{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:11:03Z","timestamp":1788869463651,"version":"build-2803163510"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Grants-in-Aid for Scientific Research","award":["19592362"],"award-info":[{"award-number":["19592362"]}]},{"name":"Grants-in-Aid for Scientific Research","award":["21592610"],"award-info":[{"award-number":["21592610"]}]},{"name":"Grants-in-Aid for Scientific Research","award":["24593106"],"award-info":[{"award-number":["24593106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Bioscience and Bioengineering"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.jbiosc.2014.08.010","type":"journal-article","created":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T13:00:56Z","timestamp":1411045256000},"page":"260-266","source":"Crossref","is-referenced-by-count":12,"title":["Retinoic acid regulates Lhx8 expression via FGF-8b to the upper jaw development of chick embryo"],"prefix":"10.1016","volume":"119","author":[{"given":"Tadahiro","family":"Shimomura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7424-4882","authenticated-orcid":false,"given":"Masayoshi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouko","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Nochioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadaaki","family":"Kirita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Wanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiosc.2014.08.010_bib1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/gene.20191","article-title":"Cell dissociation experiments reveal that positional information operates in the chicken frontonasal mass","volume":"44","author":"Kawakami","year":"2006","journal-title":"Genesis"},{"key":"10.1016\/j.jbiosc.2014.08.010_bib2","first-page":"190","article-title":"Locally released retinoic acid leads to facial clefts in the chick embryo but does not alter the expression of receptors for fibroblast growth factor","volume":"15","author":"Richman","year":"1995","journal-title":"J.\u00a0Craniofac. Genet. Dev. Biol."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/10454411920040010701","article-title":"The role of retinoids in normal and abnormal embryonic craniofacial morphogenesis","volume":"4","author":"Richman","year":"1992","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib4","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1242\/dev.128.14.2755","article-title":"Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH","volume":"128","author":"Schneider","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.jbiosc.2014.08.010_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0168-9525(99)01883-1","article-title":"Functions of LIM-homeobox genes","volume":"16","author":"Hobert","year":"2000","journal-title":"Trends Genet."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00429-006-0078-0","article-title":"Expression and regulation of the LIM homeodomain gene Lhx8 suggests a role in upper lip development of the chick embryo","volume":"211","author":"Inoue","year":"2006","journal-title":"Anat. Embryol. (Berl)"},{"key":"10.1016\/j.jbiosc.2014.08.010_bib7","first-page":"6","article-title":"Expression profiles of cIRF6, cLHX6 and cLHX7 in the facial primordia suggest specific roles during primary palatogenesis","volume":"24","author":"Washbourne","year":"2006","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib8","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.jbiosc.2013.11.015","article-title":"The Wnt antagonist Dickkopf-1 regulates maxillary development in the chick embryo","volume":"117","author":"Kawakami","year":"2014","journal-title":"J.\u00a0Biosci. Bioeng."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib9","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1242\/dev.125.11.2063","article-title":"Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development","volume":"125","author":"Grigoriou","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.jbiosc.2014.08.010_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1242\/dev.126.1.51","article-title":"Fgf-8 determines rostral-caudal polarity in the first branchial arch","volume":"126","author":"Tucker","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.jbiosc.2014.08.010_bib11","doi-asserted-by":"crossref","first-page":"15002","DOI":"10.1073\/pnas.96.26.15002","article-title":"Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene Lhx8","volume":"96","author":"Zhao","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jbiosc.2014.08.010_bib12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ydbio.2004.08.035","article-title":"Control of retinoic acid synthesis and FGF expression in the nasal pit is required to pattern the craniofacial skeleton","volume":"276","author":"Song","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/74231","article-title":"Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation","volume":"24","author":"Satokata","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ydbio.2012.02.033","article-title":"Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes","volume":"365","author":"Kennedy","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A\u00a0series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J.\u00a0Morphol."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib16","first-page":"326","article-title":"Effects of retinoids on chick face development","volume":"11","author":"Wedden","year":"1991","journal-title":"J.\u00a0Craniofac. Genet. Dev. Biol."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ydbio.2008.03.027","article-title":"FGF signals from the nasal pit are necessary for normal facial morophogenesis","volume":"318","author":"Szabo-Rogers","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ydbio.2003.10.012","article-title":"Fgf and Bmp signals repress the expression of Bapx1 in the mandibular mesenchyme and control the position of the developing jaw joint","volume":"266","author":"Wilson","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s004290050039","article-title":"Alterations in Msx1 and Msx2 expression correlate with inhibition of outgrowth of chick facial primordial induced by retinoic acid","volume":"195","author":"Brown","year":"1997","journal-title":"Anat. Embryol. (Berg)"},{"key":"10.1016\/j.jbiosc.2014.08.010_bib20","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1440-169X.2008.01069.x","article-title":"Retinoic acid affects craniofacial patterning by changing Fgf8 expression in the pharyngeal ectoderm","volume":"50","author":"Abe","year":"2008","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.jbiosc.2014.08.010_bib21","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1242\/dev.02143","article-title":"Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse","volume":"132","author":"Kawauchi","year":"2005","journal-title":"Development"}],"container-title":["Journal of Bioscience and Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389172314003004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389172314003004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T06:22:30Z","timestamp":1650176550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389172314003004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S1389172314003004"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiosc.2014.08.010","relation":{},"ISSN":["1389-1723"],"issn-type":[{"value":"1389-1723","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}