{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T17:14:55Z","timestamp":1775927695115,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Argentinian National Council of Research"},{"name":"Argentinian Agency for Promotion of Science and Technology"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.jbiotec.2019.01.001","type":"journal-article","created":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T22:14:48Z","timestamp":1548540888000},"page":"17-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Characterization of folding-sensitive nanobodies as tools to study the expression and quality of protein particle immunogens"],"prefix":"10.1016","volume":"293","author":[{"given":"Vanina","family":"Alzogaray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela","family":"Urrutia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Berguer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Zylberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1550-6181","authenticated-orcid":false,"given":"Hern\u00e1n R.","family":"Bonomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando A.","family":"Goldbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiotec.2019.01.001_bib0005","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.vaccine.2012.11.072","article-title":"Tandem repeats of the extracellular domain of Matrix 2 influenza protein exposed in Brucella lumazine synthase decameric carrier molecule induce protection in mice","volume":"31","author":"Alvarez","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0010","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1096\/fj.10-162958","article-title":"Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium","volume":"25","author":"Alzogaray","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0015","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.vaccine.2008.10.018","article-title":"Brucella spp. lumazine synthase as a bovine rotavirus antigen delivery system","volume":"27","author":"Bellido","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0020","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.4049\/jimmunol.176.4.2366","article-title":"A polymeric bacterial protein activates dendritic cells via TLR4","volume":"176","author":"Berguer","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045705","article-title":"A polymeric protein induces specific cytotoxicity in a TLR4 dependent manner in the absence of adjuvants","volume":"7","author":"Berguer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0030","doi-asserted-by":"crossref","first-page":"e9435","DOI":"10.1371\/journal.pone.0009435","article-title":"An atypical riboflavin pathway is essential for Brucella abortus virulence","volume":"5","author":"Bonomi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0035","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1016\/j.vaccine.2013.07.041","article-title":"The vaccine candidate BLSOmp31 protects mice against Brucella canis infection","volume":"31","author":"Clausse","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0040","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.vetimm.2016.11.004","article-title":"Polymeric antigen BLSOmp31 in aluminium hydroxide induces serum bactericidal and opsonic antibodies against Brucella canis in dogs","volume":"184","author":"Clausse","year":"2017","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0045","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.drudis.2012.11.006","article-title":"Characterization of epitopes recognized by monoclonal antibodies: experimental approaches supported by freely accessible bioinformatic tools","volume":"18","author":"Clementi","year":"2013","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0050","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/prot.20635","article-title":"Multiple display of a protein domain on a bacterial polymeric scaffold","volume":"61","author":"Craig","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0055","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nsb0996-803","article-title":"Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme","volume":"3","author":"Desmyter","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sbi.2015.01.001","article-title":"Camelid nanobodies: killing two birds with one stone","volume":"32","author":"Desmyter","year":"2015","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0065","first-page":"9","article-title":"Bioengineering strategies for protein-based nanoparticles","author":"Diaz","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0070","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1107\/S2053230X17005969","article-title":"Camelid nanobodies used as crystallization chaperones for different constructs of PorM, a component of the type IX secretion system from Porphyromonas gingivalis","volume":"73","author":"Duhoo","year":"2017","journal-title":"Acta Crystallogr. F Struct. Biol. Commun."