{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:15:53Z","timestamp":1790129753166,"version":"4.0.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003381","name":"Minist\u00e9rio da Educa\u00e7\u00e3o e Ci\u00eancia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["REDE\/1517\/RMN\/2005"],"award-info":[{"award-number":["REDE\/1517\/RMN\/2005"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["SFRH\/BD\/45786\/2008"],"award-info":[{"award-number":["SFRH\/BD\/45786\/2008"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/EBB-BIO\/119501\/2010"],"award-info":[{"award-number":["PTDC\/EBB-BIO\/119501\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/Multi\/04462\/2013"],"award-info":[{"award-number":["UID\/Multi\/04462\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jbiotec.2016.05.025","type":"journal-article","created":{"date-parts":[[2016,5,22]],"date-time":"2016-05-22T13:22:56Z","timestamp":1463923376000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Impact of Adenovirus infection in host cell metabolism evaluated by 1H-NMR spectroscopy"],"prefix":"10.1016","volume":"231","author":[{"given":"Ana Carina","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"P. Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1445-3556","authenticated-orcid":false,"given":"Paula","family":"M. Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jbiotec.2016.05.025_bib0005","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/nbm.1099","article-title":"In vitro (1)H NMR studies of RD human cell infection with echovirus 11","volume":"20","author":"Akhtar","year":"2007","journal-title":"NMR Biomed."},{"issue":"2","key":"10.1016\/j.jbiotec.2016.05.025_bib0010","first-page":"171","article-title":"In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units","volume":"1","author":"Barlowe","year":"1988","journal-title":"Biofactors"},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0015","series-title":"Medical Biochemistry","author":"Baynes","year":"2004"},{"issue":"12","key":"10.1016\/j.jbiotec.2016.05.025_bib0020","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1002\/bit.24983","article-title":"Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition","volume":"110","author":"Carinhas","year":"2013","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0025","doi-asserted-by":"crossref","first-page":"23529","DOI":"10.1038\/srep23529","article-title":"Metabolic flux profiling of MDCK cells during growth and canine adenovirus vector production","volume":"6","author":"Carinhas","year":"2016","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jbiotec.2016.05.025_bib0030","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1128\/JVI.02123-09","article-title":"Glutamine metabolism is essential for human cytomegalovirus infection","volume":"84","author":"Chambers","year":"2010","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.jbiotec.2016.05.025_bib0035","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00253-011-3484-z","article-title":"Insight into the roles of hypoxanthine and thymidine [corrected] on cultivating antibody-producing CHO cells: cell growth, antibody production and long-term stability","volume":"93","author":"Chen","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"8","key":"10.1016\/j.jbiotec.2016.05.025_bib0040","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nrm3841","article-title":"The growing landscape of lysine acetylation links metabolism and cell signalling","volume":"15","author":"Choudhary","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.jbiotec.2016.05.025_bib0045","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/(SICI)1097-0290(19990805)64:3<298::AID-BIT6>3.0.CO;2-U","article-title":"The adaptation of BHK cells to a non-ammoniagenic glutamate-based culture medium","volume":"64","author":"Christie","year":"1999","journal-title":"Biotechnol. Bioeng."},{"issue":"7","key":"10.1016\/j.jbiotec.2016.05.025_bib0050","first-page":"662","article-title":"High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification","volume":"8","author":"Cockett","year":"1990","journal-title":"Biotechnology (N Y)"},{"issue":"2","key":"10.1016\/j.jbiotec.2016.05.025_bib0055","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/0042-6822(58)90102-8","article-title":"Glucose and glutamine in poliovirus production by HeLa cells","volume":"6","author":"Darnell","year":"1958","journal-title":"Virology"},{"issue":"23","key":"10.1016\/j.jbiotec.2016.05.025_bib0060","doi-asserted-by":"crossref","first-page":"10696","DOI":"10.1073\/pnas.1004882107","article-title":"Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells","volume":"107","author":"Delgado","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0065","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-62703-733-4_16","article-title":"1H-NMR protocol for exometabolome analysis of cultured mammalian cells","volume":"1104","author":"Duarte","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0070","doi-asserted-by":"crossref","DOI":"10.1002\/bit.25266","article-title":"Metabolic responses of CHO cells to limitation of key amino acids","author":"Duarte","year":"2014","journal-title":"Biotechnol. Bioeng."