{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:07:16Z","timestamp":1761646036640},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Chemical Engineering at Michigan Technological University"},{"name":"MTU-REF Research Seed Grant"},{"name":"Biotechnology Research Center at Michigan Technological University"},{"DOI":"10.13039\/100000001","name":"National Science Foundation (NSF)","doi-asserted-by":"crossref","award":["CBET-1159425"],"award-info":[{"award-number":["CBET-1159425"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.jbiotec.2015.03.030","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T13:38:33Z","timestamp":1428759513000},"page":"8-11","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Enveloped virus flocculation and removal in osmolyte solutions"],"prefix":"10.1016","volume":"206","author":[{"given":"Maria F.","family":"Gencoglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caryn. L.","family":"Heldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jbiotec.2015.03.030_bib0005","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ejor.2013.05.034","article-title":"Operational issues and network effects in vaccine markets","volume":"231","author":"Adida","year":"2013","journal-title":"Eur. J. Oper. Res."},{"issue":"1","key":"10.1016\/j.jbiotec.2015.03.030_bib0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.memsci.2004.12.053","article-title":"Combined models of membrane fouling: development and application to microfiltration and ultrafiltration of biological fluids","volume":"277","author":"Bolton","year":"2006","journal-title":"J. Membr. Sci."},{"issue":"1","key":"10.1016\/j.jbiotec.2015.03.030_bib0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/btpr.705","article-title":"Precipitation of filamentous bacteriophages for their selective recovery in primary purification","volume":"28","author":"Branston","year":"2012","journal-title":"Biotechnol. Prog."},{"issue":"1","key":"10.1016\/j.jbiotec.2015.03.030_bib0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0042-6822(76)90197-5","article-title":"Antigenic characterization of two Sindbis envelope glycoproteins separated by isoelectric focusing","volume":"69","author":"Dalrymple","year":"1976","journal-title":"Virology"},{"key":"10.1016\/j.jbiotec.2015.03.030_bib0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jbiotec.2014.06.011","article-title":"Porcine Parvovirus flocculation and removal in the presence of osmolytes","volume":"186","author":"Gencoglu","year":"2014","journal-title":"J. Biotecnol."},{"issue":"1","key":"10.1016\/j.jbiotec.2015.03.030_bib0030","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/btpr.1816","article-title":"Enveloped virus inactivation using neutral arginine solutions and applications in therapeutic protein purification processes","volume":"30","author":"McCue","year":"2014","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jbiotec.2015.03.030_bib0035","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.carres.2014.01.017","article-title":"Virus adsorption of water-stable quaternized chitosan nanofibers","volume":"387","author":"Mi","year":"2014","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.jbiotec.2015.03.030_bib0040","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1038\/sj.gt.3302624","article-title":"Downstream processing of viral vectors and vaccines","volume":"12","author":"Morenweiser","year":"2005","journal-title":"Gene Ther."},{"key":"10.1016\/j.jbiotec.2015.03.030_bib0045","series-title":"Virology: Molecular Biology and Pathogenesis","author":"Norkin","year":"2010"},{"issue":"10","key":"10.1016\/j.jbiotec.2015.03.030_bib0050","article-title":"Challenges and trends in vaccine manufacturing","volume":"24","author":"Ray","year":"2011","journal-title":"Biopharm. Int."},{"issue":"10","key":"10.1016\/j.jbiotec.2015.03.030_bib0055","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1002\/jps.23668","article-title":"Effects of temperature and osmolytes on competing degradation routes for an IgG1 antibody","volume":"102","author":"Roberts","year":"2013","journal-title":"J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.jbiotec.2015.03.030_bib0060","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.biologicals.2008.06.002","article-title":"Virus inactivation by solvent\/detergent treatment using Triton X-100 in a high purity factor VIII","volume":"36","author":"Roberts","year":"2008","journal-title":"Biologicals"},{"issue":"4","key":"10.1016\/j.jbiotec.2015.03.030_bib0065","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.biologicals.2007.02.005","article-title":"Virus inactivation by protein denaturants used in affinity chromatography","volume":"35","author":"Roberts","year":"2007","journal-title":"Biologicals"},{"issue":"5","key":"10.1016\/j.jbiotec.2015.03.030_bib0070","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.tibtech.2010.02.001","article-title":"Recent advances in large-scale production of monoclonal antibodies and related proteins","volume":"28","author":"Shukla","year":"2010","journal-title":"Trends Biotechnol."},{"issue":"38","key":"10.1016\/j.jbiotec.2015.03.030_bib0075","doi-asserted-by":"crossref","first-page":"13997","DOI":"10.1073\/pnas.0606236103","article-title":"A molecular mechanism for osmolyte-induced protein stability","volume":"103","author":"Street","year":"2006","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.jbiotec.2015.03.030_bib0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.chroma.2006.12.094","article-title":"Sorption processes in ion-exchange chromatography of viruses","volume":"1142","author":"Trilisky","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jbiotec.2015.03.030_bib0085","series-title":"Global Vaccine Action Plan 2011\u20132020","author":"WHO","year":"2013"},{"issue":"8","key":"10.1016\/j.jbiotec.2015.03.030_bib0090","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1002\/jps.21224","article-title":"Arginine facilitates inactivation of enveloped viruses","volume":"97","author":"Yamasaki","year":"2008","journal-title":"J. Pharm. Sci."}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165615001650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165615001650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T15:52:37Z","timestamp":1537717957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165615001650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":18,"alternative-id":["S0168165615001650"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2015.03.030","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enveloped virus flocculation and removal in osmolyte solutions","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2015.03.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}