{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:41:23Z","timestamp":1778942483772,"version":"3.51.4"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.jbiotec.2018.06.306","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T12:33:58Z","timestamp":1528374838000},"page":"48-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Design and testing of a highly conserved human rotavirus VP8* immunogenic peptide with potential for vaccine development"],"prefix":"10.1016","volume":"281","author":[{"given":"Eileena","family":"Mohanty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Budheswar","family":"Dehury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok Kumar","family":"Satapathy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhagirathi","family":"Dwibedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiotec.2018.06.306_bib0005","doi-asserted-by":"crossref","first-page":"A110","DOI":"10.1016\/j.vaccine.2014.04.079","article-title":"Efficacy of a monovalent human-bovine (116E) rotavirus vaccine in Indian children in the second year of life","volume":"32S","author":"Bhandari","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0010","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1586\/14760584.6.4.591","article-title":"Design and development of synthetic peptide vaccines: past, present and future","volume":"6","author":"Bijker","year":"2007","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0015","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/eji.200737995","article-title":"Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation","volume":"38","author":"Bijker","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0020","series-title":"A Better Gap Penalty for Pairwise-SVM: Proceedings of the 3rd Asia-Pacific Bioinformatics","year":"2005"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0025","first-page":"45","article-title":"Prediction of the secondary structure of proteins from their amino acid sequence","volume":"47","author":"Chou","year":"1978","journal-title":"Adv. Enzymol. Relat. Areas Mol. Biol."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0030","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4149\/av_2011_03_273","article-title":"Evidence of conserved epitopes in variable region of VP8 subunit of VP4 protein of rotaviruses of P[8]-1 and P[8]-3 lineages","volume":"55","author":"Contreras","year":"2011","journal-title":"Acta Virol."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.clim.2009.01.009","article-title":"Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics","volume":"131","author":"De Groot","year":"2009","journal-title":"Clin. Immunol."},{"issue":"3","key":"10.1016\/j.jbiotec.2018.06.306_bib0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1440-1711.2002.01092.x","article-title":"Immuno-informatics: mining genomes for vaccine components","volume":"80","author":"De Groot","year":"2002","journal-title":"Immunol. Cell Biol."},{"issue":"2","key":"10.1016\/j.jbiotec.2018.06.306_bib0045","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/infdis\/jiq031","article-title":"Immune responses to rotavirus infection and vaccination and associated correlates of protection","volume":"203","author":"Desselberger","year":"2011","journal-title":"J. Infect. Dis."},{"issue":"5","key":"10.1016\/j.jbiotec.2018.06.306_bib0050","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/emboj\/21.5.885","article-title":"The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site","volume":"21","author":"Dormitzer","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0055","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0060","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1126\/science.1171491","article-title":"Antibody recognition of a highly conserved influenza virus epitope","volume":"324","author":"Ekier","year":"2009","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jbiotec.2018.06.306_bib0065","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/JVI.55.3.836-839.1985","article-title":"Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide","volume":"55","author":"Emini","year":"1985","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.jbiotec.2018.06.306_bib0070","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cll.2015.02.012","article-title":"Rotavirus","volume":"35","author":"Esona","year":"2015","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0075","series-title":"Current Protocols in Bioinformatics","article-title":"Comparative protein structure modelling with modellar","author":"Eswar","year":"2006"},{"issue":"31","key":"10.1016\/j.jbiotec.2018.06.306_bib0080","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1016\/j.vaccine.2015.05.024","article-title":"Safety and immunogenicity of a parenterally administered rotavirus VP8 subunit vaccine in healthy adults","volume":"33","author":"Fix","year":"2015","journal-title":"Vaccine"},{"issue":"15","key":"10.1016\/j.jbiotec.2018.06.306_bib0085","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1016\/j.vaccine.2005.12.048","article-title":"Immunity and correlates of protection for rotavirus vaccines","volume":"24","author":"Franco","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0090","doi-asserted-by":"crossref","first-page":"e40749","DOI":"10.1371\/journal.pone.0040749","article-title":"In silico study of rotavirus v surface accessible conserved regions for antiviral drug\/vaccine design","author":"Ghosh","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0095","first-page":"218590","article-title":"Emerging vaccine informatics","author":"He","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"issue":"1","key":"10.1016\/j.jbiotec.2018.06.306_bib0100","first-page":"5","article-title":"Rotavirus serotypes: classification and importance in epidemiology, immunity, and vaccine development","volume":"18","author":"Hoshino","year":"2000","journal-title":"J. Health Popul. Nutr."