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0075","doi-asserted-by":"crossref","first-page":"6704","DOI":"10.1016\/j.vaccine.2009.08.097","article-title":"The polymeric antigen BLSOmp31 confers protection against Brucella ovis infection in rams","volume":"27","author":"Estein","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0080","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1128\/JCM.31.8.2141-2145.1993","article-title":"Characterization of an 18-kilodalton Brucella cytoplasmic protein which appears to be a serological marker of active infection of both human and bovine brucellosis","volume":"31","author":"Goldbaum","year":"1993","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0085","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/363446a0","article-title":"Naturally occurring antibodies devoid of light chains","volume":"363","author":"Hamers-Casterman","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0090","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.4161\/hv.29300","article-title":"Use of immuno assays during the development of a Hemophilus influenzae type b vaccine for technology transfer to emerging vaccine manufacturers","volume":"10","author":"Hamidi","year":"2014","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002653","article-title":"Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate","volume":"8","author":"Keck","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4161\/mabs.22771","article-title":"Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties","volume":"5","author":"Klein","year":"2013","journal-title":"mAbs"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0105","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jmb.2005.08.017","article-title":"Crystallographic studies on decameric Brucella spp. Lumazine synthase: a novel quaternary arrangement evolved for a new function?","volume":"353","author":"Klinke","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0110","doi-asserted-by":"crossref","first-page":"20857","DOI":"10.1038\/srep20857","article-title":"Production, characterization, and epitope mapping of monoclonal antibodies against different subtypes of rabbit hemorrhagic disease virus (RHDV)","volume":"6","author":"Kong","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006636","article-title":"Nanobodies targeting norovirus capsid reveal functional epitopes and potential mechanisms of neutralization","volume":"13","author":"Koromyslova","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0120","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/prot.20248","article-title":"Engineering of a polymeric bacterial protein as a scaffold for the multiple display of peptides","volume":"57","author":"Laplagne","year":"2004","journal-title":"Proteins"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2018.04.065","article-title":"Characterization of recombinant yellow fever-dengue vaccine viruses with human monoclonal antibodies targeting key conformational epitopes","author":"Lecouturier","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0130","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00705-015-2667-9","article-title":"Identification of a conserved linear epitope using a monoclonal antibody against non-structural protein 3B of foot-and-mouth disease virus","volume":"161","author":"Li","year":"2016","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0135","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1007\/s00705-016-2984-7","article-title":"Identification of a conserved linear neutralizing epitope recognized by monoclonal antibody 9A9 against serotype A foot-and-mouth disease virus","volume":"161","author":"Liang","year":"2016","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0140","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1080\/21645515.2015.1012010","article-title":"Phase II studies to select the formulation of a multivalent HPV L1 virus-like particle (VLP) vaccine","volume":"11","author":"Luxembourg","year":"2015","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0145","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41594-018-0028-6","article-title":"Yeast surface display platform for rapid discovery of conformationally selective nanobodies","volume":"25","author":"McMahon","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0150","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.4049\/jimmunol.1300999","article-title":"Immunization with a chimera consisting of the B subunit of Shiga toxin type 2 and brucella lumazine synthase confers total protection against Shiga toxins in mice","volume":"191","author":"Mejias","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0155","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1128\/IAI.00027-14","article-title":"Protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera","volume":"82","author":"Mejias","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0160","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1586\/14760584.8.2.227","article-title":"Quality-control issues and approaches in vaccine development","volume":"8","author":"Metz","year":"2009","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0165","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virol.2014.05.001","article-title":"Polyclonal and monoclonal antibodies specific for the six-helix bundle of the human respiratory syncytial virus fusion glycoprotein as probes of the protein post-fusion conformation","volume":"460-461","author":"Palomo","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0170","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nprot.2014.039","article-title":"A general protocol for the generation of Nanobodies for structural biology","volume":"9","author":"Pardon","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0175","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature09648","article-title":"Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor","volume":"469","author":"Rasmussen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126827","article-title":"Brucella spp. Lumazine Synthase Induces a TLR4-mediated protective response against B16 melanoma in mice","volume":"10","author":"Rossi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0185","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41594-018-0038-4","article-title":"Speed up to find the right ones: rapid discovery of functional nanobodies","volume":"25","author":"Rothbauer","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0190","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1016\/S1470-2045(14)71179-9","article-title":"Next generation prophylactic human papillomavirus vaccines","volume":"16","author":"Schiller","year":"2015","journal-title":"Lancet Oncol."