{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:47:28Z","timestamp":1791614848337,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20221049"],"award-info":[{"award-number":["BK20221049"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20221030"],"award-info":[{"award-number":["BK20221030"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jbiotec.2024.09.011","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T02:25:16Z","timestamp":1727663116000},"page":"149-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Production of recombinant human type I collagen homotrimers in CHO cells and their physicochemical and functional properties"],"prefix":"10.1016","volume":"395","author":[{"given":"Chuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingtao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiadao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqi","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiotec.2024.09.011_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12010-014-0823-4","article-title":"Purification and characterization of pepsin-solubilized collagen from skin of sea cucumber holothuria parva","volume":"173","author":"Adibzadeh","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2020.105053","article-title":"Extraction of collagen-II with pepsin and ultrasound treatment from chicken sternal cartilage; physicochemical and functional properties","volume":"64","author":"Akram","year":"2020","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib3","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1016\/j.vaccine.2021.05.048","article-title":"Protein and glycan molecular weight determination of highly glycosylated HIV-1 envelope trimers by HPSEC-MALS","volume":"39","author":"Bender","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.jbiotec.2024.09.011_bib4","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/aba6fa","article-title":"Exploring the potential of the recombinant human collagens for biomedical and clinical applications: a short review","volume":"16","author":"Chen","year":"2021","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/14756360701511292","article-title":"Advances in assays of matrix metalloproteinases (MMPs) and their inhibitors","volume":"23","author":"Cheng","year":"2008","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.copbio.2019.01.011","article-title":"The fickle CHO: a review of the causes, implications, and potential alleviation of the CHO cell line instability problem","volume":"60","author":"Dahodwala","year":"2019","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.658325","article-title":"Decoupling growth and protein production in CHO cells: a targeted approach","volume":"9","author":"Donaldson","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib8","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.bpj.2016.10.023","article-title":"Circular dichroism spectroscopy of collagen fibrillogenesis: a new use for an old technique","volume":"111","author":"Drzewiecki","year":"2016","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib9","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1111\/bph.15851","article-title":"Mucin-fused myeloid-derived growth factor (MYDGF164) exhibits a prolonged serum half-life and alleviates fibrosis in chronic kidney disease","volume":"179","author":"Du","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80622-4","article-title":"Structural basis of collagen recognition by integrin \u03b12\u03b21","volume":"101","author":"Emsley","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jbiotec.2024.09.011_bib11","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1021\/la3048104","article-title":"Type I collagen self-assembly: the roles of substrate and concentration","volume":"29","author":"Fang","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.jbiotec.2024.09.011_bib12","doi-asserted-by":"crossref","first-page":"31502","DOI":"10.1074\/jbc.M103466200","article-title":"Procollagen II amino propeptide processing by ADAMTS-3","volume":"276","author":"Fernandes","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering7040155","article-title":"Three decades of research on recombinant collagens: reinventing the wheel or developing new biomedical products?","volume":"7","author":"Fertala","year":"2020","journal-title":"Bioengineering"},{"key":"10.1016\/j.jbiotec.2024.09.011_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/jfb10030039","article-title":"Production of a recombinant non-hydroxylated gelatin mimetic in pichia pastoris for biomedical applications","volume":"10","author":"Gellermann","year":"2019","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib15","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.addr.2003.08.002","article-title":"Collagens\u2014structure, function, and biosynthesis","volume":"55","author":"Gelse","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib16","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-022-04249-7","article-title":"uPARAP\/Endo180: a multifaceted protein of mesenchymal cells","volume":"79","author":"Gucciardo","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.msec.2017.03.267","article-title":"Influence of telopeptides on the structural and physical properties of polymeric and monomeric acid-soluble type I collagen","volume":"77","author":"Holmes","year":"2017","journal-title":"Mater. Sci. Eng. C. -Mater. Biol. Appl."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib18","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1038\/jid.2015.291","article-title":"Intravenously administered recombinant human type vii collagen derived from chinese hamster ovary cells reverses the disease phenotype in recessive dystrophic epidermolysis bullosa mice","volume":"135","author":"Hou","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib19","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.bbrc.2018.12.018","article-title":"Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity","volume":"508","author":"Hua","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib20","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41589-019-0435-y","article-title":"Chain alignment of collagen I deciphered using computationally designed heterotrimers","volume":"16","author":"Jalan","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib21","first-page":"39","author":"Jorge","year":"2010","journal-title":"Synth. Collagen mimics: self-Assem. homotrimers, heterotrimers High. Order Struct."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib22","first-page":"12","author":"Joshua G","year":"2021","journal-title":"S-Trimer, a COVID-19 subunit Vaccin. Candidate, induces Prot. Immun. Nonhum. Primates"},{"key":"10.1016\/j.jbiotec.2024.09.011_bib23","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00253-011-3758-5","article-title":"CHO cells in biotechnology for production of recombinant proteins: current state and further potential","volume":"93","author":"Kim","year":"2011","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib24","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1172\/JCI200215256","article-title":"Collagen-binding integrin \u03b11\u03b21 regulates intestinal inflammation in experimental colitis","volume":"110","author":"Krieglstein","year":"2002","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s13568-020-01157-6","article-title":"Screening and selection strategy for the establishment of biosimilar to trastuzumab-expressing CHO-K1 cell lines","volume":"11","author":"Lao-Gonzalez","year":"2021","journal-title":"AMB