},{"issue":"3","key":"10.1016\/j.jbiotec.2016.05.025_bib0075","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jbiotec.2005.03.009","article-title":"Effect of re-feed strategies and non-ammoniagenic medium on adenovirus production at high cell densities","volume":"119","author":"Ferreira","year":"2005","journal-title":"J. Biotechnol."},{"issue":"22","key":"10.1016\/j.jbiotec.2016.05.025_bib0080","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1007\/s10529-005-3558-z","article-title":"Two different serum-free media and osmolality effect upon human 293 cell growth and adenovirus production","volume":"27","author":"Ferreira","year":"2005","journal-title":"Biotechnol. Lett."},{"issue":"3","key":"10.1016\/j.jbiotec.2016.05.025_bib0085","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jbiotec.2007.01.010","article-title":"Effect of ammonia production on intracellular pH: consequent effect on adenovirus vector production","volume":"129","author":"Ferreira","year":"2007","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0090","first-page":"653","article-title":"Effect of vitamins or lipids addition on adenovirus production at high cell densities","volume":"2007","author":"Ferreira","year":"2016","journal-title":"Cell Technol. Cell Prod."},{"issue":"8","key":"10.1016\/j.jbiotec.2016.05.025_bib0095","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1128\/JVI.03134-13","article-title":"Vaccinia virus requires glutamine but not glucose for efficient replication","volume":"88","author":"Fontaine","year":"2014","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.jbiotec.2016.05.025_bib0100","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1128\/JVI.02309-14","article-title":"Dengue virus induces and requires glycolysis for optimal replication","volume":"89","author":"Fontaine","year":"2015","journal-title":"J. Virol."},{"issue":"14","key":"10.1016\/j.jbiotec.2016.05.025_bib0105","doi-asserted-by":"crossref","first-page":"11420","DOI":"10.1074\/jbc.M008782200","article-title":"Acetyl-CoA synthetase 2: a mitochondrial matrix enzyme involved in the oxidation of acetate","volume":"276","author":"Fujino","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.jbiotec.2016.05.025_bib0110","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.014050","article-title":"Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins","volume":"11","author":"Geiger","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0115","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1099\/0022-1317-68-3-937","article-title":"Growth of 293 cells in suspension culture","volume":"68","author":"Graham","year":"1987","journal-title":"J. Gen. Virol."},{"issue":"2","key":"10.1016\/j.jbiotec.2016.05.025_bib0120","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1242\/jcs.12.2.617","article-title":"The effects of adapting human diploid cells to grow in glutamic acid media on cell morphology: growth and metabolism","volume":"12","author":"Griffiths","year":"1973","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.jbiotec.2016.05.025_bib0125","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4155\/pbp.15.6","article-title":"Glutamine substitution: the role it can play to enhance therapeutic protein production","volume":"3","author":"Ha","year":"2015","journal-title":"Pharm. Bioprocess."},{"issue":"3","key":"10.1016\/j.jbiotec.2016.05.025_bib0130","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1242\/jcs.96.3.501","article-title":"Adaptation to non-ammoniagenic medium and selective substrate feeding lead to enhanced yields in animal cell cultures","volume":"96","author":"Hassell","year":"1990","journal-title":"J. Cell Sci."},{"issue":"5-6","key":"10.1016\/j.jbiotec.2016.05.025_bib0135","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ymben.2005.08.002","article-title":"Metabolic flux analysis of HEK-293 cells in perfusion cultures for the production of adenoviral vectors","volume":"7","author":"Henry","year":"2005","journal-title":"Metab. Eng."},{"issue":"12","key":"10.1016\/j.jbiotec.2016.05.025_bib0140","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1016\/j.procbio.2006.06.018","article-title":"Improvement of Vero cell growth in glutamate-based culture by supplementing ammoniagenic compounds","volume":"41","author":"Huang","year":"2006","journal-title":"Process Biochem."},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0145","series-title":"Animal cell technology: Developments towards the 21 st century","first-page":"193","article-title":"Formate production by cho cells: biosynthetic mechanism and potential cytotoxicity","author":"Ihrig","year":"1995"},{"issue":"1-3","key":"10.1016\/j.jbiotec.2016.05.025_bib0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1008040221630","article-title":"Comparison of manufacturing techniques for adenovirus production","volume":"30","author":"Iyer","year":"1999","journal-title":"Cytotechnology"},{"issue":"3","key":"10.1016\/j.jbiotec.2016.05.025_bib0155","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/bit.22817","article-title":"Measurement of key metabolic enzyme activities in mammalian cells using rapid and sensitive microplate-based assays","volume":"107","author":"Janke","year":"2010","journal-title":"Biotechnol. Bioeng."