{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:09:12Z","timestamp":1771261752050,"version":"3.50.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.jbiotec.2014.08.001","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T21:47:30Z","timestamp":1408571250000},"page":"15-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Proteomics analysis of altered cellular metabolism induced by insufficient copper level"],"prefix":"10.1016","volume":"189","author":[{"given":"Sohye","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Trentalange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel V.","family":"Bondarenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiotec.2014.08.001_bib0005","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cmet.2012.07.015","article-title":"NDUFA4 is a subunit of complex IV of the mammalian electron transport chain","volume":"16","author":"Balsa","year":"2012","journal-title":"Cell Metabol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0010","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/jmg.2007.052746","article-title":"Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes","volume":"44","author":"de Bie","year":"2007","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0015","doi-asserted-by":"crossref","first-page":"15196","DOI":"10.1073\/pnas.1107819108","article-title":"Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryoelectron tomography","volume":"108","author":"Dudkina","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0020","doi-asserted-by":"crossref","first-page":"C1129","DOI":"10.1152\/ajpcell.00233.2006","article-title":"Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process","volume":"291","author":"Fontanesi","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0025","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s12011-010-8858-z","article-title":"The cardiac copper chaperone proteins Sco1 and CCS are up-regulated, but Cox 1 and Cox4 are down-regulated, by copper deficiency","volume":"143","author":"Getz","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2003.058701","article-title":"Lactate metabolism: a new paradigm for the third millennium","volume":"558","author":"Gladden","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0035","first-page":"33","article-title":"The ATP dependent pathway for protein breakdown in bacteria and mitochondria","volume":"180","author":"Goldberg","year":"1985","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0040","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11011-009-9135-8","article-title":"Augmented cerebellar lactate in copper deficient rat pups originates from both blood and cerebellum","volume":"24","author":"Gybina","year":"2009","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0045","doi-asserted-by":"crossref","first-page":"19507","DOI":"10.1073\/pnas.1318431110","article-title":"Bioavailable copper modulates oxidative phosphorylation and growth of tumors","volume":"110","author":"Ishida","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0050","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.freeradbiomed.2012.08.001","article-title":"Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells","volume":"53","author":"Jarvis","year":"2012","journal-title":"Free Rad. Biol. Med."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0055","article-title":"Cell line profiling to improve monoclonal antibody production","author":"Kang","year":"2013","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbiotec.2003.09.007","article-title":"Large scale gene expression profiling of metabolic shift of mammalian cells in culture","volume":"107","author":"Korke","year":"2004","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0065","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.1128\/MCB.00849-06","article-title":"Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63","volume":"26","author":"Latysheva","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0070","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1089\/ars.2009.2704","article-title":"Structure and organization of mitochondrial respiratory complexes: a new understanding of an old subject","volume":"12","author":"Lenaz","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0075","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nbt.2624","article-title":"Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome","volume":"31","author":"Lewis","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0080","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4161\/mabs.2.5.12720","article-title":"Cell culture processes for monoclonal antibody production","volume":"2","author":"Li","year":"2010","journal-title":"mAbs"},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0085","doi-asserted-by":"crossref","first-page":"23504","DOI":"10.1074\/jbc.270.40.23504","article-title":"Degradation of plastocyanin in copper-deficient Chlamydomonas reinhardtii. Evidence for a protease-susceptible conformation of the apoprotein and regulated proteolysis","volume":"270","author":"Li","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0090","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/bit.24389","article-title":"Feeding lactate for CHO cell culture processes: impact on culture metabolism and performance","volume":"109","author":"Li","year":"2012","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0095","doi-asserted-by":"crossref","first-page":"17557","DOI":"10.1074\/jbc.M701056200","article-title":"An assembled complex IV maintains the stability and activity of complex I in mammalian mitochondria","volume":"282","author":"Li","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0100","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cmet.2011.07.014","article-title":"Metabolic flux and the regulation of mammalian cell growth","volume":"14","author":"Locasale","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0105","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0022-3476(81)80770-6","article-title":"Metabolic consequences of trichopoliodystrophy","volume":"98","author":"Loyola","year":"1981","journal-title":"J. Pediat."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0110","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/bit.23291","article-title":"Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process","volume":"109","author":"Luo","year":"2012","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0300-9629(96)00365-9","article-title":"Cardiac nuclear encoded cytochrome c oxidase subunits are decreased with copper restriction but not iron restriction: gene expression, protein synthesis and heat shock protein aspects","volume":"117","author":"Medeiros","year":"1997","journal-title":"Comparative biochemistry and physiology. Part A, Physiology"},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0115","first-page":"764","article-title":"A sex-linked recessive disorder with retardation of growth, peculiar hair, and focal cerebral and cerebellar degeneration","volume":"29","author":"Menkes","year":"1962","journal-title":"Pediatrics"},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/nrm3029","article-title":"Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation","volume":"12","author":"Mick","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0125","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ymben.2011.12.006","article-title":"On metabolic shift to lactate consumption in fed-batch culture of mammalian cells","volume":"14","author":"Mulukutla","year":"2012","journal-title":"Metab. Eng."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0130","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.braindev.2004.08.002","article-title":"The effects of copper-histidine therapy on brain metabolism in a patient with Menkes disease: a proton magnetic resonance spectroscopic study","volume":"27","author":"Munakata","year":"2005","journal-title":"Brain Dev."