},{"issue":"153","key":"10.1016\/j.jbiotec.2018.06.306_bib0105","first-page":"1","article-title":"Therapeutics insight with inclusive immunopharmacology explication of human rotavirus a for the treatment of diarrhea","volume":"7","author":"Hossain","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"171","key":"10.1016\/j.jbiotec.2018.06.306_bib0110","first-page":"1","article-title":"T cell responses to viral infections\u2014opportunities for peptide vaccination","volume":"5","author":"Huber","year":"2014","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.jbiotec.2018.06.306_bib0115","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1128\/JCM.34.7.1694-1700.1996","article-title":"Quantification of systemic and local immune responses to individual rotavirus proteins during rotavirus infection in mice","volume":"34","author":"Ishida","year":"1996","journal-title":"J. Clin. Microbiol."},{"issue":"6","key":"10.1016\/j.jbiotec.2018.06.306_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/vim.2014.0152","article-title":"Design and antigenic epitopes prediction of a new trial recombinant multiepitopic rotaviral vaccine: in silico analyses","volume":"28","author":"Jafarpour","year":"2015","journal-title":"Viral Immunol."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0125","doi-asserted-by":"crossref","DOI":"10.1038\/emi.2017.30","article-title":"Histo-blood group antigens as receptors for rotavirus, new understanding on rotavirus epidemiology and vaccine strategy","volume":"6","author":"Jiang","year":"2017","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0130","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1038\/jid.2012.109","article-title":"A promiscuous survivin-derived T-cell epitope restricted to the HLA-A3 super-type alleles","volume":"132","author":"Junker","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jbiotec.2018.06.306_bib0135","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4103\/0255-0857.29382","article-title":"Rotavirus vaccines","volume":"24","author":"Kang","year":"2016","journal-title":"Indian J. Med. Microbiol."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0140","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF01195768","article-title":"Prediction of chain flexibility in proteins\u2014a tool for the selection of peptide antigens","volume":"72","author":"Karplus","year":"1985","journal-title":"Naturwissenschaften"},{"issue":"1\u20132","key":"10.1016\/j.jbiotec.2018.06.306_bib0145","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","article-title":"A semi-empirical method for prediction of antigenic determinants on protein antigens","volume":"276","author":"Kolaskar","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0150","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.bbagen.2006.07.015","article-title":"Tandem copies of a human rotavirus VP8 epitope can induce specific neutralizing antibodies in BALB\/c mice","volume":"1760","author":"Kovacs-Nolan","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0155","doi-asserted-by":"crossref","first-page":"A75","DOI":"10.1016\/j.vaccine.2014.03.080","article-title":"Sequence analysis of VP7 and VP4 genes of G1P[8] rotaviruses circulating among diarrhoeic children in Pune, India: a comparison with rotarix and RotaTeq vaccine","volume":"32S","author":"Kulkarni","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0160","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1097\/INF.0000000000001232","article-title":"A systematic review of the effect of rotavirus vaccination on diarrhea outcomes among children younger than 5 years","volume":"35","author":"Lamberti","year":"2016","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0165","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1128\/JVI.68.7.4506-4513.1994","article-title":"First peptide vaccine providing protection against viral infection in the target animal: studies of canine parvovirus in dogs","volume":"68","author":"Langeveld","year":"1994","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.jbiotec.2018.06.306_bib0170","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1128\/JVI.66.12.7438-7443.1992","article-title":"Distribution of conserved and specific epitopes on the VP8 subunit of rotavirus VP4","volume":"66","author":"Larralde","year":"1992","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.jbiotec.2018.06.306_bib0175","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1128\/JVI.65.6.3213-3218.1991","article-title":"Serotype-specific epitope(s) present on the VP8 subunit of rotavirus VP4 protein","volume":"65","author":"Larralde","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0180","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-7580-2-2","article-title":"Improved method for predicting linear B-cell epitopes","volume":"2","author":"Larsen","year":"2006","journal-title":"Immun. Res."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0185","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK\u2014a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0190","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3390\/vaccines2030515","article-title":"Peptide vaccine: progress and challenges","volume":"2","author":"Li","year":"2014","journal-title":"Vaccines"},{"issue":"6","key":"10.1016\/j.jbiotec.2018.06.306_bib0195","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1089\/106652703322756113","article-title":"Combining pairwise sequence similarity and support vector machines for detecting remote protein evolutionary and structural relationships","volume":"10","author":"Liao","year":"2003","journal-title":"J. Comput. Biol."