{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:45:17Z","timestamp":1785879917599,"version":"3.56.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20270"],"award-info":[{"award-number":["U23A20270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304369"],"award-info":[{"award-number":["82304369"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32401271"],"award-info":[{"award-number":["32401271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["252300421678"],"award-info":[{"award-number":["252300421678"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biotechnology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jbiotec.2026.06.009","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T19:25:32Z","timestamp":1781205932000},"page":"202-214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["7,8-Dihydroxyflavone enhances recombinant proteins expression in CHO cells by modulating SIRT1 signalling to improve mitochondrial respiratory capacity and redox homeostasis"],"prefix":"10.1016","volume":"417","author":[{"given":"Mengjun","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunliu","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolei","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jbiotec.2026.06.009_bib1","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s11095-014-1541-x","article-title":"Small amounts of sub-visible aggregates enhance the immunogenic potential of monoclonal antibody therapeutics","volume":"32","author":"Ahmadi","year":"2015","journal-title":"Pharm. Res."},{"issue":"4","key":"10.1016\/j.jbiotec.2026.06.009_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/bit.10096","article-title":"Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control","volume":"76","author":"Altamirano","year":"2001","journal-title":"Biotech. & Bioeng."},{"issue":"5","key":"10.1016\/j.jbiotec.2026.06.009_bib3","doi-asserted-by":"crossref","first-page":"F551","DOI":"10.1152\/ajprenal.00218.2014","article-title":"ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease","volume":"307","author":"Beck Gooz","year":"2014","journal-title":"Am. J. Physiol. -Ren. Physiol."},{"issue":"2","key":"10.1016\/j.jbiotec.2026.06.009_bib4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/antib9020022","article-title":"Principles of N-linked glycosylation variations of IgG-based therapeutics: pharmacokinetic and functional considerations","volume":"9","author":"Boune","year":"2020","journal-title":"Antibodies"},{"issue":"1","key":"10.1016\/j.jbiotec.2026.06.009_bib5","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1080\/14756366.2020.1758691","article-title":"Biochemical Mechanism and Biological Effects of the Inhibition of Silent Information Regulator 1 (SIRT1) by EX-527 (SEN0014196 or Selisistat)","volume":"35","author":"Broussy","year":"2020","journal-title":"J. Enzym. Inhib. Med. Chem."},{"issue":"9","key":"10.1016\/j.jbiotec.2026.06.009_bib6","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/bit.26724","article-title":"Improving Culture Performance and Antibody Production in CHO Cell Culture Processes by Reducing the Warburg Effect","volume":"115","author":"Buchsteiner","year":"2018","journal-title":"Biotech. & Bioeng."},{"issue":"1","key":"10.1016\/j.jbiotec.2026.06.009_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23602","article-title":"7,8-dihydroxyflavone Displayed Antioxidant Effect through Activating HO-1 Expression and Inhibiting Caspase-3\/PARP Activation in RAW264.7 Cells","volume":"38","author":"Chen","year":"2024","journal-title":"J. Biochem. &amp Mol. Tox"},{"issue":"1","key":"10.1016\/j.jbiotec.2026.06.009_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23602","article-title":"7,8-dihydroxyflavone Displayed Antioxidant Effect through Activating HO-1 Expression and Inhibiting Caspase-3\/PARP Activation in RAW264.7 Cells","volume":"38","author":"Chen","year":"2024","journal-title":"J. Biochem. &amp Mol. Tox"},{"key":"10.1016\/j.jbiotec.2026.06.009_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111215","article-title":"SIRT1 and Aging Related Signaling Pathways","volume":"187","author":"Chen","year":"2020","journal-title":"Mech. Ageing Dev."},{"issue":"4","key":"10.1016\/j.jbiotec.2026.06.009_bib10","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/bit.27247","article-title":"Oxidative Stress-alleviating Strategies to Improve Recombinant Protein Production in CHO Cells","volume":"117","author":"Chevallier","year":"2020","journal-title":"Biotech. & Bioeng."