},{"issue":"11","key":"10.1016\/j.jbiotec.2016.05.025_bib0160","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1002\/bit.23215","article-title":"Metabolic adaptation of MDCK cells to different growth conditions: effects on catalytic activities of central metabolic enzymes","volume":"108","author":"Janke","year":"2011","journal-title":"Biotechnol. Bioeng."},{"issue":"1","key":"10.1016\/j.jbiotec.2016.05.025_bib0165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1021\/bp025585a","article-title":"PH, pCO2, and temperature effect on R-adenovirus production","volume":"19","author":"Jardon","year":"2003","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0170","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1002\/jgm.503","article-title":"Development and optimization of an adenovirus production process","volume":"6","author":"Kamen","year":"2004","journal-title":"J. Gene Med."},{"issue":"Suppl 1","key":"10.1016\/j.jbiotec.2016.05.025_bib0175","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1002\/jgm.503","article-title":"Development and optimization of an adenovirus production process","volume":"6","author":"Kamen","year":"2004","journal-title":"J. Gene Med."},{"issue":"3","key":"10.1016\/j.jbiotec.2016.05.025_bib0180","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF00767768","article-title":"The use of serum-free medium for the production of functionally active humanised monoclonal antibody from NS0 mouse myeloma cells engineered using glutamine synthetase as a selectable marker","volume":"18","author":"Keen","year":"1995","journal-title":"Cytotechnology"},{"issue":"2","key":"10.1016\/j.jbiotec.2016.05.025_bib0185","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1042\/bj1420401","article-title":"Production and utilization of acetate in mammals","volume":"142","author":"Knowles","year":"1974","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.jbiotec.2016.05.025_bib0190","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1021\/bp025638o","article-title":"Low-glutamine fed-batch cultures of 293-HEK serum-free suspension cells for adenovirus production","volume":"19","author":"Lee","year":"2003","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0195","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1038\/srep08421","article-title":"The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jbiotec.2016.05.025_bib0200","doi-asserted-by":"crossref","first-page":"e16732","DOI":"10.1371\/journal.pone.0016732","article-title":"Characterisation of human embryonic stem cells conditioning media by 1H-nuclear magnetic resonance spectroscopy","volume":"6","author":"MacIntyre","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jbiotec.2016.05.025_bib0205","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/bit.20890","article-title":"Metabolism of PER.C6 cells cultivated under fed-batch conditions at low glucose and glutamine levels","volume":"94","author":"Maranga","year":"2006","journal-title":"Biotechnol. Bioeng."},{"issue":"1","key":"10.1016\/j.jbiotec.2016.05.025_bib0210","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1242\/jcs.104.1.51","article-title":"Uptake of glutamate, not glutamine synthetase, regulates adaptation of mammalian cells to glutamine-free medium","volume":"104","author":"McDermott","year":"1993","journal-title":"J. Cell Sci."},{"issue":"12","key":"10.1016\/j.jbiotec.2016.05.025_bib0215","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1371\/journal.ppat.0020132","article-title":"Dynamics of the cellular metabolome during human cytomegalovirus infection","volume":"2","author":"Munger","year":"2006","journal-title":"PLoS Pathog."},{"issue":"7\u20138","key":"10.1016\/j.jbiotec.2016.05.025_bib0220","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0734-9750(02)00030-7","article-title":"Production of adenovirus vector for gene therapy","volume":"20","author":"Nadeau","year":"2003","journal-title":"Biotechnol. Adv."},{"issue":"5","key":"10.1016\/j.jbiotec.2016.05.025_bib0225","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1021\/bp000098l","article-title":"293SF metabolic flux analysis during cell growth and infection with an adenoviral vector","volume":"16","author":"Nadeau","year":"2000","journal-title":"Biotechnol. Prog."},{"issue":"2","key":"10.1016\/j.jbiotec.2016.05.025_bib0230","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/0006-291X(75)90856-6","article-title":"Formate as an inhibitor of cytochrome c oxidase","volume":"67","author":"Nicholls","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1-3","key":"10.1016\/j.jbiotec.2016.05.025_bib0235","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/A:1008012518961","article-title":"Modification of glucose and glutamine metabolism in hybridoma cells through metabolic engineering","volume":"30","author":"Paredes","year":"1999","journal-title":"Cytotechnology"},{"issue":"17\u201319","key":"10.1016\/j.jbiotec.2016.05.025_bib0240","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1016\/S0264-410X(00)00508-9","article-title":"The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines","volume":"19","author":"Pau","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2015.05.097","article-title":"Influence of HEK293 metabolism on the production of viral vectors and vaccine","author":"Petiot","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0250","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jbiotec.2014.03.012","article-title":"The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1. HN.AAT cells","volume":"178","author":"Rath","year":"2014","journal-title":"J. Biotechnol."