{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:32:52Z","timestamp":1772998372335,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Bioscience and Bioengineering"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.jbiosc.2020.08.004","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T08:13:32Z","timestamp":1598602412000},"page":"659-665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Switching of cell fate through the regulation of cell growth during drug-induced intrahepatic cholestasis"],"prefix":"10.1016","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-8942","authenticated-orcid":false,"given":"Rie","family":"Sonoi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5980-1764","authenticated-orcid":false,"given":"Yoshihisa","family":"Hagihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiosc.2020.08.004_bib1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1056\/NEJMra021844","article-title":"Drug-induced hepatotoxicity","volume":"85","author":"Lee","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1039\/C7LC00952F","article-title":"A\u00a0multi-throughput multi-organ-on-a-chip on a plate formatted pneumatic pressure-driven medium circulation platform","volume":"18","author":"Satoh","year":"2017","journal-title":"Lab Chip"},{"key":"10.1016\/j.jbiosc.2020.08.004_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nrd4539","article-title":"Organs-on-chips at the frontiers of drug discovery","volume":"14","author":"Esch","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd.2016.175","article-title":"Screening out irrelevant cell-based models of disease","volume":"15","author":"Horvath","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib5","doi-asserted-by":"crossref","first-page":"15655","DOI":"10.1073\/pnas.232137699","article-title":"Infection of a human hepatoma cell line by hepatitis B virus","volume":"99","author":"Gripon","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jbiosc.2020.08.004_bib6","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1053\/j.gastro.2004.01.002","article-title":"Origin and characterization of a human bipotent liver progenitor cell line","volume":"126","author":"Parent","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jbiosc.2020.08.004_bib7","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1517\/17425255.2012.685159","article-title":"The HepaRG cell line: a unique in\u00a0vitro tool for understanding drug metabolism and toxicology in human","volume":"8","author":"Andersson","year":"2012","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-60761-688-7_1","article-title":"General review on in\u00a0vitro hepatocyte models and their applications","volume":"640","author":"Guguen-Guillouzo","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib9","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1083\/jcb.201608065","article-title":"Cell\u2013cell adhesion accounts for the different orientation of columnar and hepatocytic cell divisions","volume":"216","author":"L\u00e1zaro-Di\u00e9quez","year":"2017","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.reth.2019.08.006","article-title":"Intact extracellular matrix component promotes maintenance of liver-specific functions and larger aggregates formation of primary rat hepatocytes","volume":"11","author":"Bual","year":"2019","journal-title":"Regen. Ther."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib11","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.biomaterials.2006.10.008","article-title":"Primary hepatocyte survival on non-integrin-recognizable matrices without the activation of Akt signaling","volume":"28","author":"Hoshiba","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.jbiosc.2020.08.004_bib12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/j.2040-4603.2013.tb00490.x","article-title":"Hepatocyte polarity","volume":"3","author":"Treyer","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib13","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/hep.1840170225","article-title":"The biology of the bile canaliculus, 1993","volume":"17","author":"Arias","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.jbiosc.2020.08.004_bib14","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.jhep.2015.06.015","article-title":"Structural and functional hepatocyte polarity and liver disease","volume":"63","author":"Gissen","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.cellbio.21.020604.150721","article-title":"Rho GTPases: biochemistry and biology","volume":"21","author":"Jaffe","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib16","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1124\/dmd.116.071373","article-title":"Early alterations of bile canaliculi dynamics and the Rho kinase\/myosin light chain kinase pathway are characteristics of drug-induced intrahepatic cholestasis","volume":"44","author":"Burbank","year":"2016","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib17","doi-asserted-by":"crossref","first-page":"24709","DOI":"10.1038\/srep24709","article-title":"Rho-kinase\/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs","volume":"6","author":"Sharanek","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2818.1993.tb03315.x","article-title":"Aberrations in confocal fluorescence microscopy induced by mismatches in refractive index","volume":"169","author":"Hell","year":"1993","journal-title":"J.\u00a0Microsc."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbiosc.2020.08.004_bib20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/35070009","article-title":"Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK \u2160","volume":"3","author":"Coleman","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib21","doi-asserted-by":"crossref","first-page":"14495","DOI":"10.1073\/pnas.0601911103","article-title":"Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis","volume":"103","author":"Chang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jbiosc.2020.08.004_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/BJ20101721","article-title":"LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice","volume":"434","author":"Woods","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.taap.2009.06.022","article-title":"Altered integrity and decreased expression of hepatocyte tight junctions in rifampicin-induced cholestasis in mice","volume":"240","author":"Chen","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib24","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00204-019-02437-2","article-title":"Mechanisms and in\u00a0vitro models of drug-induced cholestasis","volume":"93","author":"Gijbels","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.yexcr.2005.07.017","article-title":"Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in\u00a0vitro","volume":"310","author":"Murata","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib26","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/toxsci\/kfz154","article-title":"Novel mechanisms of valproate hepatotoxicity: impaired mrp2 trafficking and hepatocyte depolarization","volume":"171","author":"Fu","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib27","first-page":"1463","article-title":"Tight junction proteins and signal transduction pathways in hepatocytes","volume":"24","author":"Kojima","year":"2009","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jbiosc.2015.05.019","article-title":"Facilitation of uniform maturation of human retinal pigment epithelial cells through collective movement in culture","volume":"121","author":"Sonoi","year":"2016","journal-title":"J.\u00a0Biosci. Bioeng."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib29","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1167\/iovs.18-26260","article-title":"Modulation of contact inhibition by ZO-1\/ZONAB gene transfer-A new strategy to increase the endothelial cell density of corneal grafts","volume":"60","author":"Kanpik","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib30","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1681\/ASN.2009070698","article-title":"ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells","volume":"21","author":"Lima","year":"2010","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib31","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1038\/onc.2008.344","article-title":"Tight junction-based epithelial microenvironment and cell proliferation","volume":"27","author":"Tsukita","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.jbiosc.2020.08.004_bib32","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1083\/jcb.200210020","article-title":"The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density","volume":"160","author":"Balda","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbiosc.2020.08.004_bib33","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/hep.21222","article-title":"An MLCK-dependent window in late G1 controls S phase entry of proliferating rodent hepatocytes via ERK-p70S6K pathway","volume":"44","author":"Bessard","year":"2006","journal-title":"Hepatology"}],"container-title":["Journal of Bioscience and Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389172320303030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389172320303030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:58:42Z","timestamp":1761400722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389172320303030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S1389172320303030"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiosc.2020.08.004","relation":{},"ISSN":["1389-1723"],"issn-type":[{"value":"1389-1723","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Switching of cell fate through the regulation of cell growth during drug-induced intrahepatic cholestasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Bioscience and Bioengineering","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiosc.2020.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Society for Biotechnology, Japan. All rights reserved.","name":"copyright","label":"Copyright"}]}}