},{"issue":"12","key":"10.1016\/j.jbiotec.2026.06.009_bib11","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.3390\/cells11121929","article-title":"Metabolic Profiling of CHO Cells during the Production of Biotherapeutics","volume":"11","author":"Coulet","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jbiotec.2026.06.009_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.943321","article-title":"Therapeutic Application of Quercetin in Aging-Related Diseases: SIRT1 as a Potential Mechanism","volume":"13","author":"Cui","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jbiotec.2026.06.009_bib13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/metabo11060344","article-title":"Hyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower","volume":"11","author":"Da Veiga Moreira","year":"2021","journal-title":"Metabolites"},{"issue":"3","key":"10.1016\/j.jbiotec.2026.06.009_bib14","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1021\/acs.analchem.7b04608","article-title":"Capillary Isoelectric Focusing-Mass Spectrometry Method for the Separation and Online Characterization of Intact Monoclonal Antibody Charge Variants","volume":"90","author":"Dai","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jbiotec.2026.06.009_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jbiotec.2024.06.005","article-title":"Molecular Biomarkers Identification and Applications in CHO Bioprocessing","volume":"392","author":"Desmurget","year":"2024","journal-title":"J. Biotechnol."},{"issue":"10","key":"10.1016\/j.jbiotec.2026.06.009_bib16","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1002\/bit.25620","article-title":"A Multi-pronged Investigation into the Effect of Glucose Starvation and Culture Duration on Fed-batch CHO Cell Culture","volume":"112","author":"Fan","year":"2015","journal-title":"Biotech. & Bioeng."},{"key":"10.1016\/j.jbiotec.2026.06.009_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s00253-016-7348-4","article-title":"Regulation of Cell Growth and Apoptosis through Lactate Dehydrogenase C Over-Expression in Chinese Hamster Ovary Cells","author":"Fu","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"6","key":"10.1016\/j.jbiotec.2026.06.009_bib18","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/bit.23072","article-title":"High-End pH-controlled Delivery of Glucose Effectively Suppresses Lactate Accumulation in CHO Fed-batch Cultures","volume":"108","author":"Gagnon","year":"2011","journal-title":"Biotech. & Bioeng."},{"issue":"7","key":"10.1016\/j.jbiotec.2026.06.009_bib19","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/bit.23075","article-title":"Modulation of Antibody Galactosylation through Feeding of Uridine, Manganese Chloride, and Galactose","volume":"108","author":"Gramer","year":"2011","journal-title":"Biotech. &amp Bioeng."},{"issue":"1","key":"10.1016\/j.jbiotec.2026.06.009_bib20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/bit.26460","article-title":"Intracellular Response to Process Optimization and Impact on Productivity and Product Aggregates for a High-titer CHO Cell Process","volume":"115","author":"Handlogten","year":"2018","journal-title":"Biotech. & Bioeng."},{"issue":"8","key":"10.1016\/j.jbiotec.2026.06.009_bib21","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/bit.26603","article-title":"Mechanisms Driving the Lactate Switch in Chinese Hamster Ovary Cells","volume":"115","author":"Hartley","year":"2018","journal-title":"Biotech. & Bioeng."},{"issue":"8","key":"10.1016\/j.jbiotec.2026.06.009_bib22","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/bit.26603","article-title":"Mechanisms Driving the Lactate Switch in Chinese Hamster Ovary Cells","volume":"115","author":"Hartley","year":"2018","journal-title":"Biotech. & Bioeng."},{"issue":"4","key":"10.1016\/j.jbiotec.2026.06.009_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153002","article-title":"Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-Gallate: A Potential Mechanism for the Formation of Innate Antigens by Antioxidants","volume":"11","author":"Hatasa","year":"2016","journal-title":"PLoS. ONE"},{"issue":"6","key":"10.1016\/j.jbiotec.2026.06.009_bib24","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/btpr.1968","article-title":"Cell Culture Media Supplementation of Uncommonly Used Sugars Sucrose and Tagatose for the Targeted Shifting of Protein Glycosylation Profiles of Recombinant Protein Therapeutics","volume":"30","author":"Hossler","year":"2014","journal-title":"Biotechnol. Progress."},{"key":"10.1016\/j.jbiotec.2026.06.009_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jbiotec.2014.08.026","article-title":"Evaluating the Impact of Cell Culture Process Parameters on Monoclonal Antibody N-Glycosylation","volume":"188","author":"Ivarsson","year":"2014","journal-title":"J. Biotechnol."},{"issue":"4","key":"10.1016\/j.jbiotec.2026.06.009_bib26","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/btpr.2421","article-title":"Intracellular CHO Cell Metabolite Profiling Reveals Steady-State Dependent Metabolic Fingerprints in Perfusion Culture","volume":"33","author":"Karst","year":"2017","journal-title":"Biotechnol. Progress."},{"issue":"7731","key":"10.1016\/j.jbiotec.2026.06.009_bib27","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41586-018-0645-6","article-title":"De Novo NAD+ Synthesis Enhances Mitochondrial Function and Improves Health","volume":"563","author":"Katsyuba","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jbiotec.2026.06.009_bib28","author":"Kirsch","year":"2021","journal-title":"Metab. Anal. Asparagine Glutamine Dyn. Ind. CHO Fed. -Batch Process."},{"issue":"22","key":"10.1016\/j.jbiotec.2026.06.009_bib29","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.3390\/cells12222661","article-title":"Chemical and Genetic Modulation of Complex I of the Electron Transport Chain Enhances the Biotherapeutic Protein Production Capacity of CHO Cells","volume":"12","author":"Kretzmer","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jbiotec.2026.06.009_bib30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.freeradbiomed.2024.08.014","article-title":"7,8-DHF Inhibits BMSC Oxidative Stress via the TRKB\/PI3K\/AKT\/NRF2 Pathway to Improve Symptoms of Postmenopausal Osteoporosis","volume":"223","author":"Li","year":"2024","journal-title":"Free. Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.jbiotec.2026.06.009_bib31","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202255387","article-title":"XAF1 Prevents Hyperproduction of Type I Interferon upon Viral Infection by Targeting IRF7","volume":"24","author":"Liu","year":"2023","journal-title":"EMBO Rep."},{"issue":"7","key":"10.1016\/j.jbiotec.2026.06.009_bib32","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s11274-015-1864-8","article-title":"Galactose Supplementation Enhance Sialylation of Recombinant Fc-Fusion Protein in CHO Cell: An Insight into the Role of Galactosylation in Sialylation","volume":"31","author":"Liu","year":"2015","journal-title":"World J. Microbiol. Biotechnol."},{"issue":"2","key":"10.1016\/j.jbiotec.2026.06.009_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.14348\/molcells.2016.2318","article-title":"Sirt1 and the Mitochondria","volume":"39","author":"Luen Tang","year":"2016","journal-title":"Mol. Cells"},{"issue":"1","key":"10.1016\/j.jbiotec.2026.06.009_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/biot.202300397","article-title":"Rosmarinic Acid Enhances CHO Cell Productivity and Proliferation through Activation of the Unfolded Protein Response and the mTOR Pathway","volume":"19","author":"Mao","year":"2024","journal-title":"Biotechnol. J."},{"issue":"2","key":"10.1016\/j.jbiotec.2026.06.009_bib35","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/bit.24728","article-title":"Flux Balance Analysis of CHO Cells before and after a Metabolic Switch from Lactate Production to Consumption","volume":"110","author":"Mart\u00ednez","year":"2013","journal-title":"Biotech. & Bioeng."},{"issue":"23","key":"10.1016\/j.jbiotec.2026.06.009_bib36","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1016\/j.molcel.2024.11.004","article-title":"Reactive Oxygen Species Control Protein Degradation at the Mitochondrial Import Gate","volume":"84","author":"McMinimy","year":"2024","journal-title":"Mol. Cell."},{"issue":"3","key":"10.1016\/j.jbiotec.2026.06.009_bib37","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jhep.2016.10.023","article-title":"PARP Inhibition Protects against Alcoholic and Non-Alcoholic Steatohepatitis","volume":"66","author":"Mukhopadhyay","year":"2017","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.jbiotec.2026.06.009_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121561","article-title":"Multiplicity of Steady States in Glycolysis and Shift of Metabolic State in Cultured Mammalian Cells","volume":"10","author":"Mulukutla","year":"2015","journal-title":"PLoS. ONE"},{"issue":"12","key":"10.1016\/j.jbiotec.2026.06.009_bib39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.31083\/j.fbl2912402","article-title":"The Warburg Effect: Is It Always an Enemy?","volume":"29","author":"Papaneophytou","year":"2024","journal-title":"Front. Biosci. (Landmark Ed."},{"key":"10.1016\/j.jbiotec.2026.06.009_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136671","article-title":"7,8-DHF Enhances SHH in the Hippocampus and Striatum during Early Abstinence but Has Minor Effects on Alcohol Intake in IA2BC Paradigm and Abstinence-Related Anxiety-like Behavior in Rats","volume":"781","author":"Peregud","year":"2022","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.jbiotec.2026.06.009_bib41","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1124\/mol.111.073916","article-title":"Pharmacological Effects of Exogenous NAD on Mitochondrial Bioenergetics, DNA Repair, and Apoptosis","volume":"80","author":"Pittelli","year":"2011","journal-title":"Mol. Pharmacol."},{"issue":"7","key":"10.1016\/j.jbiotec.2026.06.009_bib42","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bbamcr.2010.09.019","article-title":"Metabolic Control of Mitochondrial Biogenesis through the PGC-1 Family Regulatory Network","volume":"1813","author":"Scarpulla","year":"2011","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"issue":"1","key":"10.1016\/j.jbiotec.2026.06.009_bib43","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/bit.22890","article-title":"Metabolic Flux Analysis of CHO Cell Metabolism in the Late Non-growth Phase","volume":"108","author":"Sengupta","year":"2011","journal-title":"Biotech. & Bioeng."