Express"},{"key":"10.1016\/j.jbiotec.2024.09.011_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21634-1","article-title":"S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates","volume":"12","author":"Liang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib27","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1158\/0008-5472.CAN-09-4057","article-title":"Carcinomas contain a matrix metalloproteinase\u2013resistant isoform of type i collagen exerting selective support to invasion","volume":"70","author":"Makareeva","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bcp.2019.02.033","article-title":"Inhibition of MMPs and ADAM\/ADAMTS","volume":"165","author":"Malemud","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biology11060905","article-title":"Collagen Extraction from Animal Skin","volume":"11","author":"Matinong","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.jbiotec.2024.09.011_bib30","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/yea.730","article-title":"High-level production of human type I collagen in the yeast Pichia pastoris","volume":"18","author":"Nokelainen","year":"2001","journal-title":"Yeast"},{"key":"10.1016\/j.jbiotec.2024.09.011_bib31","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nchem.1123","article-title":"Multi-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofibre and hydrogel","volume":"3","author":"O'Leary","year":"2011","journal-title":"Nat. Chem."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib32","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0021-9258(17)35290-0","article-title":"High levels of expression of a minigene version of the human pro alpha 1 (I) collagen gene in stably transfected mouse fibroblasts. Effects of deleting putative regulatory sequences in the first intron","volume":"266","author":"Olsen","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib33","doi-asserted-by":"crossref","first-page":"24038","DOI":"10.1074\/jbc.M101613200","article-title":"Production of human type i collagen in yeast reveals unexpected new insights into the molecular assembly of collagen trimers","volume":"276","author":"Olsen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib34","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0014-5793(00)01259-X","article-title":"Triple helix assembly and processing of human collagen produced in transgenic tobacco plants","volume":"469","author":"Ruggiero","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib35","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1007\/s00253-013-5447-z","article-title":"Recombinant expression of hydroxylated human collagen in Escherichia coli","volume":"98","author":"Rutschmann","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14671","article-title":"Structural basis of homo- and heterotrimerization of collagen I","volume":"8","author":"Sharma","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib37","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1007\/s00018-019-03081-w","article-title":"Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit \u03b11 promote hydroxylation and secretion of type I collagen","volume":"76","author":"Shi","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib38","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","article-title":"Collagen Structure and Stability","volume":"78","author":"Shoulders","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib39","first-page":"31","article-title":"The collagen suprafamily: from biosynthesis to advanced biomaterial development","author":"Sorushanova","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijbiomac.2017.02.057","article-title":"Characterization of acid- and pepsin-soluble collagen extracted from the skin of Nile tilapia (Oreochromis niloticus)","volume":"99","author":"Sun","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib41","doi-asserted-by":"crossref","first-page":"23303","DOI":"10.1074\/jbc.M002284200","article-title":"Production of recombinant human type i procollagen trimers using a four-gene expression system in the yeast saccharomyces cerevisiae","volume":"275","author":"Toman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib42","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/nbt.4305","article-title":"Biopharmaceutical benchmarks 2018","volume":"36","author":"Walsh","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib43","doi-asserted-by":"crossref","DOI":"10.1186\/s42825-022-00103-5","article-title":"Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotype","volume":"4","author":"Wang","year":"2022","journal-title":"J. Leather Sci. Eng."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib44","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1049\/enb.2017.0003","article-title":"Production of recombinant collagen: state of the art and challenges","volume":"1","author":"Wang","year":"2017","journal-title":"Eng. Biol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2022.107700","article-title":"Revealing the aggregation behaviors of mesostructured collagen by the evaluation of reconstituted collagen performance","volume":"130","author":"Wang","year":"2022","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib46","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/abio.2000.4524","article-title":"Refractive index of proteins in aqueous sodium chloride","volume":"280","author":"Wen","year":"2000","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.jbiotec.2024.09.011_bib47","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1080\/00986445.2011.592462","article-title":"A purification process based on self-assembly for recombinant human-like collagen","volume":"199","author":"Xing","year":"2012","journal-title":"Chem. Eng. Commun."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111559","article-title":"Unraveling the interaction mechanism between collagen and alcohols with different chain lengths and hydroxyl positions","volume":"199","author":"Xu","year":"2021","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jbiotec.2024.09.011_bib49","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00253-022-12342-x","article-title":"Progress in fed-batch culture for recombinant protein production in CHO cells","volume":"107","author":"Xu","year":"2023","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib50","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/btpr.257","article-title":"Purification and characterization of a transgenic corn grain-derived recombinant collagen type I alpha 1","volume":"25","author":"Zhang","year":"2009","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib51","article-title":"Strategies and considerations for improving recombinant antibody production and quality in Chinese hamster ovary cells","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.09.011_bib52","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1039\/C7TB02999C","article-title":"Self-assembly of collagen-based biomaterials: preparation, characterizations and biomedical applications","volume":"6","author":"Zhu","year":"2018","journal-title":"J. Mater. Chem. B"}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165624002542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165624002542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T22:25:50Z","timestamp":1730327150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165624002542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":52,"alternative-id":["S0168165624002542"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2024.09.011","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Production of recombinant human type I collagen homotrimers in CHO cells and their physicochemical and functional properties","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2024.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}