{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:03:34Z","timestamp":1785495814122,"version":"3.56.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ5258"],"award-info":[{"award-number":["2024JJ5258"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770106"],"award-info":[{"award-number":["31770106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200062"],"award-info":[{"award-number":["32200062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jbiotec.2024.10.010","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T17:13:30Z","timestamp":1730567610000},"page":"127-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Combinatorial metabolic engineering strategy of precursor pools for the yield improvement of spinosad in Saccharopolyspora spinosa"],"prefix":"10.1016","volume":"396","author":[{"given":"Li","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xirong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danlu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirui","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Rang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiotec.2024.10.010_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1096-9063(199611)48:3<261::AID-PS467>3.0.CO;2-R","article-title":"Laboratory Evaluation of the Novel Naturally Derived Compound Spinosad against Ceratitiscapitata","volume":"48","author":"Ad\u00e1n","year":"1996","journal-title":"Pestic. Sci."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3390\/applmicrobiol2010017","article-title":"Enhancing Lipase Production of Bacillus salmalaya Strain 139SI Using Different Carbon Sources and Surfactants","volume":"2","author":"Al Mohaini","year":"2022","journal-title":"Appl. Microbiol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.synbio.2021.09.008","article-title":"Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton","volume":"6","author":"An","year":"2021","journal-title":"Synth. Syst. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib4","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.1021\/bi1005305","article-title":"Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor","volume":"49","author":"Arabolaza","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbiotec.2024.10.010_bib5","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.4014\/jmb.1512.12056","article-title":"Purification and Characterization of an Alkali-Thermostable Lipase from Thermophilic Anoxybacillus flavithermus HBB 134","volume":"26","author":"Bakir","year":"2016","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib6","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/bab.2418","article-title":"Increasing production of spinosad in Saccharopolyspora spinosa by metabolic engineering","volume":"70","author":"Bridget","year":"2022","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib7","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.synbio.2024.06.007","article-title":"Enhanced triacylglycerol metabolism contributes to the efficient biosynthesis of spinosad in Saccharopolyspora spinosa","volume":"9","author":"Cao","year":"2024","journal-title":"Synth. Syst. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib8","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12934-023-02218-8","article-title":"Heterologous overproduction of oviedomycin by refactoring biosynthetic gene cluster and metabolic engineering of host strain Streptomyces coelicolor","volume":"22","author":"Gu","year":"2023","journal-title":"Micro Cell Fact."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib9","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1007\/s00253-022-11854-w","article-title":"Avermectin B1a production in Streptomyces avermitilis is enhanced by engineering aveC and precursor supply genes","volume":"106","author":"Hao","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib10","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1021\/acssynbio.1c00344","article-title":"Flaviolin-Like Gene Cluster Deletion Optimized the Butenyl-Spinosyn Biosynthesis Route in Saccharopolyspora pogona","volume":"10","author":"He","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12934-023-02092-4","article-title":"Enhancing armeniaspirols production through multi-level engineering of a native Streptomyces producer","volume":"22","author":"Heng","year":"2023","journal-title":"Micro Cell Fact."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1603\/0022-0493-94.1.190","article-title":"Evaluation of Action Thresholds and Spinosad for Lepidopteran Pest Management in Minnesota Cabbage","volume":"94","author":"Hines","year":"2001","journal-title":"J. Econ. Entomol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib13","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1002\/anie.202004248","article-title":"Unlocking Nature's Biosynthetic Power\u2014Metabolic Engineering for the Fermentative Production of Chemicals","volume":"60","author":"Hoff","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib14","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1128\/AEM.00618-16","article-title":"High Level of Spinosad Production in the Heterologous Host Saccharopolyspora erythraea","volume":"82","author":"Huang","year":"2016","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2020.126623","article-title":"Enhanced amphotericin B production by genetically engineered Streptomyces nodosus","volume":"242","author":"Huang","year":"2021","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib16","doi-asserted-by":"crossref","first-page":"727","DOI":"10.14348\/molcells.2014.0168","article-title":"Metabolic Engineering of Rational Screened Saccharopolyspora spinosa for the Enhancement of Spinosyns A and D Production","volume":"37","author":"Jha","year":"2014","journal-title":"Mol. Cells"},{"key":"10.1016\/j.jbiotec.2024.10.010_bib17","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S1389-1723(99)80162-5","article-title":"Effect of soybean oil on oxygen transfer in the production of tetracycline with an airlift bioreactor","volume":"87","author":"Jia","year":"1999","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib18","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s12010-008-8500-0","article-title":"Enhanced Production of Spinosad in Saccharopolyspora spinosa by Genome Shuffling","volume":"159","author":"Jin","year":"2009","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib19","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1021\/acssynbio.9b00528","article-title":"Cofactor Engineering Redirects Secondary Metabolism and Enhances Erythromycin Production in Saccharopolyspora erythraea","volume":"9","author":"Li","year":"2020","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/s12934-023-02023-3","article-title":"Improving spinosad production by tuning expressions of the forosamine methyltransferase and the forosaminyl transferase to reduce undesired less active byproducts in the heterologous host Streptomyces albus J1074","volume":"22","author":"Li","year":"2023","journal-title":"Microb. Cell Factor."