},{"key":"10.1016\/j.jbiotec.2026.06.009_bib44","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3389\/fneur.2018.00552","article-title":"KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts","volume":"9","author":"Seo","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jbiotec.2026.06.009_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113170","article-title":"Salidroside Prevents PM2.5-Induced BEAS-2B Cell Apoptosis via SIRT1-Dependent Regulation of ROS and Mitochondrial Function","volume":"231","author":"Shan","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.jbiotec.2026.06.009_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5753139","article-title":"Antioxidant and DNA Repair Stimulating Effect of Extracts from Transformed and Normal Roots of Rhaponticum Carthamoides against Induced Oxidative Stress and DNA Damage in CHO Cells","volume":"2016","author":"Ska\u0142a","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jbiotec.2026.06.009_bib47","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.phrs.2017.11.011","article-title":"Role of P-MKK7 in Myricetin-Induced Protection against Intestinal Ischemia\/Reperfusion Injury","volume":"129","author":"Sun","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jbiotec.2026.06.009_bib48","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2020.8590","article-title":"PM2.5 Induces Apoptosis, Oxidative Stress Injury and Melanin Metabolic Disorder in Human Melanocytes","author":"Suo","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.jbiotec.2026.06.009_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/biot.201800332","article-title":"Pyruvate Kinase Muscle-1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case Study","volume":"14","author":"Tang","year":"2019","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.jbiotec.2026.06.009_bib50","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ymben.2014.06.010","article-title":"The Impact of Anti-Apoptotic Gene Bcl-2\u2206 Expression on CHO Central Metabolism","volume":"25","author":"Templeton","year":"2014","journal-title":"Metab. Eng."},{"issue":"4","key":"10.1016\/j.jbiotec.2026.06.009_bib51","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jphs.2019.02.008","article-title":"Pretreatment with Tilianin Improves Mitochondrial Energy Metabolism and Oxidative Stress in Rats with Myocardial Ischemia\/Reperfusion Injury via AMPK\/SIRT1\/PGC-1 Alpha Signaling Pathway","volume":"139","author":"Tian","year":"2019","journal-title":"J. Pharmacol. Sci."},{"issue":"8","key":"10.1016\/j.jbiotec.2026.06.009_bib52","doi-asserted-by":"crossref","first-page":"13689","DOI":"10.3390\/molecules200813689","article-title":"Glycoprotein Quality Control and Endoplasmic Reticulum Stress","volume":"20","author":"Wang","year":"2015","journal-title":"Molecules"},{"issue":"24","key":"10.1016\/j.jbiotec.2026.06.009_bib53","doi-asserted-by":"crossref","first-page":"10343","DOI":"10.1007\/s00253-016-7749-4","article-title":"Elucidating the Effects of pH Shift on IgG1 Monoclonal Antibody Acidic Charge Variant Levels in Chinese Hamster Ovary Cell Cultures","volume":"100","author":"Xie","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.jbiotec.2026.06.009_bib54","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-020-00311-7","article-title":"NAD+ Metabolism: Pathophysiologic Mechanisms and Therapeutic Potential","volume":"5","author":"Xie","year":"2020","journal-title":"Sig Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.jbiotec.2026.06.009_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/btpr.3447","article-title":"Catechins prevent monoclonal antibody fragmentation during production via Fed-batch culture of C Hinese hamster ovary cells","volume":"40","author":"Yamaguchi","year":"2024","journal-title":"Biotechnol. Progress."},{"issue":"3","key":"10.1016\/j.jbiotec.2026.06.009_bib56","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2174\/1389201023666220603121316","article-title":"Factors and mechanisms affecting the secretion of recombinant proteinin CHO cells","volume":"24","author":"Yang","year":"2023","journal-title":"CPB"},{"issue":"4","key":"10.1016\/j.jbiotec.2026.06.009_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/btpr.2975","article-title":"Feeding tricarboxylic acid cycle intermediates improves lactate consumption and antibody production in chinese hamster ovary cell cultures","volume":"36","author":"Zhang","year":"2020","journal-title":"Biotechnol. Progress."},{"issue":"18","key":"10.1016\/j.jbiotec.2026.06.009_bib58","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.7150\/thno.45922","article-title":"Mitochondrial Sirtuin 3: new emerging biological function and therapeutic target","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jbiotec.2026.06.009_bib59","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2017.02.027","article-title":"Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1\/AMPK signaling pathway","volume":"348","author":"Zhao","year":"2017","journal-title":"Neuroscience"}],"container-title":["Journal of Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165626001872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168165626001872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:56:10Z","timestamp":1785876970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168165626001872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":59,"alternative-id":["S0168165626001872"],"URL":"https:\/\/doi.org\/10.1016\/j.jbiotec.2026.06.009","relation":{},"ISSN":["0168-1656"],"issn-type":[{"value":"0168-1656","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"7,8-Dihydroxyflavone enhances recombinant proteins expression in CHO cells by modulating SIRT1 signalling to improve mitochondrial respiratory capacity and redox homeostasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbiotec.2026.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}