{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:56:42Z","timestamp":1775854602794,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"National Research Development and Innovation Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jbiotec.2024.04.018","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T16:25:15Z","timestamp":1714407915000},"page":"61-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Complex treatment of residual metastatic germ cell cancer: A single center experience"],"prefix":"10.1016","volume":"389","author":[{"given":"Fruzsina Eszter","family":"Fazekas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Ujfaludi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Bir\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n G\u00e1bor","family":"P\u00e1hi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Buzog\u00e1ny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farkas","family":"S\u00fck\u00f6sd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Pankotai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Be\u00f6the","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jbiotec.2024.04.018_bib1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/annonc\/mdw045","article-title":"Prognostic factors in patients with poor-risk germ-cell tumors: a retrospective analysis of the Indiana University experience from 1990 to 2014","volume":"vol. 27","author":"Adra","year":"2016","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.jbiotec.2024.04.018_bib2","unstructured":"Alboukadel Kassambara, Marcin Kosinski, and Scheipl Fabian, \u201csurvminer: Drawing Survival Curves using \u2019ggplot2.\u201d 2021. Accessed: Jan. 14, 2024. [Online]. Available: \u3008https:\/\/CRAN.R-project.org\/package=survminer\u3009."},{"issue":"4","key":"10.1016\/j.jbiotec.2024.04.018_bib3","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1001\/jamaoncol.2018.6477","article-title":"Association of Inherited Pathogenic Variants in Checkpoint Kinase 2 ( CHEK2) With Susceptibility to Testicular Germ Cell Tumors","volume":"vol. 5","author":"AlDubayan","year":"2019","journal-title":"JAMA Oncol."},{"issue":"1","key":"10.1016\/j.jbiotec.2024.04.018_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/annonc\/mdr052","article-title":"2-18fluoro-deoxy-D-glucose positron emission tomography (FDG-PET) for postchemotherapy seminoma residual lesions: a retrospective validation of the SEMPET trial","volume":"vol. 23","author":"Bachner","year":"2012","journal-title":"Ann. Oncol."},{"issue":"11","key":"10.1016\/j.jbiotec.2024.04.018_bib5","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrurol.2010.166","article-title":"Serum tumor markers in the evaluation of male germ cell tumors","volume":"vol. 7","author":"Barlow","year":"2010","journal-title":"Nat. Rev. Urol."},{"issue":"5","key":"10.1016\/j.jbiotec.2024.04.018_bib6","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0741-5214(98)70055-2","article-title":"Long-term results after inferior vena caval resection during retroperitoneal lymphadenectomy for metastatic germ cell cancer","volume":"vol. 28","author":"Beck","year":"1998","journal-title":"J. Vasc. Surg."},{"issue":"14","key":"10.1016\/j.jbiotec.2024.04.018_bib7","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1200\/JCO.20.03292","article-title":"Survival and New Prognosticators in Metastatic Seminoma: Results From the IGCCCG-Update Consortium","volume":"vol. 39","author":"Beyer","year":"2021","journal-title":"J. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.jbiotec.2024.04.018_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/path.2225","article-title":"c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma","volume":"vol. 213","author":"Biermann","year":"2007","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.jbiotec.2024.04.018_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.22591\/magyurol.2022.1.boszormenyig.13","article-title":"Besz\u00e1mol\u00f3 az urol\u00f3giai fekv\u0151beteg-ell\u00e1t\u00e1sr\u00f3l a 2020-as adatok alapj\u00e1n","volume":"vol. 34","author":"B\u00f6sz\u00f6rm\u00e9nyi-Nagy","year":"2022","journal-title":"Magy. Urol. \u00f3gia"},{"issue":"1","key":"10.1016\/j.jbiotec.2024.04.018_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.22591\/magyurol.2023.1.boszormenyig.11","article-title":"Besz\u00e1mol\u00f3 az urol\u00f3giai fekv\u0151beteg-ell\u00e1t\u00e1sr\u00f3l a 2021-es adatok alapj\u00e1n","volume":"vol. 35","author":"B\u00f6sz\u00f6rm\u00e9nyi-Nagy","year":"2023","journal-title":"Magy. Urol. \u00f3gia"},{"issue":"1","key":"10.1016\/j.jbiotec.2024.04.018_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202200112","article-title":"How germline genes promote malignancy in cancer cells","volume":"vol. 