},{"issue":"Suppl 2","key":"10.1016\/j.jbiotec.2018.06.306_bib0200","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-14-S2-S10","article-title":"Prediction of B-cell epitopes using evolutionary information and propensity scales","volume":"14","author":"Lin","year":"2013","journal-title":"BMC Bioinform."},{"issue":"8","key":"10.1016\/j.jbiotec.2018.06.306_bib0205","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1021\/ci500393h","article-title":"Subangstrom accuracy in pHLA-I modeling by Rosetta FlexPepDock refinement protocol","volume":"54","author":"Liu","year":"2014","journal-title":"J. Chem. Inf. Model."},{"issue":"12","key":"10.1016\/j.jbiotec.2018.06.306_bib0210","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00251-004-0647-4","article-title":"Definition of supertypes for HLA molecules using clustering ofspecificity matrices","volume":"55","author":"Lund","year":"2004","journal-title":"Immunogenetics"},{"issue":"6364","key":"10.1016\/j.jbiotec.2018.06.306_bib0215","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/356083a0","article-title":"Assessment of protein models with three-dimensional profiles","volume":"356","author":"Luthy","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0220","first-page":"129","article-title":"Protective immunity against group A rotavirus infection and illness in infants","volume":"12","author":"Matson","year":"1996","journal-title":"Arch. Virol. Suppl."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0225","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/psc.1292","article-title":"Peptide vaccine candidates against classical swine fever virus: T cell and neutralizing antibody responses of dendrimers displaying E2 and NS2-3 epitopes","volume":"17","author":"Monso","year":"2011","journal-title":"J. Pept. Sci."},{"issue":"6","key":"10.1016\/j.jbiotec.2018.06.306_bib0230","doi-asserted-by":"crossref","first-page":"e5861","DOI":"10.1371\/journal.pone.0005861","article-title":"AllerHunter: a SVM-pairwise system for assessment of allergenicity and allergic cross-reactivity in proteins","volume":"4","author":"Muh","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0235","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3390\/ijms17050666","article-title":"A brief review of computer-assisted approaches to rational design of peptide vaccines","volume":"17","author":"Nandy","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jbiotec.2018.06.306_bib0240","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1080\/21645515.2015.1011019","article-title":"Vaccines for viral and bacterial pathogens causing acute gastroenteritis: part I: overview, vaccines for enteric viruses and vibrio cholerae","volume":"11","author":"O\u2019Ryan","year":"2015","journal-title":"Hum. Vacc. Immunother."},{"issue":"Suppl. 1","key":"10.1016\/j.jbiotec.2018.06.306_bib0245","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1093\/infdis\/174.Supplement_1.S59","article-title":"Host factors associated with protection against rotavirus disease: the skies are clearing","volume":"174","author":"Offit","year":"1996","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.jbiotec.2018.06.306_bib0250","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1128\/IAI.70.1.79-85.2002","article-title":"Identification of a promiscuous T-cell epitope in Mycobacterium tuberculosis mceproteins","volume":"70","author":"Panigada","year":"2002","journal-title":"Infect. Immun."},{"issue":"Suppl. 2","key":"10.1016\/j.jbiotec.2018.06.306_bib0255","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1093\/cid\/civ1015","article-title":"Health impact of rotavirus vaccination in developing countries: progress and way forward","volume":"62","author":"Parashar","year":"2016","journal-title":"Clin. Infect Dis."},{"issue":"19","key":"10.1016\/j.jbiotec.2018.06.306_bib0260","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1021\/bi00367a013","article-title":"New hydrophilicity scale derived from high- performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and x-ray derived accessible sites","volume":"25","author":"Parker","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0265","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S1473-3099(12)70029-4","article-title":"Fulfilling the promise of rotavirus vaccines. How far have we come since licensure?","volume":"12","author":"Patel","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0270","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.0818-9641.2004.01272.x","article-title":"Vaccine adjuvants: current state and future trends","volume":"82","author":"Petrovsky","year":"2004","journal-title":"Immunol. Cell Biol."},{"issue":"6","key":"10.1016\/j.jbiotec.2018.06.306_bib0275","doi-asserted-by":"crossref","first-page":"e11072","DOI":"10.1371\/journal.pone.0011072","article-title":"A vaccine encoding conserved promiscuous HIV CD4 epitopes induces Broad T cell responses in mice transgenic to multiple common HLA class II molecules","volume":"5","author":"Ribeiro","year":"2010","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jbiotec.2018.06.306_bib0280","doi-asserted-by":"crossref","first-page":"e1004157","DOI":"10.1371\/journal.ppat.1004157","article-title":"New insights into rotavirus entry machinery: stabilization of rotavirus spike conformation is independent of trypsin cleavage","volume":"10","author":"Rodr\u0131\u00b4guez","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0285","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1002\/eji.201343324","article-title":"Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation","volume":"43","author":"Rosalia","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0290","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/emboj.2010.322","article-title":"Atomic model of an infectious rotavirus article","volume":"30","author":"Settembre","year":"2011","journal-title":"EMBO J."