{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:12:13Z","timestamp":1758816733035},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Fondazione \u201cIstituto di Ricerca Virologica Oretta Bartolomei Corsi\u201d Florence, Italy"},{"DOI":"10.13039\/501100003500","name":"University of Padova","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009878","name":"Regione Veneto","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009878","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jbiotec.2015.06.391","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T16:23:30Z","timestamp":1434471810000},"page":"85-90","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Small RNAs targeting the 5\u2032 end of the viral polymerase gene segments specifically interfere with influenza type A virus replication"],"prefix":"10.1016","volume":"210","author":[{"given":"Francesco","family":"Martelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Salata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Calistri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Parolin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberta","family":"Azzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Pal\u00f9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Giannecchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiotec.2015.06.391_bib0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0928-0987(00)00208-6","article-title":"Antisense therapy of influenza","volume":"13","author":"Abe","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0010","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3851\/IMP2064","article-title":"The promise, pitfalls and progress of RNA-interference-based antiviral therapy for respiratory viruses","volume":"17","author":"DeVincenzo","year":"2012","journal-title":"Antiviral Ther."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0015","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/135965350801300112","article-title":"In vitro and in vivo protection against the highly pathogenic H5N1 influenza virus by an antisense phosphorothioate oligonucleotide","volume":"13","author":"Duan","year":"2008","journal-title":"Antiviral Ther."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0020","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1128\/AAC.00644-06","article-title":"Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers","volume":"50","author":"Ge","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0025","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00705-009-0380-2","article-title":"Oligonucleotides derived from the packaging signal at the 5\u2032 end of the viral PB2 segment specifically inhibit influenza virus in vitro","volume":"154","author":"Giannecchini","year":"2009","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0030","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.antiviral.2011.06.013","article-title":"Packaging signals in the 5\u2032-ends of influenza virus PA, PB1, and PB2 genes as potential targets to develop nucleic-acid based antiviral molecules","volume":"92","author":"Giannecchini","year":"2011","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0035","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1099\/vir.0.017608-0","article-title":"Genome packaging in influenza A virus","volume":"91","author":"Hutchinson","year":"2010","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12033-013-9670-8","article-title":"Cross-protective effect of antisense oligonucleotide developed against the common 3\u2032 NCR of influenza A virus genome","volume":"55","author":"Kumar","year":"2013","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0045","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00705-008-0262-z","article-title":"Inhibition of influenza A virus replication by short double-stranded oligodeoxynucleotides","volume":"154","author":"Kwok","year":"2009","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0050","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.antiviral.2012.09.013","article-title":"Targeting the host or the virus: current and novel concepts for antiviral approaches against influenza virus infection","volume":"96","author":"Lee","year":"2012","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0055","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s00705-011-1087-8","article-title":"Inhibition of influenza A virus replication by RNA interference targeted against the PB1 subunit of the RNA polymerase gene","volume":"156","author":"Li","year":"2011","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0060","series-title":"Field Virology","first-page":"1647","article-title":"Orthomyxoviridae: the viruses and their replication","author":"Palese","year":"2007"},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4161\/hv.8.1.18672","article-title":"Influenza viruses: from birds to humans","volume":"8","author":"Reperant","year":"2012","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0264-410X(99)00099-7","article-title":"The global impact of influenza on morbidity and mortality","volume":"17","author":"Simonsen","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.antiviral.2007.12.008","article-title":"Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses","volume":"78","author":"Spurgers","year":"2008","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0080","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/B978-0-12-405880-4.00006-8","article-title":"Influenza virus resistance to antiviral therapy","volume":"67","author":"Van der Vries","year":"2013","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0085","first-page":"00018","article-title":"Delivery of oligonucleotides with lipid nanoparticles","volume":"15","author":"Wang","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jbiotec.2015.06.391_bib0090","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2741\/s102","article-title":"Broad-spectrum and virus-specific nucleic acid-based antivirals against influenza","volume":"2","author":"Wong","year":"2010","journal-title":"Front. Biosci."}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165615300201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165615300201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T15:29:52Z","timestamp":1652455792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165615300201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":18,"alternative-id":["S0168165615300201"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2015.06.391","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small RNAs targeting the 5\u2032 end of the viral polymerase gene segments specifically interfere with influenza type A virus replication","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2015.06.391","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}