45","author":"Bruggeman","year":"2023","journal-title":"BioEssays"},{"issue":"1","key":"10.1016\/j.jbiotec.2024.04.018_bib12","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/bju.12804","article-title":"Robot-assisted retroperitoneal lymph node dissection: technique and initial case series of 18 patients","volume":"vol. 115","author":"Cheney","year":"2015","journal-title":"BJU Int"},{"issue":"1","key":"10.1016\/j.jbiotec.2024.04.018_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/gcc.20503","article-title":"Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: Report of 220 tumors and review of literature","volume":"vol. 47","author":"Coffey","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"issue":"6_suppl","key":"10.1016\/j.jbiotec.2024.04.018_bib14","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2021.39.6_suppl.375","article-title":"SEMS trial: Result of a prospective, multi-institutional phase II clinical trial of surgery in early metastatic seminoma","volume":"vol. 39","author":"Daneshmand","year":"2021","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.jbiotec.2024.04.018_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.urology.2008.02.054","article-title":"Vena Caval Reconstruction During Postchemotherapy Retroperitoneal Lymph Node Dissection for Metastatic Germ Cell Tumor","volume":"vol. 73","author":"Ehrlich","year":"2009","journal-title":"Urology"},{"issue":"14","key":"10.1016\/j.jbiotec.2024.04.018_bib16","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1200\/JCO.20.03296","article-title":"Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium","volume":"vol. 39","author":"Gillessen","year":"2021","journal-title":"J. Clin. Oncol."},{"issue":"20","key":"10.1016\/j.jbiotec.2024.04.018_bib17","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1200\/JCO.2009.26.4481","article-title":"American Society of Clinical Oncology Clinical Practice Guideline on Uses of Serum Tumor Markers in Adult Males With Germ Cell Tumors","volume":"vol. 28","author":"Gilligan","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jbiotec.2024.04.018_bib18","doi-asserted-by":"crossref","DOI":"10.17305\/bjbms.2017.1764","article-title":"K-RAS and N-RAS mutations in testicular germ cell tumors","author":"Hacioglu","year":"2017","journal-title":"Bosn. J. Basic Med Sci."},{"issue":"4","key":"10.1016\/j.jbiotec.2024.04.018_bib19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1308\/003588411X571098","article-title":"Retroperitoneal lymph node dissection for metastatic germ cell tumours","volume":"vol. 93","author":"Haldipur","year":"2011","journal-title":"Ann. R. Coll. Surg. Engl."},{"issue":"5","key":"10.1016\/j.jbiotec.2024.04.018_bib20","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1097\/01.ju.0000060960.18092.54","article-title":"Complications of Primary Nerve Sparing Retroperitoneal Lymph Node Dissection for Clinical Stage I Nonseminomatous Germ Cell Tumors of the Testis: Experience of the German Testicular Cancer Study Group","volume":"vol. 169","author":"Heidenreich","year":"2003","journal-title":"J. Urol."},{"issue":"2","key":"10.1016\/j.jbiotec.2024.04.018_bib21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/annonc\/mdw605","article-title":"Surgical management of complex residual masses following systemic chemotherapy for metastatic testicular germ cell tumours","volume":"vol. 28","author":"Heidenreich","year":"2017","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.jbiotec.2024.04.018_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.eururo.2008.09.027","article-title":"Postchemotherapy Retroperitoneal Lymph Node Dissection in Advanced Testicular Cancer: Radical or Modified Template Resection","volume":"vol. 55","author":"Heidenreich","year":"2009","journal-title":"Eur. Urol."},{"issue":"32","key":"10.1016\/j.jbiotec.2024.04.018_bib23","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1200\/JCO.21.00637","article-title":"Testicular Cancer in the Cisplatin Era: Causes of Death and Mortality Rates in a Population-Based Cohort","volume":"vol. 39","author":"Hellesnes","year":"2021","journal-title":"J. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.jbiotec.2024.04.018_bib24","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/cncr.10440","article-title":"Metastatic nonseminomatous germ cell tumors of the testis","volume":"vol. 94","author":"Hendry","year":"2002","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.jbiotec.2024.04.018_bib25","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.bbrc.2017.06.133","article-title":"Biophysical characterization of histone H3.3 K27M point mutation","volume":"vol. 490","author":"Hetey","year":"2017","journal-title":"Biochem Biophys. Res Commun."