},{"issue":"12","key":"10.1016\/j.jbiotec.2018.06.306_bib0295","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/bioinformatics\/17.12.1236","article-title":"ProPed: prediction of HLA-DR binding sites","volume":"17","author":"Singh","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0300","doi-asserted-by":"crossref","first-page":"289597","DOI":"10.1155\/2011\/289597","article-title":"Cytokines: the future of intranasal vaccine adjuvants","volume":"2011","author":"Thompson","year":"2011","journal-title":"Clin. Dev. Immunol."},{"issue":"17","key":"10.1016\/j.jbiotec.2018.06.306_bib0305","doi-asserted-by":"crossref","first-page":"13611","DOI":"10.1074\/jbc.M111.320374","article-title":"Structural and functional studies of trans- encoded HLA-DQ2.3 (DQA1*03:01\/DQB1*02:01) protein molecule","volume":"287","author":"Tollefsen","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0310","doi-asserted-by":"crossref","first-page":"D854","DOI":"10.1093\/nar\/gkp1004","article-title":"The immune epitope database 2.0","volume":"38","author":"Vita","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0315","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.4049\/jimmunol.154.6.2784","article-title":"Induction of protective polyclonal antibodies by immunization with a Plasmodium yoeliicircumsporozoite protein multiple antigen peptide vaccine","volume":"154","author":"Wang","year":"1995","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.jbiotec.2018.06.306_bib0320","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2147\/TCRM.S821","article-title":"Why does the world need another rotavirus vaccine?","volume":"4","author":"Ward","year":"2008","journal-title":"Ther. Clin. Risk Manag."},{"issue":"11","key":"10.1016\/j.jbiotec.2018.06.306_bib0325","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.addr.2009.07.001","article-title":"T cell epitope: friend or foe? Immunogenecity of biologics in context","volume":"61","author":"Weber","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"43","key":"10.1016\/j.jbiotec.2018.06.306_bib0330","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1016\/j.vaccine.2012.07.078","article-title":"Construction and characterization of human rotavirus recombinant VP8** subunit parenteral vaccine candidates","volume":"30","author":"Wen","year":"2012","journal-title":"Vaccine"},{"issue":"35","key":"10.1016\/j.jbiotec.2018.06.306_bib0335","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1016\/j.vaccine.2014.06.060","article-title":"Inclusion of a universal tetanus toxoid CD4 T cell epitope P2 significantly enhanced the immunogenicity of recombinant rotavirus truncated VP8** subunit parental vaccines","volume":"32","author":"Wen","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0340","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web interactive web service for the recognition of errors in three-dimensional structures of proteins","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbiotec.2018.06.306_bib0345","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jmb.2008.02.029","article-title":"Crystal structures of the response regulator DosR from mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation","volume":"378","author":"Wisedchaisri","year":"2008","journal-title":"J. Mol. Biol."},{"issue":"22","key":"10.1016\/j.jbiotec.2018.06.306_bib0350","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/j.vaccine.2015.03.068","article-title":"Characterization and protective efficacy in an animal model of a novel truncated rotavirus VP8 subunit parenteral vaccine candidate","volume":"33","author":"Xue","year":"2015","journal-title":"Vaccine"},{"issue":"3\u20134","key":"10.1016\/j.jbiotec.2018.06.306_bib0355","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0165-2427(02)00046-6","article-title":"Induction of mucosal immune responses and protection against enteric viruses: rotavirus infection of gnotobiotic pigs as a model","volume":"87","author":"Yuan","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"3","key":"10.1016\/j.jbiotec.2018.06.306_bib0360","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1128\/JCM.05590-11","article-title":"Genetic analyses reveal differences in the VP7 and VP4 antigenic epitopes between human rotaviruses circulating in Belgium and rotaviruses in Rotarix and RotaTeq","volume":"50","author":"Zeller","year":"2012","journal-title":"J. Clin. Microbiol."}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165618304838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165618304838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T22:29:16Z","timestamp":1693693756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165618304838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":72,"alternative-id":["S0168165618304838"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2018.06.306","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and testing of a highly conserved human rotavirus VP8* immunogenic peptide with potential for vaccine development","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2018.06.306","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}