},{"issue":"1","key":"10.1016\/j.jbiotec.2016.05.025_bib0255","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1128\/JVI.00769-09","article-title":"Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1 alpha-mediated glycolytic adaptation","volume":"84","author":"Ripoli","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0260","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1752-0509-4-61","article-title":"Metabolic effects of influenza virus infection in cultured animal cells: intra- and extracellular metabolite profiling","volume":"4","author":"Ritter","year":"2010","journal-title":"BMC Syst. Biol."},{"issue":"12","key":"10.1016\/j.jbiotec.2016.05.025_bib0265","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.tibtech.2014.09.010","article-title":"Cellular targets for improved manufacturing of virus-based biopharmaceuticals in animal cells","volume":"32","author":"Rodrigues","year":"2014","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0270","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.virol.2015.02.038","article-title":"Viral activation of cellular metabolism","volume":"479- 480","author":"Sanchez","year":"2015","journal-title":"Virology"},{"issue":"1-3","key":"10.1016\/j.jbiotec.2016.05.025_bib0275","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1008021428969","article-title":"A high-yielding serum-free, suspension cell culture process to manufacture recombinant adenoviral vectors for gene therapy","volume":"28","author":"Schoofs","year":"1998","journal-title":"Cytotechnology"},{"key":"10.1016\/j.jbiotec.2016.05.025_bib0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.biologicals.2008.02.002","article-title":"The tumorigenicity diversification in human embryonic kidney 293 cell line cultured in vitro","author":"Shen","year":"2008","journal-title":"Biologicals"},{"issue":"6","key":"10.1016\/j.jbiotec.2016.05.025_bib0285","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2174\/156652310793797694","article-title":"Adenovirus vector production and purification","volume":"10","author":"Silva","year":"2010","journal-title":"Curr. Gene Ther."},{"issue":"5","key":"10.1016\/j.jbiotec.2016.05.025_bib0290","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/biot.201400765","article-title":"Human amniocyte-derived cells are a promising cell host for adenoviral vector production under serum-free conditions","volume":"10","author":"Silva","year":"2015","journal-title":"Biotechnol. J."},{"issue":"16","key":"10.1016\/j.jbiotec.2016.05.025_bib0295","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1007\/s00018-004-3448-x","article-title":"Acetyl-coenzyme a synthetase (AMP forming)","volume":"61","author":"Starai","year":"2004","journal-title":"Cell Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.jbiotec.2016.05.025_bib0300","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1042\/bj2910485","article-title":"A 1H\/15 N n.m.r study of nitrogen metabolism in cultured mammalian cells","volume":"291","author":"Street","year":"1993","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.jbiotec.2016.05.025_bib0305","first-page":"1210","article-title":"Scaleable production of adenoviral vectors by transfection of adherent PER.C6 cells","volume":"23","author":"Subramanian","year":"2007","journal-title":"Biotechnol. Prog."},{"issue":"2","key":"10.1016\/j.jbiotec.2016.05.025_bib0310","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.molcel.2006.05.040","article-title":"Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription","volume":"23","author":"Takahashi","year":"2006","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.jbiotec.2016.05.025_bib0315","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.cmet.2014.03.009","article-title":"Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication","volume":"19","author":"Thai","year":"2014","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.jbiotec.2016.05.025_bib0320","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0305-0491(86)90033-7","article-title":"Acetate metabolism by tissues of the rabbit","volume":"85","author":"Woodnutt","year":"1986","journal-title":"Comp. Biochem. Physiol. B"},{"issue":"6","key":"10.1016\/j.jbiotec.2016.05.025_bib0325","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.enzmictec.2006.03.021","article-title":"The importance of 293 cell cycle phase on adenovirus vector production","volume":"39","author":"Zhang","year":"2006","journal-title":"Enzyme Microb. Technol."}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165616302826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165616302826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T02:49:09Z","timestamp":1656730149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165616302826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":65,"alternative-id":["S0168165616302826"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2016.05.025","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Adenovirus infection in host cell metabolism evaluated by 1H-NMR spectroscopy","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2016.05.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}