{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:43:41Z","timestamp":1760100221928,"version":"3.44.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["08A030100610"],"award-info":[{"award-number":["08A030100610"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","award":["20070401034007"],"award-info":[{"award-number":["20070401034007"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["KRF-2007-313-D00248"],"award-info":[{"award-number":["KRF-2007-313-D00248"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.jbiotec.2009.09.023","type":"journal-article","created":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T05:03:33Z","timestamp":1255410213000},"page":"84-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["A novel anti-EGFR monoclonal antibody inhibiting tumor cell growth by recognizing different epitopes from cetuximab"],"prefix":"10.1016","volume":"145","author":[{"given":"Kwang-Won","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Goo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Hwan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Won","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Hwan","family":"Ryoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiotec.2009.09.023_bib1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/08977190802312844","article-title":"EGFR family: structure physiology signalling and therapeutic targets","volume":"26","author":"Burgess","year":"2008","journal-title":"Growth Factors"},{"key":"10.1016\/j.jbiotec.2009.09.023_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jim.2004.01.024","article-title":"Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments","volume":"287","author":"Cochran","year":"2004","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jbiotec.2009.09.023_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0168-1656(96)01625-2","article-title":"Expression and characterization of a mouse\/human chimeric antibody specific for EGF receptor","volume":"52","author":"Ferrer","year":"1996","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1535-6108(04)00083-2","article-title":"Insights into ErbB signaling from the structure of the ErbB2\u2013pertuzumab complex","volume":"5","author":"Franklin","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbiotec.2009.09.023_bib5","doi-asserted-by":"crossref","first-page":"7755","DOI":"10.1016\/S0021-9258(17)42857-2","article-title":"Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity","volume":"259","author":"Gill","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.pharmtox.44.101802.121440","article-title":"ErbB receptors: directing key signaling networks throughout life","volume":"44","author":"Holbro","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib7","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc1913","article-title":"Comparing antibody and small-molecule therapies for cancer","volume":"6","author":"Imai","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbiotec.2009.09.023_bib8","doi-asserted-by":"crossref","first-page":"30375","DOI":"10.1074\/jbc.M401218200","article-title":"Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor","volume":"279","author":"Johns","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1073\/pnas.232686499","article-title":"A monoclonal antibody recognizing human cancers with amplification\/overexpression of the human epidermal growth factor receptor","volume":"100","author":"Jungbluth","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib10","doi-asserted-by":"crossref","first-page":"726","DOI":"10.4161\/cbt.7.5.6097","article-title":"Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425","volume":"7","author":"Kamat","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib11","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.jmb.2007.10.034","article-title":"Comparative analyses of complex formation and binding sites between human tumor necrosis factor-alpha and its three antagonists elucidate their different neutralizing mechanisms","volume":"374","author":"Kim","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/027245701753179857","article-title":"Characterization of monoclonal antibodies against carcinoembryonic antigen (CEA) and expression in E. coli","volume":"20","author":"Kim","year":"2001","journal-title":"Hybridoma"},{"key":"10.1016\/j.jbiotec.2009.09.023_bib13","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/prot.20618","article-title":"Directed evolution of the epidermal growth factor receptor extracellular domain for expression in yeast","volume":"62","author":"Kim","year":"2006","journal-title":"Proteins"},{"key":"10.1016\/j.jbiotec.2009.09.023_bib14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF01518520","article-title":"Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies","volume":"37","author":"Lewis","year":"1993","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ccr.2005.03.003","article-title":"Structural basis for inhibition of the epidermal growth factor receptor by cetuximab","volume":"7","author":"Li","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbiotec.2009.09.023_bib16","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1053\/j.seminoncol.2006.04.003","article-title":"Epidermal growth factor receptor targeting in cancer","volume":"33","author":"Mendelsohn","year":"2006","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib17","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.1158\/0008-5472.CAN-06-4766","article-title":"A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells","volume":"67","author":"Park","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib18","doi-asserted-by":"crossref","first-page":"9906","DOI":"10.1016\/S0021-9258(17)42785-2","article-title":"Monoclonal antibodies against the human epidermal growth factor receptor from A431 cells. Isolation, characterization, and use in the purification of active epidermal growth factor receptor","volume":"259","author":"Parker","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib19","first-page":"511","article-title":"Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors","volume":"1","author":"Sato","year":"1983","journal-title":"Mol. Biol. Med."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib20","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ccr.2008.02.019","article-title":"Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization","volume":"13","author":"Schmiedel","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbiotec.2009.09.023_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3858\/emm.2008.40.1.35","article-title":"Characterization of a novel anti-human TNF-alpha murine monoclonal antibody with high binding affinity and neutralizing activity","volume":"40","author":"Song","year":"2008","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jbiotec.2009.09.023_bib22","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1182\/blood-2005-02-0488","article-title":"Gefitinib induces myeloid differentiation of acute myeloid leukemia","volume":"106","author":"Stegmaier","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jbiotec.2009.09.023_bib23","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jmb.2007.05.011","article-title":"Impact of single-chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells","volume":"371","author":"Zhou","year":"2007","journal-title":"J. Mol. Biol."}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165609004301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165609004301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T12:44:51Z","timestamp":1759149891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165609004301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0168165609004301"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2009.09.023","relation":{},"ISSN":["0168-1656"],"issn-type":[{"type":"print","value":"0168-1656"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel anti-EGFR monoclonal antibody inhibiting tumor cell growth by recognizing different epitopes from cetuximab","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2009.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}