{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:03:21Z","timestamp":1788822201146,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Science and Technology (DST), New Delhi, India"},{"name":"Jawaharlal Nehru University (JNU), New Delhi, India"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.jbiotec.2014.01.033","type":"journal-article","created":{"date-parts":[[2014,2,15]],"date-time":"2014-02-15T18:00:33Z","timestamp":1392487233000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Generation of protective immune response against anthrax by oral immunization with protective antigen plant-based vaccine"],"prefix":"10.1016","volume":"176","author":[{"given":"Jyotsna","family":"Gorantala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonam","family":"Grover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Rahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prerna","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Rajwanshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neera Bhalla","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Bhatnagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiotec.2014.01.033_bib0005","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1128\/IAI.73.7.4043-4053.2005","article-title":"Oral spore vaccine based on live attenuated nontoxinogenic Bacillus anthracis expressing recombinant mutant protective antigen","volume":"73","author":"Aloni-Grinstein","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0010","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1096\/fj.04-3215fje","article-title":"Transformation of an edible crop with the pagA gene of Bacillus anthracis","volume":"19","author":"Aziz","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0015","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0006-291X(02)02625-6","article-title":"Expression of protective antigen in transgenic plants: a step towards edible vaccine against anthrax","volume":"299","author":"Aziz","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0020","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1016\/j.vaccine.2008.09.010","article-title":"Towards a human oral vaccine for anthrax: the utility of a Salmonella Typhi Ty21a-based prime-boost immunization strategy","volume":"26","author":"Baillie","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0025","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.1016\/j.vaccine.2005.06.033","article-title":"Mucosal and systemic immunization elicited by Newcastle disease virus (NDV) transgenic plants as antigens","volume":"23","author":"Berinstein","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0030","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1128\/IAI.00070-07","article-title":"Mucosal immunization with a novel nanoemulsion-based recombinant anthrax protective antigen vaccine protects against Bacillus anthracis spore challenge","volume":"75","author":"Bielinska","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0035","doi-asserted-by":"crossref","first-page":"C1402","DOI":"10.1152\/ajpcell.00582.2004","article-title":"ATR\/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis\u2019 three sites of entry: implications for the pathogenesis of anthrax infection","volume":"288","author":"Bonuccelli","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0040","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.4049\/jimmunol.170.11.5636","article-title":"Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen","volume":"170","author":"Boyaka","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0045","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.addr.2005.01.028","article-title":"Molecular basis for improved anthrax vaccines","volume":"57","author":"Brey","year":"2005","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0050","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1046\/j.1365-2672.1999.00895.x","article-title":"Antigen delivery by attenuated Bacillus anthracis: new prospects in veterinary vaccines","volume":"87","author":"Brossier","year":"1999","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013849","article-title":"Phase I study of safety and immunogenicity of an Escherichia coli-derived recombinant protective antigen (rPA) vaccine to prevent anthrax in adults","volume":"5","author":"Brown","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0060","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/biot.200800213","article-title":"Efficacy of recombinant anthrax vaccine against Bacillus anthracis aerosol spore challenge: preclinical evaluation in rabbits and Rhesus monkeys","volume":"4","author":"Chawla","year":"2009","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0065","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.micpath.2005.02.001","article-title":"The detection of protective antigen (PA) associated with spores of Bacillus anthracis and the effects of anti-PA antibodies on spore germination and macrophage interactions","volume":"38","author":"Cote","year":"2005","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0070","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tplants.2009.09.009","article-title":"Plant-made vaccine antigens and biopharmaceuticals","volume":"14","author":"Daniell","year":"2009","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0075","doi-asserted-by":"crossref","first-page":"10638","DOI":"10.1073\/pnas.1002348107","article-title":"Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax","volume":"107","author":"Datta","year":"2010","journal-title":"PNAS"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0080","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1016\/j.vaccine.2007.03.048","article-title":"Evaluation of combinatorial vaccines against anthrax and plague in a murine model","volume":"25","author":"DuBois","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0085","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.0105-2896.2005.00280.x","article-title":"Oral tolerance","volume":"206","author":"Faria","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0090","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.vetmic.2009.08.016","article-title":"Anthrax undervalued zoonosis","volume":"140","author":"Fasanella","year":"2010","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0095","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.iy.08.040190.001511","article-title":"Lymphokine control of in vivo immunoglobulin isotype selection","volume":"8","author":"Finkelman","year":"1990","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0100","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1128\/IAI.70.3.1653-1656.2002","article-title":"A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection","volume":"70","author":"Flick-Smith","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0105","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.vaccine.2004.11.010","article-title":"Mucosal adjuvants","volume":"23","author":"Freytag","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0110","first-page":"691","article-title":"Pathology of experimental inhalation anthrax in the rhesus monkey","volume":"73","author":"Fritz","year":"1995","journal-title":"Lab. Invest."