},{"issue":"1","key":"10.1016\/j.jbiotec.2024.04.018_bib26","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0022-5347(17)59652-4","article-title":"Diamminodichloroplatinum in the Chemotherapy of Testicular Tumors","volume":"vol. 112","author":"Higby","year":"1974","journal-title":"J. Urol."},{"issue":"10","key":"10.1016\/j.jbiotec.2024.04.018_bib27","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1083\/jcb.201712122","article-title":"Nuclear dynamics of the Set1C subunit Spp1 prepares meiotic recombination sites for break formation","volume":"vol. 217","author":"Kar\u00e1nyi","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbiotec.2024.04.018_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2019.00364","article-title":"Histone H3 Lysine 56 Acetylation Is Required for Formation of Normal Levels of Meiotic DNA Breaks in S. cerevisiae","volume":"vol. 7","author":"Kar\u00e1nyi","year":"2020","journal-title":"Front Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.jbiotec.2024.04.018_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-21856-3","article-title":"Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor","volume":"vol. 12","author":"Kitayama","year":"2022","journal-title":"Sci. Rep."},{"issue":"27","key":"10.1016\/j.jbiotec.2024.04.018_bib30","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.1200\/JCO.2005.19.638","article-title":"Combination of Paclitaxel, Ifosfamide, and Cisplatin Is an Effective Second-Line Therapy for Patients With Relapsed Testicular Germ Cell Tumors","volume":"vol. 23","author":"Kondagunta","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jbiotec.2024.04.018_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.831620","article-title":"Meiotic Genes and DNA Double Strand Break Repair in Cancer","volume":"vol. 13","author":"Lingg","year":"2022","journal-title":"Front Genet"},{"issue":"6","key":"10.1016\/j.jbiotec.2024.04.018_bib32","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1097\/01.ju.0000060121.33899.4b","article-title":"Is Post-Chemotherapy Resection of Seminomatous Elements Associated With Higher Acute Morbidity?","volume":"vol. 169","author":"Mosharafa","year":"2003","journal-title":"J. Urol."},{"issue":"3","key":"10.1016\/j.jbiotec.2024.04.018_bib33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nrc1568","article-title":"Testicular germ-cell tumours in a broader perspective","volume":"vol. 5","author":"Oosterhuis","year":"2005","journal-title":"Nat. Rev. Cancer"},{"issue":"9","key":"10.1016\/j.jbiotec.2024.04.018_bib34","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41568-019-0178-9","article-title":"Human germ cell tumours from a developmental perspective","volume":"vol. 19","author":"Oosterhuis","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"37","key":"10.1016\/j.jbiotec.2024.04.018_bib35","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012390","article-title":"Recent global trends in testicular cancer incidence and mortality","volume":"vol. 97","author":"Park","year":"2018","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/j.jbiotec.2024.04.018_bib36","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1038\/s41467-021-24334-y","article-title":"Identification of 22 susceptibility loci associated with testicular germ cell tumors","volume":"vol. 12","author":"Pluta","year":"2021","journal-title":"Nat. Commun."},{"issue":"1\u20132","key":"10.1016\/j.jbiotec.2024.04.018_bib37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00418-005-0073-1","article-title":"Nick-forming sequences may be involved in the organization of eukaryotic chromatin into \u223c50 kbp loops","volume":"vol. 125","author":"Sz\u00e9kv\u00f6lgyi","year":"2006","journal-title":"Histochem Cell Biol."},{"key":"10.1016\/j.jbiotec.2024.04.018_bib38","unstructured":"Terry M. Therneau, \u201cA Package for Survival Analysis in R.\u201d 2023. Accessed: Jan. 14, 2024. [Online]. Available: \u3008https:\/\/CRAN.R-project.org\/package=survival\u3009."},{"key":"10.1016\/j.jbiotec.2024.04.018_bib39","series-title":"Modeling Survival Data: Extending the Cox Model","author":"Therneau","year":"2000"}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165624001263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165624001263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T22:12:58Z","timestamp":1716588778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165624001263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":39,"alternative-id":["S0168165624001263"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2024.04.018","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complex treatment of residual metastatic germ cell cancer: A single center experience","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2024.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}