},{"issue":"Suppl 5","key":"10.1016\/j.jbiotec.2019.01.001_bib0195","doi-asserted-by":"crossref","first-page":"F123","DOI":"10.1016\/j.vaccine.2012.04.108","article-title":"A review of clinical trials of human papillomavirus prophylactic vaccines","volume":"30","author":"Schiller","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0200","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00430-014-0374-x","article-title":"Enhanced immune response to hepatitis B vaccination through immunization with a Pre-S1\/Pre-S2\/S vaccine","volume":"204","author":"Shouval","year":"2015","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0205","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1080\/21645515.2015.1136039","article-title":"Current therapeutic vaccination and immunotherapy strategies for HPV-related diseases","volume":"12","author":"Skeate","year":"2016","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0210","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1016\/j.vaccine.2013.07.043","article-title":"Development of influenza H7N9 virus like particle (VLP) vaccine: homologous A\/Anhui\/1\/2013 (H7N9) protection and heterologous A\/chicken\/Jalisco\/CPA1\/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus","volume":"31","author":"Smith","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0215","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.sbi.2011.06.011","article-title":"Nanobody stabilization of G protein-coupled receptor conformational states","volume":"21","author":"Steyaert","year":"2011","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-1759(00)00244-1","article-title":"Single-shot plasmid DNA intrasplenic immunization for the production of monoclonal antibodies. Persistent expression of DNA","volume":"244","author":"Velikovsky","year":"2000","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0225","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1128\/IAI.70.5.2507-2511.2002","article-title":"A DNA vaccine encoding lumazine synthase from Brucella abortus induces protective immunity in BALB\/c mice","volume":"70","author":"Velikovsky","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0230","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1128\/IAI.71.10.5750-5755.2003","article-title":"Brucella lumazine synthase elicits a mixed Th1-Th2 immune response and reduces infection in mice challenged with Brucella abortus 544 independently of the adjuvant formulation used","volume":"71","author":"Velikovsky","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0235","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/s41467-018-03191-2","article-title":"A peptide tag-specific nanobody enables high-quality labeling for dSTORM imaging","volume":"9","author":"Virant","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0240","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00430-009-0116-7","article-title":"Single domain antibodies: promising experimental and therapeutic tools in infection and immunity","volume":"198","author":"Wesolowski","year":"2009","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0245","article-title":"A VLP vaccine induces broad-spectrum cross-protective antibody immunity against H5N1 and H1N1 subtypes of influenza A virus","volume":"7","author":"Wu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0250","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.vaccine.2015.01.031","article-title":"Size-exclusion HPLC provides a simple, rapid, and versatile alternative method for quality control of vaccines by characterizing the assembly of antigens","volume":"33","author":"Yang","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0255","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/CVI.05355-11","article-title":"Use of pre-S protein-containing hepatitis B virus surface antigens and a powerful adjuvant to develop an immune therapy for chronic hepatitis B virus infection","volume":"19","author":"Yum","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0260","doi-asserted-by":"crossref","first-page":"6266","DOI":"10.1016\/j.vaccine.2008.09.056","article-title":"The global impact of vaccination against hepatitis B: a historical overview","volume":"26","author":"Zanetti","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0265","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4161\/hv.6.8.11935","article-title":"The establishment of a highly sensitive ELISA for detecting bovine serum albumin (BSA) based on a specific pair of monoclonal antibodies (mAb) and its application in vaccine quality control","volume":"6","author":"Zhang","year":"2010","journal-title":"Hum. Vaccin."},{"key":"10.1016\/j.jbiotec.2019.01.001_bib0270","doi-asserted-by":"crossref","first-page":"8093","DOI":"10.1074\/jbc.M312035200","article-title":"High order quaternary arrangement confers increased structural stability to Brucella sp. lumazine synthase","volume":"279","author":"Zylberman","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165619300057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165619300057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T10:12:20Z","timestamp":1606212740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165619300057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":54,"alternative-id":["S0168165619300057"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2019.01.001","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of folding-sensitive nanobodies as tools to study the expression and quality of protein particle immunogens","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2019.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}