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0115","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1371\/journal.ppat.0030076","article-title":"Primary involvement of pharynx and Peyer's patch in inhalational and intestinal anthrax","volume":"3","author":"Glomski","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0120","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1016\/j.vaccine.2011.03.082","article-title":"A plant based protective antigen [PA(dIV)] vaccine expressed in chloroplasts demonstrates protective immunity in mice against anthrax","volume":"29","author":"Gorantala","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0125","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/modpathol.3880337","article-title":"Quantitative pathology of inhalational anthrax I: quantitative microscopic findings","volume":"14","author":"Grinberg","year":"2001","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0130","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ijmm.2007.09.007","article-title":"Bacillus anthracis: balancing innocent research with dual-use potential","volume":"298","author":"Hudson","year":"2008","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0135","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/0264-410X(95)00139-R","article-title":"Experimental anthrax vaccines: efficacy of adjuvants combined with protective antigen against an aerosol Bacillus anthracis spore challenge in guinea pigs","volume":"13","author":"Ivins","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0140","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/sj.embor.7400470","article-title":"Molecular farming for new drugs and vaccines\u2014current perspectives on the production of pharmaceuticals in transgenic plants","volume":"6","author":"Ma","year":"2005","journal-title":"Embo Rep."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/mi.2007.6","article-title":"The immune geography of IgA induction and function","volume":"1","author":"Macpherson","year":"2008","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0150","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1128\/IAI.72.6.3471-3477.2004","article-title":"Contribution of immunological memory to protective immunity conferred by a Bacillus anthracis protective antigen-based vaccine","volume":"72","author":"Marcus","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0155","doi-asserted-by":"crossref","first-page":"13584","DOI":"10.1073\/pnas.0405297101","article-title":"A mucosally targeted subunit vaccine candidate eliciting HIV-1 transcytosis-blocking Abs","volume":"101","author":"Matoba","year":"2004","journal-title":"PNAS"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0160","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1016\/S0264-410X(01)00234-1","article-title":"In vitro correlate of immunity in a rabbit model of inhalational anthrax","volume":"19","author":"Pitt","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0165","doi-asserted-by":"crossref","first-page":"20124","DOI":"10.1016\/S0021-9258(18)54899-7","article-title":"Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis","volume":"266","author":"Quinn","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0170","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1128\/IAI.69.5.2888-2893.2001","article-title":"Search for correlates of protective immunity conferred by anthrax vaccine","volume":"69","author":"Reuveny","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0175","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1016\/j.vaccine.2007.05.003","article-title":"Evaluation of immune response to orally administered Sterne strain 34F2 anthrax vaccine","volume":"25","author":"Shakya","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0180","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1073\/pnas.0502159102","article-title":"Anthrax lethal factor inhibition","volume":"102","author":"Shoop","year":"2005","journal-title":"PNAS"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0185","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1128\/IAI.01242-06","article-title":"Oral administration of a Salmonella enterica-based vaccine expressing Bacillus anthracis protective antigen confers protection against aerosolized B-anthracis","volume":"75","author":"Stokes","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0190","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1073\/pnas.90.3.913","article-title":"High-frequency plastid transformation in tobacco by selection for a chimeric aadA gene","volume":"90","author":"Svab","year":"1993","journal-title":"PNAS"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0195","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1517\/14728214.10.1.185","article-title":"Transgenic plants in the biopharmaceutical market","volume":"10","author":"Twyman","year":"2005","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0200","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0958-1669(03)00026-0","article-title":"Plant cell factories and mucosal vaccines","volume":"14","author":"Walmsley","year":"2003","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0205","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-9433-4-4","article-title":"Anthrax vaccine design: strategies to achieve comprehensive protection against spore, bacillus, and toxin","volume":"4","author":"Wang","year":"2005","journal-title":"Med. Immunol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0210","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1099\/0022-1317-51-10-821","article-title":"In-vitro characterisation of the phagocytosis and fate of anthrax spores in macrophages and the effects of anti-PA antibody","volume":"51","author":"Welkos","year":"2002","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0215","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1099\/00221287-147-6-1677","article-title":"The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores","volume":"147","author":"Welkos","year":"2001","journal-title":"Microbiology\u2014SGM"},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0220","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1046\/j.1365-2672.1999.00901.x","article-title":"Presentation of protective antigen to the mouse immune system: immune sequelae","volume":"87","author":"Williamson","year":"1999","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0225","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1046\/j.1365-2672.1999.00900.x","article-title":"Expression of the protective antigen of Bacillus anthracis by Lactobacillus casei: towards the development of an oral vaccine against anthrax","volume":"87","author":"Zegers","year":"1999","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.jbiotec.2014.01.033_bib0230","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1467-7652.2006.00191.x","article-title":"Tomato is a highly effective vehicle for expression and oral immunization with Norwalk virus capsid protein","volume":"4","author":"Zhang","year":"2006","journal-title":"Plant Biotechnol. J."}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165614000571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165614000571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T18:14:16Z","timestamp":1648318456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165614000571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":46,"alternative-id":["S0168165614000571"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2014.01.033","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of protective immune response against anthrax by oral immunization with protective antigen plant-based vaccine","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2014.01.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}