{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:06:52Z","timestamp":1768349212048,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jbiotec.2015.06.385","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T23:22:57Z","timestamp":1434237777000},"page":"7-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["A non-pathogenic and optically high concentrated (R,R)-2,3-butanediol biosynthesizing Klebsiella strain"],"prefix":"10.1016","volume":"209","author":[{"given":"Soojin","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeongmo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daun","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soohyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiotec.2015.06.385_bib0005","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.biotechadv.2009.05.002","article-title":"Biotechnological production of 2,3-butanediol\u2014Current state and prospects","volume":"27","author":"Celi\u0144ska","year":"2009","journal-title":"Biotech. Adv."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0010","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1007\/s00253-014-5526-9","article-title":"Mechanism of 2,3-butanediol stereoisomer formation in Klebsiella pneumoniae","volume":"98","author":"Chen","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0015","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1016\/j.biortech.2010.03.143","article-title":"Optimization of medium for one-step fermentation of inulin extract from Jerusalem artichoke tubers using Paenibacillus polymyxa ZJ-9 to produce R,R-2,3-butanediol","volume":"101","author":"Gao","year":"2010","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0020","doi-asserted-by":"crossref","first-page":"35876","DOI":"10.1074\/jbc.M003035200","article-title":"Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product: disruption and induction of the gene","volume":"275","author":"Gonz\u00e1lez","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0025","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.biortech.2012.08.047","article-title":"Enhanced fed-batch fermentation of 2,3-butanediol by Paenibacillus polymyxa DSM 365","volume":"124","author":"H\u00e4\u00dfler","year":"2012","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0030","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.biotechadv.2011.01.007","article-title":"Microbial 2,3-butanediol production: a state-of-the-art review","volume":"29","author":"Ji","year":"2011","journal-title":"Biotech. Adv."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0035","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00253-012-3883-9","article-title":"Deletion of lactate dehydrogenase in Enterobacter aerogenes to enhance 2,3-butanediol production","volume":"95","author":"Jung","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0040","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s00253-012-4284-9","article-title":"Removal of pathogenic factors from 2,3-butanediol-producing Klebsiella species by inactivating virulence-related wabG gene","volume":"97","author":"Jung","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0045","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.4014\/jmb.1201.01044","article-title":"Enhanced 2,3-butanediol production in recombinant Klebsiella pneumoniae via overexpression of synthesis-related genes","volume":"22","author":"Kim","year":"2012","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0050","doi-asserted-by":"crossref","first-page":"e105322","DOI":"10.1371\/journal.pone.0105322","article-title":"Redistribution of carbon flux toward 2,3-butanediol production in Klebsiella pneumoniae by metabolic engineering","volume":"9","author":"Kim","year":"2014","journal-title":"PlOs One"},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0055","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.biortech.2013.07.081","article-title":"Production of 2,3-butanediol by engineered Saccharomyces cerevisiae","volume":"146","author":"Kim","year":"2013","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0060","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.biotechadv.2013.03.004","article-title":"Strain engineering of Saccharomyces cerevisiae for enhanced xylose metabolism","volume":"31","author":"Kim","year":"2013","journal-title":"Biotech. Adv."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0065","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jbiotec.2013.12.017","article-title":"Production of 2,3-butanediol from xylose by engineered Saccharomyces cerevisiae","volume":"192","author":"Kim","year":"2014","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0070","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/A:1013894403987","article-title":"Enhancement of (R,R)-2,3-butanediol production from xylose by Paenibacillus polymyxa at elevated temperatures","volume":"24","author":"Marwoto","year":"2002","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s00253-003-1435-z","article-title":"Metabolic analysis of acetate accumulation during xylose consumption by Paenibacillus polymyxa","volume":"64","author":"Marwoto","year":"2004","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0080","doi-asserted-by":"crossref","first-page":"6832","DOI":"10.1128\/AEM.00881-08","article-title":"The Bacillus subtilis ydjL (bdhA) gene encodes acetoin reductase\/2,3-butanediol dehydrogenase","volume":"74","author":"Nicholson","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0085","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/biot.200900279","article-title":"Metabolic engineering of acetoin and meso-2,3-butanediol biosynthesis in E. coli","volume":"5","author":"Nielsen","year":"2010","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0090","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/anae.1997.0083","article-title":"Molecular cloning, nucleotide sequencing, and expression of genes encoding alcohol dehydrogenases from the thermophile Thermoanaerobacter brockii and the mesophile Clostridium beijerinckii","volume":"3","author":"Peretz","year":"1997","journal-title":"Anaerobe"},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1754-6834-7-16","article-title":"Deletion of meso-2,3-butanediol dehydrogenase gene budC for enhanced d-2,3-butanediol production in Bacillus licheniformis","volume":"7","author":"Qi","year":"2014","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0100","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1023\/A:1026741625019","article-title":"Evaluation of stereoisomers of 2,3-butanediol and acetoin to differentiate Saccharomyces cerevisiae and Kloeckera apiculata wine strains","volume":"22","author":"Romano","year":"2000","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0105","first-page":"805","article-title":"(R,R)-2,3-Butanediol as chlral directing group in the synthesis of (as)-a-chioro boronic esters","volume":"5","author":"Sadhu","year":"1984","journal-title":"Organometallics"},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0110","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1128\/JB.00027-12","article-title":"Complete genome sequence of the 2,3-butanediol-producing Klebsiella pneumoniae strain KCTC 2242","volume":"194","author":"Shin","year":"2012","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0115","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1128\/AEM.01616-10","article-title":"D-2,3-butanediol production due to heterologous expression of an acetoin reductase in Clostridium acetobutylicum","volume":"77","author":"Siemerink","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0120","first-page":"1","article-title":"Genome sequence of Paenibacillus polymyxa ATCC 12,321, a promising strain for optically active (R,R) -2,3-butanediol production","author":"Tong","year":"2013","journal-title":"Genome Announc."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0125","first-page":"1610","article-title":"Metabolic engineering of thermophilic Bacillus licheniformis for chiral pure d-2,3-butanediol production","volume":"109","author":"Wang","year":"2012","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0130","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1074\/jbc.M113.525535","article-title":"Glycerol dehydrogenase plays a dual role in glycerol metabolism and 2,3-butanediol formation in Klebsiella pneumoniae","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0135","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1039\/b913501d","article-title":"Enantioselective synthesis of pure (R,R)-2,3-butanediol in E. coli with stereospecific secondary alcohol dehydrogenases","volume":"7","author":"Yan","year":"2009","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jbiotec.2015.06.385_bib0140","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1128\/AEM.02998-10","article-title":"Novel (2R,3R)-2,3-butanediol dehydrogenase from potential industrial strain Paenibacillus polymyxa ATCC 12,321","volume":"77","author":"Yu","year":"2011","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016816561530016X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016816561530016X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T20:57:36Z","timestamp":1537563456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016816561530016X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":28,"alternative-id":["S016816561530016X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2015.06.385","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A non-pathogenic and optically high concentrated (R,R)-2,3-butanediol biosynthesizing Klebsiella strain","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2015.06.385","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}