{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:13:33Z","timestamp":1778732013445,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002464","name":"Daegu Haany University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience &amp; Biotechnology","doi-asserted-by":"publisher","award":["KGM1052612"],"award-info":[{"award-number":["KGM1052612"]}],"id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jbiotec.2026.04.006","type":"journal-article","created":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T17:00:11Z","timestamp":1776013211000},"page":"145-151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ethyl acetate extract of Lactococcus lactis KR-050L suppresses IL-6\/STAT3 signaling in Hep3B cells and alleviates DSS-induced colitis in mice"],"prefix":"10.1016","volume":"415","author":[{"given":"Seon-Gyeong","family":"Bak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisansala","family":"Chandimali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5234-2537","authenticated-orcid":false,"given":"Jaehoon","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Sung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Woong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jae","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Jin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong-Seon","family":"Won","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mun Chual","family":"Rho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbiotec.2026.04.006_bib1","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s42770-023-00928-0","article-title":"Immunomodulatory effects of different strains of Lactococcus lactis in DSS-induced colitis","volume":"54","author":"Alves","year":"2023","journal-title":"Braz. J. Microbiol"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib2","article-title":"Treatment of inflammatory bowel disease: a comprehensive review","volume":"8","author":"Cai","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13020305","article-title":"Novel insights into the pathogenesis of inflammatory bowel diseases","volume":"13","author":"Calvez","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137062","article-title":"Inflammatory bowel disease: a comprehensive analysis of molecular bases, predictive biomarkers, diagnostic methods, and therapeutic options","author":"Diez-Martin","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbiotec.2026.04.006_bib5","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1053\/j.gastro.2007.06.018","article-title":"Prevention and treatment of colitis with <em>Lactococcus lactis<\/em> secreting the immunomodulatory <em>Yersinia<\/em> LcrV protein","volume":"133","author":"Foligne","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib6","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1242\/jcs.195552","article-title":"A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells","volume":"130","author":"Goicoechea","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jbiotec.2026.04.006_bib7","doi-asserted-by":"crossref","DOI":"10.1177\/2040622319899297","article-title":"Emerging treatments for inflammatory bowel disease","volume":"11","author":"Hazel","year":"2020","journal-title":"Ther. Adv. Chronic Dis."},{"key":"10.1016\/j.jbiotec.2026.04.006_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2016.05.001","article-title":"STAT3 signaling in immunity","volume":"31","author":"Hillmer","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jbiotec.2026.04.006_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/jam.13444","article-title":"Lactococcus lactis KR-050L inhibit IL-6\/STAT3 activation","volume":"122","author":"Hwang","year":"2017","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.jbiotec.2026.04.006_bib10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/jam.14116","article-title":"Lactococcus lactis KR-050L extract suppresses house dust mite induced-atopic skin inflammation through inhibition of keratinocyte and mast cell activation","volume":"126","author":"Jin","year":"2019","journal-title":"J. Appl. Microbiol"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens8030126","article-title":"Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome","volume":"8","author":"Khan","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012445","article-title":"Etiology of IBD-is it still a mystery?","volume":"23","author":"Kofla-D\u0142ubacz","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jbiotec.2026.04.006_bib13","article-title":"Lactic acid bacteria\u2013gut-microbiota-mediated intervention towards inflammatory bowel disease","author":"Li","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib14","article-title":"Lactic acid bacteria-gut-microbiota-mediated intervention towards inflammatory bowel disease","volume":"12","author":"Li","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1757-4749-6-33","article-title":"Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically induced colitis","volume":"6","author":"Luerce","year":"2014","journal-title":"Gut Pathog."},{"key":"10.1016\/j.jbiotec.2026.04.006_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cells12010184","article-title":"Probiotics mechanism of action on immune cells and beneficial effects on human health","volume":"12","author":"Mazziotta","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijwd.2020.01.009","article-title":"Sulfasalazine in dermatology: a lesser explored drug with broad therapeutic potential","volume":"6","author":"Mushtaq","year":"2020","journal-title":"Int. J. Women's. Dermatol."},{"key":"10.1016\/j.jbiotec.2026.04.006_bib18","article-title":"Advancements in inflammatory bowel disease: a narrative review of Diagnostics, Management, Epidemiology, Prevalence, patient outcomes, quality of life, and clinical presentation","volume":"15","author":"Muzammil","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jadohealth.2014.04.012","article-title":"The role of neighborhood income inequality in adolescent aggression and violence","volume":"55","author":"Pabayo","year":"2014","journal-title":"J. Adolesc. Health"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib20","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1053\/j.gastro.2020.05.060","article-title":"AGA technical review on the role of probiotics in the management of gastrointestinal disorders","volume":"159","author":"Preidis","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/foods13244097","article-title":"Probiotic microorganisms in inflammatory bowel diseases: live biotherapeutics as food","author":"Santos","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.jbiotec.2026.04.006_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4014\/jmb.1907.07050","article-title":"<em>Lactobacillus sakei<\/em> S1 improves colitis induced by 2,4,6-trinitrobenzene sulfonic acid by the inhibition of NF-\u03baB signaling in mice","volume":"30","author":"Se-Eun","year":"2020","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jbiotec.2026.04.006_bib23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12974-021-02317-6","article-title":"DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod","volume":"18","author":"Talley","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.jbiotec.2026.04.006_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/nu13103319","article-title":"Lactobacillus rhamnosus GG derived extracellular vesicles modulate gut microbiota and attenuate inflammatory in DSS-induced colitis mice","volume":"13","author":"Tong","year":"2021","journal-title":"Nutrients"}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165626001136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165626001136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:37:10Z","timestamp":1778729830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165626001136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":24,"alternative-id":["S0168165626001136"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2026.04.006","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethyl acetate extract of Lactococcus lactis KR-050L suppresses IL-6\/STAT3 signaling in Hep3B cells and alleviates DSS-induced colitis in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2026.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}