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ymben.2021.10.008","article-title":"Stepwise increase of thaxtomins production in Streptomyces albidoflavus J1074 through combinatorial metabolic engineering","volume":"68","author":"Li","year":"2021","journal-title":"Metab. Eng."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.copbio.2020.11.006","article-title":"Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces","volume":"69","author":"Li","year":"2021","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib23","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1111\/1751-7915.13965","article-title":"Multiplying the heterologous production of spinosad through tandem amplification of its biosynthetic gene cluster in Streptomyces coelicolor","volume":"15","author":"Li","year":"2021","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ymben.2022.04.002","article-title":"A butenolide signaling system synergized with biosynthetic gene modules led to effective activation and enhancement of silent oviedomycin production in Streptomyces","volume":"72","author":"Li","year":"2022","journal-title":"Metab. Eng."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00763-20","article-title":"Enhanced Triacylglycerol Metabolism Contributes to Efficient Oil Utilization and High-Level Production of Salinomycin in Streptomyces albus ZD11","volume":"86","author":"Li","year":"2020","journal-title":"Appl. Environ. Microbiol"},{"key":"10.1016\/j.jbiotec.2024.10.010_bib26","doi-asserted-by":"crossref","DOI":"10.1007\/s00284-022-02867-9","article-title":"Improvement of Rimocidin Biosynthesis by Increasing Supply of Precursor Malonyl-CoA via Over-expression of Acetyl-CoA Carboxylase in Streptomyces rimosus M527","volume":"79","author":"Liao","year":"2022","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib27","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s00253-021-11164-7","article-title":"Engineering of primary metabolic pathways for titer improvement of milbemycins in Streptomyces bingchenggensis","volume":"105","author":"Liu","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/s12934-021-01630-2","article-title":"Effects of acuC on the growth development and spinosad biosynthesis of Saccharopolyspora spinosa","volume":"20","author":"Liu","year":"2021","journal-title":"Microb. Cell Factor."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib29","doi-asserted-by":"crossref","first-page":"14660","DOI":"10.1021\/acs.jafc.0c04443","article-title":"RNA-Seq-Based Transcriptomic Analysis of Saccharopolyspora spinosa Revealed the Critical Function of PEP Phosphonomutase in the Replenishment Pathway","volume":"68","author":"Liu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib30","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.1038\/s41598-019-43223-5","article-title":"A novel multidomain acyl-CoA carboxylase in Saccharopolyspora erythraea provides malonyl-CoA for de novo fatty acid biosynthesis","volume":"9","author":"Livieri","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.872397","article-title":"Improving the Yield and Quality of Daptomycin in Streptomyces roseosporus by Multilevel Metabolic Engineering","volume":"13","author":"Lyu","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib32","doi-asserted-by":"crossref","first-page":"e00508","DOI":"10.1128\/AEM.00508-20","article-title":"<AccR, a TetR Family Transcriptional Repressor, Coordinates Short-Chain Acyl Coenzyme A Homeostasis in Streptomyces","volume":"86","author":"Lyu","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2024.108401","article-title":"Relieving metabolic burden to improve robustness and bioproduction by industrial microorganisms","volume":"74","author":"Mao","year":"2024","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib34","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1073\/pnas.1721203115","article-title":"Rewiring Yarrowia lipolytica toward triacetic acid lactone for materials generation","volume":"115","author":"Markham","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib35","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.3389\/fmicb.2017.01428","article-title":"Identification of FadAB Complexes Involved in Fatty Acid beta-Oxidation in Streptomyces coelicolor and Construction of a Triacylglycerol Overproducing strain","volume":"8","author":"Menendez-Bravo","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jbiotec.2024.10.010_bib36","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nbt1128","article-title":"Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes","volume":"23","author":"Menzella","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib37","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1099\/00221287-140-4-931","article-title":"Importance of stored triacylglycerols in Streptomyces: possible carbon source for antibiotics","volume":"140","author":"Olukoshi","year":"1994","journal-title":"Microbiology"},{"key":"10.1016\/j.jbiotec.2024.10.010_bib38","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ymben.2019.11.006","article-title":"Engineering 4-coumaroyl-CoA derived polyketide production in Yarrowia lipolytica through a beta-oxidation mediated strategy","volume":"57","author":"Palmer","year":"2020","journal-title":"Metab. Eng."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib39","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s10529-010-0481-8","article-title":"Improvement of spinosad production by overexpression of gtt and gdh controlled by promoter PermE* in Saccharopolyspora spinosa SIPI-A2090","volume":"33","author":"Pan","year":"2010","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib40","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02283-17","article-title":"Expanding Primary Metabolism Helps Generate the Metabolic Robustness To Facilitate Antibiotic Biosynthesis in Streptomyces","volume":"9","author":"Schniete","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.jbiotec.2024.10.010_bib41","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1007\/s00253-020-10564-5","article-title":"Fungal elicitor-induced transcriptional changes of genes related to branched-chain amino acid metabolism in Streptomyces natalensis HW-2","volume":"104","author":"Shen","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib42","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1021\/acssynbio.6b00330","article-title":"Heterologous Biosynthesis of Spinosad: An Omics-Guided Large Polyketide Synthase Gene Cluster Reconstitution in Streptomyces","volume":"6","author":"Tan","year":"2017","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib43","doi-asserted-by":"crossref","first-page":"12554","DOI":"10.1021\/acs.jafc.1c03654","article-title":"Comparative Proteomics Reveals the Effect of the Transcriptional Regulator Sp13016 on Butenyl-Spinosyn Biosynthesis in Saccharopolyspora pogona","volume":"69","author":"Tang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib44","doi-asserted-by":"crossref","DOI":"10.1186\/s12934-021-01651-x","article-title":"Bacterioferritin: a key iron storage modulator that affects strain growth and butenyl-spinosyn biosynthesis in Saccharopolyspora pogona","volume":"20","author":"Tang","year":"2021","journal-title":"Microb. Cell Factor."