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0135","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1128\/MCB.15.8.4441","article-title":"Multiple genes, including a member of the AAA family, are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria","volume":"15","author":"Nakai","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0140","doi-asserted-by":"crossref","first-page":"791S","DOI":"10.1093\/ajcn\/63.5.791","article-title":"Copper as an essential nutrient","volume":"63","author":"Olivares","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0145","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/bit.21460","article-title":"Proteome analysis of antibody-producing CHO cell lines with different metabolic profiles","volume":"98","author":"Pascoe","year":"2007","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0150","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00418-013-1123-8","article-title":"Golgi in copper homeostasis: a view from the membrane trafficking field","volume":"140","author":"Polishchuk","year":"2013","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0155","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/btpr.630","article-title":"Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells","volume":"27","author":"Qian","year":"2011","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0160","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s002940050145","article-title":"The role of protein degradation in mitochondrial function and biogenesis","volume":"30","author":"Rep","year":"1996","journal-title":"Curr. Genet."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0165","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1023\/A:1005675012708","article-title":"Oxidative abnormalities in Menkes disease","volume":"23","author":"Rizzo","year":"2000","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0170","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/emboj\/19.8.1777","article-title":"Supercomplexes in the respiratory chains of yeast and mammalian mitochondria","volume":"19","author":"Schagger","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0175","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/bp010101g","article-title":"Proteomic investigation of metabolic shift in mammalian cell culture","volume":"17","author":"Seow","year":"2001","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0180","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1074\/mcp.M500230-MCP200","article-title":"Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition","volume":"5","author":"Silva","year":"2006","journal-title":"Mol. Cell. Proteom. MCP"},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0185","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1021\/pr049941r","article-title":"Using immobilized metal affinity chromatography, two-dimensional electrophoresis and mass spectrometry to identify hepatocellular proteins with copper-binding ability","volume":"3","author":"Smith","year":"2004","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0190","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.bbabio.2011.09.005","article-title":"Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core","volume":"1817","author":"Soto","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0195","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1074\/jbc.M805733200","article-title":"Complex I function is defective in complex IV-deficient Caenorhabditis elegans","volume":"284","author":"Suthammarak","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0200","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1126\/science.7652554","article-title":"Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A","volume":"269","author":"Tsukihara","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0205","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1126\/science.272.5265.1136","article-title":"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A","volume":"272","author":"Tsukihara","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0210","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/ejhg.2009.187","article-title":"Menkes disease","volume":"18","author":"Tumer","year":"2010","journal-title":"Euro. J. Hum. Genet. EJHG"},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0215","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1038\/onc.2012.624","article-title":"Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer","volume":"32","author":"Turner-Ivey","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0220","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1074\/jbc.R800055200","article-title":"New roles for copper metabolism in cell proliferation, signaling, and disease","volume":"284","author":"Turski","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0225","doi-asserted-by":"crossref","first-page":"e32527","DOI":"10.1371\/journal.pone.0032527","article-title":"Proteomic profile of reversible protein oxidation using PROP, purification of reversibly oxidized proteins","volume":"7","author":"Victor","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0230","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pep.2006.11.014","article-title":"Cox17, a copper chaperone for cytochrome c oxidase: expression, purification, and formation of mixed disulphide adducts with thiol reagents","volume":"53","author":"Voronova","year":"2007","journal-title":"Protein Express. Purif."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0235","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2527\/1999.773677x","article-title":"The influence of betaine on untrained and trained horses exercising to fatigue","volume":"77","author":"Warren","year":"1999","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0240","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cmet.2013.02.004","article-title":"Iron and copper in mitochondrial diseases","volume":"17","author":"Xu","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0245","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nbt.1932","article-title":"The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line","volume":"29","author":"Xu","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0250","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.tcb.2009.06.004","article-title":"Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes","volume":"19","author":"Yanez-Mo","year":"2009","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0255","doi-asserted-by":"crossref","DOI":"10.1002\/btpr.1868","article-title":"Effects of copper on CHO cells: Insights from gene expression analyses","author":"Yuk","year":"2014","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0260","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.nbt.2012.05.021","article-title":"Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity","volume":"30","author":"Zagari","year":"2013","journal-title":"New Biotechnol."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0265","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/jn\/137.1.14","article-title":"Copper deficiency decreases complex IV but not complex I, II, III, or V in the mitochondrial respiratory chain in rat heart","volume":"137","author":"Zeng","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0270","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1021\/ac049951b","article-title":"Prediction of low-energy collision-induced dissociation spectra of peptides","volume":"76","author":"Zhang","year":"2004","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0275","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1021\/ac050857k","article-title":"Prediction of low-energy collision-induced dissociation spectra of peptides with three or more charges","volume":"77","author":"Zhang","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jbiotec.2014.08.001_bib0280","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1021\/ac901193n","article-title":"Large-scale identification and quantification of covalent modifications in therapeutic proteins","volume":"81","author":"Zhang","year":"2009","journal-title":"Anal. Chem."}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165614007986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165614007986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T04:41:20Z","timestamp":1565757680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165614007986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":57,"alternative-id":["S0168165614007986"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2014.08.001","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomics analysis of altered cellular metabolism induced by insufficient copper level","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2014.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}