Z","timestamp":1793382475138,"version":"4.5.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001863","name":"New Energy and Industrial Technology Development Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Bioscience and Bioengineering"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.jbiosc.2010.01.001","type":"journal-article","created":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T04:18:41Z","timestamp":1265343521000},"page":"8-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering"],"prefix":"10.1016","volume":"110","author":[{"given":"Junichiro","family":"Marui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiko","family":"Ohashi-Kunihiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Machida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiosc.2010.01.001_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/dnares\/dsn020","article-title":"Genomics of Aspergillus oryzae: learning from the history of Koji mold and exploration of its future","volume":"15","author":"Machida","year":"2008","journal-title":"DNA Res."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF00183230","article-title":"On the safety of Aspergillus oryzae: a review","volume":"36","author":"Barbesgaard","year":"1992","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib3","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.fgb.2008.09.006","article-title":"Identification of a novel polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) gene required for the biosynthesis of cyclopiazonic acid in Aspergillus oryzae","volume":"45","author":"Tokuoka","year":"2008","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib4","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nature04300","article-title":"Genome sequencing and analysis of Aspergillus oryzae","volume":"438","author":"Machida","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jbiosc.2010.01.001_bib5","first-page":"45","article-title":"Regulation of penicillin biosynthesis in filamentous fungi","volume":"88","author":"Brakhage","year":"2004","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib6","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nrmicro1286","article-title":"Fungal secondary metabolism \u2014 from biochemistry to genomics","volume":"3","author":"Keller","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib7","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.fgb.2008.03.014","article-title":"The VeA regulatory system and its role in morphological and chemical development in fungi","volume":"45","author":"Calvo","year":"2008","journal-title":"Fungal. Genet. Biol."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib8","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.fgb.2007.12.010","article-title":"A defect of LigD (human Lig4 homolog) for nonhomologous end joining significantly improves efficiency of gene-targeting in Aspergillus oryzae","volume":"45","author":"Mizutani","year":"2008","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib9","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1128\/AAC.39.6.1211","article-title":"A functional classification scheme for \u03b2-lactamases and its correlation with molecular structure","volume":"39","author":"Bush","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib10","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S1389-1723(03)80174-3","article-title":"Overexpression of Aspergillus aculeatus cellobiohydrolase I in Aspergillus oryzae","volume":"95","author":"Kanamasa","year":"2003","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s002530051260","article-title":"Utilization of the TEF1-\u03b1 gene (TEF1) promoter for expression of polygalacturonase genes, pgaA and pgaB, in Aspergillus oryzae","volume":"50","author":"Kitamoto","year":"1998","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib12","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S1389-1723(01)80155-9","article-title":"A second pectin lyase gene (pel2) from Aspergillus oryzae KBN616: its sequence analysis and overexpression, and characterization of the gene products","volume":"91","author":"Kitamoto","year":"2001","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib13","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1263\/jbb.102.564","article-title":"Expression of Aspergillus oryzae phytase gene in Aspergillus oryzae RIB40 niaD(-)","volume":"102","author":"Uchida","year":"2006","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s004380050312","article-title":"\u03b4-(l-\u03b1-aminoadipyl)-l-cysteinyl-d-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans","volume":"253","author":"Kennedy","year":"1996","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1271\/bbb.70.119","article-title":"Construction of a positive selection marker by a lethal gene with the amber stop codon(s) regulator","volume":"70","author":"Ohashi-Kunihiro","year":"2006","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jbiosc.2010.01.001_bib16","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1271\/bbb.60591","article-title":"The \u03b2-1,3-exoglucanase gene exgA (exg1) of Aspergillus oryzae is required to catabolize extracellular glucan, and is induced in growth on a solid surface","volume":"71","author":"Tamano","year":"2007","journal-title":"Biosci. Biotechnol. Biochem."}],"container-title":["Journal of Bioscience and Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389172310000022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389172310000022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:48:19Z","timestamp":1761400099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389172310000022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S1389172310000022"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiosc.2010.01.001","relation":{},"ISSN":["1389-1723"],"issn-type":[{"value":"1389-1723","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering","name":"articletitle","label":"Article Title"},{"value":"Journal of Bioscience and Bioengineering","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiosc.2010.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}