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/fishes7030140","article-title":"Conversion of Fishery Waste to Proteases by Streptomyces speibonae and Their Application in Antioxidant Preparation","volume":"7","author":"Tran","year":"2022","journal-title":"Fishes"},{"key":"10.1016\/j.jbiotec.2024.10.010_bib46","article-title":"Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus via metabolic engineering","volume":"12","author":"Virolle","year":"2017","journal-title":"Plos One"},{"key":"10.1016\/j.jbiotec.2024.10.010_bib47","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1023\/A:1010289901631","article-title":"A cluster of genes for the biosynthesis of spinosyns, novel macrolide insect control agents produced by Saccharopolyspora spinosa","volume":"78","author":"Waldron","year":"2000","journal-title":"Antonie Van. Leeuwenhoek"},{"key":"10.1016\/j.jbiotec.2024.10.010_bib48","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1074-5521(01)00029-1","article-title":"Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa","volume":"8","author":"Waldron","year":"2001","journal-title":"Chem. Biol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41587-019-0335-4","article-title":"Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces","volume":"38","author":"Wang","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib50","article-title":"Increasing the Ascomycin Yield by Relieving the Inhibition of Acetyl\/Propionyl-CoA Carboxylase by the Signal Transduction Protein GlnB","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tibtech.2014.10.009","article-title":"Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes","volume":"33","author":"Weber","year":"2015","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib52","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1111\/1751-7915.14145","article-title":"Salinomycin biosynthesis reversely regulates the \u03b2-oxidation pathway in Streptomyces albus by carrying a 3-hydroxyacyl-CoA dehydrogenase gene in its biosynthetic gene cluster","volume":"15","author":"Wei","year":"2022","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib53","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02298-21","article-title":"Polyketide Starter and Extender Units Serve as Regulatory Ligands to Coordinate the Biosynthesis of Antibiotics in Actinomycetes","volume":"12","author":"Wu","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.jbiotec.2024.10.010_bib54","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12934-021-01660-w","article-title":"Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis","volume":"20","author":"Wu","year":"2021","journal-title":"Micro Cell Fact."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib55","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bej.2013.01.007","article-title":"Stepwise increase of spinosad production in Saccharopolyspora spinosa by metabolic engineering","volume":"72","author":"Xue","year":"2013","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib56","article-title":"A New Medium for Improving Spinosad Production by Saccharopolyspora spinosa","volume":"9","author":"Yang","year":"2016","journal-title":"Jundishapur J. Microbiol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib57","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ymben.2015.03.018","article-title":"Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products","volume":"29","author":"Yang","year":"2015","journal-title":"Metab. Eng."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib58","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10295-018-2024-6","article-title":"Production of pikromycin using branched chain amino acid catabolism in Streptomyces venezuelae ATCC 15439","volume":"45","author":"Yi","year":"2018","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib59","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jbiotec.2019.10.020","article-title":"Engineering Streptomyces coelicolor for production of monomethyl branched chain fatty acids","volume":"307","author":"Yi","year":"2020","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib60","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1021\/acssynbio.8b00396","article-title":"Precursor Supply for Erythromycin Biosynthesis: Engineering of Propionate Assimilation Pathway Based on Propionylation Modification","volume":"8","author":"You","year":"2019","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib61","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ymben.2013.10.002","article-title":"Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus","volume":"20","author":"Zabala","year":"2013","journal-title":"Metab. Eng."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib62","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000477543","article-title":"Heterologous Expression of Spinosyn Biosynthetic Gene Cluster in Streptomyces Species Is Dependent on the Expression of Rhamnose Biosynthesis Genes","volume":"27","author":"Zhao","year":"2017","journal-title":"Microb. Physiol."},{"key":"10.1016\/j.jbiotec.2024.10.010_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22235-8","article-title":"Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor","volume":"12","author":"Zou","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165624002736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165624002736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T01:04:06Z","timestamp":1732410246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165624002736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":63,"alternative-id":["S0168165624002736"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2024.10.010","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combinatorial metabolic engineering strategy of precursor pools for the yield improvement of spinosad in Saccharopolyspora spinosa","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2024.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}